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Recent progress on regulation of the mitochondrial permeability transition pore; a cyclosporin-sensitive pore in the inner mitochondrial membrane

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The permeability transition pore. Control points of a cyclosporin A-sensitive mitochondrial channel involved in cell death

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Complexes between kinases, mitochondrial porin and adenylate translocator in rat brain resemble the permeability transition pore

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The parkinsonian neurotoxin MPP+ opens the mitochondrial permeability transition pore and releases cytochrome c in isolated mitochondria via an oxidative mechanism

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Cyclosporin and carnitine prevent the anoxic death of cultured hepatocytes by inhibiting the mitochondrial permeability transition

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Melatonin in Relation to Cellular Antioxidative Defense Mechanisms

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Deletion mutants are functionally dominant over wild-type mitochondrial genomes in skeletal muscle fiber segments in mitochondrial disease

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Opening of the mitochondrial permeability transition pore by uncoupling or inorganic phosphate in the presence of Ca²⁺ is dependent on mitochondrial‐generated reactive oxygen species

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Simultaneous Overexpression of Copper- and Zinc-containing Superoxide Dismutase and Catalase Retards Age-related Oxidative Damage and Increases Metabolic Potential in Drosophila melanogaster

1995 • 239 citations

Accumulation of deletions in human mitochondrial DNA during normal aging: analysis by quantitative PCR

1992 • 237 citations

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Intracranial microdialysis of salicylic acid to detect hydroxyl radical generation through dopamine autooxidation in the caudate nucleus: Effects of MPP+

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The Mitochondrial Permeability Transition Pore is Modulated by Oxidative Agents Through Both Pyridine Nucleotides and Glutathione at Two Separate Sites

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Mitochondrial Permeability Transition in the Central Nervous System: Induction by Calcium Cycling‐Dependent and ‐Independent Pathways

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Respiratory chain abnormalities in skeletal muscle from patients with Parkinson's disease

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Inhibition of the mitochondrial permeability transition by cyclosporin A during long time frame experiments: relationship between pore opening and the activity of mitochondrial phospholipases

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Bovine Erythrocyte Superoxide Dismutase

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An Emerging Hypothesis: Synergistic Induction of Aging by Free Radicals and Maillard Reactions

1992 • 220 citations

Ancient mtDNA sequences in the human nuclear genome: A potential source of errors in identifying pathogenic mutations

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Apoptosis and DNA degradation induced by 1-methyl-4-phenylpyridinium in neurons

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The Peptide Mastoparan Is a Potent Facilitator of the Mitochondrial Permeability Transition

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Reduced platelet cytochrome c oxidase activity in Alzheimer's disease

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Evidence of an oxidative challenge in the Alzheimer's brain

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Superoxide dismutase activity in Alzheimer's disease: possible mechanism for paired helical filament formation

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Cytopathology of amyotrophic lateral sclerosis.

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Effect of age-related lipid peroxidation on membrane fluidity and phospholipase A2: Modulation by dietary restriction

1992 • 190 citations

Pramipexole Reduces Reactive Oxygen Species Production In Vivo and In Vitro and Inhibits the Mitochondrial Permeability Transition Produced by the Parkinsonian Neurotoxin Methylpyridinium Ion

1998 • 188 citations

Quantitative determination of deleted mitochondrial DNA relative to normal DNA in parkinsonian striatum by a kinetic PCR analysis

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Establishment of a Cell-Free System of Neuronal Apoptosis: Comparison of Premitochondrial, Mitochondrial, and Postmitochondrial Phases

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Ca(2+)-induced mitochondrial membrane permeabilization: role of coenzyme Q redox state

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Neuritic plaque evolution in Alzheimer's disease is accompanied by transition of activated microglia from primed to enlarged to phagocytic forms

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Mitochondria in Sporadic Amyotrophic Lateral Sclerosis

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Oxidative Glycation and Free Radical Production: A Causal Mechanism of Diabetic Complications

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Activation of NF-kappa B and elevation of MnSOD gene expression by thiol reducing agents in lung adenocarcinoma (A549) cells

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The reversible Ca2+-induced permeabilization of rat liver mitochondria

