Heterogeneous Vascular Dependence of Tumor Cell Populations

Patterns and Emerging Mechanisms of the Angiogenic Switch during Tumorigenesis

1996 • 6,878 citations

Tumor Angiogenesis and Metastasis — Correlation in Invasive Breast Carcinoma

1991 • 5,657 citations

Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis

1998 • 2,427 citations

Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours

1996 • 2,304 citations

The Histological Structure of Some Human Lung Cancers and the Possible Implications for Radiotherapy

1955 • 2,174 citations

Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastases.

1999 • 2,168 citations

Antiangiogenic therapy of experimental cancer does not induce acquired drug resistance

1997 • 1,705 citations

Tumor angiogenesis correlates with metastasis in invasive prostate carcinoma.

1993 • 1,646 citations

Interstitial pH and pO2 gradients in solid tumors in vivo: High-resolution measurements reveal a lack of correlation

1997 • 1,590 citations

Antiangiogenic scheduling of chemotherapy improves efficacy against experimental drug-resistant cancer.

2000 • 1,536 citations

Continuous low-dose therapy with vinblastine and VEGF receptor-2 antibody induces sustained tumor regression without overt toxicity

2000 • 1,159 citations

Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1alpha.

2000 • 1,087 citations

Interferon Alfa-2a Therapy for Life-Threatening Hemangiomas of Infancy

1992 • 1,076 citations

Vascular Endothelial Growth Factor Induces Expression of the Antiapoptotic Proteins Bcl-2 and A1 in Vascular Endothelial Cells

1998 • 996 citations

Effects of Angiogenesis Inhibitors on Multistage Carcinogenesis in Mice

1999 • 990 citations

Biological Diversity in Metastatic Neoplasms: Origins and Implications

1982 • 937 citations

Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1α

2000 • 893 citations

Current pathologic methods for measuring intratumoral microvessel density within breast carcinoma and other solid tumors

1995 • 724 citations

Vascular Endothelial Growth Factor (VEGF)-Mediated Angiogenesis Is Associated with Enhanced Endothelial Cell Survival and Induction of Bcl-2 Expression

1999 • 638 citations

Hypoxia induces accumulation of p53 protein, but activation of a G1-phase checkpoint by low-oxygen conditions is independent of p53 status.

1994 • 620 citations

Inhibition of tumor angiogenesis as a strategy to circumvent acquired resistance to anti‐cancer therapeutic agents

1991 • 441 citations

Control of Apoptosis during Angiogenesis by Survivin Expression in Endothelial Cells

2000 • 347 citations

Marked Induction of the IAP Family Antiapoptotic Proteins Survivin and XIAP by VEGF in Vascular Endothelial Cells

1999 • 342 citations

Tumor heterogeneity: biological implications and therapeutic consequences

1983 • 303 citations

Heterogeneity in drug sensitivity among tumor cell subpopulations of a single mammary tumor.

1978 • 281 citations

Tumor heterogeneity.

1984 • 264 citations

Antiangiogenic Therapy of a Recurrent Giant Cell Tumor of the Mandible With Interferon Alfa-2a

1999 • 245 citations

Consequences of angiogenesis for tumor progression, metastasis and cancer therapy

1995 • 243 citations

Oncogenic transformation and hypoxia synergistically act to modulate vascular endothelial growth factor expression.

1996 • 240 citations

Synergy between angiostatin and endostatin: inhibition of ovarian cancer growth.

2000 • 228 citations

Reciprocal paracrine interactions between tumour cells and endothelial cells: the ‘angiogenesis progression’ hypothesis

1996 • 212 citations

Hypoxia Induces Accumulation of p53 Protein, but Activation of a G₁-Phase Checkpoint by Low-Oxygen Conditions Is Independent of p53 Status

1994 • 144 citations

Pharmacokinetics, binding and distribution of Hoechst 33342 in spheroids and murine tumours

1985 • 137 citations

On the genesis and regulation of cellular heterogeneity in malignant tumors.

1982 • 122 citations

Cell selection from a murine tumour using the fluorescent probe Hoechst 33342

1985 • 120 citations

DNA alterations in cancer : genetic and epigenetic changes

2000 • 73 citations

Intraneoplastic diversity

1982 • 73 citations

Treating cancer by inhibiting angiogenesis: new hopes and potential pitfall

1996 • 69 citations

Role of vascular endothelial growth factor (VEGF) in endothelial cell protection against cytotoxic agents

2000 • 54 citations