Stress-Dependent Regulation of FOXO Transcription Factors by the SIRT1 Deacetylase

Akt Promotes Cell Survival by Phosphorylating and Inhibiting a Forkhead Transcription Factor

1999 • 6,443 citations

Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan

2003 • 3,673 citations

Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase

2000 • 3,355 citations

hSIR2SIRT1 Functions as an NAD-Dependent p53 Deacetylase

2001 • 2,550 citations

The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms

1999 • 2,199 citations

Negative Control of p53 by Sir2α Promotes Cell Survival under Stress

2001 • 2,042 citations

The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans

1997 • 1,905 citations

Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans

2001 • 1,892 citations

Requirement of NAD and SIR2 for Life-Span Extension by Calorie Restriction in Saccharomyces cerevisiae

2000 • 1,756 citations

Why do we age?

2000 • 1,696 citations

Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress

2002 • 1,506 citations

daf-16 : An HNF-3/forkhead Family Member That Can Function to Double the Life-Span of Caenorhabditis elegans

1997 • 1,468 citations

AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1

2000 • 1,431 citations

Phylogenetic Classification of Prokaryotic and Eukaryotic Sir2-like Proteins

2000 • 1,360 citations

Protein kinase B/Akt-mediated phosphorylation promotes nuclear exclusion of the winged helix transcription factor FKHR1

1999 • 1,102 citations

Direct control of the Forkhead transcription factor AFX by protein kinase B

1999 • 1,080 citations

Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice

2003 • 1,075 citations

DNA Repair Pathway Stimulated by the Forkhead Transcription Factor FOXO3a Through the Gadd45 Protein

2002 • 849 citations

Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence

2002 • 842 citations

Redox Regulation of Forkhead Proteins Through a p66shc -Dependent Signaling Pathway

2002 • 810 citations

Sir2 links chromatin silencing, metabolism, and aging

2000 • 725 citations

Nicotinamide and PNC1 govern lifespan extension by calorie restriction in Saccharomyces cerevisiae

2003 • 706 citations

A phylogenetically conserved NAD ⁺ -dependent protein deacetylase activity in the Sir2 protein family

2000 • 703 citations

Sir2 Regulates Skeletal Muscle Differentiation as a Potential Sensor of the Redox State

2003 • 578 citations

FKHR-L1 can act as a critical effector of cell death induced by cytokine withdrawal

2002 • 368 citations

FoxO6, a Novel Member of the FoxO Class of Transcription Factors with Distinct Shuttling Dynamics

2003 • 329 citations