Targeting the TGFβ signaling network in human neoplasia

TGF-β SIGNAL TRANSDUCTION

1998 • 7,582 citations

TGFβ Signaling in Growth Control, Cancer, and Heritable Disorders

2000 • 2,354 citations

DPC4 , A Candidate Tumor Suppressor Gene at Human Chromosome 18q21.1

1996 • 2,320 citations

TGF-β signaling in tumor suppression and cancer progression

2001 • 2,235 citations

Identification of Smad7, a TGFβ-inducible antagonist of TGF-β signalling

1997 • 1,774 citations

Phosphatidylinositol 3-Kinase Function Is Required for Transforming Growth Factor β-mediated Epithelial to Mesenchymal Transition and Cell Migration

2000 • 956 citations

TGF-beta induced transdifferentiation of mammary epithelial cells to mesenchymal cells: involvement of type I receptors.

1994 • 937 citations

Molecular Predictors of Survival after Adjuvant Chemotherapy for Colon Cancer

2001 • 878 citations

Immune-mediated eradication of tumors through the blockade of transforming growth factor-β signaling in T cells

2001 • 759 citations

Ras and TGFβ cooperatively regulate epithelial cell plasticity and metastasis

2002 • 693 citations

TGF-beta1 and Ha-Ras collaborate in modulating the phenotypic plasticity and invasiveness of epithelial tumor cells.

1996 • 680 citations

Smad3 Mutant Mice Develop Metastatic Colorectal Cancer

1998 • 677 citations

TGFβ signaling is necessary for carcinoma cell invasiveness and metastasis

1998 • 630 citations

TGFβ1 Inhibits the Formation of Benign Skin Tumors, but Enhances Progression to Invasive Spindle Carcinomas in Transgenic Mice

1996 • 619 citations

Inhibition of Transforming Growth Factor (TGF)-β1–Induced Extracellular Matrix with a Novel Inhibitor of the TGF-β Type I Receptor Kinase Activity: SB-431542

2002 • 609 citations

Blockade of TGF-β inhibits mammary tumor cell viability, migration, and metastases

2002 • 490 citations

Blockade of TGF-β inhibits mammary tumor cell viability, migration, and metastases

2002 • 406 citations

Lifetime exposure to a soluble TGF-β antagonist protects mice against metastasis without adverse side effects

2002 • 375 citations

Metastasis is driven by sequential elevation of H-ras and Smad2 levels

2002 • 365 citations

Anti-transforming growth factor (TGF)-beta antibodies inhibit breast cancer cell tumorigenicity and increase mouse spleen natural killer cell activity. Implications for a possible role of tumor cell/host TGF-beta interactions in human breast cancer progression.

1993 • 356 citations

Lifetime exposure to a soluble TGF-β antagonist protects mice against metastasis without adverse side effects

2002 • 326 citations

Transforming growth factor-β1 is a new form of tumor suppressor with true haploid insufficiency

1998 • 319 citations

Mammary tumor suppression by transforming growth factor beta 1 transgene expression.

1995 • 292 citations

Inhibition of mammary duct development but not alveolar outgrowth during pregnancy in transgenic mice expressing active TGF-beta 1.

1993 • 260 citations

The TGF-β signaling inhibitor Smad7 enhances tumorigenicity in pancreatic cancer

1999 • 259 citations

Haploid loss of the tumor suppressor Smad4/Dpc4 initiates gastric polyposis and cancer in mice

2000 • 241 citations

Synthesis and Activity of New Aryl- and Heteroaryl-Substituted Pyrazole Inhibitors of the Transforming Growth Factor-β Type I Receptor Kinase Domain

2003 • 231 citations

Transforming growth factor beta1 suppresses nonmetastatic colon cancer at an early stage of tumorigenesis.

1999 • 221 citations

Transgenic mice overexpressing a dominant-negative mutant type II transforming growth factor beta receptor show enhanced tumorigenesis in the mammary gland and lung in response to the carcinogen 7,12-dimethylbenz-[a]-anthracene.

1997 • 195 citations

Transforming Growth Factor β Enhances Epithelial Cell Survival via Akt-dependent Regulation of FKHRL1

2001 • 178 citations

Autocrine Transforming Growth Factor-β Signaling Mediates Smad-independent Motility in Human Cancer Cells

2003 • 157 citations

Transforming growth factor-beta and breast cancer: Tumor promoting effects of transforming growth factor-β

2000 • 155 citations

Circulating transforming growth factor beta 1 as a predictor of liver metastasis after resection in colorectal cancer.

2001 • 150 citations

Transforming growth factor beta1 is a target for the von Hippel-Lindau tumor suppressor and a critical growth factor for clear cell renal carcinoma.

1999 • 147 citations

Antitumor activity of a recombinant soluble betaglycan in human breast cancer xenograft.

2002 • 144 citations

Transforming growth factor beta 1 can induce estrogen-independent tumorigenicity of human breast cancer cells in athymic mice.

1993 • 138 citations

Tumor–host interactions in the gallbladder suppress distal angiogenesis and tumor growth: Involvement of transforming growth factor β1

1999 • 137 citations

Transforming Growth Factor-β and Breast Cancer Risk in Women With Mammary Epithelial Hyperplasia

1999 • 134 citations

Human antitransforming growth factor β 2 monoclonal antibody—a new modulator of wound healing in trabeculectomy

2002 • 132 citations

Association Between the T29→C Polymorphism in the Transforming Growth Factor β1 Gene and Breast Cancer Among Elderly White Women

2001 • 132 citations

The glioblastoma‐derived T‐cell suppressor factor/transforming growth factor beta₂ inhibits the generation of lymphokineactivated killer (LAK) cells

1988 • 131 citations

Reversal of Tumor-induced Immunosuppression by TGF-β Inhibitors

2003 • 122 citations

Transforming growth factor beta 1 induces cachexia and systemic fibrosis without an antitumor effect in nude mice.

1991 • 121 citations

Inducible expression of transforming growth factor beta1 in papillomas causes rapid metastasis.

2001 • 119 citations

A soluble transforming growth factor beta type III receptor suppresses tumorigenicity and metastasis of human breast cancer MDA-MB-231 cells.

1999 • 116 citations

Dominant-negative interference of the transforming growth factor beta type II receptor in mammary gland epithelium results in alveolar hyperplasia and differentiation in virgin mice.

1998 • 113 citations

Antisense oligonucleotides specific for transforming growth factor beta2 inhibit the growth of malignant mesothelioma both in vitro and in vivo.

1997 • 101 citations

Soluble type II transforming growth factor-beta (TGF-beta) receptor inhibits TGF-beta signaling in COLO-357 pancreatic cancer cells in vitro and attenuates tumor formation.

2001 • 90 citations

Enhanced Expression of the Type II Transforming Growth Factor-β Receptor Is Associated with Decreased Survival in Human Pancreatic Cancer

1999 • 82 citations

Blockade of Smad4 in transformed keratinocytes containing a Ras oncogene leads to hyperactivation of the Ras-dependent Erk signalling pathway associated with progression to undifferentiated carcinomas

2000 • 78 citations

Repression of autocrine transforming growth factor beta 1 and beta 2 in quiescent CBS colon carcinoma cells leads to progression of tumorigenic properties.

1993 • 69 citations

Transforming Growth Factor-β and Breast Cancer

1999 • 9 citations