Substantial pharmacokinetic interaction between digoxin and ritonavir in healthy volunteers*1

Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues.

1987 • 2,788 citations

Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver

2001 • 722 citations

Reservoirs for HIV-1: Mechanisms for Viral Persistence in the Presence of Antiviral Immune Responses and Antiretroviral Therapy

2000 • 528 citations

Localization and Genomic Organization of a New Hepatocellular Organic Anion Transporting Polypeptide

2000 • 516 citations

Ritonavir

1998 • 472 citations

Inhibition of P-Glycoprotein–Mediated Drug Transport

1999 • 395 citations

Pharmacological inhibition of P-glycoprotein transport enhances the distribution of HIV-1 protease inhibitors into brain and testes.

2000 • 384 citations

Drugs as P-glycoprotein substrates, inhibitors, and inducers

2002 • 364 citations

Xenobiotic Transport across Isolated Brain Microvessels Studied by Confocal Microscopy

2000 • 310 citations

Inhibition of P-Glycoprotein by Newer Antidepressants

2003 • 290 citations

Protease Inhibitors as Inhibitors of Human Cytochromes P450: High Risk Associated with Ritonavir

1998 • 252 citations

Effect of clarithromycin on renal excretion of digoxin: Interaction with P-glycoprotein*

1998 • 201 citations

HIV protease inhibitor ritonavir: a more potent inhibitor of P-glycoprotein than the cyclosporine analog SDZ PSC 833

1999 • 184 citations

Interactions of HIV Protease Inhibitors with ATP-Dependent Drug Export Proteins

1999 • 181 citations

Digoxin-verapamil interaction

1981 • 177 citations

P-Glycoprotein Limits Oral Availability, Brain, and Fetal Penetration of Saquinavir Even with High Doses of Ritonavir

2001 • 171 citations

The MDR1 gene product, P-glycoprotein, mediates the transport of the cardiac glycoside, digoxin

1992 • 171 citations

P‐glycoprotein‐mediated intestinal and biliary digoxin transport in humans

2003 • 156 citations

Human Immunodeficiency Virus Protease Inhibitors Serve as Substrates for Multidrug Transporter Proteins MDR1 and MRP1 but Retain Antiviral Efficacy in Cell Lines Expressing These Transporters

1998 • 146 citations

Contribution of increased oral bioavailability and reduced nonglomerular renal clearance of digoxin to the digoxin–clarithromycin interaction

2003 • 138 citations

Pharmacokinetics of digoxin in normal subjects after intravenous bolus and infusion doses

1975 • 125 citations

By-passing of P-glycoprotein Using Immunoliposomes

2002 • 123 citations

Assessment of active transport of HIV protease inhibitors in various cell lines and the in vitro blood–brain barrier

2001 • 120 citations

Role of P-glycoprotein in renal tubular secretion of digoxin in the isolated perfused rat kidney.

1993 • 107 citations

Determinants of the renal clearance of digoxin

1975 • 80 citations

The protease inhibitor ritonavir inhibits the functional activity of the multidrug resistance related-protein 1 (MRP-1)

2002 • 80 citations

Pharmacokinetics of Digoxin and Main Metabolites/Derivatives in Healthy Humans

1991 • 75 citations

Drug Interactions at the Renal Level

1998 • 74 citations

Interactions of HIV protease inhibitors with a human organic cation transporter in a mammalian expression system.

2000 • 74 citations

Pharmacokinetics of digoxin in patients subjected to the quinidine‐ digoxin interaction.

1981 • 72 citations

Digoxin pharmacokinetics: multicompartmental analysis and its clinical implications.

1976 • 70 citations

Longitudinal assessment of a P-glycoprotein?mediated drug interaction of valspodar on digoxin

1999 • 63 citations

The influence of efavirenz on the pharmacokinetics of a twice‐daily combination of indinavir and low‐dose ritonavir in healthy Volunteers

2002 • 61 citations

Digoxin-quinidine interaction

1980 • 59 citations

Resolution of P‐glycoprotein and non‐P‐glycoprotein effects on drug permeability using intestinal tissues from mdr1a (−/−) mice

2002 • 51 citations

Ritonavir increases loperamide plasma concentrations without evidence for P‐glycoprotein involvement

2001 • 51 citations

Toxic digoxin-drug interactions: the major role of renal P-glycoprotein.

1998 • 49 citations

Reduction of digoxin-induced inotropism during quinidine administration

1980 • 48 citations

Evidence for a non-MDR1 component in digoxin secretion by human intestinal Caco-2 epithelial layers

2002 • 44 citations

Effect of quinine on digoxin kinetics

1980 • 40 citations

Interactions between digoxin and potassium-sparing diuretics

1983 • 33 citations

Effect of Clarithromycin on Steady-State Digoxin Concentrations

2003 • 30 citations

Quinidine-digoxin interaction: are the pharmacokinetics of both drugs altered?

1985 • 23 citations

Effects of quinidine on the renal tubular and biliary transport of digoxin: in vivo and in vitro studies in the dog.

1988 • 11 citations

Pitfalls in, and new methods for, the radioimmunoassay for digoxin in urine.

1985 • 4 citations