Antioxidants as treatment for neurodegenerative disorders

Mutation in the α-Synuclein Gene Identified in Families with Parkinson's Disease

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Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis

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Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes

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Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein

1984 • 5,166 citations

Chronic Parkinsonism in Humans Due to a Product of Meperidine-Analog Synthesis

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The Effect of Vitamin E and Beta Carotene on the Incidence of Lung Cancer and Other Cancers in Male Smokers

1994 • 4,626 citations

Inflammation and Alzheimer's disease

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Amyloid plaque core protein in Alzheimer disease and Down syndrome.

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The Free Radical Theory of Aging Matures

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Chronic systemic pesticide exposure reproduces features of Parkinson's disease

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Aggregation of Huntingtin in Neuronal Intranuclear Inclusions and Dystrophic Neurites in Brain

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The mitochondrial generation of hydrogen peroxide. General properties and effect of hyperbaric oxygen

1973 • 2,608 citations

Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein

1995 • 2,456 citations

A Controlled Trial of Selegiline, Alpha-Tocopherol, or Both as Treatment for Alzheimer's Disease

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Mitochondrial Complex I Deficiency in Parkinson's Disease

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Hydrogen peroxide mediates amyloid β protein toxicity

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Strategies of antioxidant defense

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Parkinson's Disease

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Oxidative Damage Is the Earliest Event in Alzheimer Disease

2001 • 1,833 citations

Dopaminergic Loss and Inclusion Body Formation in α-Synuclein Mice: Implications for Neurodegenerative Disorders

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Effect of oestrogen during menopause on risk and age at onset of Alzheimer's disease

1996 • 1,640 citations

Mice Lacking α-Synuclein Display Functional Deficits in the Nigrostriatal Dopamine System

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Translating cell biology into therapeutic advances in Alzheimer's disease

1999 • 1,592 citations

Enhanced Neurofibrillary Degeneration in Transgenic Mice Expressing Mutant Tau and APP

2001 • 1,543 citations

Apoptosis in neurodegenerative disorders

2000 • 1,542 citations

Oxidative Damage Linked to Neurodegeneration by Selective α-Synuclein Nitration in Synucleinopathy Lesions

2000 • 1,526 citations

The Curry Spice Curcumin Reduces Oxidative Damage and Amyloid Pathology in an Alzheimer Transgenic Mouse

2001 • 1,482 citations

Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology

1997 • 1,438 citations

Treatment with a Copper-Zinc Chelator Markedly and Rapidly Inhibits β-Amyloid Accumulation in Alzheimer's Disease Transgenic Mice

2001 • 1,418 citations

Microtubule-associated protein tau (tau) is a major antigenic component of paired helical filaments in Alzheimer disease.

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A subset of NSAIDs lower amyloidogenic Aβ42 independently of cyclooxygenase activity

2001 • 1,382 citations

Estrogen Actions in the Central Nervous System¹

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Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes

1998 • 1,336 citations

Iron accumulation in Alzheimer disease is a source of redox-generated free radicals

1997 • 1,304 citations

Huntingtin-Encoded Polyglutamine Expansions Form Amyloid-like Protein Aggregates In Vitro and In Vivo

1997 • 1,283 citations

Huntington Disease

1998 • 1,255 citations

Widespread Peroxynitrite-Mediated Damage in Alzheimer’s Disease

1997 • 1,241 citations

Molecular pathways involved in the neurotoxicity of 6-OHDA, dopamine and MPTP: contribution to the apoptotic theory in Parkinson's disease

2001 • 1,210 citations

Effects of Tocopherol and Deprenyl on the Progression of Disability in Early Parkinson's Disease

1993 • 1,208 citations

Nonsteroidal Antiinflammatory Drugs and the Risk of Alzheimer's Disease

2001 • 1,183 citations

Parkinson's Disease

1998 • 1,150 citations

Oxidative stress and Alzheimer disease

2000 • 1,127 citations

Alterations in glutathione levels in Parkinson's disease and other neurodegenerative disorders affecting basal ganglia

1994 • 1,120 citations

Kinetic Stabilization of the α-Synuclein Protofibril by a Dopamine-α-Synuclein Adduct

2001 • 1,116 citations

Amyloid β-Protein Fibrillogenesis

1997 • 1,103 citations

Interference by Huntingtin and Atrophin-1 with CBP-Mediated Transcription Leading to Cellular Toxicity

2001 • 1,085 citations

Antioxidant therapy: a new pharmacological approach in shock, inflammation, and ischemia/reperfusion injury.

