Interstitial pH and pO2 gradients in solid tumors in vivo: High-resolution measurements reveal a lack of correlation

Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis

1992 • 4,631 citations

Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: a review.

1989 • 3,308 citations

Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours

1996 • 2,304 citations

The Concentration of Oxygen Dissolved in Tissues at the Time of Irradiation as a Factor in Radiotherapy

1953 • 2,102 citations

Acid pH in tumors and its potential for therapeutic exploitation.

1989 • 1,633 citations

Tumor oxygenation predicts for the likelihood of distant metastases in human soft tissue sarcoma.

1996 • 1,183 citations

Cellular pH gradient in tumor versus normal tissue: potential exploitation for the treatment of cancer.

1996 • 1,120 citations

The relevance of tumour pH to the treatment of malignant disease

1984 • 886 citations

THE METABOLISM OF TUMORS

1931 • 825 citations

Intratumoral pO2 predicts survival in advanced cancer of the uterine cervix

1993 • 811 citations

An optical method for measurement of dioxygen concentration based upon quenching of phosphorescence.

1987 • 592 citations

Are cancer cells acidic?

1991 • 576 citations

Classification of antineoplastic agents by their selective toxicities toward oxygenated and hypoxic tumor cells.

1981 • 552 citations

Extracellular pH distribution in human tumours

1995 • 511 citations

Angiogenesis, microvascular architecture, microhemodynamics, and interstitial fluid pressure during early growth of human adenocarcinoma LS174T in SCID mice.

1992 • 368 citations

Induction of apoptosis as well as necrosis by hypoxia and predominant prevention of apoptosis by Bcl-2 and Bcl-XL.

1996 • 360 citations

Heterogeneous oxygen partial pressure and pH distribution in C3H mouse mammary adenocarcinoma.

1981 • 339 citations

Variations in tumor cell growth rates and metabolism with oxygen concentration, glucose concentration, and extracellular pH

1992 • 337 citations

Noninvasive measurement of interstitial pH profiles in normal and neoplastic tissue using fluorescence ratio imaging microscopy.

1994 • 315 citations

Delivery of Molecular Medicine to Solid Tumors

1996 • 314 citations

Oxygenation and differentiation in multicellular spheroids of human colon carcinoma.

1986 • 240 citations

THE INTERSTITIAL FLUID OF SOLID TUMORS.

1964 • 240 citations

Correlation of high lactate levels in human cervical cancer with incidence of metastasis.

1995 • 216 citations

Magnetic resonance spectroscopy of tumors and potential in vivo clinical applications: A review

1989 • 194 citations

Noninvasive measurement of microvascular and interstitial oxygen profiles in a human tumor in SCID mice.

1994 • 189 citations

Drug Resistance in Oncology

1994 • 173 citations

Microvessel PO2 measurements by phosphorescence decay method

1993 • 148 citations

The effect of hydralazine on the tumor cytotoxicity of the hypoxic cell cytotoxin RSU-1069: Evidence for therapeutic gain

1987 • 142 citations

Glucose diffusivity in multicellular tumor spheroids.

1988 • 137 citations

Perivascular oxygen tensions in a transplantable mammary tumor growing in a dorsal flap window chamber.

1992 • 103 citations

2-Nitroimidazole (EF5) binding predicts radiation resistance in individual 9L s.c. tumors.

1996 • 99 citations

Continuous Noninvasive Monitoring of pH and Temperature in Rat Walker 256 Carcinoma During Normoglycemia and Hyperglycemia23

1984 • 94 citations

Perivascular Oxygen Tensions in a Transplantable Mammary Tumor Growing in a Dorsal Flap Window Chamber

1992 • 86 citations

Fluorescence ratio imaging of interstitial pH in solid tumours: effect of glucose on spatial and temporal gradients

1996 • 82 citations

PET in clinical oncology

1988 • 80 citations

Selective cellular acidification and toxicity of weak organic acids in an acidic microenvironment

1993 • 75 citations

Determination of PO2 and its heterogeneity in single capillaries

1996 • 75 citations

Influence of tumour physico-chemical conditions on interleukin-2-stimulated lymphocyte proliferation

1992 • 68 citations

Invited review: Response of tumours to hyperglycaemia: characterization, significance and role in hyperthermia

1988 • 67 citations

The cytotoxicity of melphalan and its relationship to pH, hypoxia and drug uptake.

1995 • 65 citations

Tumor extracellular pH as a prognostic factor in thermoradiotherapy

1994 • 60 citations

Hypoxia arrests ovarian carcinoma cell cycle progression, but invasion is unaffected.

1996 • 60 citations

Relationship between oxygen and glucose consumption by transplanted tumors in vivo.

1967 • 59 citations

Hydrogen ion-mediated enhancement of cytotoxicity of bis-chloroethylating drugs in rat mammary carcinoma cells in vitro.

1989 • 54 citations

Influence of glucose and buffer capacity in the culture medium on growth and pH in spheroids of human thyroid carcinoma and human glioma origin.

1987 • 48 citations

Increased release of tumour cells by collagenase at acid pH: A possible mechanism for metastasis

1979 • 20 citations

Substratum acidification by murine B16F10 melanoma cultures

1992 • 7 citations

Tumor Oxygenation and Radiosensitivity

1995 • 5 citations