The logic of TGFβ signaling

TGF-β SIGNAL TRANSDUCTION

1998 • 7,582 citations

Mechanisms of TGF-β Signaling from Cell Membrane to the Nucleus

2003 • 5,611 citations

Smad-dependent and Smad-independent pathways in TGF-β family signalling

2003 • 5,052 citations

Stress-Dependent Regulation of FOXO Transcription Factors by the SIRT1 Deacetylase

2004 • 3,100 citations

The Transforming Growth Factor-beta Family

1990 • 3,028 citations

A multigenic program mediating breast cancer metastasis to bone

2003 • 2,539 citations

Smad transcription factors

2005 • 2,366 citations

TGFβ Signaling in Growth Control, Cancer, and Heritable Disorders

2000 • 2,354 citations

Mechanism of activation of the TGF-β receptor

1994 • 2,298 citations

TGF-β signaling in tumor suppression and cancer progression

2001 • 2,235 citations

Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals

1994 • 2,154 citations

Transforming growth factor beta

2011 • 1,990 citations

p27Kip1, a cyclin-Cdk inhibitor, links transforming growth factor-beta and contact inhibition to cell cycle arrest.

1994 • 1,970 citations

pl5INK4B is a potentia| effector of TGF-β-induced cell cycle arrest

1994 • 1,932 citations

How cells read TGF-β signals

2000 • 1,843 citations

Controlling TGF-beta signaling.

2000 • 1,806 citations

SPECIFICITY AND VERSATILITY IN TGF-β SIGNALING THROUGH SMADS

2005 • 1,804 citations

Cytostatic and apoptotic actions of TGF-β in homeostasis and cancer

2003 • 1,572 citations

Controlling TGF-β signaling

2000 • 1,522 citations

TGFβ signals through a heteromeric protein kinase receptor complex

1992 • 1,519 citations

Mammalian SIRT1 Represses Forkhead Transcription Factors

2004 • 1,352 citations

TGF-ß Signaling in Fibroblasts Modulates the Oncogenic Potential of Adjacent Epithelia

2004 • 1,346 citations

FoxOs at the Crossroads of Cellular Metabolism, Differentiation, and Transformation

2004 • 1,294 citations

TGF-β directly targets cytotoxic T cell functions during tumor evasion of immune surveillance

2005 • 1,173 citations

Integration of Smad and Forkhead Pathways in the Control of Neuroepithelial and Glioblastoma Cell Proliferation

2004 • 1,008 citations

A mechanism of repression of TGFbeta / Smad signaling by oncogenic Ras

1999 • 1,004 citations

TGF-β signaling blockade inhibits PTHrP secretion by breast cancer cells and bone metastases development

1999 • 969 citations

Kip/Cip and Ink4 Cdk inhibitors cooperate to induce cell cycle arrest in response to TGF-beta.

1995 • 959 citations

Transforming growth factor beta induces the cyclin-dependent kinase inhibitor p21 through a p53-independent mechanism.

1995 • 938 citations

Human Smad3 and Smad4 Are Sequence-Specific Transcription Activators

1998 • 916 citations

Partnership between DPC4 and SMAD proteins in TGF-β signalling pathways

1996 • 899 citations

Opposing BMP and EGF signalling pathways converge on the TGF-β family mediator Smad1

1997 • 867 citations

Regulation of the Polarity Protein Par6 by TGFß Receptors Controls Epithelial Cell Plasticity

2005 • 852 citations

IκB Kinase Promotes Tumorigenesis through Inhibition of Forkhead FOXO3a

2004 • 845 citations

Growth inhibition by TGF-β linked to suppression of retinoblastoma protein phosphorylation

1990 • 812 citations

Transforming growth factor-β in T-cell biology

2002 • 787 citations

The Transforming Growth Factor-βs

1990 • 741 citations

The two faces of transforming growth factor β in carcinogenesis

2003 • 740 citations

The transforming growth factor-β system, a complex pattern of cross-reactive ligands and receptors

