Tumor Induction of VEGF Promoter Activity in Stromal Cells

Patterns and Emerging Mechanisms of the Angiogenic Switch during Tumorigenesis

1996 • 6,878 citations

Mechanisms of angiogenesis

1997 • 5,696 citations

Tight control of gene expression in mammalian cells by tetracycline-responsive promoters.

1992 • 4,885 citations

Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis

1992 • 4,631 citations

The Biology of Vascular Endothelial Growth Factor

1997 • 4,359 citations

Tumors: Wounds That Do Not Heal

1986 • 4,202 citations

Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo

1993 • 3,605 citations

Vascular permeability factor/vascular endothelial growth factor, microvascular hyperpermeability, and angiogenesis.

1995 • 3,139 citations

FACS-optimized mutants of the green fluorescent protein (GFP)

1996 • 2,539 citations

The human gene for vascular endothelial growth factor. Multiple protein forms are encoded through alternative exon splicing

1991 • 1,991 citations

Antiangiogenic therapy of experimental cancer does not induce acquired drug resistance

1997 • 1,705 citations

Interstitial pH and pO2 gradients in solid tumors in vivo: High-resolution measurements reveal a lack of correlation

1997 • 1,590 citations

Engineering green fluorescent protein for improved brightness, longer wavelengths and fluorescence resonance energy transfer

1996 • 1,462 citations

Transcriptional Regulation of the Rat Vascular Endothelial Growth Factor Gene by Hypoxia

1995 • 1,087 citations

Vascular permeability factor (vascular endothelial growth factor) gene is expressed differentially in normal tissues, macrophages, and tumors.

1992 • 900 citations

Expression of vascular permeability factor (vascular endothelial growth factor) by epidermal keratinocytes during wound healing.

1992 • 880 citations

Regulation of Vascular Endothelial Growth Factor Expression in Cultured Keratinocytes.

1995 • 764 citations

Post-transcriptional Regulation of Vascular Endothelial Growth Factor by Hypoxia

1996 • 639 citations

Hypoxia induces accumulation of p53 protein, but activation of a G1-phase checkpoint by low-oxygen conditions is independent of p53 status.

1994 • 620 citations

Codon usage limitation in the expression of HIV-1 envelope glycoprotein

1996 • 528 citations

Molecular mechanisms of angiogenesis: fibroblast growth factor signal transduction

1995 • 461 citations

Stabilization of Vascular Endothelial Growth Factor mRNA by Hypoxia and Hypoglycemia and Coregulation with Other Ischemia-Induced Genes

1995 • 453 citations

Inhibition of tumor angiogenesis as a strategy to circumvent acquired resistance to anti‐cancer therapeutic agents

1991 • 441 citations

Angiogenesis, microvascular architecture, microhemodynamics, and interstitial fluid pressure during early growth of human adenocarcinoma LS174T in SCID mice.

1992 • 368 citations

Antiangiogenic therapy of transgenic mice impairs de novo tumor growth.

1996 • 349 citations

Hypoxic induction of vascular endothelial growth factor (VEGF) in human epithelial cells is mediated by increases in mRNA stability

1995 • 308 citations

Delivery of molecular and cellular medicine to solid tumors

1997 • 268 citations

Modulation of the Organ Microenvironment for Treatment of Cancer Metastasis

1995 • 244 citations

Regulation of Proliferation-Survival Decisions during Tumor Cell Hypoxia

1998 • 221 citations

Activation of the c-Src tyrosine kinase is required for the induction of mammary tumors in transgenic mice.

1994 • 203 citations

Up-regulation of vascular endothelial growth factor expression in a rat glioma is conferred by two distinct hypoxia-driven mechanisms.

1997 • 196 citations

Immunohistologic and immunoelectron microscopic characterization of the mucosal lymphocytes of human small intestine by the use of monoclonal antibodies.

1983 • 189 citations

Severe colitis in mice with aberrant thymic selection

1995 • 186 citations

Mammary fibroblasts may influence breast tumor angiogenesis via hypoxia-induced vascular endothelial growth factor up-regulation and protein expression.

1994 • 185 citations

Role of nitric oxide in tumor microcirculation. Blood flow, vascular permeability, and leukocyte-endothelial interactions.

1997 • 168 citations

Mice lacking E-selectin show normal numbers of rolling leukocytes but reduced leukocyte stable arrest on cytokine-activated microvascular endothelium.

1998 • 92 citations

Landis award lecture

1977 • 72 citations

A new model for studying microcirculatory changes during dermal wound healing

1991 • 29 citations

Characterization of the DNase I hypersensitive site 3' of the human beta globin gene domain

1993 • 27 citations

Mice Lacking E-Selectin Show Normal Numbers of Rolling Leukocytes but Reduced Leukocyte Stable Arrest on Cytokine-Activated Microvascular Endothelium

1998 • 12 citations