2001 • 1,083 citations

Reversal of Neuropathology and Motor Dysfunction in a Conditional Model of Huntington's Disease

2000 • 1,063 citations

Phagocytes and oxidative stress

2000 • 1,055 citations

Amyloid β-Protein Fibrillogenesis

1999 • 1,041 citations

4‐Hydroxynonenal‐Derived Advanced Lipid Peroxidation End Products Are Increased in Alzheimer's Disease

1997 • 1,018 citations

Clinical trial of indomethacin in Alzheimer's disease

1993 • 996 citations

Estrogen Replacement Therapy for Treatment of Mild to Moderate Alzheimer Disease

2000 • 985 citations

Evidence of active nerve cell degeneration in the substantia nigra of humans years after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine exposure

1999 • 967 citations

Chemical sympathectomy by selective destruction of adrenergic nerve endings with 6-hydroxydopamine

1968 • 862 citations

Parkinson Disease in Twins<SUBTITLE>An Etiologic Study</SUBTITLE>

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Extension of Drosophila lifespan by overexpression of human SOD1 in motorneurons

1998 • 852 citations

Flavonoids protect neuronal cells from oxidative stress by three distinct mechanisms

2001 • 831 citations

Antioxidants, Oxidative Stress, and Degenerative Neurological Disorders

1999 • 828 citations

Oxidative stress induced-neurodegenerative diseases: the need for antioxidants that penetrate the blood brain barrier

2001 • 812 citations

Increased Lipid Peroxidation Precedes Amyloid Plaque Formation in an Animal Model of Alzheimer Amyloidosis

2001 • 776 citations

Oxidative Alterations in Alzheimer's Disease

1999 • 772 citations

Cu(II) Potentiation of Alzheimer Aβ Neurotoxicity

1999 • 748 citations

Evidence that 4-Hydroxynonenal Mediates Oxidative Stress-Induced Neuronal Apoptosis

1997 • 727 citations

Intramuscular desferrioxamine in patients with Alzheimer's disease

1991 • 723 citations

Neuroprotective effects of creatine in a transgenic animal model of amyotrophic lateral sclerosis

1999 • 680 citations

Anatomic and Disease Specificity of NADH CoQ₁ Reductase (Complex I) Deficiency in Parkinson's Disease

1990 • 676 citations

Prospective study of caffeine consumption and risk of Parkinson's disease in men and women

2001 • 659 citations

Benefit of vitamin E, riluzole, and gababapentin in a transgenic model of familial amyotrophic lateral sclerosis

1996 • 654 citations

Nitric oxide in the pathogenesis of vascular disease

2000 • 649 citations

Genetic analysis of ageing: role of oxidative damage and environmental stresses

1996 • 647 citations

The antioxidant paradox

2000 • 643 citations

Elevated thiobarbituric acid-reactive substances and antioxidant enzyme activity in the brain in Alzheimer's disease

1995 • 641 citations

The Effect of Deprenyl (Selegiline) on the Natural History of Parkinson's Disease

1989 • 621 citations

Experimental models of Parkinson's disease

2001 • 617 citations

A placebo-controlled, double-blind, randomized trial of an extract of Ginkgo biloba for dementia. North American EGb Study Group

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Chemistry and Biochemistry of Oxidative Stress in Neurodegenerative Disease

2001 • 610 citations

Mitochondrial dysfunction in neurodegenerative diseases

1998 • 606 citations

Formation of high molecular weight complexes of mutant Cu,Zn-superoxide dismutase in a mouse model for familial amyotrophic lateral sclerosis

2000 • 604 citations

Commentary Oxidative Stress, Nutrition and Health. Experimental Strategies for Optimization of Nutritional Antioxidant Intake in Humans

1996 • 584 citations

Vitamin E protects nerve cells from amyloid βprotein toxicity

1992 • 583 citations

The Efficacy of Ginkgo biloba on Cognitive Function in Alzheimer Disease

1998 • 579 citations

Dityrosine Cross-linking Promotes Formation of Stable α-Synuclein Polymers

2000 • 561 citations

The antioxidant action of taurine, hypotaurine and their metabolic precursors

1988 • 558 citations

Glycated tau protein in Alzheimer disease: a mechanism for induction of oxidant stress.

