Integration of Smad and Forkhead Pathways in the Control of Neuroepithelial and Glioblastoma Cell Proliferation

WAF1, a potential mediator of p53 tumor suppression

1993 • 8,360 citations

Akt Promotes Cell Survival by Phosphorylating and Inhibiting a Forkhead Transcription Factor

1999 • 6,443 citations

The phosphatidylinositol 3-Kinase–AKT pathway in human cancer

2002 • 5,914 citations

Mechanisms of TGF-β Signaling from Cell Membrane to the Nucleus

2003 • 5,611 citations

PTEN , a Putative Protein Tyrosine Phosphatase Gene Mutated in Human Brain, Breast, and Prostate Cancer

1997 • 4,753 citations

A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002).

1994 • 3,249 citations

TGFβ Signaling in Growth Control, Cancer, and Heritable Disorders

2000 • 2,354 citations

TGF-β signaling in tumor suppression and cancer progression

2001 • 2,235 citations

Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans

2003 • 2,209 citations

The β-Catenin/TCF-4 Complex Imposes a Crypt Progenitor Phenotype on Colorectal Cancer Cells

2002 • 1,984 citations

NEW EMBO MEMBERS REVIEW: Transcriptional control by the TGF-beta/Smad signaling system

2000 • 1,935 citations

Cofactor Dynamics and Sufficiency in Estrogen Receptor–Regulated Transcription

2000 • 1,658 citations

Cytostatic and apoptotic actions of TGF-β in homeostasis and cancer

2003 • 1,572 citations

AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1

2000 • 1,431 citations

Co-crystal structure of the HNF-3/fork head DNA-recognition motif resembles histone H5

1993 • 1,269 citations

Unified nomenclature for the winged helix/forkhead transcription factors

2000 • 1,136 citations

Cytoplasmic localization of p21Cip1/WAF1 by Akt-induced phosphorylation in HER-2/neu-overexpressing cells

2001 • 1,107 citations

Direct control of the Forkhead transcription factor AFX by protein kinase B

1999 • 1,080 citations

Transcriptional Activators of TGF-β Responses: Smads

1998 • 1,024 citations

Expression of the pro-apoptotic Bcl-2 family member Bim is regulated by the forkhead transcription factor FKHR-L1

2000 • 983 citations

PKB/Akt phosphorylates p27, impairs nuclear import of p27 and opposes p27-mediated G1 arrest

2002 • 940 citations

Human Smad3 and Smad4 Are Sequence-Specific Transcription Activators

1998 • 916 citations

Partnership between DPC4 and SMAD proteins in TGF-β signalling pathways

1996 • 899 citations

TGF-β signaling: positive and negative effects on tumorigenesis

2002 • 830 citations

Growth inhibition by TGF-β linked to suppression of retinoblastoma protein phosphorylation

1990 • 812 citations

Tissue-Specific Activities of C. elegans DAF-16 in the Regulation of Lifespan

2003 • 782 citations

PKB/Akt mediates cell-cycle progression by phosphorylation of p27Kip1 at threonine 157 and modulation of its cellular localization

2002 • 778 citations

Crystal Structure of a Smad MH1 Domain Bound to DNA

1998 • 709 citations

Neuronal or Glial Progeny

2003 • 706 citations

Cytoplasmic relocalization and inhibition of the cyclin-dependent kinase inhibitor p27Kip1 by PKB/Akt-mediated phosphorylation in breast cancer

2002 • 701 citations

A transcriptional partner for MAD proteins in TGF-β signalling

1996 • 699 citations

Myc suppression of the p21Cip1 Cdk inhibitor influences the outcome of the p53 response to DNA damage

2002 • 676 citations

Two major Smad pathways in TGF‐β superfamily signalling

2002 • 647 citations

DAF-16 Target Genes That Control C. elegans Life-Span and Metabolism

2003 • 644 citations

Identification of the differential distribution patterns of mRNAs and consensus binding sequences for mouse DAF-16 homologues

2000 • 608 citations

Dividing Precursor Cells of the Embryonic Cortical Ventricular Zone Have Morphological and Molecular Characteristics of Radial Glia

2002 • 607 citations

Repression of p15INK4b expression by Myc through association with Miz-1

2001 • 571 citations

The forkhead transcription factor Foxo1 (Fkhr) confers insulin sensitivity onto glucose-6-phosphatase expression

2001 • 570 citations

Winged helix transcription factor BF-1 is essential for the development of the cerebral hemispheres

1995 • 569 citations

Smad4 and FAST-1 in the assembly of activin-responsive factor

1997 • 567 citations

Phosphorylation of Serine 256 by Protein Kinase B Disrupts Transactivation by FKHR and Mediates Effects of Insulin on Insulin-like Growth Factor-binding Protein-1 Promoter Activity through a Conserved Insulin Response Sequence

1999 • 542 citations

A Self-Enabling TGFβ Response Coupled to Stress Signaling

2003 • 539 citations

The forkhead transcription factor Foxo1 (Fkhr) confers insulin sensitivity onto glucose-6-phosphatase expression

2001 • 517 citations

Smad2 and Smad3 Positively and Negatively Regulate TGFβ-Dependent Transcription through the Forkhead DNA-Binding Protein FAST2

1998 • 513 citations

Regulation of C. elegans DAF-16 and its human ortholog FKHRL1 by the daf-2 insulin-like signaling pathway

