The role of transforming growth factor beta in glioma progression.

The retinoblastoma protein and cell cycle control

1995 • 4,873 citations

Participation of p53 protein in the cellular response to DNA damage.

1991 • 3,818 citations

A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4

1993 • 3,680 citations

The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

1992 • 3,110 citations

A Cell Cycle Regulator Potentially Involved in Genesis of Many Tumor Types

1994 • 2,821 citations

Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals

1994 • 2,154 citations

p27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21

1994 • 2,071 citations

Mammalian G1 cyclins

1993 • 1,990 citations

p27Kip1, a cyclin-Cdk inhibitor, links transforming growth factor-beta and contact inhibition to cell cycle arrest.

1994 • 1,970 citations

pl5INK4B is a potentia| effector of TGF-β-induced cell cycle arrest

1994 • 1,932 citations

The p21 inhibitor of cyclin-dependent kinases controls DNA replication by interaction with PCNA

1994 • 1,669 citations

Transforming growth factor-beta in human platelets. Identification of a major storage site, purification, and characterization.

1983 • 1,613 citations

TGFβ signals through a heteromeric protein kinase receptor complex

1992 • 1,519 citations

p53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest

1994 • 1,475 citations

Functional interactions of the retinoblastoma protein with mammalian D-type cyclins

1993 • 1,047 citations

Evidence that transforming growth factor-β is a hormonally regulated negative growth factor in human breast cancer cells

1987 • 998 citations

TGF-β stimulation and inhibition of cell proliferation: New mechanistic insights

1990 • 992 citations

New class of transforming growth factors potentiated by epidermal growth factor: isolation from non-neoplastic tissues.

1981 • 925 citations

Retinoblastoma-protein-dependent cell-cycle inhibition by the tumour suppressor p16

1995 • 894 citations

Growth inhibition by TGF-β linked to suppression of retinoblastoma protein phosphorylation

1990 • 812 citations

Growth Inhibitor from BSC-1 Cells Closely Related to Platelet Type β Transforming Growth Factor

1984 • 779 citations

Cloning of a TGF$beta; type I receptor that forms a heteromeric complex with the TGF$beta; type II receptor

1993 • 779 citations

TGF-β induces bimodal proliferation of connective tissue cells via complex control of an autocrine PDGF loop

1990 • 756 citations

Mechanism of activation of latent recombinant transforming growth factor beta 1 by plasmin.

1990 • 740 citations

Microinjection of the ras oncogene protein into PC12 cells induces morphological differentiation

1985 • 738 citations

Growth suppression by p18, a p16INK4/MTS1- and p14INK4B/MTS2-related CDK6 inhibitor, correlates with wild-type pRb function.

1994 • 731 citations

Human D-type cyclin

1991 • 712 citations

Clonal expansion of p53 mutant cells is associated with brain tumour progression

1992 • 687 citations

TGF-β1 inhibition of c-myc transcription and growth in keratinocytes is abrogated by viral transforming proteins with pRB binding domains

1990 • 612 citations

Hypermethylation-associated inactivation indicates a tumor suppressor role for p15INK4B.

1996 • 585 citations

Negative Regulation of G1 in Mammalian Cells: Inhibition of Cyclin E-Dependent Kinase by TGF-β

1993 • 578 citations

Amplification and overexpression of the MDM2 gene in a subset of human malignant gliomas without p53 mutations.

1993 • 565 citations

Reduced tumor incidence, metastatic potential, and cytokine responsiveness of nm3-transfected melanoma cells

1991 • 548 citations

TGFβ inhibition of Cdk4 synthesis is linked to cell cycle arrest

1993 • 544 citations

Induction of c-sis mRNA and activity similar to platelet-derived growth factor by transforming growth factor beta: a proposed model for indirect mitogenesis involving autocrine activity.

1986 • 541 citations

Clonal genomic alterations in glioma malignancy stages.

1988 • 520 citations

Subunit rearrangement of the cyclin-dependent kinases is associated with cellular transformation.

1993 • 514 citations

Transforming growth factor production by chemically transformed cells.

1981 • 506 citations

Transforming growth factor-beta 1 in the rat brain: increase after injury and inhibition of astrocyte proliferation

1992 • 486 citations

How many mutations are required for tumorigenesis? implications from human cancer data

1993 • 466 citations

CDKN2 (p16/MTS1) gene deletion or CDK4 amplification occurs in the majority of glioblastomas.