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Protective roles of cytokines against radiation: Induction of mitochondrial MnSOD

1995 • 172 citations

Free Radicals in the Genesis of Alzheimer's Diseasea

1993 • 171 citations

Mitochondrial respiratory failure in skeletal muscle from patients with Parkinson's disease and multiple system atrophy

1994 • 170 citations

Decreased Catalase Activity but Unchanged Superoxide Dismutase Activity in Brains of Patients with Dementia of Alzheimer Type

1995 • 168 citations

Correspondence

1996 • 164 citations

Regional Distributions of Thiobarbituric Acid‐Reactive Products, Activities of Enzymes Regulating the Metabolism of Oxygen Free Radicals, and Some of the Related Enzymes in Adult and Aged Rat Brains

1986 • 163 citations

Involvement of a Caspase‐3‐Like Cysteine Protease in 1‐Methyl‐4‐Phenylpyridinium‐Mediated Apoptosis of Cultured Cerebellar Granule Neurons

1997 • 161 citations

Protection of DNA damage by dietary restriction

1992 • 161 citations

Inhibition of dopamine neuron firing by pramipexole, a dopamine D3 receptor-preferring agonist: comparison to other dopamine receptor agonists

1996 • 160 citations

NGF restores decrease in catalase activity and increases superoxide dismutase and glutathione peroxidase activity in the brain of aged rats

1992 • 158 citations

Neuroprotective strategies for treatment of lesions produced by mitochondrial toxins: Implications for neurodegenerative diseases

1996 • 157 citations

Amyloidogenicity of rodent and human βA4 sequences

1993 • 155 citations

Altered Calcium Homeostasis in Cells Transformed by Mitochondria from Individuals with Parkinson's Disease

1997 • 151 citations

Localization of superoxide dismutases in Alzheimer's disease and Down's syndrome neocortex and hippocampus.

1995 • 150 citations

Glutathione depletion potentiates MPTP and MPP+ toxicity in nigral dopaminergic neurones

1996 • 148 citations

Point mutations of mitochondrial genome in Parkinson's disease

1995 • 147 citations

On the effects of paraquat on isolated mitochondria. Evidence that paraquat causes opening of the cyclosporin A-sensitive permeability transition pore synergistically with nitric oxide

1995 • 146 citations

The permeability transition in heart mitochondria is regulated synergistically by ADP and cyclosporin A.

1992 • 146 citations

Therapeutic potential of neurotrophic factors for neurological disorders

1996 • 143 citations

Astrocytes, brain aging, and neurodegeneration

1996 • 139 citations

Autosomal dominant progressive external ophthalmoplegia with multiple deletions of mtDNA

1997 • 137 citations

Apoptosis is induced by 1-methyl-4-phenylpyridinium ion (MPP+) in ventral mesencephalic-striatal co-culture in rat

1994 • 137 citations

Molecular Structure of a Functional Rat Gene for Manganese-containing Superoxide Dismutase

1991 • 136 citations

Luft's disease

1976 • 136 citations

Dopamine Neurons from Transgenic Mice with a Knockout of the p53 Gene Resist MPTP Neurotoxicity

1996 • 135 citations

Oxidative stress as a potential pathogenic mechanism in an animal model of Duchenne muscular dystrophy

1997 • 134 citations

Protoporphyrin IX, an endogenous ligand of the peripheral benzodiazepine receptor, potentiates induction of the mitochondrial permeability transition and the killing of cultured hepatocytes by rotenone.

1994 • 133 citations

Relationships between the mitochondrial transmembrane potential, ATP concentration, and cytotoxicity in isolated rat hepatocytes

1990 • 133 citations

Hepatic Ultrastructural Changes and Liver Dysfunction in Amyotrophic Lateral Sclerosis

1987 • 133 citations

Neuroprotective effects of the dopamine D 2 /D 3 agonist pramipexole against postischemic or methamphetamine-induced degeneration of nigrostriatal neurons

1996 • 131 citations

Mitochondrial toxins in models of neurodegenerative diseases. I: in vivo brain hydroxyl radical production during sytemic MPTP treatment or following microdialysis infusion of methylpyridinium or azide ions

