Free Radical‐Mediated Molecular Damage

Melatonin : a potent, endogenous hydroxyl radical scavenger

1993 • 1,673 citations

Mitochondria and Neuronal Survival

2000 • 1,206 citations

Oxidative damage in the central nervous system: protection by melatonin

1998 • 852 citations

Mitochondria as regulators of apoptosis: doubt no more

1998 • 838 citations

Oxidative processes and antioxidative defense mechanisms in the aging brain ¹

1995 • 810 citations

Biochemical Reactivity of Melatonin with Reactive Oxygen and Nitrogen Species: A Review of the Evidence

2001 • 692 citations

Significance of Melatonin in Antioxidative Defense System: Reactions and Products

2000 • 558 citations

Pharmacological actions of melatonin in oxygen radical pathophysiology

1997 • 496 citations

Neurohormone melatonin prevents cell damage: effect on gene expression for antioxidant enzymes

1996 • 471 citations

Melatonin directly scavenges hydrogen peroxide: a potentially new metabolic pathway of melatonin biotransformation

2000 • 467 citations

The significance of the metabolism of the neurohormone melatonin: Antioxidative protection and formation of bioactive substances

1993 • 434 citations

Melatonin, mitochondria, and cellular bioenergetics

2001 • 397 citations

Evidence for melatonin synthesis in mouse and human bone marrow cells

2000 • 377 citations

Distribution of melatonin in mammalian tissues: The relative importance of nuclear versus cytosolic localization

1993 • 356 citations

Melatonin—A Highly Potent Endogenous Radical Scavenger and Electron Donor: New Aspects of the Oxidation Chemistry of this Indole Accessed in vitroa

1994 • 356 citations

Potent Neuroprotective Properties against the Alzheimer β-Amyloid by an Endogenous Melatonin-related Indole Structure, Indole-3-propionic Acid

1999 • 351 citations

Identification of highly elevated levels of melatonin in bone marrow: its origin and significance

1999 • 347 citations

Evaluation of the antioxidant activity of melatonin in vitro

1996 • 341 citations

Melatonin but not vitamins C and E maintains glutathione homeostasis in t‐butyl hydroperoxide‐induced mitochondrial oxidative stress

2000 • 340 citations

Nuclear localization of melatonin in different mammalian tissues: Immunocytochemical and radioimmunoassay evidence

1993 • 329 citations

Melatonin induces γ-glutamylcysteine synthetase mediated by activator protein-1 in human vascular endothelial cells

1999 • 329 citations

A Novel Melatonin Metabolite, Cyclic 3-Hydroxymelatonin: A Biomarker ofin VivoHydroxyl Radical Generation

1998 • 322 citations

Melatonin is a scavenger of peroxynitrite

1997 • 320 citations

Melatonin: Lowering the High Price of Free Radicals

2000 • 309 citations

Melatonin prevents changes in microsomal membrane fluidity during induced lipid peroxidation

1997 • 307 citations

The contribution of extrapineal sites of melatonin synthesis to circulating melatonin levels in higher vertebrates

1993 • 302 citations

Inhibition of cerebellar nitric oxide synthase and cyclic GMP production by melatonin via complex formation with calmodulin

1997 • 282 citations

Melatonin‐induced increased activity of the respiratory chain complexes I and IV can prevent mitochondrial damage induced by ruthenium red in vivo

2000 • 282 citations

Reaction of Melatonin and Related Indoles With Hydroxyl Radicals: EPR and Spin Trapping Investigations

1997 • 281 citations

Randomized, double‐blind clinical trial, controlled with placebo, of the toxicology of chronic melatonin treatment

2000 • 278 citations

Effect of tryptophan administration on circulating melatonin levels in chicks and rats: Evidence for stimulation of melatonin synthesis and release in the gastrointestinal tract

1992 • 270 citations

Mitochondrial physiology and pathology; concepts of programmed death of organelles, cells and organisms

1999 • 266 citations

Melatonin inhibits expression of the inducible isoform of nitric oxide synthase in murine macrophages: role of inhibition of NFκB activation

1998 • 261 citations

Pharmacology and Physiology of Melatonin in the Reduction of Oxidative Stress in vivo

2000 • 256 citations

An assessment of the antioxidant and the antiamyloidogenic properties of melatonin: implications for Alzheimer's disease

2000 • 246 citations

High physiological levels of melatonin in the bile of mammals

1999 • 237 citations

Gene expression of the key enzymes of melatonin synthesis in extrapineal tissues of the rat

2001 • 236 citations

Melatonin protects neurons from singlet oxygen‐induced apoptosis

1995 • 223 citations

High Melatonin Concentrations in Third Ventricular Cerebrospinal Fluid Are Not due to Galen Vein Blood Recirculating through the Choroid Plexus1

1999 • 218 citations

Rhythms of glutathione peroxidase and glutathione reductase in brain of chick and their inhibition by light

1998 • 210 citations

Scavenging of reactive oxygen species by melatonin

1998 • 207 citations

Melatonin stimulates the activity of the detoxifying enzyme glutathione peroxidase in several tissues of chicks

1995 • 196 citations

Melatonin and its precursors scavenge nitric oxide

1999 • 185 citations

The orphan receptor family RZR/ROR, melatonin and 5‐lipoxygenase: An unexpected relationship

1995 • 180 citations

The Complex Role of Nitric Oxide in the Pathophysiology of Focal Cerebral Ischemia

1994 • 176 citations

Monozygotic twins with Alzheimer's disease treated with melatonin: Case report

1998 • 169 citations

Nitrosation of melatonin by nitric oxide and peroxynitrite

2000 • 169 citations

Antioxidant properties of melatonin: a pulse radiolysis study

1999 • 166 citations

Melatonin: Daily Cycle in Plasma and Cerebrospinal Fluid of Calves

1977 • 157 citations

Clinical trials of controlled‐release melatonin in children with sleep–wake cycle disorders

2000 • 155 citations

Extrapineal melatonin: location and role within diffuse neuroendocrine system.

