Ubiquinone (Coenzyme Q<sub>10</sub>) and Mitochondria in Oxidative Stress of Parkinson’s Disease

Neuropathological stageing of Alzheimer-related changes

1991 • 14,533 citations

Mutation in the α-Synuclein Gene Identified in Families with Parkinson's Disease

1997 • 7,814 citations

Oxidants, antioxidants, and the degenerative diseases of aging.

1993 • 6,011 citations

Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

1998 • 5,063 citations

Chronic Parkinsonism in Humans Due to a Product of Meperidine-Analog Synthesis

1983 • 4,822 citations

AGEING AND PARKINSON'S DISEASE: SUBSTANTIA NIGRA REGIONAL SELECTIVITY

1991 • 3,275 citations

Free radicals, antioxidants, and human disease: curiosity, cause, or consequence?

1994 • 3,002 citations

A primate model of parkinsonism: selective destruction of dopaminergic neurons in the pars compacta of the substantia nigra by N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.

1983 • 2,149 citations

Dopaminergic Loss and Inclusion Body Formation in α-Synuclein Mice: Implications for Neurodegenerative Disorders

2000 • 1,729 citations

MITOCHONDRIAL COMPLEX I DEFICIENCY IN PARKINSON'S DISEASE

1989 • 1,717 citations

Mice Lacking α-Synuclein Display Functional Deficits in the Nigrostriatal Dopamine System

2000 • 1,628 citations

Synuclein: a neuron-specific protein localized to the nucleus and presynaptic nerve terminal

1988 • 1,518 citations

Molecular cloning of cDNA encoding an unrecognized component of amyloid in Alzheimer disease.

1993 • 1,426 citations

DISEASES OF THE MITOCHONDRIAL DNA

1992 • 1,294 citations

Inhibition of NADH-linked oxidation in brain mitochondria by 1-methyl-4-phenyl-pyridine, a metabolite of the neurotoxin, 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine

1985 • 1,236 citations

Effects of Tocopherol and Deprenyl on the Progression of Disability in Early Parkinson's Disease

1993 • 1,208 citations

Alterations in glutathione levels in Parkinson's disease and other neurodegenerative disorders affecting basal ganglia

1994 • 1,120 citations

Oxidative damage to DNA during aging: 8-hydroxy-2'-deoxyguanosine in rat organ DNA and urine.

1990 • 1,100 citations

Abnormalities of the electron transport chain in idiopathic parkinson's disease

1989 • 1,067 citations

The Neuron-Specific Protein PGP 9.5 Is a Ubiquitin Carboxyl-Terminal Hydrolase

1989 • 864 citations

Characterization of a novel protein regulated during the critical period for song learning in the zebra finch

1995 • 826 citations

The synucleins: a family of proteins involved in synaptic function, plasticity, neurodegeneration and disease

1998 • 756 citations

Superoxide dismutase delays neuronal apoptosis: A role for reactive oxygen species in programmed neuronal death

1995 • 744 citations

Redox regulation of transcriptional activators

1996 • 690 citations

Aging and Extrapyramidal Function

1977 • 650 citations

Anatomy, pigmentation, ventral and dorsal subpopulations of the substantia nigra, and differential cell death in Parkinson's disease.

1991 • 543 citations

Six unidentified reading frames of human mitochondrial DNA encode components of the respiratory-chain NADH dehydrogenase

1985 • 517 citations

Selective Increase of Iron in Substantia Nigra Zona Compacta of Parkinsonian Brains

1991 • 516 citations

Oxidoreductive regulation of nuclear factor kappa B. Involvement of a cellular reducing catalyst thioredoxin

1993 • 490 citations

Energy-dependent uptake of N-methyl-4-phenylpyridinium, the neurotoxic metabolite of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, by mitochondria.

1986 • 404 citations

Antioxidant defense of the brain: a role for astrocytes

1997 • 400 citations

Nigral and Cortical Lewy Bodies and Dystrophic Nigral Neurites in Parkinsonʼs Disease and Cortical Lewy Body Disease Contain α-synuclein Immunoreactivity

1998 • 393 citations

Substrate Specificity of Deubiquitinating Enzymes: Ubiquitin C-Terminal Hydrolases

1998 • 386 citations

Pathologic and biochemical studies of juvenile parkinsonism linked to chromosome 6q

1998 • 366 citations

Isolation of PGP 9.5, a New Human Neurone‐Specific Protein Detected by High‐Resolution Two‐Dimensional Electrophoresis

