Inactivation of Smad-Transforming Growth Factor β Signaling by Ca²⁺-Calmodulin-Dependent Protein Kinase II

TGF-β SIGNAL TRANSDUCTION

1998 • 7,582 citations

High-efficiency transformation of mammalian cells by plasmid DNA.

1987 • 5,377 citations

Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes

1991 • 4,043 citations

Mechanism of activation of the TGF-β receptor

1994 • 2,298 citations

Controlling TGF-beta signaling.

2000 • 1,806 citations

Differential activation of transcription factors induced by Ca2+ response amplitude and duration

1997 • 1,533 citations

Controlling TGF-β signaling

2000 • 1,522 citations

Growth factor signaling by receptor tyrosine kinases

1992 • 1,450 citations

Sensitivity of CaM Kinase II to the Frequency of Ca ²⁺ Oscillations

1998 • 1,263 citations

NUCLEOCYTOPLASMIC TRANSPORT: The Soluble Phase

1998 • 1,184 citations

A mechanism of repression of TGFbeta / Smad signaling by oncogenic Ras

1999 • 1,004 citations

Human Smad3 and Smad4 Are Sequence-Specific Transcription Activators

1998 • 916 citations

Mice lacking Smad3 show accelerated wound healing and an impaired local inflammatory response

1999 • 912 citations

Targeted disruption of SMAD3 results in impaired mucosal immunity and diminished T cell responsiveness to TGF-beta

1999 • 890 citations

Opposing BMP and EGF signalling pathways converge on the TGF-β family mediator Smad1

1997 • 867 citations

Stabilization of calcium release channel (ryanodine receptor) function by FK506-binding protein

1994 • 818 citations

The Multifunctional Calcium/Calmodulin-Dependent Protein Kinase: From Form to Function

1995 • 812 citations

Specificity, diversity, and regulation in TGF-beta superfamily signaling.

1999 • 788 citations

Crystal Structure of a Smad MH1 Domain Bound to DNA

1998 • 709 citations

Smad3 Mutant Mice Develop Metastatic Colorectal Cancer

1998 • 677 citations

Specificity, diversity, and regulation in TGF‐β superfamily signaling

1999 • 644 citations

Smad4 and FAST-1 in the assembly of activin-responsive factor

1997 • 567 citations

Interdependent SMAD and JNK Signaling in Transforming Growth Factor-β-mediated Transcription

1999 • 534 citations

Smad2 and Smad3 Positively and Negatively Regulate TGFβ-Dependent Transcription through the Forkhead DNA-Binding Protein FAST2

1998 • 513 citations

Calcineurin associated with the inositol 1,4,5-trisphosphate receptor-FKBP12 complex modulates Ca2+ flux

1995 • 484 citations

TβRI Phosphorylation of Smad2 on Ser465 and Ser467 Is Required for Smad2-Smad4 Complex Formation and Signaling

1997 • 470 citations

The L45 loop in type I receptors for TGF‐β family members is a critical determinant in specifying Smad isoform activation

1998 • 390 citations

Phosphorylation of Ser465 and Ser467 in the C Terminus of Smad2 Mediates Interaction with Smad4 and Is Required for Transforming Growth Factor-β Signaling

1997 • 383 citations

Mutations increasing autoinhibition inactivate tumour suppressors Smad2 and Smad4

1997 • 365 citations

Mechanism of TGFβ receptor inhibition by FKBP12

1997 • 342 citations

Neu and its ligands: From an oncogene to neural factors

1993 • 286 citations

Smad proteins exist as monomers in vivo and undergo homo- and hetero-oligomerization upon activation by serine/threonine kinase receptors

1998 • 281 citations

Characterization of Human FAST-1, a TGFβ and Activin Signal Transducer

1998 • 230 citations

Identification and characterization of δB-CaM kinase and δC-CaM kinase from rat heart, two new multifunctional Ca2+/calmodulin-dependent protein kinase isoforms

1994 • 178 citations

MEKK-1, a Component of the Stress (Stress-activated Protein Kinase/c-Jun N-terminal Kinase) Pathway, Can Selectively Activate Smad2-mediated Transcriptional Activation in Endothelial Cells

1999 • 171 citations

Developmental and regional expression of multifunctional Ca2+/calmodulin-dependent protein kinase isoforms in rat brain

1995 • 164 citations

HER2 cytoplasmic domain generates normal mitogenic and transforming signals in a chimeric receptor.

1989 • 144 citations

A distinct nuclear localization signal in the N terminus of Smad 3 determines its ligand-induced nuclear translocation

2000 • 136 citations

Oncogenic forms of the neu/HER2 tyrosine kinase are permanently coupled to phospholipase C gamma.

1991 • 117 citations

Epidermal growth factor (EGF) induces oligomerization of soluble, extracellular, ligand-binding domain of EGF receptor. A low resolution projection structure of the ligand-binding domain

1991 • 105 citations

Smad Proteins Physically Interact with Calmodulin

1998 • 81 citations

Regulation of intrasteric inhibition of the multifunctional calcium/calmodulin-dependent protein kinase.

1992 • 77 citations

Transforming growth factor beta and epidermal growth factor alter calcium influx and phosphatidylinositol turnover in rat-1 fibroblasts.

1988 • 76 citations

The Kinase Domain and Membrane Localization Determine Intracellular Interactions between Epidermal Growth Factor Receptors

1995 • 73 citations

Ca2+/Calmodulin-dependent Kinase II Phosphorylates the Epidermal Growth Factor Receptor on Multiple Sites in the Cytoplasmic Tail and Serine 744 within the Kinase Domain to Regulate Signal Generation

1999 • 70 citations

Regulation of the Transforming Growth Factor β-responsive Transcription Factor CTF-1 by Calcineurin and Calcium/ Calmodulin-dependent Protein Kinase IV

1997 • 59 citations

Analysis of platelet-derived growth factor receptor domain function using a novel chimeric receptor approach

1991 • 35 citations

Ca2+/calmodulin kinase types II and IV regulate c-fos transcription in the AtT20 corticotroph cell line

1996 • 30 citations

Calcium signals in the cell nucleus. Strasbourg, France, August 20-23, 1998

1999 • 28 citations

Calcium as a second messenger of the action of transforming growth factor-β on insulin secretion

1996 • 22 citations

HER-2/c-erbB2 is phosphorylated by calmodulin-dependent protein kinase II on a single site in the cytoplasmic tail at threonine-1172.

1996 • 16 citations