1994 • 439 citations

The 1993 Walter Hubert Lecture: the role of the p53 tumour-suppressor gene in tumorigenesis

1994 • 428 citations

Deletion of p16 and p15 genes in brain tumors.

1994 • 416 citations

A highly immunogenic tumor transfected with a murine transforming growth factor type beta 1 cDNA escapes immune surveillance.

1990 • 409 citations

Transforming growth factor beta stimulates mammary adenocarcinoma cell invasion and metastatic potential.

1990 • 398 citations

Immunosuppression and transforming growth factor-beta in glioblastoma. Preferential production of transforming growth factor-beta 2.

1989 • 391 citations

Absence of WAF1 mutations in a variety of human malignancies

1994 • 390 citations

Inactivation of the Type II Receptor Reveals Two Receptor Pathways for the Diverse TGF-β Activities

1993 • 388 citations

Complementary DNA for human glioblastoma-derived T cell suppressor factor, a novel member of the transforming growth factor-beta gene family.

1987 • 387 citations

Inhibition of Ras-Induced Proliferation and Cellular Transformation by p16 ^INK4

1995 • 382 citations

Type I receptors specify growth-inhibitory and transcriptional responses to transforming growth factor beta and activin.

1994 • 377 citations

Transforming growth factor beta and cell cycle regulation.

1995 • 368 citations

T cell suppressor factor from human glioblastoma cells is a 12.5-kd protein closely related to transforming growth factor-beta.

1987 • 337 citations

A novel inhibitor of cyclin-Cdk activity detected in transforming growth factor beta-arrested epithelial cells.

1994 • 332 citations

Absence of TGF-β Receptors and Growth Inhibitory Responses in Retinoblastoma Cells

1988 • 331 citations

Analysis of the p53 gene and its expression in human glioblastoma cells.

1994 • 329 citations

Molecular analysis of the cyclin-dependent kinase inhibitor gene p27/Kip1 in human malignancies.

1995 • 327 citations

Absence of p16(INK4) protein is restricted to the subset of lung cancer lines that retains wildtype RB

1995 • 314 citations

Pathways leading to glioblastoma multiforme: a molecular analysis of genetic alterations in 65 astrocytic tumors

1994 • 304 citations

Abrogation of oncogene-associated apoptosis allows transformation of p53-deficient cells.

1994 • 290 citations

Transforming growth factor beta effects on expression of G1 cyclins and cyclin-dependent protein kinases.

1993 • 276 citations

Responsiveness to transforming growth factor-beta (TGF-beta) restored by genetic complementation between cells defective in TGF-beta receptors I and II

1991 • 252 citations

p53 mutations in human malignant gliomas: comparison of loss of heterozygosity with mutation frequency.

1992 • 248 citations

Alterations of the TP53 gene in human gliomas.

1994 • 246 citations

Potential Role of WAF1/Cip1/p21 as a Mediator of TGF-β Cytoinhibitory Effect

1995 • 244 citations

Progression of colorectal cancer is associated with multiple tumor suppressor gene defects but inhibition of tumorigenicity is accomplished by correction of any single defect via chromosome transfer.

1992 • 237 citations

Adenovirus-mediated transfer of the p53 gene produces rapid and generalized death of human glioma cells via apoptosis.

1996 • 232 citations

Activation of p21ras by transforming growth factor beta in epithelial cells.

1992 • 223 citations

The retinoblastoma gene is involved in malignant progression of astrocytomas

1994 • 220 citations

Enhanced jun gene expression is an early genomic response to transforming growth factor beta stimulation.

1989 • 213 citations

Cyclin D1 oncoprotein aberrantly accumulates in malignancies of diverse histogenesis.

1995 • 207 citations

Transforming growth factor beta 1 inhibition of p34cdc2 phosphorylation and histone H1 kinase activity is associated with G1/S-phase growth arrest.

1991 • 203 citations

Platelet-derived growth factor receptor-beta is induced during tumor development and upregulated during tumor progression in endothelial cells in human gliomas.

1992 • 202 citations

Type beta transforming growth factor/growth inhibitor stimulates entry of monolayer cultures of AKR-2B cells into S phase after a prolonged prereplicative interval.

1985 • 191 citations

Selective upregulation of platelet-derived growth factor alpha receptors by transforming growth factor beta in scleroderma fibroblasts.

