Phagocytes and oxidative stress

Superoxide Dismutase

1969 • 12,578 citations

Harrison's Principles of Internal Medicine.

1988 • 11,687 citations

Oxygen-Derived Free Radicals in Postischemic Tissue Injury

1985 • 5,488 citations

SUPEROXIDE RADICAL AND SUPEROXIDE DISMUTASES

1995 • 3,305 citations

Biological Defense Mechanisms. THE PRODUCTION BY LEUKOCYTES OF SUPEROXIDE, A POTENTIAL BACTERICIDAL AGENT

1973 • 2,955 citations

Binding site on macrophages that mediates uptake and degradation of acetylated low density lipoprotein, producing massive cholesterol deposition

1979 • 2,458 citations

NADPH Oxidase: An Update

1999 • 2,134 citations

Low Density Lipoprotein Oxidation and Its Pathobiological Significance

1997 • 1,642 citations

The chemistry of peroxynitrite: a product from the reaction of nitric oxide with superoxide

1995 • 1,512 citations

Inside the Neutrophil Phagosome: Oxidants, Myeloperoxidase, and Bacterial Killing

1998 • 1,443 citations

Inside the Neutrophil Phagosome: Oxidants, Myeloperoxidase, and Bacterial Killing

1998 • 1,249 citations

The Biochemical Basis of Phagocytosis

1959 • 1,240 citations

Canine myocardial reperfusion injury. Its reduction by the combined administration of superoxide dismutase and catalase.

1984 • 915 citations

Nitric oxide synthase: Aspects concerning structure and catalysis

1994 • 865 citations

Evidence for nitric oxide‐mediated oxidative damage in chronic inflammation Nitrotyrosine in serum and synovial fluid from rheumatoid patients

1994 • 718 citations

Leukocyte myeloperoxidase deficiency and disseminated candidiasis: the role of myeloperoxidase in resistance to Candida infection

1969 • 697 citations

Regulation of Phagocyte Oxygen Radical Production by the GTP-Binding Protein Rac 2

1991 • 669 citations

Biochemical Aspects of Phagocytosis

1961 • 657 citations

Peroxynitrite Reaction with Carbon Dioxide/Bicarbonate: Kinetics and Influence on Peroxynitrite-Mediated Oxidations

1996 • 583 citations

Intravascular activation of complement and acute lung injury. Dependency on neutrophils and toxic oxygen metabolites.

1982 • 554 citations

Monocytes and Neutrophils Oxidize Low Density Lipoprotein Making It Cytotoxic

1985 • 536 citations

Elastases and emphysema. Current assessment of the protease-antiprotease hypothesis.

1985 • 515 citations

Progressive impairment of regional myocardial perfusion after initial restoration of postischemic blood flow.

1989 • 468 citations

Direct evidence that oxygen-derived free radicals contribute to postischemic myocardial dysfunction in the intact dog.

1989 • 467 citations

Purified cytochrome b from human granulocyte plasma membrane is comprised of two polypeptides with relative molecular weights of 91,000 and 22,000.

1987 • 459 citations

Purification of the inducible murine macrophage nitric oxide synthase. Identification as a flavoprotein.

1991 • 458 citations

Lung neutrophils in the adult respiratory distress syndrome. Clinical and pathophysiologic significance

1987 • 452 citations

Phagocytes as Carcinogens: Malignant Transformation Produced by Human Neutrophils

1985 • 443 citations

Formation of Nitrating and Chlorinating Species by Reaction of Nitrite with Hypochlorous Acid

1996 • 440 citations

Role of Neutrophils in Myocardial Ischemia and Reperfusion

1995 • 431 citations

Human mononuclear phagocyte inducible nitric oxide synthase (iNOS): analysis of iNOS mRNA, iNOS protein, biopterin, and nitric oxide production by blood monocytes and peritoneal macrophages

1995 • 420 citations

Macrophage Microbicidal Mechanisms In Vivo: Reactive Nitrogen versus Oxygen Intermediates in the Killing of Intracellular Visceral Leishmania donovani

1999 • 417 citations

Chlorination of endogenous amines by isolated neutrophils. Ammonia-dependent bactericidal, cytotoxic, and cytolytic activities of the chloramines.

1984 • 397 citations

THE EXTRA RESPIRATION OF PHAGOCYTOSIS

1932 • 394 citations

Cloning of a 67-kD Neutrophil Oxidase Factor with Similarity to a Noncatalytic Region of p60 ^c-src

1990 • 393 citations

Neutrophil nicotinamide adenine dinucleotide phosphate oxidase assembly. Translocation of p47-phox and p67-phox requires interaction between p47-phox and cytochrome b558.

