E2F4/5 and p107 as Smad Cofactors Linking the TGFβ Receptor to c-myc Repression

TGF-β SIGNAL TRANSDUCTION

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Normal keratinization in a spontaneously immortalized aneuploid human keratinocyte cell line.

1988 • 4,008 citations

TGF-β signalling from cell membrane to nucleus through SMAD proteins

1997 • 3,650 citations

Transforming growth factor type beta: rapid induction of fibrosis and angiogenesis in vivo and stimulation of collagen formation in vitro.

1986 • 2,878 citations

TGFβ Signaling in Growth Control, Cancer, and Heritable Disorders

2000 • 2,354 citations

TGF-β signaling in tumor suppression and cancer progression

2001 • 2,235 citations

NEW EMBO MEMBERS REVIEW: Transcriptional control by the TGF-beta/Smad signaling system

2000 • 1,935 citations

The Myc/Max/Mad Network and the Transcriptional Control of Cell Behavior

2000 • 1,307 citations

Sibling rivalry in the E2F family

2002 • 1,158 citations

E2F integrates cell cycle progression with DNA repair, replication, and G₂/M checkpoints

2002 • 1,102 citations

Formation and Activation of a Cyclin E-cdk2 Complex During the G ₁ Phase of the Human Cell Cycle

1992 • 1,046 citations

Transcriptional Activators of TGF-β Responses: Smads

1998 • 1,024 citations

A mechanism of repression of TGFbeta / Smad signaling by oncogenic Ras

1999 • 1,004 citations

Kip/Cip and Ink4 Cdk inhibitors cooperate to induce cell cycle arrest in response to TGF-beta.

1995 • 959 citations

SARA, a FYVE Domain Protein that Recruits Smad2 to the TGFβ Receptor

1998 • 952 citations

Mice lacking Smad3 show accelerated wound healing and an impaired local inflammatory response

1999 • 912 citations

Crystal Structure of a Smad MH1 Domain Bound to DNA

1998 • 709 citations

Smad3 Mutant Mice Develop Metastatic Colorectal Cancer

1998 • 677 citations

Analysis of promoter binding by the E2F and pRB families in vivo: distinct E2F proteins mediate activation and repression

2000 • 619 citations

The E2F1–3 transcription factors are essential for cellular proliferation

2001 • 595 citations

Targeted disruption of the three Rb-related genes leads to loss of G₁ control and immortalization

2000 • 583 citations

Smad4 and FAST-1 in the assembly of activin-responsive factor

1997 • 567 citations

A Smad Transcriptional Corepressor

1999 • 563 citations

The tumor suppressor Smad4/DPC4 and transcriptional adaptor CBP/p300 are coactivators for Smad3 in TGF-β-induced transcriptional activation

1998 • 527 citations

Genetic programs of epithelial cell plasticity directed by transforming growth factor-β

2001 • 520 citations

Smad2 and Smad3 Positively and Negatively Regulate TGFβ-Dependent Transcription through the Forkhead DNA-Binding Protein FAST2

1998 • 513 citations

TGF-β-stimulated cooperation of Smad proteins with the coactivators CBP/p300

1998 • 503 citations

Smads and early developmental signaling by the TGFβ superfamily

1998 • 485 citations

TGFβ influences Myc, Miz-1 and Smad to control the CDK inhibitor p15INK4b

2001 • 479 citations

The Ski oncoprotein interacts with the Smad proteins to repress TGFbeta signaling

1999 • 471 citations

A structural basis for mutational inactivation of the tumour suppressor Smad4

1997 • 459 citations

The retinoblastoma protein binds to a family of E2F transcription factors.

1993 • 436 citations

OAZ Uses Distinct DNA- and Protein-Binding Zinc Fingers in Separate BMP-Smad and Olf Signaling Pathways

2000 • 428 citations

Shared role of the pRB-related p130 and p107 proteins in limb development.

1996 • 424 citations

Transforming growth factor beta and cell cycle regulation.

1995 • 368 citations

Determinants of specificity in TGF-β signal transduction

1998 • 364 citations

The TGFβ Receptor Activation Process

2001 • 360 citations

Physical and Functional Interaction of SMADs and p300/CBP

1998 • 351 citations

The subcellular locations of p15(Ink4b) and p27(Kip1) coordinate their inhibitory interactions with cdk4 and cdk2.

1997 • 344 citations

The retinoblastoma gene family: cousins with overlapping interests

1998 • 337 citations

Targeted disruption of p107: functional overlap between p107 and Rb.