1992 • 181 citations

Receptors for Transforming Growth Factor-β

1993 • 181 citations

High levels of transforming growth factor beta 1 correlate with disease progression in human colon cancer.

1995 • 179 citations

Mutation of the p53 gene in human soft tissue sarcomas: association with abnormalities of the RB1 gene.

1990 • 175 citations

Transforming growth factor β stimulates mamary adenocarcinoma cell invasion and metastasis potential

1990 • 164 citations

Allelotype of human malignant astrocytoma.

1990 • 163 citations

Altered metabolic and adhesive properties and increased tumorigenesis associated with increased expression of transforming growth factor beta 1.

1992 • 155 citations

TGF‐β stimulates primary human skin fibroblast DNA synthesis via an autocrine production of PDGF‐related peptides

1989 • 154 citations

Control of human glioma cell growth, migration and invasion in vitro by transforming growth factor β1

1994 • 150 citations

The effect of transforming growth factor-β2-specific phosphorothioate-anti-sense oligodeoxynucleotides in reversing cellular immunosuppression in malignant glioma

1993 • 142 citations

Growth Factor Synthesis and Human Breast Cancer Progression

1995 • 140 citations

Chromosomal evolution in malignant human gliomas starts with specific and usually numerical deviations

1986 • 139 citations

Transforming growth factor beta 1 can induce estrogen-independent tumorigenicity of human breast cancer cells in athymic mice.

1993 • 138 citations

Differential regulation of expression of two platelet-derived growth factor receptor subunits by transforming growth factor-β

1989 • 136 citations

p53-mediated apoptosis in HeLa cells can be overcome by excess pRB.

1995 • 136 citations

Transforming growth factor-beta 1 inhibits cyclin D1 expression in intestinal epithelial cells.

1995 • 134 citations

Stimulation of hyaluronan biosynthesis by platelet-derived growth factor-BB and transforming growth factor-β1 involves activation of protein kinase C

1995 • 133 citations

The glioblastoma‐derived T‐cell suppressor factor/transforming growth factor beta₂ inhibits the generation of lymphokineactivated killer (LAK) cells

1988 • 131 citations

Enhanced expression of transforming growth factor‐β and its type‐I and type‐II receptors in human glioblastoma

1995 • 127 citations

Agents that increase cAMP accumulation block endothelial c-sis induction by thrombin and transforming growth factor-beta.

1987 • 126 citations

Prolonged induction of p21Cip1/WAF1/CDK2/PCNA complex by epidermal growth factor receptor activation mediates ligand-induced A431 cell growth inhibition.

1995 • 124 citations

A Correlative Study of p53 Protein Alteration and p53 Gene Mutation in Glioblastoma Multiforme

1993 • 119 citations

Introduction of v-Ha-ras oncogene induces differentiation of cultured human medullary thyroid carcinoma cells.

1987 • 116 citations

Increased transforming growth factor beta expression inhibits cell proliferation in vitro, yet increases tumorigenicity and tumor growth of Meth A sarcoma cells.

1993 • 113 citations

Loss of growth factor dependence and conversion of transforming growth factor-beta 1 inhibition to stimulation in metastatic H-ras-transformed murine fibroblasts.

1988 • 113 citations

Transforming growth factor‐βs inhibit mitogen‐stimulated proliferation of astrocytes

1993 • 109 citations

Immunocytochemical study of transforming growth factor expression in benign and malignant gliomas.

1989 • 108 citations

TGFβ₁ and TGFβ₂ are potential growth regulators for low‐grade and malignant gliomas in vitro: Evidence in support of an autocrine hypothesis

1991 • 107 citations

p53 Mutation, Expression, and DNA Ploidy in Evolving Gliomas: Evidence for Two Pathways of Progression

1994 • 104 citations

Stabilised p53 facilitates aneuploid clonal divergence in colorectal cancer.

1993 • 102 citations

Transforming growth factors type β1 and β2 suppress rat astrocyte autoantigen presentation and antagonize hyperinduction of class II major histocompatibility complex antigen expression by interferon-γ and tumor necrosis factor-α

1990 • 99 citations

Transforming growth factor-β1 regulates platelet-derived growth factor receptor β subunit in human liver fat-storing cells

1995 • 99 citations

The tumor suppressor protein p53

1995 • 98 citations

Differential effects of epidermal growth factor, transforming growth factor, and insulin on DNA and protein synthesis and morphology in serum-free cultures of AKR-2B cells.

