Different signal transduction properties of KDR and Flt1, two receptors for vascular endothelial growth factor.

THE ATTRACTIONS OF PROTEINS FOR SMALL MOLECULES AND IONS

1949 • 19,979 citations

The pathogenesis of atherosclerosis: a perspective for the 1990s

1993 • 10,730 citations

Preparation of Iodine-131 Labelled Human Growth Hormone of High Specific Activity

1962 • 6,970 citations

Vascular Endothelial Growth Factor Is a Secreted Angiogenic Mitogen

1989 • 4,988 citations

Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis

1992 • 4,631 citations

Oncogenes and signal transduction

1991 • 2,816 citations

Vascular endothelial growth factor is a potential tumour angiogenesis factor in human gliomas in vivo

1992 • 2,293 citations

Vascular Permeability Factor, an Endothelial Cell Mitogen Related to PDGF

1989 • 2,090 citations

The fms -Like Tyrosine Kinase, a Receptor for Vascular Endothelial Growth Factor

1992 • 2,042 citations

High affinity VEGF binding and developmental expression suggest Flk-1 as a major regulator of vasculogenesis and angiogenesis

1993 • 1,961 citations

Molecular and Biological Properties of the Vascular Endothelial Growth Factor Family of Proteins

1992 • 1,612 citations

The Emerging Concept of Vascular Remodeling

1994 • 1,563 citations

Identification of the KDR tyrosine kinase as a receptor for vascular endothelial cell growth factor

1992 • 1,528 citations

THE ULTRASTRUCTURAL BASIS OF CAPILLARY PERMEABILITY STUDIED WITH PEROXIDASE AS A TRACER

1967 • 1,495 citations

Inhibition of vascular endothelial cell growth factor activity by an endogenously encoded soluble receptor.

1993 • 1,391 citations

Tumor vascular permeability factor stimulates endothelial cell growth and angiogenesis.

1989 • 1,282 citations

Therapeutic angiogenesis. A single intraarterial bolus of vascular endothelial growth factor augments revascularization in a rabbit ischemic hind limb model.

1994 • 1,058 citations

Nucleotide sequence and expression of a novel human receptor-type tyrosine kinase gene (flt) closely related to the fms family.

1990 • 982 citations

Vascular permeability factor: a tumor-derived polypeptide that induces endothelial cell and monocyte procoagulant activity, and promotes monocyte migration.

1990 • 857 citations

Fetal liver kinase 1 is a receptor for vascular endothelial growth factor and is selectively expressed in vascular endothelium.

1993 • 764 citations

Scatter factor induces blood vessel formation in vivo.

1993 • 704 citations

Distinct phosphotyrosines on a growth factor receptor bind to specific molecules that mediate different signaling pathways

1992 • 692 citations

Association between the PDGF receptor and members of the src family of tyrosine kinases

1990 • 650 citations

Tumor interactions with the vasculature: angiogenesis and tumor metastasis

1990 • 598 citations

Angiogenesis in skeletal and cardiac muscle

1992 • 595 citations

Role of Phosphatidylinositol Kinase in PDGF Receptor Signal Transduction

1989 • 516 citations

A receptor tyrosine kinase cDNA isolated from a population of enriched primitive hematopoietic cells and exhibiting close genetic linkage to c-kit.

1991 • 516 citations

Isolation and characterization of a newly identified endothelial cell mitogen produced by AtT-20 cells.

1989 • 497 citations

Tie-1 and tie-2 define another class of putative receptor tyrosine kinase genes expressed in early embryonic vascular system.

1993 • 470 citations

Vascular endothelial growth factor receptor expression during embryogenesis and tissue repair suggests a role in endothelial differentiation and blood vessel growth.

1993 • 460 citations

Heregulin induces tyrosine phosphorylation of HER4/p180erbB4

1993 • 445 citations

Regulation of chemotaxis by the platelet-derived growth factor receptor-β

1994 • 441 citations

Changes in protein phosphorylation in Rous sarcoma virus-transformed chicken embryo cells.

1981 • 440 citations

Activation of Phosphatidylinositol-3′ Kinase by Src-Family Kinase SH3 Binding to the p85 Subunit

1994 • 437 citations

tek, a novel tyrosine kinase gene located on mouse chromosome 4, is expressed in endothelial cells and their presumptive precursors.

1992 • 410 citations

A novel endothelial cell surface receptor tyrosine kinase with extracellular epidermal growth factor homology domains.

