Gliomagenesis: genetic alterations and mouse models

PTEN , a Putative Protein Tyrosine Phosphatase Gene Mutated in Human Brain, Breast, and Prostate Cancer

1997 • 4,753 citations

Mammalian Neural Stem Cells

2000 • 4,689 citations

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

1992 • 4,648 citations

A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4

1993 • 3,680 citations

Protein kinases and phosphatases: The Yin and Yang of protein phosphorylation and signaling

1995 • 2,907 citations

Effects of an Rb mutation in the mouse

1992 • 1,779 citations

Role of the INK4a Locus in Tumor Suppression and Cell Mortality

1996 • 1,580 citations

Tumor Suppression at the Mouse INK4a Locus Mediated by the Alternative Reading Frame Product p19

1997 • 1,568 citations

The Ink4a Tumor Suppressor Gene Product, p19Arf, Interacts with MDM2 and Neutralizes MDM2's Inhibition of p53

1998 • 1,538 citations

Pathology of Tumors of the Nervous System.

1964 • 1,494 citations

Combined activation of Ras and Akt in neural progenitors induces glioblastoma formation in mice

2000 • 885 citations

Essential role for oncogenic Ras in tumour maintenance

1999 • 880 citations

Reversible Tumorigenesis by MYC in Hematopoietic Lineages

1999 • 871 citations

Structural alterations of the epidermal growth factor receptor gene in human gliomas.

1992 • 853 citations

Overexpression of the EGF Receptor and p53 Mutations are Mutually Exclusive in the Evolution of Primary and Secondary Glioblastomas

1996 • 733 citations

Role of the p16 tumor suppressor gene in cancer.

1998 • 710 citations

The catalytic domain of the neurofibromatosis type 1 gene product stimulates ras GTPase and complements ira mutants of S. cerevisiae

1990 • 684 citations

The ARF/p53 pathway

2000 • 647 citations

Genes for epidermal growth factor receptor, transforming growth factor alpha, and epidermal growth factor and their expression in human gliomas in vivo.

1991 • 634 citations

FGF modulates the PDGF-driven pathway of oligodendrocyte development

1990 • 586 citations

Cooperation between two growth factors promotes extended self-renewal and inhibits differentiation of oligodendrocyte-type-2 astrocyte (O-2A) progenitor cells.

1990 • 573 citations

A constitutively active epidermal growth factor receptor cooperates with disruption of G₁ cell-cycle arrest pathways to induce glioma-like lesions in mice

1998 • 560 citations

Regulation of neurogenesis by growth factors and neurotransmitters

1998 • 483 citations

Reversible Activation of c-Myc in Skin

1999 • 468 citations

MMAC1/PTEN mutations in primary tumor specimens and tumor cell lines.

1997 • 464 citations

TOR signalling and control of cell growth

1997 • 458 citations

Nf1;Trp53 mutant mice develop glioblastoma with evidence of strain-specific effects

2000 • 420 citations

A public database for gene expression in human cancers.

1999 • 417 citations

Deletion of p16 and p15 genes in brain tumors.

1994 • 416 citations

Multiple Routes to Astrocytic Differentiation in the CNS

1998 • 389 citations

Tumor spectrum in ARF-deficient mice.

1999 • 339 citations

Subsets of Glioblastoma Multiforme Defined by Molecular Genetic Analysis

1993 • 334 citations

Proliferation of human malignant astrocytomas is dependent on Ras activation

1997 • 331 citations

Structural Development in Gliomas

1938 • 310 citations

The p53 Gene and Protein in Human Brain Tumors

1994 • 303 citations

Expression of PDGF and PDGF receptors in human astrocytoma operation specimens supports the existence of an autocrine loop

1995 • 298 citations

Induction of brain tumors in mice using a recombinant platelet-derived growth factor B-chain retrovirus.

1998 • 290 citations

Extensive contribution of Rb-deficient cells to adult chimeric mice with limited histopathological consequences.

