The α1β1 and α2β1 Integrins Provide Critical Support for Vascular Endothelial Growth Factor Signaling, Endothelial Cell Migration, and Tumor Angiogenesis

Calcium's Role in Mechanotransduction during Muscle Development

2014 • 14,293 citations

Integrins: Versatility, modulation, and signaling in cell adhesion

1992 • 9,986 citations

Tumor Cells Secrete a Vascular Permeability Factor That Promotes Accumulation of Ascites Fluid

1983 • 3,942 citations

Integrin Signaling

1999 • 3,705 citations

The MAPK signaling cascade

1995 • 3,300 citations

Vascular permeability factor/vascular endothelial growth factor, microvascular hyperpermeability, and angiogenesis.

1995 • 3,139 citations

Integrin αvβ3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels

1994 • 2,293 citations

Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cells

1989 • 2,267 citations

Vascular Endothelial Growth Factor Regulates Endothelial Cell Survival through the Phosphatidylinositol 3′-Kinase/Akt Signal Transduction Pathway

1998 • 1,963 citations

Vascular endothelial growth factor acts as a survival factor for newly formed retinal vessels and has implications for retinopathy of prematurity

1995 • 1,608 citations

Definition of Two Angiogenic Pathways by Distinct α _v Integrins

1995 • 1,333 citations

Migration and proliferation of endothelial cells in preformed and newly formed blood vessels during tumor angiogenesis

1977 • 1,286 citations

Vascular permeability factor (VPF, VEGF) in tumor biology

1993 • 839 citations

A simple, quantitative method for assessing angiogenesis and antiangiogenic agents using reconstituted basement membrane, heparin, and fibroblast growth factor.

1992 • 807 citations

β3-integrin–deficient mice are a model for Glanzmann thrombasthenia showing placental defects and reduced survival

1999 • 731 citations

Time-dependent vascular regression and permeability changes in established human tumor xenografts induced by an anti-vascular endothelial growth factor/vascular permeability factor antibody

1996 • 718 citations

Extensive Vasculogenesis, Angiogenesis, and Organogenesis Precede Lethality in Mice Lacking All αv Integrins

1998 • 649 citations

Regulation of Angiogenesis in Vivo by Ligation of Integrin α5β1 with the Central Cell-Binding Domain of Fibronectin

2000 • 622 citations

Regulation of vascular endothelial growth factor-dependent retinal neovascularization by insulin-like growth factor-1 receptor

1999 • 560 citations

Stimulation of endothelial cell migration by vascular permeability factor/vascular endothelial growth factor through cooperative mechanisms involving the alphavbeta3 integrin, osteopontin, and thrombin.

1996 • 555 citations

Endothelial receptor tyrosine kinases involved in angiogenesis.

1995 • 537 citations

Angiogenesis promoted by vascular endothelial growth factor: Regulation through α₁β₁and α₂β₁ integrins

1997 • 516 citations

Purification and NH2-terminal amino acid sequence of guinea pig tumor-secreted vascular permeability factor.

1990 • 503 citations

Regulation of Vascular Endothelial Growth Factor by Oxygen in a Model of Retinopathy of Prematurity

1996 • 498 citations

A Mechanism for Modulation of Cellular Responses to VEGF Activation of the Integrins

2000 • 441 citations

Nitric Oxide Is an Upstream Signal of Vascular Endothelial Growth Factor-induced Extracellular Signal-regulated Kinase½ Activation in Postcapillary Endothelium

1998 • 436 citations

The role of vascular endothelial growth factor in pathological angiogenesis

1995 • 419 citations

Elevated matrix metalloprotease and angiostatin levels in integrin α1 knockout mice cause reduced tumor vascularization

2000 • 388 citations

An α2β1 Integrin-Dependent Pinocytic Mechanism Involving Intracellular Vacuole Formation and Coalescence Regulates Capillary Lumen and Tube Formation in Three-Dimensional Collagen Matrix

1996 • 352 citations

An antagonist of integrin αvβ3 prevents maturation of blood vessels during embryonic neovascularization

1995 • 304 citations

Thrombospondin-2: A potent endogenous inhibitor of tumor growth and angiogenesis

1999 • 301 citations

Growth factor activation of MAP kinase requires cell adhesion

1997 • 301 citations

Integrins, adhesion and apoptosis

1997 • 274 citations

Regulation of inflammation by collagen-binding integrins α1β1 and α2β1 in models of hypersensitivity and arthritis

2000 • 215 citations

Regulation of anchorage-dependent signal transduction by protein kinase A and p21-activated kinase

2000 • 210 citations

Focal Adhesion Kinase Mediates the Integrin Signaling Requirement for Growth Factor Activation of Map Kinase

1999 • 205 citations

Cell Anchorage Permits Efficient Signal Transduction Between Ras and Its Downstream Kinases

1997 • 192 citations

Trans-dominant inhibition of integrin function.

1996 • 174 citations

Vascular endothelial growth factor promotes tumor dissemination by a mechanism distinct from its effect on primary tumor growth.

1996 • 130 citations

Fibronectin receptor functions in embryonic cells deficient in alpha 5 beta 1 integrin can be replaced by alpha V integrins.

1996 • 127 citations

Confluence of Vascular Endothelial Cells Induces Cell Cycle Exit by Inhibiting p42/p44 Mitogen-Activated Protein Kinase Activity

1999 • 108 citations

Expression of Vascular Endothelial Growth Factor Induces an Invasive Phenotype in Human Squamous Cell Carcinomas

2000 • 87 citations

Collagen and elastin of human dermis.

1960 • 72 citations

Anchorage-dependent Regulation of the Mitogen-activated Protein Kinase Cascade by Growth Factors Is Supported by a Variety of Integrin α Chains

1999 • 66 citations

Targeted Mutations in Integrins and their Ligands: Their Implications for Vascular Biology

1997 • 65 citations

Collagen and Elastin of Human Dermis**From the Divisions of Dermatology and Cardiology of the Department of Medicine, University of Miami School of Medicine and Howard Hughes Medical Institute, Miami, Florida.This investigation was supported in part by Grants A-2586 and 2G-224, from the N.I.H., U.S. Public Health Service.

1960 • 63 citations

Glomerular epithelial and mesangial cells differentially modulate the binding specificities of VLA-1 and VLA-2.

1995 • 58 citations

Tumor Angiogenesis and Microcirculation

2001 • 41 citations

Tumor Angiogenesis and Microcirculation

2001 • 31 citations

VLA‐2 mediates the interaction of collagen with endothelium during in vitro vascular tube formation.

1994 • 24 citations

Integrins.

1994 • 17 citations