Transforming growth factor β-induced cell cycle arrest of human hematopoietic cells requires p57KIP2 up-regulation

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2000 • 27,569 citations

pl5INK4B is a potentia| effector of TGF-β-induced cell cycle arrest

1994 • 1,932 citations

Cytostatic and apoptotic actions of TGF-β in homeostasis and cancer

2003 • 1,572 citations

Hematopoietic Stem Cell Quiescence Maintained by p21 ^cip1/waf1

2000 • 1,326 citations

Kip/Cip and Ink4 Cdk inhibitors cooperate to induce cell cycle arrest in response to TGF-beta.

1995 • 959 citations

p57KIP2, a structurally distinct member of the p21CIP1 Cdk inhibitor family, is a candidate tumor suppressor gene.

1995 • 956 citations

Cloning of p57KIP2, a cyclin-dependent kinase inhibitor with unique domain structure and tissue distribution.

1995 • 910 citations

Altered cell differentiation and proliferation in mice lacking p57KIP2 indicates a role in Beckwith–Wiedemann syndrome

1997 • 753 citations

GS domain mutations that constitutively activate T beta R-I, the downstream signaling component in the TGF-beta receptor complex.

1995 • 682 citations

A Smad Transcriptional Corepressor

1999 • 563 citations

A Self-Enabling TGFβ Response Coupled to Stress Signaling

2003 • 539 citations

E2F4/5 and p107 as Smad Cofactors Linking the TGFβ Receptor to c-myc Repression

2002 • 475 citations

Regional loss of imprinting and growth deficiency in mice with a targeted deletion of KvDMR1

2002 • 463 citations

Two forms of transforming growth factor-β distinguished by multipotential haematopoietic progenitor cells

1987 • 407 citations

An imprinted gene p57KIP2 is mutated in Beckwith–Wiedemann syndrome

1996 • 390 citations

Loss of imprinting of a paternally expressed transcript, with antisense orientation to K _V LQT1, occurs frequently in Beckwith–Wiedemann syndrome and is independent of insulin-like growth factor II imprinting

1999 • 360 citations

Induction of Inhibitory Smad6 and Smad7 mRNA by TGF-β Family Members

1998 • 355 citations

Stem cell repopulation efficiency but not pool size is governed by p27kip1

2000 • 352 citations

Repression of the gene encoding the TGF-β type II receptor is a major target of the EWS-FLI1 oncoprotein

1999 • 338 citations

Imprinting of the gene encoding a human cyclin-dependent kinase inhibitor, p57KIP2, on chromosome 11p15.

1996 • 302 citations

Beckwith-Wiedemann syndrome: imprinting in clusters revisited

2000 • 299 citations

Transforming growth factor-β: pleiotropic role in the regulation of hematopoiesis

2000 • 298 citations

In vivo self-renewing divisions of haematopoietic stem cells are increased in the absence of the early G1-phase inhibitor, p18INK4C

2004 • 271 citations

Resistance to inhibition of cell growth by transforming growth factor-beta and its role in oncogenesis.

1993 • 239 citations

Genome imprinting regulated by the mouse Polycomb group protein Eed

2003 • 235 citations

Mutations in the tumor suppressors Smad2 and Smad4 inactivate transforming growth factor β signaling by targeting Smads to the ubiquitin–proteasome pathway

2000 • 192 citations

Analysis of the expression of cell cycle regulators in Ewing cell lines: EWS-FLI-1 modulates p57KIP2 and c-Myc expression

2001 • 172 citations

Suppression of cell transformation by the cyclin-dependent kinase inhibitor p57 ^KIP2 requires binding to proliferating cell nuclear antigen

1998 • 152 citations

Transcriptional Regulation of the Transforming Growth Factor-β-inducible Mouse Germ Line Ig α Constant Region Gene by Functional Cooperation of Smad, CREB, and AML Family Members

2000 • 132 citations

Aberrant DNA methylation of p57KIP2 identifies a cell-cycle regulatory pathway with prognostic impact in adult acute lymphocytic leukemia

2003 • 130 citations

Aberrant DNA methylation ofp57KIP2 gene in the promoter region in lymphoid malignancies of B-cell phenotype

2002 • 128 citations

Inactivation of p57KIP2 by regional promoter hypermethylation and histone deacetylation in human tumors

2002 • 119 citations

Reduction in levels of the cyclin-dependent kinase inhibitor p27 ^kip-1 coupled with transforming growth factor β neutralization induces cell-cycle entry and increases retroviral transduction of primitive human hematopoietic cells

1998 • 119 citations

Induction of p57 ^KIP2 expression by p73β

2002 • 96 citations

Inhibition of the Transforming Growth Factor β1 Signaling Pathway by the AML1/ETO Leukemia-associated Fusion Protein

2000 • 93 citations

Mutations of the Smad4 gene in acute myelogeneous leukemia and their functional implications in leukemogenesis

2001 • 85 citations

Transforming growth factor β1 mediates cell-cycle arrest of primitive hematopoietic cells independent of p21Cip1/Waf1or p27Kip1

2001 • 78 citations

Distant cis-elements regulate imprinted expression of the mouse p57 Kip2 (Cdkn1c) gene: implications for the human disorder, Beckwith-Wiedemann syndrome

2001 • 73 citations

Characterization of the human p57KIP2 gene: Alternative splicing, insertion/deletion polymorphisms in VNTR sequences in the coding region, and mutational analysis

1996 • 70 citations

Smad-mediated Transcription Is Required for Transforming Growth Factor-β1-induced p57Kip2 Proteolysis in Osteoblastic Cells

2001 • 56 citations

Disruption of an imprinted gene cluster by a targeted chromosomal translocation in mice

2001 • 51 citations

Molecular mechanism of transforming growth factor β–mediated cell-cycle modulation in primary human CD34+ progenitors

2002 • 35 citations

Expression of cell cycle regulatory genes in chronic myelogenous leukemia.

1998 • 18 citations

Megakaryocytic differentiation of a leukemic cell line, MC3, by phorbol ester: Induction of glycoprotein IIb/IIIa and effects on expression of IL-6, IL-6 receptor, mpl and GATA genes

1995 • 14 citations