1994 • 558 citations

Green tea polyphenol (–)‐epigallocatechin‐3‐gallate prevents N‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine‐induced dopaminergic neurodegeneration

2001 • 557 citations

Estrogen for Alzheimer’s disease in women

2000 • 555 citations

Coenzyme Q ₁₀ administration increases brain mitochondrial concentrations and exerts neuroprotective effects

1998 • 546 citations

Utility of the Apolipoprotein E Genotype in the Diagnosis of Alzheimer's Disease

1998 • 546 citations

Neuroprotective Effects of Creatine in a Transgenic Mouse Model of Huntington's Disease

2000 • 526 citations

Methamphetamine neurotoxicity: necrotic and apoptotic mechanisms and relevance to human abuse and treatment

2001 • 520 citations

Phenolic anti-inflammatory antioxidant reversal of Aβ-induced cognitive deficits and neuropathology

2001 • 508 citations

Estrogen Replacement Therapy and Risk of Alzheimer Disease

1996 • 504 citations

Neuropathology in mice expressing human alpha-synuclein.

2000 • 499 citations

Parkinson’s disease and parkinsonism in a longitudinal study

2000 • 495 citations

A Role for 12-lipoxygenase in Nerve Cell Death Caused by Glutathione Depletion

1997 • 495 citations

<scp>d</scp> -β-Hydroxybutyrate protects neurons in models of Alzheimer's and Parkinson's disease

2000 • 492 citations

Oxidative Stress in Huntington's Disease

1999 • 491 citations

Animal models of Parkinson's disease: An empirical comparison with the phenomenology of the disease in man

1996 • 488 citations

Recent Trends in Glutathione Biochemistry—Glutathione–Protein Interactions: A Molecular Link between Oxidative Stress and Cell Proliferation?

1998 • 482 citations

A randomized controlled trial of prednisone in Alzheimer’s disease

2000 • 452 citations

Alzheimer's disease and oxidative stress: implications for novel therapeutic approaches

1999 • 446 citations

Acrolein is increased in Alzheimer’s disease brain and is toxic to primary hippocampal cultures

2001 • 438 citations

Increased life expectancy resulting from addition of l-deprenyl to Madopar� treatment in Parkinson's disease: A longterm study

1985 • 437 citations

Neuroprotective Effects of Creatine and Cyclocreatine in Animal Models of Huntington’s Disease

1998 • 431 citations

Ginkgo Biloba Extract (EGb 761) and CNS Functions Basic Studies and Clinical Applications

2000 • 426 citations

Induction of α-Synuclein Aggregation by Intracellular Nitrative Insult

2001 • 425 citations

Inhibition of neuronal nitric oxide synthase prevents MPTP–induced parkinsonism in baboons

1996 • 422 citations

Lesions of Central Norepinephrine Terminals with 6-OH-Dopamine: Biochemistry and Fine Structure

1969 • 421 citations

Ketone Bodies, Potential Therapeutic Uses

2001 • 411 citations

Replicating Huntington's disease phenotype in experimental animals

1999 • 410 citations

Energy metabolism defects in Huntington's disease and effects of coenzyme Q₁₀

1997 • 407 citations

The antioxidant neuroprotective effects of estrogens and phenolic compounds are independent from their estrogenic properties

1999 • 407 citations

Oxidative Stress and Genetics in the Pathogenesis of Parkinson's Disease

2000 • 405 citations

Molecular genetics: Unmasking polyglutamine triggers in neurodegenerative disease

2000 • 397 citations

Anti‐inflammatory agents as a therapeutic approach to Alzheimer's disease

1992 • 396 citations

Protein‐Bound Acrolein

1999 • 394 citations

An evaluation of the role of mitochondria in neurodegenerative diseases: mitochondrial mutations and oxidative pathology, protective nuclear responses, and cell death in neurodegeneration

1999 • 393 citations

A double-blind, placebo-controlled trial of diclofenac/misoprostol in Alzheimer’s disease

1999 • 393 citations

Free Radical‐Mediated Molecular Damage

2001 • 392 citations

Proof of Efficacy of the Ginkgo Biloba Special Extract EGb 761 in Outpatients Suffering from Mild to Moderate Primary Degenerative Dementia of the Alzheimer Type or Multi-infarct Dementia

