Dietary flavone is a potent apoptosis inducer in human colon carcinoma cells.

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Cancer Cell Cycles

1996 • 5,379 citations

Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis

1995 • 4,003 citations

The Flavonoids Advances in Research Since 1986

2017 • 1,550 citations

Modulation of apoptosis and Bcl-2 expression by prostaglandin E2 in human colon cancer cells.

1998 • 1,130 citations

p53 mutations in colorectal cancer.

1990 • 1,030 citations

Control of inducible chemoresistance: Enhanced anti-tumor therapy through increased apoptosis by inhibition of NF-κB

1999 • 1,001 citations

Colon Cancer: A Review of the Epidemiology

1993 • 791 citations

Dietary Flavonoids and the Risk of Lung Cancer and Other Malignant Neoplasms

1997 • 779 citations

The impact of plant flavonoids on mammalian biology: implications for immunity, inflammation and cancer

2017 • 507 citations

Apoptosis and APC in colorectal tumorigenesis.

1996 • 491 citations

Comparative analysis of the effects of flavonoids on proliferation, cytotoxicity, and apoptosis in human colon cancer cell lines

1999 • 475 citations

Genetic determinants of p53-induced apoptosis and growth arrest.

1996 • 472 citations

Quercetin and rutin as inhibitors of azoxymethanol-induced colonic neoplasia

1991 • 453 citations

Cell-cycle arrest versus cell death in cancer therapy

1997 • 394 citations

Antioxidants enhance the cytotoxicity of chemotherapeutic agents in colorectal cancer: A p53-independent induction of p21WAF1/CIP1 via C/EBPβ

1997 • 340 citations

Elevated expression of Bcl-X and reduced Bak in primary colorectal adenocarcinomas.

1996 • 325 citations

Chemoprevention of azoxymethane-induced rat colon carcinogenesis by the naturally occurring flavonoids, diosmin and hesperidin

1997 • 301 citations

Dietary flavonoids protect human colonocyte DNA from oxidative attack in vitro

1999 • 242 citations

Abrogation of an S-phase checkpoint and potentiation of camptothecin cytotoxicity by 7-hydroxystaurosporine (UCN-01) in human cancer cell lines, possibly influenced by p53 function.

1997 • 241 citations

Predictive value of proliferation, differentiation and apoptosis as intermediate markers for colon tumorigenesis

1997 • 230 citations

Flavonoids activate wild-type p53.

1996 • 228 citations

DNA damage and p53-mediated cell cycle arrest: A reevaluation

1996 • 216 citations

Increased membrane permeability of apoptotic thymocytes: A flow cytometric study

1993 • 200 citations

Relation of Vegetable, Fruit, and Grain Consumption to Colorectal Adenomatous Polyps

1996 • 187 citations

The p21 cyclin–dependent kinase inhibitor suppresses tumorigenicity in vivo

1995 • 182 citations

Inhibition of Bacterial Mutagenesis byCitrusFlavonoids

1996 • 144 citations

Early expression of cyclo-oxygenase-2 during sporadic colorectal carcinogenesis

1999 • 134 citations

p21/WAF1/CIP1 EXPRESSION IN NORMAL MUCOSA AND IN ADENOMAS AND ADENOCARCINOMAS OF THE COLON: ITS RELATIONSHIP WITH DIFFERENTIATION

1996 • 110 citations

Increased apoptosis accompanies neoplastic development in the human colorectum.

1996 • 107 citations

A phase III study of irinotecan (CPT-11) versus best supportive care in patients with metastatic colorectal cancer who have failed 5-fluorouracil therapy. V301 Study Group.

1999 • 97 citations

Induction of cell cycle arrest by the endogenous product of lipid peroxidation, malondialdehyde

1998 • 91 citations

Glucosinolates and phenolics as antioxidants from plant foods.

1998 • 87 citations

Upregulation of CASP genes in human tumor cells undergoing etoposide-induced apoptosis

1998 • 84 citations

Immunohistochemistry of Caspase3/CPP32 in human stomach and its correlation with cell proliferation and apoptosis.

1999 • 82 citations

COX-2 inhibitors for colorectal cancer

1998 • 71 citations

Expression of cyclin E in colorectal adenomas and adenocarcinomas: correlation with expression of Ki-67 antigen and p53 protein

1996 • 63 citations

The isolation and culture of adult mouse colonic epithelium.

1995 • 60 citations

Promoter activation and following induction of the p21/WAF1 gene by flavone is involved in G₁ phase arrest in A549 lung adenocarcinoma cells

1998 • 59 citations

Detection of poly(ADP-ribose) polymerase cleavage in response to treatment with topoisomerase I inhibitors: a potential surrogate end point to assess treatment effectiveness.

1999 • 58 citations

Loss of p21WAF1/Cip1 protein expression accompanies progression of sporadic colorectal neoplasms but not hereditary nonpolyposis colorectal cancers.

1998 • 56 citations

Induction of p53‐independent Apoptosis Associated with G2M Arrest Following DNA Damage in Human Colon Cancer Cell Lines

1997 • 40 citations

Flavonoids: Inhibitors of Cytokine Induced Gene Expression

1998 • 38 citations

Transepithelial transport and accumulation of flavone in human intestinal CACO-2 cells

1998 • 30 citations

Sulindac sulfide alters the expression of cyclin proteins in HT-29 colon adenocarcinoma cells

1998 • 29 citations

Expression of bcl-2, bax, and bcl-XL proteins in azoxymethane-induced rat colonic adenocarcinomas

1997 • 29 citations

Diffuse mucosal damage in the large intestine associated with Irinotecan (CPT-11).

1998 • 13 citations