1987 • 710 citations

MADR1, a MAD-Related Protein That Functions in BMP2 Signaling Pathways

1996 • 710 citations

Crystal Structure of a Smad MH1 Domain Bound to DNA

1998 • 709 citations

A transcriptional partner for MAD proteins in TGF-β signalling

1996 • 699 citations

Myc suppression of the p21Cip1 Cdk inhibitor influences the outcome of the p53 response to DNA damage

2002 • 676 citations

A human Mad protein acting as a BMP-regulated transcriptional activator

1996 • 674 citations

Germline mutations of the gene encoding bone morphogenetic protein receptor 1A in juvenile polyposis

2001 • 626 citations

TGFβ1 Inhibits the Formation of Benign Skin Tumors, but Enhances Progression to Invasive Spindle Carcinomas in Transgenic Mice

1996 • 619 citations

Negative Regulation of G1 in Mammalian Cells: Inhibition of Cyclin E-Dependent Kinase by TGF-β

1993 • 578 citations

Repression of p15INK4b expression by Myc through association with Miz-1

2001 • 571 citations

The TGF-beta family mediator Smad1 is phosphorylated directly and activated functionally by the BMP receptor kinase.

1997 • 569 citations

Winged helix transcription factor BF-1 is essential for the development of the cerebral hemispheres

1995 • 569 citations

Breast cancer bone metastasis mediated by the Smad tumor suppressor pathway

2005 • 543 citations

A Self-Enabling TGFβ Response Coupled to Stress Signaling

2003 • 539 citations

Drosophila Mad binds to DNA and directly mediates activation of vestigial by Decapentaplegic

1997 • 524 citations

Genetic programs of epithelial cell plasticity directed by transforming growth factor-β

2001 • 520 citations

Novel activin receptors: Distinct genes and alternative mRNA splicing generate a repertoire of serine/threonine kinase receptors

1992 • 495 citations

The tumor suppressor gene Smad4/Dpc4 is required for gastrulation and later for anterior development of the mouse embryo

1998 • 494 citations

Cyclin-dependent kinases regulate the antiproliferative function of Smads

2004 • 485 citations

TGFβ influences Myc, Miz-1 and Smad to control the CDK inhibitor p15INK4b

2001 • 479 citations

E2F4/5 and p107 as Smad Cofactors Linking the TGFβ Receptor to c-myc Repression

2002 • 475 citations

Gliomagenesis: genetic alterations and mouse models

2001 • 460 citations

Crystal Structure of the Cytoplasmic Domain of the Type I TGF β Receptor in Complex with FKBP12

1999 • 433 citations

Transforming growth factor β signaling impairs Neu-induced mammary tumorigenesis while promoting pulmonary metastasis

2003 • 433 citations

The Many Forks in FOXO's Road

2003 • 425 citations

Synexpression groups in eukaryotes

1999 • 417 citations

Integration of IGF, FGF, and anti-BMP signals via Smad1 phosphorylation in neural induction

2003 • 411 citations

Nucleocytoplasmic Shuttling of Smads 2, 3, and 4 Permits Sensing of TGF-β Receptor Activity

2002 • 397 citations

Mutational inactivation of transforming growth factor beta receptor type II in microsatellite stable colon cancers.

1999 • 395 citations

Foxg1 Suppresses Early Cortical Cell Fate

2004 • 369 citations

Transforming growth factor beta and cell cycle regulation.

1995 • 368 citations

The TGFβ Receptor Activation Process

2001 • 360 citations

Ubiquitin-dependent degradation of TGF-β-activated Smad2

1999 • 343 citations

The role for transforming growth factor-beta (TGF-beta) in human cancer.

1999 • 323 citations

Defective repression of c- myc in breast cancer cells: A loss at the core of the transforming growth factor β growth arrest program

2001 • 320 citations

Direct signaling by the BMP type II receptor via the cytoskeletal regulator LIMK1

2003 • 319 citations

Crystal Structure of a Phosphorylated Smad2

2001 • 295 citations

Structural Basis of Smad2 Recognition by the Smad Anchor for Receptor Activation

2000 • 291 citations

Genetic alterations of the transforming growth factor beta receptor genes in pancreatic and biliary adenocarcinomas.

