Smad2 Nucleocytoplasmic Shuttling by Nucleoporins CAN/Nup214 and Nup153 Feeds TGFβ Signaling Complexes in the Cytoplasm and Nucleus

TGF-β SIGNAL TRANSDUCTION

1998 • 7,582 citations

CRM1 Is an Export Receptor for Leucine-Rich Nuclear Export Signals

1997 • 2,062 citations

Transport Between the Cell Nucleus and the Cytoplasm

1999 • 2,001 citations

NEW EMBO MEMBERS REVIEW: Transcriptional control by the TGF-beta/Smad signaling system

2000 • 1,935 citations

Nuclei from Rat Liver: Isolation Method That Combines Purity with High Yield

1966 • 1,687 citations

The HIV-1 rev trans-activator acts through a structured target sequence to activate nuclear export of unspliced viral mRNA

1989 • 1,280 citations

NUCLEOCYTOPLASMIC TRANSPORT: The Soluble Phase

1998 • 1,184 citations

A novel ubiquitin-like modification modulates the partitioning of the Ran-GTPase-activating protein RanGAP1 between the cytosol and the nuclear pore complex.

1996 • 1,161 citations

SARA, a FYVE Domain Protein that Recruits Smad2 to the TGFβ Receptor

1998 • 952 citations

Leptomycin B Inhibition of Signal-Mediated Nuclear Export by Direct Binding to CRM1

1998 • 801 citations

Protein import into nuclei: association and dissociation reactions involving transport substrate, transport factors, and nucleoporins

1995 • 767 citations

A transcriptional partner for MAD proteins in TGF-β signalling

1996 • 699 citations

Identification and characterization of a nuclear pore complex protein

1986 • 610 citations

The human homologue of yeast CRM1 is in a dynamic subcomplex with CAN/Nup214 and a novel nuclear pore component Nup88

1997 • 480 citations

E2F4/5 and p107 as Smad Cofactors Linking the TGFβ Receptor to c-myc Repression

2002 • 475 citations

Structural Basis for the Interaction between FxFG Nucleoporin Repeats and Importin-β in Nuclear Trafficking

2000 • 440 citations

The Mex67p-mediated nuclear mRNA export pathway is conserved from yeast to human

1999 • 431 citations

Nuclear localization signal-independent and importin/karyopherin-independent nuclear import of β-catenin

1998 • 429 citations

Regulation of Smad Activity

2000 • 419 citations

Intramolecular masking of the nuclear location signal and dimerization domain in the precursor for the p50 NF-κB subunit

1992 • 399 citations

The translocation (6;9), associated with a specific subtype of acute myeloid leukemia, results in the fusion of two genes, dek and can, and the expression of a chimeric, leukemia-specific dek-can mRNA.

1992 • 377 citations

Dominant-negative mutants of importin-beta block multiple pathways of import and export through the nuclear pore complex

1997 • 365 citations

Determinants of specificity in TGF-β signal transduction

1998 • 364 citations

The TGFβ Receptor Activation Process

2001 • 360 citations

Ubiquitin-dependent degradation of TGF-β-activated Smad2

1999 • 343 citations

A nuclear pore complex protein that contains zinc finger motifs, binds DNA, and faces the nucleoplasm

1993 • 308 citations

Intramolecular Masking of Nuclear Import Signal on NF-AT4 by Casein Kinase I and MEKK1

1998 • 306 citations

Crystal Structure of a Phosphorylated Smad2

2001 • 295 citations

Structural Basis of Smad2 Recognition by the Smad Anchor for Receptor Activation

2000 • 291 citations

Sphingosylphosphorylcholine is a ligand for ovarian cancer G-protein-coupled receptor 1

2000 • 291 citations

Gradient of Increasing Affinity of Importin β for Nucleoporins along the Pathway of Nuclear Import

2001 • 274 citations

Transforming Growth Factor β-Independent Shuttling of Smad4 between the Cytoplasm and Nucleus

2000 • 266 citations

Mammalian karyopherin alpha 1 beta and alpha 2 beta heterodimers: alpha 1 or alpha 2 subunit binds nuclear localization signal and beta subunit interacts with peptide repeat-containing nucleoporins.

1995 • 264 citations

A Conserved Biogenesis Pathway for Nucleoporins: Proteolytic Processing of a 186-Kilodalton Precursor Generates Nup98 and the Novel Nucleoporin, Nup96

1999 • 254 citations

The human Tap protein is a nuclear mRNA export factor that contains novel RNA-binding and nucleocytoplasmic transport sequences

1999 • 246 citations

The human CAN protein, a putative oncogene productassociated with myeloid leukemogenesis, is a nuclear pore complex protein thatfaces the cytoplasm.

1994 • 238 citations

Structural Basis for the Recognition of a Nucleoporin FG Repeat by the NTF2-like Domain of the TAP/p15 mRNA Nuclear Export Factor

2001 • 233 citations

The nucleoporin Nup153 is required for nuclear pore basket formation, nuclear pore complex anchoring and import of a subset of nuclear proteins

2001 • 231 citations

Nup153 is an M9-containing mobile nucleoporin with a novel Ran-binding domain

1999 • 217 citations

Nucleocytoplasmic Shuttling Factors Including Ran and CRM1 Mediate Nuclear Export of NFAT In Vitro

1998 • 175 citations

The nuclear import function of Smad2 is masked by SARA and unmasked by TGFb-dependent phosphorylation

2000 • 165 citations

Importin β Mediates Nuclear Translocation of Smad 3

2000 • 165 citations

Transforming Growth Factor-β Induces Nuclear Import of Smad3 in an Importin-β1 and Ran-dependent Manner

2001 • 165 citations

The Nucleoporin Nup153 Plays a Critical Role in Multiple Types of Nuclear Export

1999 • 142 citations

Regulation of intracellular dynamics of Smad4 by its leucine‐rich nuclear export signal

2000 • 139 citations

G2 arrest and impaired nucleocytoplasmic transport in mouse embryos lacking the proto-oncogene CAN/Nup214.

1996 • 133 citations

Distinct Oligomeric States of SMAD Proteins in the Transforming Growth Factor-β Pathway

2000 • 118 citations

Import and export of the nuclear protein import receptor transportin by a mechanism independent of GTP hydrolysis

1998 • 113 citations

Transforming growth factor β-inducible independent binding of SMAD to the Smad7 promoter

2000 • 108 citations

Different Smad2 partners bind a common hydrophobic pocket in Smad2 via a defined proline-rich motif

2002 • 91 citations

Identification of an NTF2-Related Factor That Binds Ran-GTP and Regulates Nuclear Protein Export

1999 • 91 citations

Nuclear Pore Complex Proteins

1996 • 67 citations

Using viral species specificity to define a critical protein/RNA interaction surface

2001 • 28 citations