1983 • 360 citations

Energy Thresholds in Brain Mitochondria

1998 • 354 citations

Ubiquitin carboxyl‐terminal hydrolase (PGP 9.5) is selectively present in ubiquitinated inclusion bodies characteristic of human neurodegenerative diseases

1990 • 351 citations

Oxidative damage to mitochondrial DNA and its relationship to ageing

1995 • 350 citations

Platelet mitochondria function in Parkinson's disease

1992 • 350 citations

Increase of deleted mitochondrial DNA in the striatum in Parkinson's disease and senescence

1990 • 345 citations

URF6, Last Unidentified Reading Frame of Human mtDNA, Codes for an NADH Dehydrogenase Subunit

1986 • 344 citations

Oxidative stress and antioxidant therapy in Parkinson's disease

1996 • 342 citations

Oxidative Phosphorylation Diseases

1990 • 338 citations

The rat brain synucleins; family of proteins transiently associated with neuronal membrane

1991 • 326 citations

The Synuclein Family

1998 • 316 citations

Protection and Recycling of α-Tocopherol in Human Erythrocytes by Intracellular Ascorbic Acid

1998 • 315 citations

Apoptosis and necrosis: Intracellular ATP level as a determinant for cell death modes

1997 • 296 citations

Hydrogen peroxide release by mitochondria increases during aging

1991 • 292 citations

Reactive Oxygen Species and Antioxidants in Signal Transduction and Gene Expression

2009 • 281 citations

Identification of residues in the human DNA repair enzyme HAP1 (Ref-1) that are essential for redox regulation of Jun DNA binding.

1993 • 270 citations

Uptake of the neurotoxin 1-methyl-4-phenylpyridine (MPP+) by mitochondria and its relation to the inhibition of the mitochondrial oxidation of NAD+-linked substrates by MPP+

1986 • 267 citations

Age‐Dependent Impairment of Mitochondrial Function in Primate Brain

1993 • 265 citations

The ADP-ATP Translocation in mitochondria, a membrane potential controlled transport

1980 • 262 citations

ALZHEIMER'S DISEASE, PARKINSON'S DISEASE, AND MOTONEURONE DISEASE: ABIOTROPIC INTERACTION BETWEEN AGEING AND ENVIRONMENT?

1986 • 257 citations

Coenzyme Q10 attenuates the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) induced loss of striatal dopamine and dopaminergic axons in aged mice

1998 • 255 citations

Inhibition of mitochondrial NADH dehydrogenase by pyridine derivatives and its possible relation to experimental and idiopathic parkinsonism

1986 • 250 citations

Studies on the Neurotoxicity of 1‐Methyl‐4‐Phenyl‐1,2,3,6‐Tetrahydropyridine: Inhibition of NAD‐Linked Substrate Oxidation by Its Metabolite, 1‐Methyl‐4‐Phenylpyridinium

1986 • 241 citations

Mitochondrial DNA in Aging and Disease

1997 • 227 citations

Lazaroids improve the survival of grafted rat embryonic dopamine neurons.

1994 • 225 citations

Cell death mechanisms in Parkinson's disease

2000 • 224 citations

Age-associated accumulation of 8-hydroxydeoxyguanosine in mitochondrial DNA of human diaphragm

1991 • 203 citations

Expression of ?-synuclein, parkin, and ubiquitin carboxy-terminal hydrolase L1 mRNA in human brain: Genes associated with familial Parkinson's disease

2000 • 195 citations

Physical and Functional Sensitivity of Zinc Finger Transcription Factors to Redox Change

1996 • 192 citations

Quantitative determination of deleted mitochondrial DNA relative to normal DNA in parkinsonian striatum by a kinetic PCR analysis

1990 • 188 citations

[54] In Vivo Oxidative DNA damage: Measurement of 8-Hydroxy-2′-deoxyguanosine in DNA and urine by high-performance liquid chromatography with electrochemical detection

1990 • 186 citations

Full length article

1997 • 173 citations

Melatonin prevents apoptosis induced by 6‐hydroxydopamine in neuronal cells: Implications for Parkinson's disease

1998 • 153 citations

Cyanide‐induced parkinsonism

1985 • 139 citations

Overexpressing Cu/Zn superoxide dismutase enhances survival of transplanted neurons in a rat model of Parkinson's disease

1995 • 132 citations

Studies on the electron transfer pathway, topography of iron-sulfur centers, and site of coupling in NADH-Q oxidoreductase.

