Parkinson's Disease

Mutation in the α-Synuclein Gene Identified in Families with Parkinson's Disease

1997 • 7,814 citations

Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

1998 • 5,063 citations

Consensus guidelines for the clinical and pathologic diagnosis of dementia with Lewy bodies (DLB)

1996 • 3,940 citations

The relevance of the Lewy body to the pathogenesis of idiopathic Parkinson's disease.

1988 • 3,339 citations

AGEING AND PARKINSON'S DISEASE: SUBSTANTIA NIGRA REGIONAL SELECTIVITY

1991 • 3,275 citations

Uneven Pattern of Dopamine Loss in the Striatum of Patients with Idiopathic Parkinson's Disease

1988 • 1,881 citations

Aging, energy, and oxidative stress in neurodegenerative diseases

1995 • 1,453 citations

Oxidative stress and the pathogenesis of Parkinson's disease

1996 • 967 citations

Functional recovery in parkinsonian monkeys treated with GDNF

1996 • 955 citations

A Clinicopathologic Study of 100 Cases of Parkinson's Disease

1993 • 950 citations

Prevalence of parkinsonism and Parkinson's disease in Europe: the EUROPARKINSON Collaborative Study. European Community Concerted Action on the Epidemiology of Parkinson's disease.

1997 • 835 citations

Clinical features and natural history of multiple system atrophy

1994 • 766 citations

Mesencephalic dopaminergic neurons protected by GDNF from axotomy-induced degeneration in the adult brain

1995 • 659 citations

Prevalence of Parkinsonian Signs and Associated Mortality in a Community Population of Older People

1996 • 641 citations

Origin and functional consequences of the complex I defect in Parkinson's disease

1996 • 629 citations

Accuracy of Clinical Diagnosis in Parkinsonism — A Prospective Study

1991 • 594 citations

Rate of cell death in parkinsonism indicates active neuropathological process

1988 • 545 citations

Anatomy, pigmentation, ventral and dorsal subpopulations of the substantia nigra, and differential cell death in Parkinson's disease.

1991 • 543 citations

A susceptibility locus for Parkinson's disease maps to chromosome 2p13

1998 • 461 citations

Low platelet mitochondrial complex I and complex II/III activity in early untreated parkinson's disease

1995 • 430 citations

Parkinson's disease and exposure to agricultural work and pesticide chemicals

1992 • 429 citations

The Occurrence of Depression in Parkinson's Disease

1996 • 414 citations

Pathology and Biology of the Lewy Body

1993 • 394 citations

Cigarette smoking and protection from Parkinson's disease

1995 • 372 citations

[sup 123 I] beta-CIT/SPECT imaging demonstrates bilateral loss of dopamine transporters in hemi-Parkinson's disease

1996 • 363 citations

An [¹⁸F]dopa–PET and clinical study of the rate of progression in Parkinson’s disease

1996 • 359 citations

Parkinson's disease in 65 pairs of twins and in a set of quadruplets

1983 • 353 citations

Platelet mitochondria function in Parkinson's disease

1992 • 350 citations

BRAIN, SKELETAL MUSCLE AND PLATELET HOMOGENATE MITOCHONDRIAL FUNCTION IN PARKINSON'S DISEASE

1992 • 341 citations

Worldwide Occurrence of Parkinson's Disease: An Updated Review

1993 • 339 citations

Frequency of Dementia in Parkinson Disease

1996 • 292 citations

Amygdala pathology in Parkinson's disease

1994 • 281 citations

Parkinson's disease

1993 • 281 citations

Dietary Antioxidants and Parkinson Disease

1997 • 235 citations

Long‐term changes of striatal dopamine D₂ Receptors in patients with Parkinson's disease: A study with positron emission tomography and [¹¹C]Raclopride

1997 • 204 citations

The relationship between dementia and direct involvement of the hippocampus and amygdala in Parkinson's disease

1997 • 195 citations

Ropinirole in the treatment of early Parkinson's disease: A 6‐month interim report of a 5‐year levodopa‐controlled study

1998 • 181 citations

Epidemiologic observations on Parkinson's disease

1996 • 181 citations

Alterations in opioid receptor binding in Parkinson's disease patients with levodopa‐induced dyskinesias