1996 • 377 citations

The ginkgo biloba extract (EGb 761) protects hippocampal neurons against cell death induced by β‐amyloid

2000 • 376 citations

Creatine and Cyclocreatine Attenuate MPTP Neurotoxicity

1999 • 372 citations

The Inflammatory Reaction Following 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine Intoxication in Mouse

1999 • 372 citations

Human glutathione transferase A4-4: an Alpha class enzyme with high catalytic efficiency in the conjugation of 4-hydroxynonenal and other genotoxic products of lipid peroxidation

1998 • 372 citations

Micronutrients prevent cancer and delay aging

1998 • 365 citations

Age‐Dependent Vulnerability of the Striatum to the Mitochondrial Toxin 3‐Nitropropionic Acid

1993 • 360 citations

Oxygen and nitrogen are pro-carcinogens. Damage to DNA by reactive oxygen, chlorine and nitrogen species: measurement, mechanism and the effects of nutrition

1999 • 358 citations

Blood-Brain Barrier Permeation: Molecular Parameters Governing Passive Diffusion

1998 • 357 citations

Glutamine Repeats and Neurodegenerative Diseases: Molecular Aspects

2002 • 354 citations

Induction of cell cycle arrest and apoptosis in human breast cancer cells by quercetin

2001 • 353 citations

Oxidation of cysteine-322 in the repeat domain of microtubule-associated protein tau controls the in vitro assembly of paired helical filaments.

1995 • 347 citations

Synthetic combined superoxide dismutase/catalase mimetics are protective as a delayed treatment in a rat stroke model: a key role for reactive oxygen species in ischemic brain injury.

1998 • 334 citations

Mitochondrial oxidative phosphorylation defects in parkinson's disease

1991 • 334 citations

Neuronal Oxidative Stress Precedes Amyloid-β Deposition in Down Syndrome

2000 • 321 citations

Coenzyme Q₁₀ levels correlate with the activities of complexes I and II/III in mitochondria from parkinsonian and nonparkinsonian subjects

1997 • 321 citations

Association of vitamin E and C supplement use with cognitive function and dementia in elderly men

2000 • 318 citations

α-Synuclein occurs in lipid-rich high molecular weight complexes, binds fatty acids, and shows homology to the fatty acid-binding proteins

2001 • 310 citations

Dietary flavone is a potent apoptosis inducer in human colon carcinoma cells.

2000 • 306 citations

Acetyl-L-carnitine physical-chemical, metabolic, and therapeutic properties: relevance for its mode of action in Alzheimer's disease and geriatric depression

2000 • 304 citations

Inhibition of the cyclooxygenase isoenzymes COX-1 and COX-2 provide neuroprotection in the MPTP-mouse model of Parkinson's disease

2000 • 303 citations

A one-hit model of cell death in inherited neuronal degenerations

2000 • 299 citations

A randomized, placebo-controlled trial of coenzyme Q ₁₀ and remacemide in Huntington’s disease

2001 • 296 citations

Postmenopausal estrogen replacement therapy and risk of AD

1999 • 293 citations

Effects of estrogen on cognition, mood, and cerebral blood flow in AD

2000 • 292 citations

Complete Genomic Screen in Parkinson Disease

2001 • 289 citations

Elevated free nitrotyrosine levels, but not protein-bound nitrotyrosine or hydroxyl radicals, throughout amyotrophic lateral sclerosis (ALS)-like disease implicate tyrosine nitration as an aberrant in vivo property of one familial ALS-linked superoxide dismutase 1 mutant

1997 • 287 citations

Redox regulation of c‐Jun DNA binding by reversible S‐glutathiolation

1999 • 285 citations

Tetrahydrobiopterin Regulates Superoxide and Nitric Oxide Generation by Recombinant Endothelial Nitric Oxide Synthase

1997 • 281 citations

Ebselen: prospective therapy for cerebral ischaemia

2000 • 279 citations

MPTP induces alpha-synuclein aggregation in the substantia nigra of baboons

2000 • 277 citations

Familial Aggregation of Parkinson's Disease in Iceland

2000 • 274 citations

EUK-134, a synthetic superoxide dismutase and catalase mimetic, prevents oxidative stress and attenuates kainate-induced neuropathology

1999 • 266 citations

Estrogen Is Essential for Maintaining Nigrostriatal Dopamine Neurons in Primates: Implications for Parkinson's Disease and Memory

2000 • 265 citations

Vitamin E and Alzheimer disease: the basis for additional clinical trials

2000 • 263 citations

High-dose estradiol improves cognition for women with AD

2001 • 262 citations

Mitochondrial energy metabolism is regulated via nuclear-coded subunits of cytochrome c oxidase11This article is dedicated to the memory of the late Professor Lars Ernster.

