Vascular endothelial growth factor C promotes tumor lymphangiogenesis and intralymphatic tumor growth.

Expression of the fms-like tyrosine kinase 4 gene becomes restricted to lymphatic endothelium during development.

1995 • 1,421 citations

Hyperplasia of Lymphatic Vessels in VEGF-C Transgenic Mice

1997 • 1,280 citations

Vascular endothelial growth factor D (VEGF-D) is a ligand for the tyrosine kinases VEGF receptor 2 (Flk1) and VEGF receptor 3 (Flt4)

1998 • 1,192 citations

Cardiovascular Failure in Mouse Embryos Deficient in VEGF Receptor-3

1998 • 876 citations

Proteolytic processing regulates receptor specificity and activity of VEGF-C

1997 • 773 citations

Estrogen-dependent, tamoxifen-resistant tumorigenic growth of MCF-7 cells transfected with HER2/neu

1992 • 769 citations

VEGF-C receptor binding and pattern of expression with VEGFR-3 suggests a role in lymphatic vascular development

1996 • 684 citations

Vascular endothelial growth factor C induces angiogenesis in vivo

1998 • 558 citations

VEGFR-3 and Its Ligand VEGF-C Are Associated with Angiogenesis in Breast Cancer

1999 • 550 citations

VEGF and VEGF-C: Specific Induction of Angiogenesis and Lymphangiogenesis in the Differentiated Avian Chorioallantoic Membrane

1997 • 501 citations

Mouse LYVE-1 Is an Endocytic Receptor for Hyaluronan in Lymphatic Endothelium

2001 • 469 citations

Absence of functional lymphatics within a murine sarcoma: a molecular and functional evaluation.

2000 • 466 citations

Vascular endothelial growth factor receptors in the regulation of angiogenesis and lymphangiogenesis

2000 • 423 citations

Vascular Endothelial Growth Factor-C (VEGF-C/VEGF-2) Promotes Angiogenesis in the Setting of Tissue Ischemia

1998 • 353 citations

Vascular Endothelial Growth Factors VEGF-B and VEGF-C Are Expressed in Human Tumors

1998 • 328 citations

Lack of lymphatic vascular specificity of vascular endothelial growth factor receptor 3 in 185 vascular tumors

1999 • 296 citations

Oncotic pressure in solid tumors is elevated.

2000 • 293 citations

Vascular endothelial growth factor-C expression in human prostatic carcinoma and its relationship to lymph node metastasis

1999 • 282 citations

Vascular endothelial growth factors are differentially regulated by steroid hormones and antiestrogens in breast cancer cells

1999 • 234 citations

Involvement of vascular endothelial growth factor receptor-3 in maintenance of integrity of endothelial cell lining during tumor angiogenesis

2000 • 218 citations

Adenovirus-Mediated Gene Transfer to Lower Limb Artery of Patients with Chronic Critical Leg Ischemia

1998 • 198 citations

The prognostic value of lymphatic and blood vessel invasion in operable breast cancer

1995 • 177 citations

Structure, Expression and Receptor-Binding Properties of Novel Vascular Endothelial Growth Factors

1999 • 170 citations

High-frequency transformation of human repair-deficient cell lines by an Epstein-Barr virus-based cDNA expression vector

1991 • 55 citations

Vascular Endothelial Growth Factor-C and Its Receptor VEGFR-3 in the Nasal Mucosa and in Nasopharyngeal Tumors

2000 • 50 citations

Cell death induced by TNF or serum starvation is independent of ErbB receptor signaling in MCF-7 breast carcinoma cells

2000 • 30 citations

Overexpression of fibroblast growth factor 1 in MCF-7 breast cancer cells facilitates tumor cell dissemination but does not support the development of macrometastases in the lungs or lymph nodes.

1999 • 29 citations

IDENTIFICATION OF THE SENTINEL NODE IN PATIENTS WITH BREAST CANCER

2000 • 14 citations