1997 • 179 citations

Mortality From Parkinson Disease

1997 • 168 citations

An estimate of the incidence of dementia in idiopathic Parkinson's disease

1990 • 167 citations

Early differential diagnosis of Parkinson's disease with ¹⁸ F‐fluorodeoxyglucose and positron emission tomography

1995 • 161 citations

Prevalence of Movement Disorders in Elderly Community Residents

1994 • 156 citations

Differentiation of multiple system atrophy from idiopathic Parkinson's disease using proton magnetic resonance spectroscopy

1995 • 155 citations

Dopamine transporter messenger RNA in Parkinson's disease and control substantia nigra neurons

1994 • 155 citations

Measurement of the dopaminergic degeneration in Parkinson’s disease with [123I]β-CIT and SPECT

1997 • 155 citations

Positron emission tomographic evidence for progression of human MPTP‐induced dopaminergic lesions

1994 • 153 citations

On the question of apoptosis in the parkinsonian substantia nigra

1997 • 145 citations

Positron emission tomography in manganese intoxication

1989 • 143 citations

Proton magnetic resonance spectroscopic imaging in progressive supranuclear palsy, Parkinson's disease and corticobasal degeneration

1997 • 142 citations

Association of slow acetylator genotype for N-acetyltransferase 2 with familial Parkinson's disease

1997 • 120 citations

Paralysis agitans and levodopa in “Ayurveda”: Ancient Indian medical treatise

1990 • 119 citations

Ubiquitin-positive degenerating neurites in the brainstem in Parkinson's disease

1995 • 99 citations

Maternal inheritance in Parkinson's disease

1997 • 95 citations

P450 enzymes and Parkinson's disease: The story so far

1998 • 93 citations

The awakening of α-synuclein

1997 • 92 citations

Smoking and Parkinson's disease: a case-control study in Germany

1997 • 91 citations

Is idiopathic parkinsonism the consequence of an event or a process?

1994 • 88 citations

Projected Neurodegenerative Disease Mortality in the United States, 1990–2040

1993 • 81 citations

Striatal opioid receptor binding in Parkinson's disease, striatonigral degeneration and Steele-Richardson-Olszewski syndrome

1995 • 76 citations

Changes in putamen N-acetylaspartate and choline ratios in untreated and levodopa-treated Parkinson's disease: A proton magnetic resonance spectroscopy study

1997 • 76 citations

Does a long preclinical period occur in Parkinson's disease?

1991 • 72 citations

Does a long preclinical period occur in Parkinson's disease?

1991 • 70 citations

How far are we in understanding the cause of Parkinson's disease?

1996 • 66 citations

Smoking and Parkinson's disease

1997 • 60 citations

Magnetic resonance spectroscopic study of parkinsonism related to boxing.

1995 • 59 citations

Striatonigral Degeneration: Iron Deposition in Putamen Correlates with the Slit-like Void Signal of Magnetic Resonance Imaging

1994 • 59 citations

Phosphorylation of Neuronal Cytoskeletal Proteins in Alzheimer's Disease and Lewy Body Dementias^a

1994 • 53 citations

Comparison of striatal ¹⁸ F‐dopa uptake in adult‐onset dystonia‐parkinsonism, Parkinson's disease, and dopa‐responsive dystonia

1993 • 51 citations

Hemiparkinsonism‐hemiatrophy syndrome

1990 • 50 citations

Genetic aspects of Parkinson's disease

1998 • 48 citations

Presymptomatic Hypertension Is a Major Feature in the Diagnosis of Progressive Supranuclear Palsy

1997 • 46 citations

Biology of Glial Cell Line-derived Neurotrophic Factor (GDNF): Implications for the Use of GDNF to Treat Parkinson's Disease

1996 • 43 citations

Nuclear and mitochondrial genetics in Parkinson's disease.

1995 • 31 citations

A Gene for Parkinson Disease

1997 • 23 citations

Contributions of Positron Emission Tomography to elucidating the pathogenesis of Idiopathic Parkinsonism and Dopa Responsive Dystonia

1997 • 20 citations