1997 • 130 citations

Effect of exercise training on antioxidant system in brain regions of rat

1995 • 129 citations

Increased antioxidant enzyme activity in amyloid beta protein-resistant cells

1996 • 128 citations

Peripheral antioxidant enzyme activities and selenium in elderly subjects and in dementia of Alzheimer's type—Place of the extracellular glutathione peroxidase

1996 • 127 citations

Modelling the effects of age-related mtDNA mutation accumulation; Complex I deficiency, superoxide and cell death

1995 • 124 citations

Hydrogen peroxide stimulates transcription of c-jun in vascular smooth muscle cells: role of arachidonic acid.

1993 • 123 citations

MPTP‐induced oxidative stress and neurotoxicity are age‐dependent: Evidence from measures of reactive oxygen species and striatal dopamine levels

1994 • 121 citations

Effects of Nerve Growth Factor on Glutathione Peroxidase and Catalase in PC 12 Cells

1994 • 118 citations

Catalase-overexpressing transgenic mouse heart is resistant to ischemia-reperfusion injury

1997 • 117 citations

A Defect in Mitochondrial Electron-Transport Activity (NADH–Coenzyme Q Oxidoreductase) in Leber's Hereditary Optic Neuropathy

1989 • 114 citations

Amyotrophic Lateral Sclerosis in a High Selenium Environment

1977 • 114 citations

Effects of oxidative stress on expression of extracellular superoxide dismutase, CuZn-superoxide dismutase and Mn-superoxide dismutase in human dermal fibroblasts

1994 • 109 citations

Amyotrophic Lateral Sclerosis after Long-Term Exposure to Drinking Water with High Selenium Content

1996 • 109 citations

Influence of metabolic inhibitors on mitochondrial permeability transition and glutathione status

1995 • 109 citations

MPP+ and MPDP+ induced oxygen radical formation with mitochondrial enzymes

1993 • 106 citations

Cyclosporin A Increases Resting Mitochondrial Membrane Potential in SY5Y Cells and Reverses the Depressed Mitochondrial Membrane Potential of Alzheimer's Disease Cybrids

1998 • 101 citations

Heavy metals and the etiology of Parkinson's disease and other movement disorders

1995 • 100 citations

Iron, selenium and glutathione peroxidase activity are elevated in sporadic motor neuron disease

1994 • 98 citations

Ubiquinone Protects Cultured Neurons against Spontaneous and Excitotoxin-Induced Degeneration

1992 • 98 citations

Oxidative Injury of Synapse and Alteration of Antioxidative Defense Systems in Rats, and Its Prevention by Vitamin E

1997 • 95 citations

Maternal inheritance in Parkinson's disease

1997 • 95 citations

Nitric-Oxide Kills Hepatocytes by Mobilizing Mitochondrial Calcium

1994 • 94 citations

Simultaneous Increase of Mitochondrial DNA Deletions and Lipid Peroxidation in Human Aginga

1996 • 93 citations

Induction of the mitochondrial permeability transition by protease activity in rats: A mechanism of hepatocyte necrosis

1996 • 88 citations

Ca²⁺ and Cell Death^a

1992 • 86 citations

Selective inhibition of the mitochondrial permeability transition pore at the oxidation‐reduction sensitive dithiol by monobromobimane

1995 • 85 citations

Impaired oxidative decarboxylation of pyruvate in fibroblasts from patients with Parkinson's disease

1994 • 83 citations

Blood Activity of Cu/Zn Superoxide Dismutase, Glutathione Peroxidase and Catalase in Alzheimer’s Disease: A Case-Control Study

1990 • 83 citations

Isoforms of Mammalian Cytochrome c Oxidase:Correlation with Human Cytochrome c Oxidase Deficiency

1990 • 82 citations

Genetic factors in Alzheimer's disease: A review of recent advances

1996 • 81 citations

Free radicals induce gene expression of NGF and bFGF in rat astrocyte culture

1992 • 79 citations

Ca2+ depletion prevents anoxic death of hepatocytes by inhibiting mitochondrial permeability transition

1995 • 79 citations

Permeability transition pore of the inner mitochondrial membrane can operate in two open states with different selectivities

1996 • 79 citations

Mammalian mitochondrial endonuclease activities specific for ultraviolet-irradiated DNA

1990 • 79 citations

Does Induced or Spontaneous Abortion Affect the Risk of Breast Cancer?