1991 • 379 citations

Mechanisms of myocardial reperfusion injury

1999 • 337 citations

Reactive oxygen species in acute lung injury

1998 • 336 citations

Reperfusion injury: Experimental evidence and clinical implications

1999 • 333 citations

Cloning of the cDNA and functional expression of the 47-kilodalton cytosolic component of human neutrophil respiratory burst oxidase.

1989 • 310 citations

Molecular basis of chronic granulomatous disease [see comments]

1991 • 290 citations

Reaction of Myeloperoxidase Compound I with Chloride, Bromide, Iodide, and Thiocyanate

1998 • 283 citations

The Biochemical Basis of Phagocytosis

1960 • 267 citations

Intracellular singlet oxygen generation by phagocytosing neutrophils in response to particles coated with a chemical trap.

1992 • 259 citations

Antioxidant status in patients with acute respiratory distress syndrome

1999 • 257 citations

Iron and free radical reactions: two aspects of antioxidant protection

1986 • 249 citations

Activated neutrophils induce prolonged DNA damage in neighboring cells

1988 • 243 citations

Regulation of Cytosolic Guanylyl Cyclase by Nitric Oxide: The NO-Cyclic GMP Signal Transduction System

1994 • 232 citations

Myeloperoxidase-catalyzed inactivation of alpha 1-protease inhibitor by human neutrophils.

1981 • 222 citations

Minimally modified low density lipoprotein is biologically active in vivo in mice.

1991 • 212 citations

Molecular basis of chronic granulomatous disease [see comments]

1991 • 210 citations

Failure of superoxide dismutase to limit size of myocardial infarction after 40 minutes of ischemia and 4 days of reperfusion in dogs.

1987 • 199 citations

Oxygen radicals in the adult respiratory distress syndrome, in myocardial ischemia and reperfusion injury, and in cerebral vascular damage

1985 • 189 citations

Failure of superoxide dismutase and catalase to alter size of infarction in conscious dogs after 3 hours of occlusion followed by reperfusion.

1986 • 189 citations

Clinical manifestation of myeloperoxidase deficiency

1998 • 182 citations

PREFACE

1999 • 179 citations

Oxidants spontaneously released by alveolar macrophages of cigarette smokers can inactivate the active site of alpha 1-antitrypsin, rendering it ineffective as an inhibitor of neutrophil elastase.

1987 • 162 citations

Neutrophil-Dependent, Oxygen-Radical Mediated Lung Injury Associated with Acute Pancreatitis

1989 • 158 citations

Cardioprotection by Cu, Zn-superoxide dismutase is lost at high doses in the reoxygenated heart

1990 • 157 citations

Identification of a highly mobilizable subset of human neutrophil intracellular vesicles that contains tetranectin and latent alkaline phosphatase.

1990 • 157 citations

Antioxidant role and subcellular location of hypotaurine and taurine in human neutrophils

1991 • 155 citations

Structure of the Green Heme in Myeloperoxidase

1995 • 155 citations

Eosinophils Preferentially Use Bromide to Generate Halogenating Agents

1989 • 148 citations

Increased carbonyl content of proteins in synovial fluid from patients with rheumatoid arthritis.

1989 • 143 citations

Damage to the bases in DNA induced by stimulated human neutrophils.

1989 • 139 citations

EUK-8, a synthetic superoxide dismutase and catalase mimetic, ameliorates acute lung injury in endotoxemic swine.

1995 • 132 citations

Myeloperoxidase-catalyzed incorporation of amines into proteins: role of hypochlorous acid and dichloramines

1982 • 132 citations

Identification of intracellular sites of superoxide production in stimulated neutrophils

1998 • 131 citations

Thiocyanate is the major substrate for eosinophil peroxidase in physiologic fluids. Implications for cytotoxicity.

1991 • 129 citations

Antioxidant enzyme expression in rat lungs during hyperoxia

1996 • 128 citations

Oxidants, antioxidants and the pathogenesis of emphysema.

1985 • 125 citations

Pretreatment with inhaled nitric oxide inhibits neutrophil migration and oxidative activity resulting in attenuated sepsis-induced acute lung injury

1997 • 123 citations

Oxidant-dependent metabolic activation of polycyclic aromatic hydrocarbons by phorbol ester-stimulated human polymorphonuclear leukocytes: possible link between inflammation and cancer.

1985 • 119 citations

Reexamination of the mechanism of hydroxyl radical adducts formed from the reaction between familial amyotrophic lateral sclerosis-associated Cu,Zn superoxide dismutase mutants and H ₂ O ₂

1998 • 118 citations

Biochemical requirements for singlet oxygen production by purified human myeloperoxidase.