1998 • 284 citations

Early-onset multifocal inflammation in the transforming growth factor beta 1-null mouse is lymphocyte mediated.

1995 • 275 citations

Regulation of Smurf2 Ubiquitin Ligase Activity by Anchoring the E2 to the HECT Domain

2005 • 270 citations

C/EBPβ at the core of the TGFβ cytostatic response and its evasion in metastatic breast cancer cells

2006 • 268 citations

Limited overlapping roles of P15INK4b and P18INK4c cell cycle inhibitors in proliferation and tumorigenesis

2000 • 258 citations

Smad2 Nucleocytoplasmic Shuttling by Nucleoporins CAN/Nup214 and Nup153 Feeds TGFβ Signaling Complexes in the Cytoplasm and Nucleus

2002 • 252 citations

Targeting the TGFβ signaling network in human neoplasia

2003 • 245 citations

Transforming growth factor β-induced cell cycle arrest of human hematopoietic cells requires p57KIP2 up-regulation

2004 • 240 citations

Activation of LIMK1 by binding to the BMP receptor, BMPRII, regulates BMP-dependent dendritogenesis

2004 • 217 citations

Brain Factor-1Controls the Proliferation and Differentiation of Neocortical Progenitor Cells through Independent Mechanisms

2002 • 188 citations

Inactivation of Smad-Transforming Growth Factor β Signaling by Ca²⁺-Calmodulin-Dependent Protein Kinase II

2000 • 161 citations

McBindall—A Better Name for CCAAT/Enhancer Binding Proteins?

2001 • 156 citations

Transforming growth factor beta type I receptor kinase mutant associated with metastatic breast cancer.

1998 • 154 citations

Medea is a Drosophila Smad4 homolog that is differentially required to potentiate DPP responses

1998 • 153 citations

Targeting Endogenous Transforming Growth Factor β Receptor Signaling in SMAD4-Deficient Human Pancreatic Carcinoma Cells Inhibits Their Invasive Phenotype

2004 • 133 citations

Identification of phosphatases for Smad in the BMP/DPP pathway

2006 • 131 citations

Unique players in the BMP pathway: Small C-terminal domain phosphatases dephosphorylate Smad1 to attenuate BMP signaling

2006 • 125 citations

Analysis of specific gene mutations in the transforming growth factor-beta signal transduction pathway in human ovarian cancer.

2000 • 123 citations

Reversal of Tumor-induced Immunosuppression by TGF-β Inhibitors

2003 • 122 citations

Distinct Domain Utilization by Smad3 and Smad4 for Nucleoporin Interaction and Nuclear Import

2003 • 118 citations

The role of C/EBPbeta in mammary gland development and breast cancer.

2003 • 109 citations

Nuclear exclusion of Smad2 is a mechanism leading to loss of competence

2002 • 106 citations

The role of transforming growth factor beta in glioma progression.

1998 • 89 citations

Microsatellite instability is uncommon in breast cancer.

1999 • 83 citations

TGF beta-induced growth inhibition in primary fibroblasts requires the retinoblastoma protein.

1996 • 81 citations

Microsatellite instability and mutated type II transforming growth factor-β receptor gene in gliomas

1997 • 79 citations

The role of transforming growth factor-beta in primary brain tumors

2003 • 75 citations

Molecular Characterization of Rat Transforming Growth Factor-β Type II Receptor

1993 • 74 citations

Essential Requirement of CCAAT/Enhancer Binding Proteins in Embryogenesis

2004 • 74 citations

Nuclear Targeting of Transforming Growth Factor-β-activated Smad Complexes

2005 • 67 citations

Molecular Characterization of a Type I Serine-Threonine Kinase Receptor for TGF-β and Activin in the Rat Pituitary Tumor Cell Line GH3

1995 • 22 citations

A transcriptional partner for MAD proteins in TGF-β signalling

1997 • 19 citations