1996 • 79 citations

Cytochrome Oxidase Inhibition: A Novel Animal Model of Alzheimer's Disease

1992 • 74 citations

Peroxynitrite Stimulates the Pyridine Nucleotide-Linked Ca²⁺ Release from Intact Rat Liver Mitochondria

1996 • 72 citations

Effect of MPTP and <scp>l</scp>‐Deprenyl on Antioxidant Enzymes and Lipid Peroxidation Levels in Mouse Brain

1995 • 71 citations

Heat Shock-induced Manganese Superoxide Dismutase Enhances the Tolerance of Cardiac Myocytes to Hypoxia–Reoxygenation Injury

1997 • 71 citations

Oxygen toxicity protecting enzymes in the human brain

1988 • 67 citations

Regulation of the oxidative stress protective enzymes, catalase and superoxide dismutase in Xanthomonas — a review

1996 • 65 citations

Interaction of hydrogen peroxide with superoxide dismutase from erythrocytes

1972 • 65 citations

Relationships between the NAD(P) redox state, fatty acid oxidation, and inner membrane permeability in rat liver mitochondria

1989 • 65 citations

The hepatotoxicity of rhein involves impairment of mitochondrial functions

1997 • 64 citations

Spin Trapping of Azidyl and Hydroxyl Radicals in Azide-Inhibited Rat Brain Submitochondrial Particles

1994 • 64 citations

Reduction of MPP+-induced hydroxyl radical formation and nigrostriatal MPTP toxicity by inhibiting nitric oxide synthase

1994 • 62 citations

Regional Brain Activity of Free Radical Defense Enzymes in Autopsy Samples from Patients with Alzheimer's Disease and from Nondemented Controls

1994 • 60 citations

Aging and Disease: Extending Functional Life Span

1996 • 57 citations

Protection from oxidation enhances the survival of cultured mesencephalic neurons

1995 • 55 citations

Coenzyme Q10 in the central nervous system and its potential usefulness in the treatment of neurodegenerative diseases

1997 • 54 citations

Blood Superoxide Dismutase, Catalase and Glutathione Peroxidase Activities in Familial and Sporadic Amyotrophic Lateral Sclerosis

1996 • 53 citations

A comparison of the effects of cyanide, hydrogen peroxide, and phenylglyoxal on eucaryotic and procaryotic Cu,Zn superoxide dismutases

1985 • 53 citations

Cu/Zn superoxide dismutase-like immunoreactivity is present in Lewy bodies from Parkinson disease: a light and electron microscopic immunocytochemical study

1995 • 53 citations

The possible role of peroxynitrite in Alzheimer's disease: a simple hypothesis that could be tested more thoroughly

1997 • 51 citations

Serum antioxidant enzyme activity in Parkinson's disease

1992 • 51 citations

Age-releated changes in Cu,Zn superoxide dismutase, Se-dependent and -independent glutathione peroxidase and catalase activities in specific areas of rat brain☆

1991 • 51 citations

Motor neuron-astrocyte interactions and levels of Cu, Zn superoxide dismutase in sporadic amyotrophic lateral sclerosis

1995 • 48 citations

The density of [125I]-transferrin binding sites on perikarya of melanized neurons of the substantia nigra is decreased in Parkinson's disease

1997 • 47 citations

Expression of Human Cu-Zn Superoxide Dismutase Gene in Transgenic Mice: Model for Gene Dosage Effect in Down Syndrome

1991 • 46 citations

A Hypothesis on the Pathogenesis of Alzheimer's Disease

1996 • 46 citations

Exposure to the parkinsonian neurotoxin 1-methyl-4-phenylpyridinium (MPP+) and nitric oxide simultaneously causes cyclosporin A-sensitive mitochondrial calcium efflux and depolarisation

1996 • 42 citations

Protection by cyclosporin A of cultured hepatocytes from the toxic consequences of the loss of mitochondrial energization produced by 1-methyl-4-phenylpyridinium