1992 • 351 citations

The Src family tyrosine kinases are required for platelet-derived growth factor-mediated signal transduction in NIH 3T3 cells.

1993 • 338 citations

cDNA cloning and expression of a human platelet-derived growth factor (PDGF) receptor specific for B-chain-containing PDGF molecules.

1988 • 338 citations

Purification and properties of an endothelial cell growth factor from human platelets.

1987 • 330 citations

A major part of platelet-derived growth factor purified from human platelets is a heterodimer of one A and one B chain.

1988 • 317 citations

Phosphorylation sites in the PDGF receptor with different specificities for binding GAP and PI3 kinase in vivo.

1992 • 317 citations

Hypoxia Is a Strong Inducer of Vascular Endothelial Growth Factor mRNA Expression in the Heart

1993 • 308 citations

Membrane ruffling and chemotaxis transduced by the PDGF beta-receptor require the binding site for phosphatidylinositol 3' kinase.

1994 • 303 citations

A glioma-derived PDGF a chain homodimer has different functional activities from a PDGF AB heterodimer purified from human platelets

1988 • 264 citations

Differential effects of the various isoforms of platelet-derived growth factor on chemotaxis of fibroblasts, monocytes, and granulocytes.

1990 • 263 citations

PDGF alpha- and beta-receptors activate unique and common signal transduction pathways.

1992 • 259 citations

A new communication system between hepatocytes and sinusoidal endothelial cells in liver through vascular endothelial growth factor and Flt tyrosine kinase receptor family (Flt-1 and KDR/Flk-1).

1994 • 258 citations

Phosphorylation of the PDGF receptor beta subunit creates a tight binding site for phosphatidylinositol 3 kinase.

1990 • 244 citations

Phosphatidylinositol kinase activity associates with viral p60src protein.

1989 • 194 citations

The endothelial-specific receptor tyrosine kinase, tek, is a member of a new subfamily of receptors.

1993 • 179 citations

Identification and Structural Analysis of the A Type Receptor for Platelet-derived Growth Factor

1989 • 179 citations

Ligand-induced polyubiquitination of the platelet-derived growth factor beta-receptor.

1992 • 173 citations

B-type receptor for platelet-derived growth factor mediates a chemotactic response by means of ligand-induced activation of the receptor protein-tyrosine kinase.

1990 • 169 citations

Transfer of motogenic and invasive response to scatter factor/hepatocyte growth factor by transfection of human MET protooncogene.

1993 • 159 citations

Induction of circular membrane ruffling on human fibroblasts by platelet-derived growth factor

1988 • 156 citations

Chemotaxis and Inflammation

1983 • 140 citations

Interaction of vasculotropin/vascular endothelial cell growth factor with human umbilical vein endothelial cells: Binding, internalization, degradation, and biological effects

1991 • 128 citations

Heterogeneity of the endothelial cell and its role in organ preference of tumour metastasis

1991 • 128 citations

Expression of Three Recombinant Homodimeric Isoforms of PDGF inSaccharomyces cerevisiae: Evidence for Difference in Receptor Binding and Functional Activities

1989 • 126 citations

Ligand-induced interaction between .alpha.- and .beta.-type platelet-derived growth factor (PDGF) receptors: role of receptor heterodimers in kinase activation

1991 • 93 citations

NYK/FLK-1: a putative receptor protein tyrosine kinase isolated from E10 embryonic neuroepithelium is expressed in endothelial cells of the developing embryo.

1993 • 90 citations

Expression of Protein Tyrosine Kinases in Islet Cells: Possible Role of the Flk-1 Receptor forβ-Cell Maturation from Duct Cells

1994 • 88 citations

Enhancement of the detection of alkali-resistant phosphoproteins in polyacrylamide gels

1988 • 48 citations

Identification of a hydrophobic region in the carboxyl terminus of the platelet-derived growth factor beta-receptor which is important for ligand-mediated endocytosis.

1991 • 46 citations

Ligand-Induced Homo-and Hetero-Dimerization of Platelet-Derived Growth Factor α- and β-Receptors in Intact Cells

1992 • 43 citations

Phosphatidylinositol 3′-kinase associates with p145c-kit as part of a cell type characteristic multimeric signalling complex.

1993 • 24 citations

A novel endothelial tyrosine kinase cDNA homologous to platelet-derived growth factor receptor cDNA

1992 • 23 citations