1988 • 131 citations

Oxidative injury in the nervous system

1998 • 122 citations

Redox Signaling and the Control of Cell Growth and Death

1996 • 120 citations

A Defect in Mitochondrial Electron-Transport Activity (NADH–Coenzyme Q Oxidoreductase) in Leber's Hereditary Optic Neuropathy

1989 • 114 citations

A NEW MANIFESTATION OF LEBER'S DISEASE AND A NEW EXPLANATION FOR THE AGENCY RESPONSIBLE FOR ITS UNUSUAL PATTERN OF INHERITANCE

1970 • 113 citations

Oxidative Phosphorylation Diseases and Mitochondrial DNA Mutations: Diagnosis and Treatment

1994 • 112 citations

Antioxidants, Redox-Regulated Transcription Factors, and Inflammation

1996 • 109 citations

Reduced neurotoxicity in transgenic mice overexpressing human copper-zinc-superoxide dismutase.

1990 • 103 citations

Structure–activity relationships of some complex I inhibitors

1998 • 100 citations

Monoaminergic neurotransmitter systems in presenile Alzheimer's disease and in senile dementia of Alzheimer type.

1984 • 98 citations

Altered redox state of platelet coenzyme Q 10 in Parkinson's disease

2000 • 91 citations

Molecular cloning of cDNA coding for human PGP 9.5 protein

1987 • 89 citations

Novel mutations of mitochondrial complex I in pathologically proven Parkinson disease

1998 • 88 citations

Redox regulation of AP-1: a link between transcription factor signaling and DNA repair.

1996 • 83 citations

An analysis of the polypeptide composition of bovine heart mitochondrial NADH-ubiquinone oxidoreductase by two-dimensional polyacrylamide-gel electrophoresis

1979 • 80 citations

Apoptosis and Free Radicals

1996 • 79 citations

N-Acetylcysteine elicited increase in complex I activity in synaptic mitochondria from aged mice: implications for treatment of Parkinson's disease

2000 • 75 citations

Familial Parkinson's Disease: Possible Role of Environmental Factors

1987 • 74 citations

Pathological changes in dendrites of substantia nigra neurons in Parkinson's disease: a Golgi study.

1991 • 72 citations

Mechanism of inhibition of mitochondrial respiratory complex I by 6-hydroxydopamine and its prevention by desferrioxamine

1998 • 70 citations

Energy, Life, and ATP

1998 • 66 citations

Role of Zinc-Coordination and of the Glutathione Redox Couple in the Redox Susceptibility of Human Transcription Factor Sp1

1994 • 63 citations

Neuronal changes in the aging mouse: Spinal cord and lower brain stem☆

1977 • 63 citations

The structure of the human gene encoding protein gene product 9.5 (PGP9.5), a neuron-specific ubiquitin C-terminal hydrolase

1990 • 61 citations

Differential expression of the parkin gene in the human brain and peripheral leukocytes

1998 • 53 citations

Serum levels of coenzyme Q10 in patients with Parkinson's disease

2000 • 52 citations

Tandem Duplications and Large‐Scale Deletions of Mitochondrial DNA Are Early Molecular Events of Human Aging Processa

1996 • 48 citations

MPP+-Induced Mitochondrial Dysfunction Is Potentiated by Dopamine

2000 • 39 citations

Mitochondrial dysfunction and oxidative damage in neurodegenerative diseases

1995 • 37 citations

Age, environments, and the number of substantia nigra neurons.

1990 • 37 citations

As We Live And Breathe: Free Radicals and Aging

1994 • 35 citations

Mitochondrial and metabolic toxicity of 1-methyl-4-(2'-methylphenyl)-1,2,3,6-tetrahydropyridine.

1987 • 31 citations

Genetic elevation of monoamine oxidase levels in dopaminergic PC12 cells results in increased free radical damage and sensitivity to MPTP

1996 • 30 citations

Possible Relationship between Conditions Associated with Chronic Hypoxia and Brain Mitochondrial DNA Deletions

1996 • 25 citations

Neuronal Changes in the Substantia Nigra with Aging

1995 • 25 citations

Selegiline protects dopaminergic neurons in culture from toxic factor(s) present in the cerebrospinal fluid of patients with Parkinson's disease

1995 • 23 citations

Aging and the nigro-striatal pathway

1997 • 17 citations

Neuronal changes in the nigrostriatal pathway of 1-methyl-4-phenylpyridine-treated mice.

1992 • 8 citations

Symposium on the Etiology, Pathogenesis, and Prevention of Parkinson's Disease

1988 • 4 citations