Quantitative prediction of in vivo drug-drug interactions from in vitro data based on physiological pharmacokinetics: use of maximum unbound concentration of inhibitor at the inlet to the liver.

Use of In Vitro and In Vivo Data to Estimate the Likelihood of Metabolic Pharmacokinetic Interactions

1997 • 755 citations

Prediction of pharmacokinetic alterations caused by drug-drug interactions: metabolic interaction in the liver.

1998 • 497 citations

Methotrexate Pharmacokinetics

1971 • 481 citations

Animal scale-up

1973 • 389 citations

QUANTITATIVE PREDICTION OF IN VIVO DRUG CLEARANCE AND DRUG INTERACTIONS FROM IN VITRO DATA ON METABOLISM, TOGETHER WITH BINDING AND TRANSPORT

1998 • 280 citations

SULPHAPHENAZOLE-INDUCED HYPOGLYCÆMIC ATTACKS IN TOLBUTAMIDE-TREATED DIABETICS

1963 • 198 citations

Tolbutamide hydroxylation by human liver microsomes

1988 • 198 citations

In Vitro Approaches to Predicting Drug Interactions In Vivo

1998 • 196 citations

The Metabolic Fate of Tolbutamide in Man and in the Rat

1966 • 137 citations

Validation of the tolbutamide metabolic ratio for population screening with use of sulfaphenazole to produce model phenotypic poor metabolizers

1990 • 107 citations

Kinetics of carboxytolbutamide excretion following tolbutamide and carboxytolbutamide administration.

1961 • 42 citations

Prediction of drug-drug interaction from In vitro plasma protein binding and metabolism

1981 • 32 citations

Computer simulation of sulfobromophthalein kinetics in the rat using flow-limited models with extrapolation to man

1975 • 29 citations

Lack of relationship between tolbutamide metabolism and debrisoquine oxidation phenotype

1987 • 24 citations

Genetic factors influencing the metabolism of tolbutamide

1989 • 21 citations

Effect of Sulfaphenazole on Tolbutamide Distribution in Rabbits: Analysis of Interspecies Differences in Tissue Distribution of Tolbutamide

1984 • 17 citations

High pressure liquid chromatographic analysis and preliminary pharmacokinetics of sulfaphenazole and its N2-glucuronide and N4-acetyl metabolites in plasma and urine of man

1990 • 15 citations

Kinetic analysis of tolbutamide-sulfonamide interaction in rabbits based on clearance concept. Prediction of species difference from in vitro plasma protein binding and metabolism.

1984 • 15 citations