A Self-Enabling TGFβ Response Coupled to Stress Signaling

TGF-β SIGNAL TRANSDUCTION

1998 • 7,582 citations

Normal keratinization in a spontaneously immortalized aneuploid human keratinocyte cell line.

1988 • 4,008 citations

TGFβ Signaling in Growth Control, Cancer, and Heritable Disorders

2000 • 2,354 citations

Transforming growth factor beta

2011 • 1,990 citations

Bone morphogenetic proteins: multifunctional regulators of vertebrate development.

1996 • 1,959 citations

NEW EMBO MEMBERS REVIEW: Transcriptional control by the TGF-beta/Smad signaling system

2000 • 1,935 citations

How cells read TGF-β signals

2000 • 1,843 citations

Isolation and Characterization of a Spontaneously Immortalized Human Breast Epithelial Cell Line, MCF-10

1990 • 1,495 citations

Peptide Growth Factors and Their Receptors

1991 • 1,221 citations

Transcriptional Activators of TGF-β Responses: Smads

1998 • 1,024 citations

Defective haematopoiesis and vasculogenesis in transforming growth factor-β1 knock out mice

1995 • 1,020 citations

A mechanism of repression of TGFbeta / Smad signaling by oncogenic Ras

1999 • 1,004 citations

SARA, a FYVE Domain Protein that Recruits Smad2 to the TGFβ Receptor

1998 • 952 citations

Id1 and Id3 are required for neurogenesis, angiogenesis and vascularization of tumour xenografts

1999 • 919 citations

Mice lacking Smad3 show accelerated wound healing and an impaired local inflammatory response

1999 • 912 citations

Identification and Functional Characterization of Distinct Critically Important Bone Morphogenetic Protein-specific Response Elements in the Id1 Promoter

2002 • 849 citations

Disruption of the ARF-Mdm2-p53 tumor suppressor pathway in Myc-induced lymphomagenesis

1999 • 828 citations

Growth inhibition by TGF-β linked to suppression of retinoblastoma protein phosphorylation

1990 • 812 citations

The molecular biology and nomenclature of the activating transcription factor/cAMP responsive element binding family of transcription factors: activating transcription factor proteins and homeostasis

2001 • 784 citations

Transforming growth factor-beta: Vasculogenesis, angiogenesis, and vessel wall integrity

1997 • 715 citations

Crystal Structure of a Smad MH1 Domain Bound to DNA

1998 • 709 citations

A transcriptional partner for MAD proteins in TGF-β signalling

1996 • 699 citations

Myc suppression of the p21Cip1 Cdk inhibitor influences the outcome of the p53 response to DNA damage

2002 • 676 citations

ATF3 and stress responses.

1999 • 621 citations

Analysis of promoter binding by the E2F and pRB families in vivo: distinct E2F proteins mediate activation and repression

2000 • 619 citations

From receptors to stress-activated MAP kinases

1999 • 525 citations

Smad2 and Smad3 Positively and Negatively Regulate TGFβ-Dependent Transcription through the Forkhead DNA-Binding Protein FAST2

1998 • 513 citations

Id2 is a retinoblastoma protein target and mediates signalling by Myc oncoproteins

2000 • 504 citations

Overexpression of Id protein inhibits the muscle differentiation program: in vivo association of Id with E2A proteins.

1992 • 480 citations

E2F4/5 and p107 as Smad Cofactors Linking the TGFβ Receptor to c-myc Repression

2002 • 475 citations

p53 Mutations in human immortalized epithelial cell lines

1993 • 441 citations

Id helix—loop—helix proteins in cell growth and differentiation

1998 • 413 citations

Nucleocytoplasmic Shuttling of Smads 2, 3, and 4 Permits Sensing of TGF-β Receptor Activity

2002 • 397 citations

Repression of the CDK activator Cdc25A and cell-cycle arrest by cytokine TGF-β in cells lacking the CDK inhibitor p15

1997 • 378 citations

Signaling inputs converge on nuclear effectors in TGF-β signaling

2000 • 359 citations

The role for transforming growth factor-beta (TGF-beta) in human cancer.

1999 • 323 citations

Defective repression of c- myc in breast cancer cells: A loss at the core of the transforming growth factor β growth arrest program

2001 • 320 citations

Mice Lacking Smad3 Are Protected Against Cutaneous Injury Induced by Ionizing Radiation

2002 • 281 citations

Direct Binding of Smad1 and Smad4 to Two Distinct Motifs Mediates Bone Morphogenetic Protein-specific Transcriptional Activation ofId1 Gene

2002 • 279 citations

Smad2 Nucleocytoplasmic Shuttling by Nucleoporins CAN/Nup214 and Nup153 Feeds TGFβ Signaling Complexes in the Cytoplasm and Nucleus

2002 • 252 citations

The human Tap protein is a nuclear mRNA export factor that contains novel RNA-binding and nucleocytoplasmic transport sequences

1999 • 246 citations

ATF3 and ATF3 delta Zip. Transcriptional repression versus activation by alternatively spliced isoforms.

1994 • 240 citations

A role for Id-1 in the aggressive phenotype and steroid hormone response of human breast cancer cells.

2000 • 237 citations

The Id proteins and angiogenesis

2001 • 224 citations

Expression patterns ofId1, Id2, andId3 are highly related but distinct from that ofId4 during mouse embryogenesis

1996 • 184 citations

Homocysteine-responsive ATF3 gene expression in human vascular endothelial cells: activation of c-Jun NH2-terminal kinase and promoter response element

2000 • 176 citations

Overexpression of Id-1 protein is a marker for unfavorable prognosis in early-stage cervical cancer.

2001 • 163 citations

gadd153/Chop10, a Potential Target Gene of the Transcriptional Repressor ATF3

1997 • 155 citations

Smad4/DPC4 Silencing and Hyperactive Ras Jointly Disrupt Transforming Growth Factor-β Antiproliferative Responses in Colon Cancer Cells

1999 • 146 citations

Transcription of the Dominant-Negative Helix-Loop-Helix Protein Id1 Is Regulated by a Protein Complex Containing the Immediate-Early Response Gene Egr-1†

1996 • 119 citations

Id proteins are dynamically expressed in normal epidermis and dysregulated in squamous cell carcinoma.

2000 • 114 citations

Id: A Negative Regulator of Helix‐Loop‐Helix DNA Binding Proteins

1990 • 113 citations

Transcriptional Autorepression of the Stress-inducible GeneATF3

2000 • 99 citations

Establishment of human peripheral lung epithelial cell lines (HPL1) retaining differentiated characteristics and responsiveness to epidermal growth factor, hepatocyte growth factor, and transforming growth factor beta1.

1997 • 79 citations

Id1 expression is associated with histological grade and invasive behavior in endometrial carcinoma

2001 • 69 citations

The Human Tap Nuclear RNA Export Factor Contains a Novel Transportin-dependent Nuclear Localization Signal That Lacks Nuclear Export Signal Function

1999 • 65 citations

TGFβ Signal Transduction

2010 • 65 citations

In situ demonstration of phosphorylated c-jun and p38 MAP kinase in epidermal keratinocytes following ultraviolet B irradiation of human skin

2001 • 57 citations

Analysis of Hornozygous TGFβ1 Null Mouse Embryos Demonstrates Defects in Yolk Sac. Vasculogenesis and Hematopoiesis

1995 • 44 citations

The Id proteins: targets for inhibiting tumor cells and their blood supply

2001 • 25 citations