2001 • 494 citations

TGFβ influences Myc, Miz-1 and Smad to control the CDK inhibitor p15INK4b

2001 • 479 citations

E2F4/5 and p107 as Smad Cofactors Linking the TGFβ Receptor to c-myc Repression

2002 • 475 citations

Gliomagenesis: genetic alterations and mouse models

2001 • 460 citations

Dual role of the Smad4/DPC4 tumor suppressor in TGFβ-inducible transcriptional complexes

1997 • 439 citations

AKT/PKB Phosphorylation of p21Cip/WAF1 Enhances Protein Stability of p21Cip/WAF1 and Promotes Cell Survival

2002 • 435 citations

The Many Forks in FOXO's Road

2003 • 425 citations

Telencephalon-restricted expression of BF-1, a new member of the HNF-3/ fork head gene family, in the developing rat brain

1992 • 417 citations

Smad2, Smad3 and Smad4 cooperate with Sp1 to induce p15Ink4B transcription in response to TGF-β

2000 • 392 citations

Foxg1 Suppresses Early Cortical Cell Fate

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Transforming growth factor beta and cell cycle regulation.

1995 • 368 citations

Localization and actions of transforming growth factor-βs in the embryonic nervous system

1991 • 360 citations

Regulation of the human p21/WAF1/Cip1 promoter in hepatic cells by functional interactions between Sp1 and Smad family members

1998 • 348 citations

Hepatocyte nuclear factor 3/fork head or "winged helix" proteins: a family of transcription factors of diverse biologic function.

1993 • 329 citations

Cell cycle parameters and patterns of nuclear movement in the neocortical proliferative zone of the fetal mouse

1993 • 324 citations

The Molecular and Genetic Basis of Neurological Tumours

2002 • 307 citations

Negative Regulation of the Mammalian UV Response by Myc through Association with Miz-1

2002 • 306 citations

Myc represses differentiation-induced p21CIP1 expression via Miz-1-dependent interaction with the p21 core promoter

2003 • 303 citations

Radial glia is a progenitor of neocortical neurons in the developing cerebral cortex

2001 • 277 citations

A role for transcriptional repression of p21 ^CIP1 by c-Myc in overcoming transforming growth factor β-induced cell-cycle arrest

2000 • 249 citations

Targeting the TGFβ signaling network in human neoplasia

2003 • 245 citations

Alternatively Spliced Variant of Smad2 Lacking Exon 3

1999 • 235 citations

The Forkhead Transcription Factor AFX Activates Apoptosis by Induction of the BCL-6 Transcriptional Repressor

2002 • 222 citations

Hierarchical model of gene regulation by transforming growth factor β

2003 • 209 citations

FoxH1 (Fast) functions to specify the anterior primitive streak in the mouse

2001 • 201 citations

Brain Factor-1Controls the Proliferation and Differentiation of Neocortical Progenitor Cells through Independent Mechanisms

2002 • 188 citations

Protein Kinase B/Akt Mediates Effects of Insulin on Hepatic Insulin-like Growth Factor-binding Protein-1 Gene Expression through a Conserved Insulin Response Sequence

1998 • 164 citations

Constitutive mutant and putative regulatory serine phosphorylation site of mammalian MAP kinase kinase (MEK1).

1994 • 128 citations

The Winged-Helix Protein Brain Factor 1 Interacts with Groucho and Hes Proteins To Repress Transcription

2001 • 123 citations

TGF-β signaling

2005 • 121 citations

FAST-1 is a key maternal effector of mesoderm inducers in the early Xenopus embryo

1999 • 118 citations

Transforming Growth Factor-β-mediated p15INK4BInduction and Growth Inhibition in Astrocytes Is SMAD3-dependent and a Pathway Prominently Altered in Human Glioma Cell Lines

1999 • 117 citations

Interkinetic and Migratory Behavior of a Cohort of Neocortical Neurons Arising in the Early Embryonic Murine Cerebral Wall

1996 • 114 citations

BF-1 Interferes with Transforming Growth Factor β Signaling by Associating with Smad Partners

2000 • 105 citations

Mad Upregulation and Id2 Repression Accompany Transforming Growth Factor (TGF)-β-mediated Epithelial Cell Growth Suppression

2003 • 91 citations

Human PLU-1 Has Transcriptional Repression Properties and Interacts with the Developmental Transcription Factors BF-1 and PAX9

2003 • 90 citations

The role of transforming growth factor beta in glioma progression.

1998 • 89 citations

The role of transforming growth factor-beta in primary brain tumors

2003 • 75 citations

Expression of transforming growth factor‐β in developing rat cerebral cortex: Effects of prenatal exposure to ethanol

2003 • 65 citations

Loss of Sin3/Rpd3 Histone Deacetylase Restores the DNA Damage Response in Checkpoint-Deficient Strains of Saccharomyces cerevisiae

2003 • 59 citations

Functional Cloning of the Proto-oncogene Brain Factor-1 (BF-1) As a Smad-binding Antagonist of Transforming Growth Factor-β Signaling

2001 • 51 citations

Transforming Growth Factor-β2 Is a Transcriptional Target for Akt/Protein Kinase B via Forkhead Transcription Factor

2002 • 42 citations

Distribution of phosphorylated Smad2 identifies target tissues of TGFβ ligands in mouse development

2003 • 36 citations

Transforming growth factor beta as a potential tumor progression factor among hyperdiploid glioblastoma cultures: evidence for the role of platelet-derived growth factor.

1997 • 23 citations