1994 • 289 citations

Ciliary neurotrophic factor and leukemia inhibitory factor promote the generation, maturation and survival of oligodendrocytes in vitro

1994 • 285 citations

Human glioblastomas with no alterations of the CDKN2A (p16INK4A, MTS1) and CDK4 genes have frequent mutations of the retinoblastoma gene.

1996 • 267 citations

Myogenic signaling of phosphatidylinositol 3-kinase requires the serine-threonine kinase Akt/protein kinase B

1999 • 261 citations

Differential expression of MMAC/PTEN in glioblastoma multiforme: relationship to localization and prognosis.

1999 • 257 citations

Biology and treatment of malignant glioma.

2000 • 210 citations

Gliogenesis in the central nervous system

2000 • 207 citations

Purification and Characterization of Astrocyte Precursor Cells in the Developing Rat Optic Nerve

1999 • 193 citations

p38 MAPK signalling cascades: ancient roles and new functions

2000 • 190 citations

Development and malignant progression of astrocytomas in GFAP-v-src transgenic mice

1997 • 179 citations

Cyclin-dependent kinase 6 (CDK6) amplification in human gliomas identified using two-dimensional separation of genomic DNA.

1997 • 174 citations

Development of a flexible and specific gene delivery system for production of murine tumor models

1999 • 170 citations

Correlation of basic fibroblast growth factor expression levels with the degree of malignancy and vascularity in human gliomas

1992 • 166 citations

Differentiation of the immortalized adult neuronal progenitor cell line HC2S2 into neurons by regulatable suppression of the v-myc oncogene.

1996 • 163 citations

p53 gene mutation and ink4a-arf deletion appear to be two mutually exclusive events in human glioblastoma

2000 • 149 citations

Splicing into Senescence: The Curious Case of p16 and p19ARF

1997 • 148 citations

Insights into cancer from transgenic mouse models

1999 • 138 citations

Acquisition of the Glioblastoma Phenotype during Astrocytoma Progression Is Associated with Loss of Heterozygosity on 10q25-qter

1999 • 126 citations

Modeling mutations in the G₁ arrest pathway in human gliomas: overexpression of CDK4 but not loss of INK4a–ARF induces hyperploidy in cultured mouse astrocytes

1998 • 124 citations

Growth factor-mediated angiogenesis in the malignant progression of glial tumors: A review

1998 • 122 citations

Mechanisms of Glioma Invasion: Role of Matrix-Metalloproteinases

1997 • 120 citations

p53 Mutation, Expression, and DNA Ploidy in Evolving Gliomas: Evidence for Two Pathways of Progression

1994 • 104 citations

Astrocytes Derived from p53-Deficient Mice Provide a Multistep In Vitro Model for Development of Malignant Gliomas

1995 • 100 citations

Astrocytes Give Rise to Oligodendrogliomas and Astrocytomas after Gene Transfer of Polyoma Virus Middle T Antigen in Vivo

2000 • 81 citations

The inhibition of oligodendrocytic differentiation of O‐2A progenitors caused by basic fibroblast growth factor is overridden by astrocytes

1993 • 72 citations

Dominant-negative mutations of the tumor suppressor p53 relating to early onset of glioblastoma multiforme.

1999 • 67 citations

Opposite Functions for E2F1 and E2F4 in Human Epidermal Keratinocyte Differentiation

2000 • 54 citations

Analysis of glioma cell lines for amplification and overexpression of MDM2

1994 • 53 citations

Retrodifferentiation and Cell Death

1994 • 49 citations

Histological Characteristics and Expression of Acidic and Basic Fibroblast Growth Factor Genes in Intracerebral Xenogeneic Transplants of Human Glioma Cells

1994 • 48 citations

Growth factors, glia and gliomas.

1997 • 44 citations

CNTF and its receptor subunits in human gliomas.

1999 • 25 citations

Transgenic and gene disruption techniques in the study of neurocarcinogenesis

1995 • 25 citations

Exploitation of immune mechanisms in the treatment of central nervous system cancer

2000 • 25 citations

Gene therapy strategies for intracranial tumours: glioma and pituitary adenomas.

2000 • 9 citations