Flt-1 but not KDR/Flk-1 tyrosine kinase is a receptor for placenta growth factor, which is related to vascular endothelial growth factor.

THE ATTRACTIONS OF PROTEINS FOR SMALL MOLECULES AND IONS

1949 • 19,979 citations

LIGAND: A versatile computerized approach for characterization of ligand-binding systems

1980 • 8,534 citations

Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis

1992 • 4,631 citations

Tumor Cells Secrete a Vascular Permeability Factor That Promotes Accumulation of Ascites Fluid

1983 • 3,942 citations

Vascular endothelial growth factor is a potential tumour angiogenesis factor in human gliomas in vivo

1992 • 2,293 citations

The fms -Like Tyrosine Kinase, a Receptor for Vascular Endothelial Growth Factor

1992 • 2,042 citations

High affinity VEGF binding and developmental expression suggest Flk-1 as a major regulator of vasculogenesis and angiogenesis

1993 • 1,961 citations

Different signal transduction properties of KDR and Flt1, two receptors for vascular endothelial growth factor.

1994 • 1,661 citations

Identification of the KDR tyrosine kinase as a receptor for vascular endothelial cell growth factor

1992 • 1,528 citations

Inhibition of vascular endothelial cell growth factor activity by an endogenously encoded soluble receptor.

1993 • 1,391 citations

Glioblastoma growth inhibited in vivo by a dominant-negative Flk-1 mutant

1994 • 1,249 citations

Dual regulation of vascular endothelial growth factor bioavailability by genetic and proteolytic mechanisms.

1992 • 1,145 citations

Placenta growth factor. Potentiation of vascular endothelial growth factor bioactivity, in vitro and in vivo, and high affinity binding to Flt-1 but not to Flk-1/KDR.

1994 • 1,104 citations

Isolation of a human placenta cDNA coding for a protein related to the vascular permeability factor.

1991 • 999 citations

Nucleotide sequence and expression of a novel human receptor-type tyrosine kinase gene (flt) closely related to the fms family.

1990 • 982 citations

Fetal liver kinase 1 is a receptor for vascular endothelial growth factor and is selectively expressed in vascular endothelium.

1993 • 764 citations

Vasculogenesis and angiogenesis in embryonic-stem-cell-derived embryoid bodies

1988 • 667 citations

The vascular endothelial growth factor family of polypeptides

1991 • 652 citations

A receptor tyrosine kinase cDNA isolated from a population of enriched primitive hematopoietic cells and exhibiting close genetic linkage to c-kit.

1991 • 516 citations

The binding of vascular endothelial growth factor to its receptors is dependent on cell surface-associated heparin-like molecules.

1992 • 495 citations

A unique signal transduction from FLT tyrosine kinase, a receptor for vascular endothelial growth factor VEGF.

1995 • 480 citations

New procedures for preparation and isolation of conjugates of proteins and a synthetic copolymer of D-amino acids and immunochemical characterization of such conjugates

1979 • 463 citations

The mode of development of the vascular system of the retina, with some observations on its significance for certain retinal diseases

1948 • 456 citations

The proteins encoded by the VpreB and lambda 5 pre-B cell-specific genes can associate with each other and with mu heavy chain.

1990 • 352 citations

Role of Vegf-Flt Receptor System in Normal and Tumor Angiogenesis

1995 • 332 citations

Two alternative mRNAs coding for the angiogenic factor, placenta growth factor (PlGF), are transcribed from a single gene of chromosome 14.

1993 • 317 citations

The related FLT4, FLT1, and KDR receptor tyrosine kinases show distinct expression patterns in human fetal endothelial cells.

1993 • 263 citations

Developmental expression of binding sites and messenger ribonucleic acid for vascular endothelial growth factor suggests a role for this protein in vasculogenesis and angiogenesis.

1993 • 262 citations

Two molecules related to the VEGF receptor are expressed in early endothelial cells during avian embryonic development

1993 • 209 citations

The fourth immunoglobulin domain of the stem cell factor receptor couples ligand binding to signal transduction

1995 • 160 citations

FLT4, a novel class III receptor tyrosine kinase in chromosome 5q33-qter.

1992 • 121 citations

VEGF Receptor Subtypes KDR and FLT1 Show Different Sensitivities to Heparin and Placenta Growth Factor

1994 • 98 citations

Specificity of Vascular Endothelial Cell Growth Factor Receptor Ligand Binding Domains

1994 • 83 citations

Identification, Purification, and Characterization of Cell-surface Retention Sequence-binding Proteins from Human SK-Hep Cells and Bovine Liver Plasma Membranes

1995 • 22 citations