1996 • 333 citations

E2F-4 Switches from p130 to p107 and pRB in Response to Cell Cycle Reentry

1996 • 327 citations

Defective repression of c- myc in breast cancer cells: A loss at the core of the transforming growth factor β growth arrest program

2001 • 320 citations

Deconstructing Myc: Figure 1.

2001 • 311 citations

TGF-β induces assembly of a Smad2–Smurf2 ubiquitin ligase complex that targets SnoN for degradation

2001 • 304 citations

Functional interaction between E2F-4 and p130: evidence for distinct mechanisms underlying growth suppression by different retinoblastoma protein family members.

1995 • 299 citations

Crystal Structure of a Phosphorylated Smad2

2001 • 295 citations

E2F4 and E2F5 Play an Essential Role in Pocket Protein–Mediated G1 Control

2000 • 292 citations

Structural Basis of Smad2 Recognition by the Smad Anchor for Receptor Activation

2000 • 291 citations

Homeodomain and winged-helix transcription factors recruit activated Smads to distinct promoter elements via a common Smad interaction motif

2000 • 277 citations

Structural basis of DNA recognition by the heterodimeric cell cycle transcription factor E2F-DP

1999 • 275 citations

Interaction of the Ski Oncoprotein with Smad3 Regulates TGF-β Signaling

1999 • 265 citations

The L3 loop: a structural motif determining specific interactions between SMAD proteins and TGF-beta receptors

1998 • 265 citations

A role for transcriptional repression of p21 ^CIP1 by c-Myc in overcoming transforming growth factor β-induced cell-cycle arrest

2000 • 249 citations

p107 and p130: Versatile Proteins with Interesting Pockets

2001 • 242 citations

c-myc Is a Downstream Target of the Smad Pathway

2002 • 238 citations

Myc Downregulation by Transforming Growth Factor β Required for Activation of the p15^Ink4b G₁ Arrest Pathway

1999 • 224 citations

TGF-β–induced Phosphorylation of Smad3 Regulates Its Interaction with Coactivator p300/CREB-binding Protein

1998 • 211 citations

Biology of TGF-β in knockout and transgenic mouse models

1997 • 178 citations

Cell Cycle Regulation of E2F Site Occupation in Vivo

1996 • 152 citations

Smad4/DPC4 Silencing and Hyperactive Ras Jointly Disrupt Transforming Growth Factor-β Antiproliferative Responses in Colon Cancer Cells

1999 • 146 citations

Strain-Dependent Myeloid Hyperplasia, Growth Deficiency, and Accelerated Cell Cycle in Mice Lacking the Rb-Related p107 Gene

1998 • 142 citations

The Retinoblastoma Protein Binds to a Family of E2F Transcription Factors

1993 • 135 citations

E2F and Histone Deacetylase Mediate Transforming Growth Factor β Repression of cdc25A during Keratinocyte Cell Cycle Arrest

1999 • 132 citations

Distinct Oligomeric States of SMAD Proteins in the Transforming Growth Factor-β Pathway

2000 • 118 citations

Structural Basis of Smad1 Activation by Receptor Kinase Phosphorylation

2001 • 106 citations

Different Smad2 partners bind a common hydrophobic pocket in Smad2 via a defined proline-rich motif

2002 • 91 citations

SMIF, a Smad4-interacting protein that functions as a co-activator in TGFβ signalling

2002 • 90 citations

Cloning and characterization of human DP2, a novel dimerization partner of E2F.

1995 • 81 citations

Transforming Growth Factor β₁Selectively Inhibits the Cyclic AMP-dependent Proliferation of Primary Thyroid Epithelial Cells by Preventing the Association of Cyclin D3–cdk4 with Nuclear p27^kip1

2000 • 77 citations

TGFβ Signal Transduction

2010 • 65 citations

The Human Tap Nuclear RNA Export Factor Contains a Novel Transportin-dependent Nuclear Localization Signal That Lacks Nuclear Export Signal Function

1999 • 65 citations

Transforming growth factor β modulates growth and differentiation of fetal hepatocytes in primary culture

1995 • 60 citations

Constitutive Protection of E2F Recognition Sequences in the Human Thymidine Kinase Promoter during Cell Cycle Progression

1997 • 56 citations

Molecular and functional characterisation of E2F-5, a new member of the E2F family.

1995 • 43 citations

The Retinoblastoma Protein

2018 • 32 citations