2000 • 261 citations

The electrophile counterattack response: Protection against neoplasia and toxicity

1993 • 260 citations

The effect of estrogen replacement on early Parkinson’s disease

1999 • 260 citations

Peroxynitrite decomposition catalysts: Therapeutics for peroxynitrite-mediated pathology

1998 • 259 citations

Traumatic brain injury as a risk factor for Alzheimer's disease: a review.

2000 • 259 citations

L-Cysteine, a Bicarbonate-Sensitive Endogenous Excitotoxin

1990 • 259 citations

A double-blind, placebo-controlled randomized clinical trial of α-tocopherol (vitamin E) in the treatment of amyotrophic lateral sclerosis

2001 • 257 citations

The Impact of Gender and Estrogen on Striatal Dopaminergic Neurotoxicity

1998 • 256 citations

Coenzyme Q10 attenuates the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) induced loss of striatal dopamine and dopaminergic axons in aged mice

1998 • 255 citations

Impact of sustained deprenyl (selegiline) in levodopa-treated Parkinson's disease: A randomized placebo-controlled extension of the deprenyl and tocopherol antioxidative therapy of parkinsonism trial

2002 • 255 citations

An improved method of preparing the amyloid β-protein for fibrillogenesis and neurotoxicity experiments

2000 • 249 citations

Molecular factors underlying selective vulnerability of motor neurons to neurodegeneration in amyotrophic lateral sclerosis

2000 • 246 citations

An assessment of the antioxidant and the antiamyloidogenic properties of melatonin: implications for Alzheimer's disease

2000 • 246 citations

The in vivo neuromodulatory effects of the herbal medicine ginkgo biloba

2001 • 242 citations

Protective effects of idebenone and α‐tocopherol on β‐amyloid‐(1–42)‐induced learning and memory deficits in rats: implication of oxidative stress in β‐amyloid‐induced neurotoxicity in vivo

1999 • 240 citations

Cyclooxygenase-2 contributes to N-methyl-D-aspartate-mediated neuronal cell death in primary cortical cell culture.

2000 • 235 citations

Neurobehavioral aspects of antioxidants in aging

2000 • 235 citations

Parkinson Disease, the Effect of Levodopa, and the ELLDOPA Trial

1999 • 234 citations

Long‐term acetyl‐L‐carnitine treatment in Alzheimer's disease

1991 • 233 citations

Potential for creatine and other therapies targeting cellular energy dysfunction in neurological disorders

2001 • 232 citations

Dopamine, 6-hydroxydopamine, iron, and dioxygen — their mutual interactions and possible implication in the development of Parkinson's disease

1996 • 232 citations

Electrophile and antioxidant regulation of enzymes that detoxify carcinogens.

1995 • 230 citations

Cancer Chemoprevention and Apoptosis Mechanisms Induced by Dietary Polyphenolics

2000 • 228 citations

Free Radical Involvement in Aging

1993 • 226 citations

Controlled trial of N-acetylcysteine for patients with probable Alzheimer's disease

2001 • 225 citations

The Ginkgo biloba Extract (EGb 761) Protects and Rescues Hippocampal Cells Against Nitric Oxide‐Induced Toxicity

2000 • 222 citations

The Role of Iron in Neurodegeneration

1999 • 220 citations

Oxidative Stress and Motor Neurone Disease

1999 • 220 citations

Disruption of the taurine transporter gene (taut) leads to retinal degeneration in mice

2001 • 219 citations

The determination of hydroxydopamines and other trace amines in the urine of Parkinsonian patients and normal controls

1993 • 219 citations

beta-Amyloid toxicity in organotypic hippocampal cultures: protection by EUK-8, a synthetic catalytic free radical scavenger.

