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Cell Signaling by Receptor Tyrosine Kinases

2010 • 7,477 citations

Untangling the ErbB signalling network

2001 • 6,623 citations

Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal-regulated kinase activation

1995 • 4,589 citations

Cell Signaling by Receptor Tyrosine Kinases

2000 • 3,570 citations

TGFβ Signaling in Growth Control, Cancer, and Heritable Disorders

2000 • 2,354 citations

DPC4 , A Candidate Tumor Suppressor Gene at Human Chromosome 18q21.1

1996 • 2,320 citations

Transport Between the Cell Nucleus and the Cytoplasm

1999 • 2,001 citations

NEW EMBO MEMBERS REVIEW: Transcriptional control by the TGF-beta/Smad signaling system

2000 • 1,935 citations

Direct binding of Smad3 and Smad4 to critical TGFbeta -inducible elements in the promoter of human plasminogen activator inhibitor-type 1gene

1998 • 1,763 citations

Tyrosine Kinase Inhibition: An Approach to Drug Development

1995 • 1,655 citations

SB-431542 Is a Potent and Specific Inhibitor of Transforming Growth Factor-β Superfamily Type I Activin Receptor-Like Kinase (ALK) Receptors ALK4, ALK5, and ALK7

2002 • 1,572 citations

The SRF accessory protein Elk-1 contains a growth factor-regulated transcriptional activation domain

1993 • 1,313 citations

Smad7 Binds to Smurf2 to Form an E3 Ubiquitin Ligase that Targets the TGFβ Receptor for Degradation

2000 • 1,299 citations

Transcriptional Regulation by Extracellular signals: Mechanisms and Specificity

1995 • 1,287 citations

TGF-beta receptor-mediated signalling through Smad2, Smad3 and Smad4

1997 • 1,023 citations

SARA, a FYVE Domain Protein that Recruits Smad2 to the TGFβ Receptor

1998 • 952 citations

Smad regulation in TGF-β signal transduction

2001 • 917 citations

c-Cbl/Sli-1 regulates endocytic sorting and ubiquitination of the epidermal growth factor receptor

1998 • 865 citations

TGF-β signaling: positive and negative effects on tumorigenesis

2002 • 830 citations

Smurf1 Interacts with Transforming Growth Factor-β Type I Receptor through Smad7 and Induces Receptor Degradation

2001 • 828 citations

Leptomycin B Inhibition of Signal-Mediated Nuclear Export by Direct Binding to CRM1

1998 • 801 citations

Inhibition of Transforming Growth Factor (TGF)-β1–Induced Extracellular Matrix with a Novel Inhibitor of the TGF-β Type I Receptor Kinase Activity: SB-431542

2002 • 609 citations

Leptomycin B targets a regulatory cascade of crm1, a fission yeast nuclear protein, involved in control of higher order chromosome structure and gene expression.

1994 • 453 citations

Functional analysis of a growth factor-responsive transcription factor complex

1993 • 386 citations

Regulation of Transcriptional Activation Domain Function by Ubiquitin

2001 • 363 citations

Ubiquitin-dependent degradation of TGF-β-activated Smad2

1999 • 343 citations

Identification of Novel Inhibitors of the Transforming Growth Factor β1 (TGF-β1) Type 1 Receptor (ALK5)

2002 • 306 citations

Crystal Structure of a Phosphorylated Smad2

2001 • 295 citations

Sphingosylphosphorylcholine is a ligand for ovarian cancer G-protein-coupled receptor 1

2000 • 291 citations

A mutant EGF-receptor defective in ubiquitylation and endocytosis unveils a role for Grb2 in negative signaling

2002 • 280 citations

Microtubule Binding to Smads May Regulate TGFβ Activity

2000 • 277 citations

Homeodomain and winged-helix transcription factors recruit activated Smads to distinct promoter elements via a common Smad interaction motif

2000 • 277 citations

Transforming Growth Factor β-Independent Shuttling of Smad4 between the Cytoplasm and Nucleus

2000 • 266 citations

Smad3-Smad4 and AP-1 Complexes Synergize in Transcriptional Activation of the c-Jun Promoter by Transforming Growth Factor β

1999 • 261 citations

Endogenous patterns of TGFβ superfamily signaling during early Xenopus development

2000 • 256 citations

Exportin 4: a mediator of a novel nuclear export pathway in higher eukaryotes

2000 • 219 citations

Ligand-dependent Degradation of Smad3 by a Ubiquitin Ligase Complex of ROC1 and Associated Proteins

2001 • 219 citations

Differential Usage of Signal Transduction Pathways Defines Two Types of Serum Response Factor Target Gene

2001 • 193 citations

ERK activation induces phosphorylation of Elk-1 at multiple S/T-P motifs to high stoichiometry

1999 • 179 citations

Filamin Associates with Smads and Regulates Transforming Growth Factor-β Signaling

2001 • 169 citations

Importin β Mediates Nuclear Translocation of Smad 3

2000 • 165 citations

The nuclear import function of Smad2 is masked by SARA and unmasked by TGFb-dependent phosphorylation

2000 • 165 citations

The L3 loop and C-terminal phosphorylation jointly define Smad protein trimerization.

2001 • 141 citations

Regulation of intracellular dynamics of Smad4 by its leucine‐rich nuclear export signal

2000 • 139 citations

A distinct nuclear localization signal in the N terminus of Smad 3 determines its ligand-induced nuclear translocation

2000 • 136 citations

Formation of a Stable Heterodimer between Smad2 and Smad4

2001 • 85 citations

Continuous recycling: a mechanism for modulatory signal transduction

2001 • 80 citations

Endocytosis and intracellular sorting of receptor tyrosine kinases

1998 • 69 citations