1984 • 113 citations

Oxidation of neutrophil glutathione and protein thiols by myeloperoxidase-derived hypochlorous acid

1997 • 104 citations

Clinical Features and Current Management of Chronic Granulomatous Disease

1988 • 99 citations

Hydrogen peroxide formation and DNA base modification by tumor promoter-activated polymorphonuclear leukocytes

1987 • 97 citations

Leukemia inhibitory factor and tumor necrosis factor induce manganese superoxide dismutase and protect rabbit hearts from reperfusion injury

1995 • 90 citations

Effect of clinical factors on length of stay after coronary artery bypass surgery: Results of the Cooperative Cardiovascular Project

1999 • 81 citations

The role of oxidative processes in emphysema.

1983 • 81 citations

Superoxide-dependent hydroxylation by myeloperoxidase.

1994 • 78 citations

Interleukin-1-induced lung neutrophil accumulation and oxygen metabolite-mediated lung leak in rats

1994 • 71 citations

Intraarticular ferritin‐bound iron in rheumatoid arthritis: A factor that increases oxygen free radical‐induced tissue destruction

1986 • 68 citations

Protective Effects of Human Recombinant Mnsod in Adjuvant Arthritis and Bleomycin-Induced Lung Fibrosis

1991 • 64 citations

Preservation of complement-induced lung injury in mice with deficiency of NADPH oxidase.

1996 • 62 citations

Taurine scavenges oxidized chlorine in biological systems.

1985 • 62 citations

Role of selectins in myocardial ischemia-reperfusion injury

1995 • 51 citations

The effects of calcium channel antagonist treatment and oxygen radical scavenging on infarct size and the no-reflow phenomenon in reperfused hearts

1993 • 51 citations

Altered function of synovial fluid granulocytes in patients with acute inflammatory arthritis

1986 • 45 citations

Neutrophil-generated free radicals: possible mechanisms of injury in adult respiratory distress syndrome.

1994 • 45 citations

Myeloperoxidase (MPO) gene mutation in hereditary MPO deficiency

1994 • 43 citations

Extracellular Elastolytic Activity in Human Lung Lavage: A Comparative study between Smokers and Non-Smokers

1985 • 40 citations

Role of the β2-integrins and immunoglobulin superfamily members in myocardial ischemia-reperfusion

1999 • 38 citations

Recombinant-human Superoxide Dismutase Attenuates Endotoxin-induced Lung Injury in Awake Sheep

1992 • 38 citations

Iron Enhancement of Ascorbate Toxicity

1988 • 37 citations

Complement and neutrophil-mediated injury of perfused rat lungs.

1986 • 37 citations

The suppressive effect of gelatin-conjugated superoxide dismutase on disease development and severity of collagen-induced arthritis in mice

1993 • 35 citations

Enhanced Oxidative Response of Polymorphonuclear Leukocytes from Synovial Fluids of Patients with Rheumatoid Arthritis

1988 • 34 citations

Comparison of Smoker and Nonsmoker Lavage Fluid for the Rate of Association with Neutrophil Elastase

1989 • 29 citations

Activation of neutrophils by soluble and insoluble immunoglobulin aggregates from synovial fluid of patients with rheumatoid arthritis.

1993 • 29 citations

Oxidative Modification of Low Density Lipoproteins by Human Polymorphonuclear Leukocytes

1993 • 21 citations

Oxidative modification of low-density lipoprotein by human polymorphonuclear leucocytes to a form recognised by the lipoprotein scavenger pathway

1994 • 20 citations

Capability of human blood cells to form the DNA adduct, C8-(N-aminofluorenyl)-deoxyguanosine-3'-5'-diphosphate from 2-aminofluorene

1990 • 16 citations

Tumorigenic Conversion of a Rat Urothelial Cell Line by Human Polymorphonuclear Leukocytes Activated by Lipopolysaccharide

1999 • 16 citations

Human macrophage metabolism of low density lipoprotein oxidized by stimulated neutrophils and ferritin

1994 • 15 citations

Interleukin-1 induced lung neutrophil accumulation and oxygen metabolite mediated lung leak in rats

1993 • 14 citations

Superoxide production from cytokine-treated adherent rheumatoid neutrophils.

1994 • 9 citations

Measurement of Oxygen Free Radicals in a Rabbit Shock Lung Model

1996 • 8 citations

Superoxide anion production by monocytes and synovial fluid macrophages of patients with chronic inflammatory joint disorders.

1987 • 4 citations

Complement and experimental respiratory failure

1986 • 4 citations

Rheumatoid factor modulation of neutrophil superoxide generation enhancing activity of preformed immune complexes

1990 • 4 citations

Deleted Work

1955 • 0 citations