1996 • 214 citations

A pilot trial of high-dose alpha-tocopherol and ascorbate in early Parkinson's disease

1992 • 214 citations

Tissue distribution and neuroprotective effects of citrus flavonoid tangeretin in a rat model of Parkinson's disease

2001 • 214 citations

Creatine monohydrate increases strength in patients with neuromuscular disease

1999 • 212 citations

Effect of hydroxychloroquine on progression of dementia in early Alzheimer's disease: an 18-month randomised, double-blind, placebo-controlled study

2001 • 212 citations

A Mitochondrial Paradigm for Degenerative Diseases and Ageing

2001 • 207 citations

Dopamine D2 receptor-mediated antioxidant and neuroprotective effects of ropinirole, a dopamine agonist

1999 • 205 citations

Facilitated Glutamatergic Transmission in the Striatum of D₂ Dopamine Receptor-Deficient Mice

2001 • 204 citations

Copernicus revisited: amyloid beta in Alzheimer's disease

2001 • 203 citations

In Alzheimer's Disease, Heme Oxygenase Is Coincident with Alz50, an Epitope of τ Induced by 4‐Hydroxy‐2‐Nonenal Modification

2000 • 202 citations

Powerful and prolonged protection of human retinal pigment epithelial cells, keratinocytes, and mouse leukemia cells against oxidative damage: The indirect antioxidant effects of sulforaphane

2001 • 200 citations

Cause of neural death in neurodegenerative diseases attributable to expansion of glutamine repeats

2001 • 199 citations

Expression of mutant alpha-synuclein causes increased susceptibility to dopamine toxicity

2000 • 198 citations

Inflammation in Parkinson's disease.

2001 • 195 citations

Progression after chronic manganese exposure

1993 • 194 citations

Melatonin protects against 6‐OHDA‐induced neurotoxicity in rats: a role for mitochondrial complex I activity

2001 • 188 citations

The allosteric ATP‐inhibition of cytochrome c oxidase activity is reversibly switched on by cAMP‐dependent phosphorylation

2000 • 187 citations

Estrogen improves motor disability in parkinsonian postmenopausal women with motor fluctuations

2000 • 186 citations

Apoptosis and Alzheimer's disease

2000 • 185 citations

The Efficacy of Ginkgo for Elderly People with Dementia and Age‐Associated Memory Impairment: New Results of a Randomized Clinical Trial

2000 • 184 citations

Levodopa therapy

1998 • 183 citations

Synthetic superoxide dismutase/catalase mimetics reduce oxidative stress and prolong survival in a mouse amyotrophic lateral sclerosis model

2001 • 183 citations

Neuroprotective properties of 17β‐estradiol, progesterone, and raloxifene in MPTP C57Bl/6 mice

2001 • 182 citations

Randomized, Double-Blind, Controlled Trial of Acetylcysteine in Amyotrophic Lateral Sclerosis

1995 • 180 citations

Methamphetamine‐Induced Dopaminergic Neurotoxicity: Role of Peroxynitrite and Neuroprotective Role of Antioxidants and Peroxynitrite Decomposition Catalysts

2001 • 173 citations

Population-Based Case-Control Study of Amyotrophic Lateral Sclerosis in Western Washington State. I. Cigarette Smoking and Alcohol Consumption

2000 • 170 citations

The Importance of Using Scientific Principles in the Development of Medicinal Agents from Plants

2001 • 167 citations

Cyclooxygenase and inflammation in Alzheimer's disease: Experimental approaches and clinical interventions

1998 • 167 citations

Mortality in DATATOP: A Multicenter trial in early Parkinson's disease

1998 • 166 citations

Sustained efficacy and safety of idebenone in the treatment of Alzheimer’s disease: update on a 2-year double-blind multicentre study

1998 • 164 citations

Impact of deprenyl and tocopherol treatment on Parkinson's disease in DATATOP subjects not requiring levodopa

1996 • 162 citations

Intramembrane proteolysis by presenilins

2000 • 161 citations

Abortive apoptosis in Alzheimer's disease

2001 • 157 citations

Risk Factors for Parkinson’s Disease: The Leisure World Cohort Study

2001 • 156 citations

DATATOP: a decade of neuroprotective inquiry. Parkinson Study Group. Deprenyl And Tocopherol Antioxidative Therapy Of Parkinsonism.

