Vessel Cooption, Regression, and Growth in Tumors Mediated by Angiopoietins and VEGF

Tumor Angiogenesis: Therapeutic Implications

1971 • 9,898 citations

Angiogenesis in cancer, vascular, rheumatoid and other disease

1995 • 7,717 citations

Patterns and Emerging Mechanisms of the Angiogenic Switch during Tumorigenesis

1996 • 6,878 citations

Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice

1995 • 3,977 citations

Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo

1993 • 3,605 citations

Angiopoietin-2, a Natural Antagonist for Tie2 That Disrupts in vivo Angiogenesis

1997 • 3,470 citations

Transplacental Carcinogenesis by Stilbestrol

1971 • 2,595 citations

Isolation of Angiopoietin-1, a Ligand for the TIE2 Receptor, by Secretion-Trap Expression Cloning

1996 • 1,969 citations

Dormancy of micrometastases: Balanced proliferation and apoptosis in the presence of angiogenesis suppression

1995 • 1,863 citations

Distinct roles of the receptor tyrosine kinases Tie-1 and Tie-2 in blood vessel formation

1995 • 1,808 citations

Selective ablation of immature blood vessels in established human tumors follows vascular endothelial growth factor withdrawal

1999 • 1,248 citations

Dominant-negative and targeted null mutations in the endothelial receptor tyrosine kinase, tek, reveal a critical role in vasculogenesis of the embryo.

1994 • 979 citations

Increased Vascularization in Mice Overexpressing Angiopoietin-1

1998 • 818 citations

Regulation by vascular endothelial growth factor of human colon cancer tumorigenesis in a mouse model of experimental liver metastasis.

1995 • 699 citations

Induction of vascular endothelial growth factor expression by hypoxia and by glucose deficiency in multicell spheroids: implications for tumor angiogenesis.

1995 • 598 citations

Vascular Endothelial Growth Factor: Molecular and Biological Aspects

1999 • 542 citations

Cell Type-Specific Expression of Angiopoietin-1 and Angiopoietin-2 Suggests a Role in Glioblastoma Angiogenesis

1998 • 491 citations

Tie-1 and tie-2 define another class of putative receptor tyrosine kinase genes expressed in early embryonic vascular system.

1993 • 470 citations

Angiopoietins 3 and 4: Diverging gene counterparts in mice and humans

1999 • 463 citations

Comparison of VEGF, VEGF-B, VEGF-C and Ang-1 mRNA regulation by serum, growth factors, oncoproteins and hypoxia

1997 • 459 citations

Paracrine expression of a native soluble vascular endothelial growth factor receptor inhibits tumor growth, metastasis, and mortality rate

1998 • 455 citations

Dominant-negative inhibition of Flk-1 suppresses the growth of many tumor types in vivo.

1996 • 423 citations

Direct actions of angiopoietin-1 on human endothelium: evidence for network stabilization, cell survival, and interaction with other angiogenic growth factors.

1999 • 418 citations

Tie2 Expression and Phosphorylation in Angiogenic and Quiescent Adult Tissues

1997 • 410 citations

tek, a novel tyrosine kinase gene located on mouse chromosome 4, is expressed in endothelial cells and their presumptive precursors.

1992 • 410 citations

Alternative forms of rat TrkC with different functional capabilities

1993 • 374 citations

A novel endothelial cell surface receptor tyrosine kinase with extracellular epidermal growth factor homology domains.

1992 • 351 citations

Non-small-cell lung carcinoma tumor growth without morphological evidence of neo-angiogenesis.

1997 • 330 citations

Expression of tie-2, a member of a novel family of receptor tyrosine kinases, in the endothelial cell lineage

1993 • 275 citations

Brain-derived neurotrophic factor (BDNF) prevents the degeneration of medial septal cholinergic neurons following fimbria transection

1993 • 254 citations

Molecular Cloning and Characterization of Mouse TIE and TEK Receptor Tyrosine Kinase Genes and Their Expression in Hematopoietic Stem Cells

1993 • 224 citations

Invasion of experimental rat brain tumor: early morphological changes following microinjection of C6 glioma cells

1993 • 140 citations

Distinct rat genes with related profiles of expression define a TIE receptor tyrosine kinase family.

1993 • 129 citations

Quantitative immunohistological analysis of the microvasculature in untreated human glioblastoma multiforme

1994 • 111 citations

Molecular cloning and characterization of a novel receptor protein tyrosine kinase from human placenta.

1993 • 107 citations

Contrasting roles for c-Myc and L-Myc in the regulation of cellular growth and differentiation in vivo.

1995 • 57 citations