Mechanisms of Neurodegenerative Disorders

Gene Dose of Apolipoprotein E Type 4 Allele and the Risk of Alzheimer's Disease in Late Onset Families

1993 • 8,888 citations

β-Secretase Cleavage of Alzheimer's Amyloid Precursor Protein by the Transmembrane Aspartic Protease BACE

1999 • 3,692 citations

Immunization with amyloid-β attenuates Alzheimer-disease-like pathology in the PDAPP mouse

1999 • 3,112 citations

Seeding “one-dimensional crystallization” of amyloid: A pathogenic mechanism in Alzheimer's disease and scrapie?

1993 • 2,146 citations

Hydrogen peroxide mediates amyloid β protein toxicity

1994 • 2,065 citations

RAGE and amyloid-β peptide neurotoxicity in Alzheimer's disease

1996 • 1,955 citations

An Increased Percentage of Long Amyloid β Protein Secreted by Familial Amyloid β Protein Precursor (βApp ₇₁₇ ) Mutants

1994 • 1,463 citations

Accelerated in vitro fibril formation by a mutant α-synuclein linked to early-onset Parkinson disease

1998 • 1,460 citations

Huntingtin-Encoded Polyglutamine Expansions Form Amyloid-like Protein Aggregates In Vitro and In Vivo

1997 • 1,283 citations

Dramatic Aggregation of Alzheimer Aβ by Cu(II) Is Induced by Conditions Representing Physiological Acidosis

1998 • 988 citations

Mutation-Specific Functional Impairments in Distinct Tau Isoforms of Hereditary FTDP-17

1998 • 954 citations

β-sheet breaker peptides inhibit fibrillogenesis in a rat brain model of amyloidosis: Implications for Alzheimer's therapy

1998 • 839 citations

Alpha-2 macroglobulin is genetically associated with Alzheimer disease

1998 • 647 citations

α-Synuclein Shares Physical and Functional Homology with 14-3-3 Proteins

1999 • 550 citations

Oxidative stress induces amyloid-like aggregate formation of NACP/α-synuclein in vitro

1999 • 421 citations

alpha2-Macroglobulin as a beta-amyloid peptide-binding plasma protein.

1997 • 131 citations

Anti‐Inflammatory Drugs in the Fight against Alzheimer's Diseasea

1996 • 123 citations