1998 • 156 citations

Oxidative Stress and Parkinson's Diseasea

1996 • 154 citations

Positron emission tomographic evidence for progression of human MPTP‐induced dopaminergic lesions

1994 • 153 citations

A 1-year multicenter placebo-controlled study of acetyl-L-carnitine in patients with Alzheimer's disease

1996 • 149 citations

Postmenopausal estrogen use and Parkinson's disease with and without dementia

1998 • 149 citations

Excitotoxins in Neuronal Apoptosis and Necrosis

1999 • 146 citations

Mitochondrial Production of Hydrogen Peroxide Regulation by Nitric Oxide and the Role of Ubisemiquinone

2000 • 145 citations

Melatonin Reverses the Profibrillogenic Activity of Apolipoprotein E4 on the Alzheimer Amyloid Aβ Peptide

2001 • 145 citations

Ubiquinone (Coenzyme Q&lt;sub&gt;10&lt;/sub&gt;) and Mitochondria in Oxidative Stress of Parkinson’s Disease

2001 • 145 citations

Melatonin treatment stabilizes chronobiologic and cognitive symptoms in Alzheimer's disease.

2000 • 141 citations

Population-Based Case-Control Study of Amyotrophic Lateral Sclerosis in Western Washington State. II. Diet

2000 • 140 citations

N-t-Butyl Hydroxylamine, a Hydrolysis Product of α-Phenyl-N-t-butyl Nitrone, Is More Potent in Delaying Senescence in Human Lung Fibroblasts

2000 • 139 citations

Recent advances in amyotrophic lateral sclerosis

2000 • 139 citations

Current Evidence for Neuroprotective Effects of Nicotine and Caffeine Against Parkinson??s Disease

2001 • 135 citations

Analysis of free and protein-bound nitrotyrosine in human plasma by a gas chromatography/mass spectrometry method that avoids nitration artifacts

2000 • 135 citations

Risk factors of Parkinson's disease in Indian patients

2001 • 135 citations

N-acetyl-L-cysteine improves survival and preserves motor performance in an animal model of familial amyotrophic lateral sclerosis

2000 • 134 citations

Trial of d-alpha-tocopherol in Huntington's disease

1995 • 132 citations

Accelerated Accumulation of Amyloid β Proteins on Oxidatively Damaged Lipid Membranes

2000 • 132 citations

Neuroprotective Role of Dopamine Against Hippocampal Cell Death

2000 • 126 citations

Short-term effects of high-dose 17β-estradiol in postmenopausal PD patients

1999 • 124 citations

Increases in cortical glutamate concentrations in transgenic amyotrophic lateral sclerosis mice are attenuated by creatine supplementation

2001 • 122 citations

A Controlled Study of 2 Doses of Idebenone in the Treatment of Alzheimer’s Disease

1997 • 121 citations

Influence of neurotoxins and oxidative stress on the onset and progression of Parkinson’s disease

2000 • 115 citations

Mitochondrial DNA mutations in complex I and tRNA genes in Parkinson’s disease

2000 • 113 citations

Hormone replacement therapy and reduced cognitive decline in older women

2001 • 113 citations

Absorption, tolerability, and effects on mitochondrial activity of oral coenzyme Q ₁₀ in parkinsonian patients

1998 • 112 citations

Lipoic acid improves survival in transgenic mouse models of Huntington's disease

2001 • 111 citations

Alzheimer disease: protective factors

2000 • 111 citations

Mitochondrial Production of Hydrogen Peroxide Regulation by Nitric Oxide and the Role of Ubisemiquinone

2000 • 111 citations

Cytoprotective antioxidant function of tyrosine and tryptophan residues in transmembrane proteins

2000 • 109 citations

Transition metal‐mediated glycoxidation accelerates cross‐linking of β‐amyloid peptide

2000 • 109 citations

The Antioxidant Ebselen Prevents Neurotoxicity and Clinical Symptoms in a Primate Model of Parkinson's Disease

2000 • 108 citations

Effect of lazabemide on the progression of disability in early Parkinson's disease

1996 • 104 citations

A 1-year controlled trial of acetyl- <scp>l</scp> -carnitine in early-onset AD

2000 • 104 citations

Coenzyme Q10 and nicotinamide and a free radical spin trap protect against MPTP neurotoxicity

1995 • 102 citations

The Selective Toxicity of 1-Methyl-4-phenylpyridinium to Dopaminergic Neurons: The Role of Mitochondrial Complex I and Reactive Oxygen Species Revisited