1984 • 93 citations

Retinoblastoma gene deletions in human glioblastomas.

1991 • 89 citations

Expression of multi-cytokine resistance and multi-growth factor independence in advanced stage metastatic cancer. Malignant melanoma as a paradigm.

1992 • 89 citations

Mitogenic effect of transforming growth factor β1 on human fibroblasts involves the induction of platelet‐derived growth factor α receptors

1990 • 88 citations

Colon carcinoma cells switch their response to transforming growth factor beta 1 with tumor progression.

1994 • 87 citations

Regulation of platelet-derived growth factor gene expression by transforming growth factor beta and phorbol ester in human leukemia cell lines.

1987 • 86 citations

Development of resistance mechanisms to the growth-inhibitory effects of transforming growth factor-beta during tumor progression.

1993 • 86 citations

Overexpression of multiple oncogenes related to histological grade of astrocytic glioma

1992 • 85 citations

Effects of Transforming Growth Factor β1 on Astroglial Cells in Culture

1990 • 85 citations

Stimulatory role of transforming growth factors in multistage skin carcinogenesis: Possible explanation for the tumor‐inducing effect of wounding in initiated nmri mouse skin

1989 • 83 citations

Control of astrocytosis by interleukin-1 and transforming growth factor-β1 in human brain

1993 • 77 citations

Transforming growth factor β‐1 positively modulates the bioactivity of fibroblast growth factor on corneal endothelial cells

1989 • 73 citations

Effects of Transforming Growth Factor-β1 on Collagen Synthesis, Integrin Expression, Adhesion an Invasion of Glioma Cells

1995 • 73 citations

Overexpression of human cyclin D1 reduces the transforming growth factor beta (TGF-beta) type II receptor and growth inhibition by TGF-beta 1 in an immortalized human esophageal epithelial cell line.

1994 • 71 citations

Type I Receptors Specify Growth-Inhibitory and Transcriptional Responses to Transforming Growth Factor β and Activin

1994 • 70 citations

Induction of transforming growth factor beta 1 resistance by the E1A oncogene requires binding to a specific set of cellular proteins.

1991 • 69 citations

Transforming growth factor‐β1 inhibits the proliferation of rat astrocytes induced by serum and growth factors

1995 • 69 citations

Mutant p53 tumor suppressor gene causes resistance to transforming growth factor beta 1 in murine keratinocytes.

1993 • 68 citations

Transforming growth factor beta-treated normal fibroblasts eliminate transformed fibroblasts by induction of apoptosis.

1994 • 65 citations

Transforming growth factor β1 is a powerful modulator of platelet‐derived growth factor action in vascular smooth muscle cells

1992 • 64 citations

Progression of Colorectal Cancer Is Associated with Multiple Tumor Suppressor Gene Defects but Inhibition of Tumorigenicity Is Accomplished by Correction of Any Single Defect via Chromosome Transfer

1992 • 64 citations

A Novel Inhibitor of Cyclin-Cdk Activity Detected in Transforming Growth Factor β-Arrested Epithelial Cells

1994 • 60 citations

Transforming growth factor-beta inhibits phosphorylation of the retinoblastoma susceptibility gene product in human monocytic leukemia cell line JOSK-I.

1992 • 59 citations

Transforming growth factor β1 treatment of AKR-2B cells is coupled through a pertussis-toxin-sensitive G-protein(s)

1989 • 57 citations

Transforming Growth Factor-β Induces Platelet-Derived Growth Factor (PDGF) Messenger RNA and PDGF Secretion while Inhibiting Growth in Normal Human Mammary Epithelial Cells

1990 • 50 citations

Transforming growth factor beta-induced activation of cyclin E-cdk2 kinase and down-regulation of p27Kip1 in C3H 10T1/2 mouse fibroblasts.

1995 • 45 citations

Differential effects of transforming growth factor beta 1 on the growth of poorly and highly metastatic murine melanoma cells.

1990 • 44 citations

Enhanced jun Gene Expression Is an Early Genomic Response to Transforming Growth Factor β Stimulation

1989 • 41 citations

Transforming growth factor beta as a potent promoter in two-stage BALB/c 3T3 cell transformation.

1988 • 39 citations

TGFβ1 and TGFβ2 are potential growth regulators for medulloblastomas, primitive neuroectodermal tumors, and ependymomas: Evidence in support of an autocrine hypothesis

1994 • 38 citations

Molecular genetics of human glioma

1995 • 38 citations

Lack of correlation between sensitivity to growth inhibition and receptor number for transforming growth factor beta in human squamous carcinoma cell lines.