1992 • 41 citations

(—)Deprenyl Increases the Life Span as Well as Activities of Superoxide Dismutase and Catalase but Not of Glutathione Peroxidase in Selective Brain Regions in Fischer Rats

1994 • 41 citations

Differential regulation of glutathione peroxidase by selenomethionine and hyperoxia in endothelial cells

1995 • 41 citations

Monoamines and related metabolite levels in the cerebrospinal fluid of patients with dementia of Alzheimer type. Influence of treatment with L-deprenyl

1991 • 39 citations

Effects of nerve growth factor on catalase and glutathione peroxidase in a hydrogen peroxide-resistant pheochromocytoma subclone

1994 • 39 citations

A Mitochondrial Signal Peptide fromNeurospora crassaIncreases the Permeability of Isolated Rat Liver Mitochondria

1996 • 39 citations

Aging and superoxide dismutase activity in cerebrospinal fluid

1996 • 37 citations

Deficiencies of NADH and succinate dehydrogenases in degenerative diseases and myopathies

1995 • 37 citations

An immunohistochemical study on manganese superoxide dismutase in Parkinson's disease

1997 • 36 citations

Determination of Superoxide Dismutase Activity by the Polarographic Method of Catalytic Currents in the Cerebrospinal Fluid of Aging Brain and Neurologic Degenerative Diseases

1991 • 36 citations

Membrane inserted APP fragments containing the βA4 sequence of Alzheimer's disease do not aggregate

1992 • 35 citations

Evidence That Two Reports of mtDNA Cytochrome c Oxidase “Mutations” in Alzheimer's Disease Are Based on nDNA Pseudogenes of Recent Evolutionary Origin

1998 • 35 citations

Calcium, energy metabolism and the development of selective neuronal loss following short-term cerebral ischemia

1995 • 34 citations

Erythrocyte antioxidant activity in human patients with Parkinson's disease

1987 • 34 citations

Muscle GSH-Px activity after prolonged exercise, training, and selenium supplementation

1995 • 32 citations

Expression of human Mn SOD in Chinese hamster ovary cells confers protection from oxidant injury

1993 • 31 citations

Superoxide Dismutase Expression in Parkinson's Disease

1994 • 31 citations

Role of intracellular redox status in apoptosis induction of human T-cell leukemia virus type I-infected lymphocytes by 13-cis-retinoic acid.

1997 • 29 citations

Mitochondrial Aging and Lipoperoxidative Productsa

1996 • 28 citations

Cu,Zn superoxide dismutase in vascular cells: changes during cell cycling and exposure to hyperoxia

1993 • 26 citations

The reaction of 4-hydroxy-2-nonenal with Nα-acetyl-l-histidine

1995 • 25 citations

Amyotrophic lateral sclerosis in a high selenium environment

1977 • 24 citations

Ca²⁺‐triggered membrane permeability transition in deenergized mitochondria from rat liver

1995 • 23 citations

A mitochondrial bottleneck hypothesis of Alzheimer's disease

1995 • 23 citations

Parkinson's Disease and Free Radicals

1996 • 20 citations

MPP+ induced SH-SY5Y apoptosis is potentiated by cyclosporin A and inhibited by aristolochic acid

1998 • 20 citations

Localization of manganese superoxide dismutase in the cerebral cortex and hippocampus of Alzheimer-type senile dementia.

1997 • 16 citations

Comparison of the membrane-related effects of cytarabine and other agents on model membranes

1985 • 13 citations

Increased manganese superoxide dismutase activity, protein, and mRNA levels and concurrent induction of tumor necrosis factor α in radiation-initiated Syrian hamster cells

1996 • 12 citations

Are Free Radicals Involved in the Pathogenesis of Idiopathic Parkinson’s Disease?

1993 • 12 citations

Excitation of type II anterior caudate neurons by stimulation of dopamine D3 receptors

1997 • 9 citations

Mice with duplications and deletions at the Tme locus have altered MnSOD activity.

1994 • 9 citations

Delay in manifestations of aging by grafting NGF cultured cromaffin cells in adulthood

1995 • 6 citations