2000 • 102 citations

Assessment of coenzyme q10 tolerability in huntington's disease

1996 • 102 citations

Tauroursodeoxycholic Acid Partially Prevents Apoptosis Induced by 3‐Nitropropionic Acid

2000 • 101 citations

Do NSAIDs prevent Alzheimer's disease? And, if so, why? The epidemiological evidence

2001 • 101 citations

Extending Functional Life Span

1998 • 101 citations

Effects of R- and S-apomorphine on MPTP-induced nigro-striatal dopamine neuronal loss

2001 • 97 citations

What do Animal Cancer Tests Tell us About Human Cancer Risk?: Overview of Analyses of the Carcinogenic Potency Database

1998 • 97 citations

Dietary ortho phenols that induce glutathione S-transferase and increase the resistance of cells to hydrogen peroxide are potential cancer chemopreventives that act by two mechanisms: the alleviation of oxidative stress and the detoxification of mutagenic xenobiotics

2000 • 96 citations

Effects of α-phenyl-tert-butyl nitrone on neuronal survival and motor function following intrastriatal injections of quinolinate or 3-nitropropionate

1996 • 95 citations

A controlled trial of idebenone in Huntington's disease

1996 • 94 citations

Investigation by Parkinson's Disease Research Group of United Kingdom into excess mortality seen with combined levodopa and selegiline treatment in patients with early, mild Parkinson's disease: further results of randomised trial and confidential inquiry

1998 • 94 citations

Nutritional Factors in Cerebral Aging and Dementia: Epidemiological Arguments for a Role of Oxidative Stress

2001 • 92 citations

Altered redox state of platelet coenzyme Q 10 in Parkinson's disease

2000 • 91 citations

Can estrogen keep you smart? Evidence from clinical studies.

1999 • 89 citations

Prevention and Suppression of Autoimmune Encephalomyelitis by EUK-8, a Synthetic Catalytic Scavenger of Oxygen-Reactive Metabolites

1997 • 89 citations

In vitro peroxidase oxidation induces stable dimers of β-amyloid (1-42) through dityrosine bridge formation

1999 • 88 citations

Cytokine-Stimulated, But Not HIV-Infected, Human Monocyte-Derived Macrophages Produce Neurotoxic Levels of <scp>l</scp>-Cysteine

2000 • 88 citations

3-Nitropropionic acid induced in vivo protein oxidation in striatal and cortical synaptosomes: insights into Huntington's disease

2000 • 86 citations

A Therapeutic Role For Melatonin Antagonism in Experimental Models of Parkinson’s Disease

1999 • 85 citations

Effects of an Inhibitor of Poly(ADP-Ribose) Polymerase, Desmethylselegiline, Trientine, and Lipoic Acid in Transgenic ALS Mice

2001 • 85 citations

Agricultural work and the risk of Parkinson's disease in Denmark, 1981-1993

2000 • 84 citations

Neurological sequelae of cyanide intoxication — the patterns of clinical, magnetic resonance imaging, and positron emission tomography findings

1995 • 83 citations

Effect of overexpression of wild‐type and mutant Cu/Zn‐superoxide dismutases on oxidative damage and antioxidant defences: relevance to Down's syndrome and familial amyotrophic lateral sclerosis

2001 • 83 citations

Safety and Efficacy of Idebenone versus Tacrine in Patients with Alzheimer's Disease: Results of a Randomized, Double-Blind, Parallel-Group Multicenter Study

2002 • 82 citations

The Activation of Dopamine D4 Receptors Inhibits Oxidative Stress-Induced Nerve Cell Death

2001 • 82 citations

Neuronal apoptosis resulting from high doses of the isoflavone genistein: role for calcium and p42/44 mitogen-activated protein kinase.

2001 • 82 citations

Creatine reduces 3-nitropropionic-acid-induced cognitive and motor abnormalities in rats

2000 • 80 citations

Benefit of a combined treatment with trientine and ascorbate in familial amyotrophic lateral sclerosis model mice

1999 • 79 citations

Transgenic animal models of familial amyotrophic lateral sclerosis

1997 • 79 citations

Increased nitrotyrosine immunoreactivity in substantia nigra neurons in MPTP treated baboons is blocked by inhibition of neuronal nitric oxide synthase

1999 • 78 citations

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