1999 • 153 citations

Minireview: Cell protective role of melatonin in the brain

1995 • 147 citations

Glial cell survival is enhanced during melatonin-induced neuroprotection against cerebral ischemia

2000 • 142 citations

Localization of Melatonin in the Digestive Tract of the Rat

1980 • 135 citations

Melatonin and structurally-related, endogenous indoles act as potent electron donors and radical scavengers in vitro

1996 • 134 citations

Protective effects of melatonin in ischemic brain injury

2000 • 132 citations

On the antioxidant activity of melatonin

1999 • 122 citations

Potent Protective Effect of Melatonin on Chromium(VI)-Induced DNA Single-Strand Breaks, Cytotoxicity, and Lipid Peroxidation in Primary Cultures of Rat Hepatocytes

1997 • 118 citations

Melatonin as a Pharmacological Agent against Neuronal Loss in Experimental Models of Huntington's Disease, Alzheimer's Disease and Parkinsonism

1999 • 116 citations

Melatonin is an efficient antioxidant

1995 • 113 citations

Increased levels of oxidatively damaged DNA induced by chromium(III) and H₂O₂: protection by melatonin and related molecules

2000 • 113 citations

Interactions of melatonin with membrane models: Portioning of melatonin in AOT and lecithin reversed micelles

1999 • 112 citations

Reaction of Peroxynitrite with Melatonin: A Mechanistic Study

1999 • 112 citations

Reaction of Melatonin With Lipoperoxyl Radicals in Phospholipid Bilayers

1997 • 111 citations

Melatonin scavenges hydroxyl radical and protects isolated rat hearts from ischemic reperfusion injury

2000 • 104 citations

Endogenous rhythms of melatonin, total antioxidant status and superoxide dismutase activity in several tissues of chick and their inhibition by light

2001 • 103 citations

Melatonin protects against stress‐induced gastric lesions by scavenging the hydroxyl radical

2000 • 102 citations

Characterization of the antioxidant effects of melatonin and related indoleamines in vitro

1996 • 102 citations

The Reaction of Melatonin with Peroxynitrite: Formation of Melatonin Radical Cation and Absence of Stable Nitrated Products

1998 • 101 citations

Role of pinoline and melatonin in stabilizing hepatic microsomal membranes against oxidative stress.

1999 • 98 citations

Beneficial effects of melatonin in a rat model of splanchnic artery occlusion and reperfusion

2000 • 96 citations

Scavenging effect of melatonin on hydroxyl radicals generated by alloxan

2000 • 95 citations

Preservation of the antioxidant status in chemically-induced diabetes mellitus by melatonin

2000 • 91 citations

Comparative effects of melatonin, <scp>l</scp>‐deprenyl, Trolox and ascorbate in the suppression of hydroxyl radical formation during dopamine autoxidation in vitro

2000 • 88 citations

Melatonin affects the metabolism of the β‐amyloid precursor protein in different cell types

1999 • 76 citations

Comparison of the antioxidant activity of melatonin and pinoline in vitro

1998 • 75 citations

The neurotoxicity of iron and nitric oxide. Relevance to the etiology of Parkinson's disease.

1993 • 74 citations

The protective role of endogenous melatonin in carrageenan‐induced pleurisy in the rat

1999 • 66 citations

Melatonin as a pharmacological agent against oxidative damage to lipids and DNA.

1998 • 63 citations

Antioxidative effects of melatonin in Drosophila melanogaster: Antagonization of damage induced by the inhibition of catalase

1999 • 62 citations

Oxidative Toxicity in Models of Neurodegeneration: Responses to Melatonin

1998 • 56 citations

Protective effect of melatonin against oxidative stress induced by ligature of extra‐hepatic biliary duct in rats: comparison with the effect of S‐adenosyl‐<scp>l</scp>‐methionine

2000 • 54 citations

ROLE OF MELATONIN IN REDUCTION OF LIPID PEROXIDATION AND PEROXYNITRITE FORMATION IN NON-SEPTIC SHOCK INDUCED BY ZYMOSAN

1999 • 51 citations

Presence of a Distinct 24‐Hour Melatonin Rhythm in the Ventricular Cerebrospinal Fluid of the Goat

1989 • 43 citations

Melatonin reduces paraquat-induced genotoxicity in mice

1998 • 39 citations

Melatonin Prevents Pigment Gallstone Formation Induced by Bile Duct Ligation in Guinea Pigs

2000 • 37 citations

Protective effect of melatonin against α‐naphthylisothiocyanate‐induced liver injury in rats

2000 • 33 citations

Antioxidants suitable for use with chemiluminescence to identify oxyradical species

1999 • 32 citations

Reactions of melatonin with radicals in deoxygenated aqueous solution

1998 • 30 citations

2-Nitropropane-induced lipid peroxidation: antitoxic effects of melatonin

1998 • 23 citations

Melatonin prevents oxidative damage to protein and lipid induced by ascorbate-Fe(3+)-EDTA: Comparison with glutathione and alpha-tocopherol.

2000 • 21 citations