Angiozyme: A Novel angiogenesis inhibitor

Tumor Angiogenesis: Therapeutic Implications

1971 • 9,898 citations

Vascular Endothelial Growth Factor Is a Secreted Angiogenic Mitogen

1989 • 4,988 citations

Tumor Cells Secrete a Vascular Permeability Factor That Promotes Accumulation of Ascites Fluid

1983 • 3,942 citations

Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo

1993 • 3,605 citations

Vascular endothelial growth factor (VEGF) and its receptors

1999 • 3,498 citations

Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium

1995 • 2,650 citations

Transplacental Carcinogenesis by Stilbestrol

1971 • 2,595 citations

Selective ablation of immature blood vessels in established human tumors follows vascular endothelial growth factor withdrawal

1999 • 1,248 citations

Clinical applications of angiogenic growth factors and their inhibitors

1999 • 1,017 citations

A Requirement for Flk1 in Primitive and Definitive Hematopoiesis and Vasculogenesis

1997 • 938 citations

Vascular Endothelial Growth Factor Inhibits the Development of Dendritic Cells and Dramatically Affects the Differentiation of Multiple Hematopoietic Lineages In Vivo

1998 • 933 citations

Vascular Endothelial Growth Factor Inhibits the Development of Dendritic Cells and Dramatically Affects the Differentiation of Multiple Hematopoietic Lineages In Vivo

1998 • 828 citations

Binding sites for vascular endothelial growth factor are localized on endothelial cells in adult rat tissues.

1992 • 443 citations

Role of Vegf-Flt Receptor System in Normal and Tumor Angiogenesis

1995 • 332 citations

The Tetrahymena ribozyme acts like an RNA restriction endonuclease

1986 • 285 citations

Enhancement of Tumor Growth and Vascular Density by Transfection of Vascular Endothelial Cell Growth Factor Into MCF-7 Human Breast Carcinoma Cells

1995 • 270 citations

Correlation of Vascular Endothelial Growth Factor Content With Recurrences, Survival, and First Relapse Site in Primary Node-Positive Breast Carcinoma After Adjuvant Treatment

2000 • 255 citations

Vascular endothelial growth factor up-regulates its receptor fms-like tyrosine kinase 1 (FLT-1) and a soluble variant of FLT-1 in human vascular endothelial cells.

1997 • 225 citations

VASCULAR ENDOTHELIAL GROWTH FACTOR AS PROGNOSTIC FACTOR IN RENAL CELL CARCINOMA

2000 • 222 citations

Vascular Endothelial Growth Factor in Human Colon Cancer: Biology and Therapeutic Implications

2000 • 198 citations

Expression of vascular endothelial growth factor (VEGF) and its two receptors (VEGF‐R1‐Flt1 and VEGF‐R2‐Flk1/KDR) in non‐small cell lung carcinomas (NSCLCs): correlation with angiogenesis and survival

1999 • 177 citations

Vascular endothelial growth factor expression in non-small-cell lung cancer: Prognostic significance in squamous cell carcinoma

1998 • 175 citations

Antitumor and antimetastatic activity of ribozymes targeting the messenger RNA of vascular endothelial growth factor receptors.

2000 • 156 citations

Melanoma Cell Lines Express VEGF Receptor KDR and Respond to Exogenously Added VEGF

1995 • 144 citations

Factors Promoting Tumor Angiogenesis

1999 • 98 citations

Bioactivity of anti-angiogenic ribozymes targeting Flt-1 and KDR mRNA

1999 • 78 citations

Production of VEGF and expression of the VEGF receptors Flt-1 and KDR in primary cultures of epithelial and stromal cells derived from breast tumours

1999 • 65 citations

A Catalytic RNA and Its Gene from Salmonella typhimurium

1985 • 58 citations

Nucleic Acids and Molecular Biology

1995 • 56 citations

Tumor angiogenesis and recurrence in stage I non-small cell lung cancer

1999 • 52 citations

Hammerhead ribozyme engineering

1996 • 51 citations

Pharmacokinetics of an Antiangiogenic Ribozyme (ANGIOZYME™) in the Mouse

1999 • 45 citations

Design, Synthesis, and Function of Therapeutic Hammerhead Ribozymes

1996 • 34 citations

Cellular Uptake Properties of a 2‵-Amino/2‵-O-Methyl-Modified Chimeric Hammerhead Ribozyme Targeted to the Epidermal Growth Factor Receptor mRNA

1997 • 27 citations