1989 • 37 citations

Retinoic acid induces secretion of latent transforming growth factor beta 1 and beta 2 in normal and human papillomavirus type 16-immortalized human keratinocytes.

1992 • 37 citations

Loss of transforming growth factor beta 1 (TGF-beta 1)-induced growth arrest and p34cdc2 regulation in ras-transfected epithelial cells.

1992 • 36 citations

Control of the expression of c-sis mRNA in human glioblastoma cells by phorbol ester and transforming growth factor beta 1.

1989 • 34 citations

Cdk4 integrates growth stimulatory and inhibitory signals during G1 phase of hematopoietic cells.

1995 • 34 citations

Transforming growth factor-β in neural embryogenesis and neoplasia

1993 • 34 citations

Expression of platelet-derived growth factor and transforming growth factor and their correlation with cellular morphology in glial tumors

1991 • 34 citations

Transforming growth factor beta stimulates phosphoinositol metabolism and translocation of protein kinase C in cultured astrocytes

1988 • 32 citations

Modifications of cell cycle controlling nuclear proteins by transforming growth factor beta in the HaCaT keratinocyte cell line.

1992 • 32 citations

Distribution of transforming growth factor-β1 in human astrocytomas

1992 • 31 citations

The effects of type beta transforming growth factor on proliferation and epidermal growth factor receptor expression in a human glioblastoma cell line

1988 • 31 citations

Transforming Growth Factor β1 Inhibition of p34^cdc2 Phosphorylation and Histone H1 Kinase Activity Is Associated with G1/S-Phase Growth Arrest

1991 • 31 citations

Inactivation of the retinoblastoma gene does not lead to loss of TGF-beta receptors or response to TGF-beta in breast cancer cell lines.

1991 • 29 citations

Immunophenotypic differences between normal glia, astrocytomas and malignant gliomas: correlations with karyotype, natural history and survival

1989 • 28 citations

Expression of multi-cytokine resistance and multi-growth factor independence in advanced stage metastatic cancer. Malignant melanoma as a paradigm.

1992 • 26 citations

Interaction between p53 and TGF beta 1 in control of epithelial cell proliferation.

1995 • 26 citations

Reduction of TGF‐beta activity abrogates growth promoting tumor cell‐cell interactions in vivo

1991 • 26 citations

The properties of p53 proteins selected for the loss of suppression of transformation.

1994 • 23 citations

Tumor‐promoting activity of epstein‐barr‐ virus‐inducing factor transforming growth factor type beta (EIF/TGF‐β) is due to the induction of irreversible transformation

1991 • 20 citations

Interaction of acidic fibroblast growth factor and transforming growth factor-β in normal and transformed glia in vitro

1992 • 20 citations

RESISTANCE TO TGF-BETA-INDUCED ELIMINATION OF TRANSFORMED-CELLS IS REQUIRED DURING TUMOR PROGRESSION (REVIEW-HYPOTHESIS)

1995 • 18 citations

Transforming growth factor beta isoform-specific differences in interactions with type I and II transforming growth factor beta receptors.

1995 • 16 citations

Phenotypic alterations in fibroblasts and fibrosarcoma cells that overexpress latent transforming growth factor-beta 1.

1992 • 16 citations

TGF‐β induces an inhibitory effect of normal cells directed against transformed cells

1993 • 15 citations

Regulation of Platelet-Derived Growth Factor Gene Expression by Transforming Growth Factor β and Phorbol Ester in Human Leukemia Cell Lines

1987 • 14 citations

EFFECT OF TRANSFORMING GROWTH FACTOR‐β1 ON PLATELET‐DERIVED GROWTH FACTOR RECEPTOR BINDING AND GENE EXPRESSION IN VASCULAR SMOOTH MUSCLE CELLS FROM SHR AND WKY RATS

1994 • 13 citations

DNA index and S-phase in primary brain tumors

1994 • 10 citations

Suppressive Effect of Transforming Growth Factor-β on the Phosphorylation of Endogenous Substrates by Conventional and Novel Protein Kinase C in Primary Cultured Mouse Epidermal Cells

1993 • 9 citations

Direct transforming activity of TGF‐β on rat fibroblasts

1995 • 4 citations