Dityrosine Cross-linking Promotes Formation of Stable α-Synuclein Polymers

Mutation in the α-Synuclein Gene Identified in Families with Parkinson's Disease

1997 • 7,814 citations

Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly

1996 • 5,498 citations

α-Synuclein in filamentous inclusions of Lewy bodies from Parkinson’s disease and dementia with Lewy bodies

1998 • 2,898 citations

Aggregation of alpha-synuclein in Lewy bodies of sporadic Parkinson's disease and dementia with Lewy bodies.

1998 • 1,546 citations

Stabilization of α-Synuclein Secondary Structure upon Binding to Synthetic Membranes

1998 • 1,507 citations

NACP, A Protein Implicated in Alzheimer's Disease and Learning, Is Natively Unfolded

1996 • 1,480 citations

Accelerated in vitro fibril formation by a mutant α-synuclein linked to early-onset Parkinson disease

1998 • 1,460 citations

Widespread Peroxynitrite-Mediated Damage in Alzheimer’s Disease

1997 • 1,241 citations

Identification of two distinct synucleins from human brain

1994 • 1,031 citations

Biological Tyrosine Nitration: A Pathophysiological Function of Nitric Oxide and Reactive Oxygen Species

1998 • 1,024 citations

Filamentous α-synuclein inclusions link multiple system atrophy with Parkinson's disease and dementia with Lewy bodies

1998 • 949 citations

Formation of Reactive Nitrogen Species during Peroxidase-catalyzed Oxidation of Nitrite

1997 • 778 citations

The synucleins: a family of proteins involved in synaptic function, plasticity, neurodegeneration and disease

1998 • 756 citations

Both Familial Parkinson's Disease Mutations Accelerate α-Synuclein Aggregation

1999 • 695 citations

α-Synuclein Fibrillogenesis Is Nucleation-dependent

1999 • 686 citations

Glial cytoplasmic inclusions in white matter oligodendrocytes of multiple system atrophy brains contain insoluble α‐synuclein

1998 • 647 citations

Peroxynitrite‐mediated oxidative protein modifications

1995 • 611 citations

α-Synuclein immunoreactivity in glial cytoplasmic inclusions in multiple system atrophy

1998 • 599 citations

Protein Nitration in Parkinsonʼs Disease

1998 • 551 citations

Lewy Bodies Contain Altered α-Synuclein in Brains of Many Familial Alzheimer's Disease Patients with Mutations in Presenilin and Amyloid Precursor Protein Genes

1998 • 515 citations

Mutant and Wild Type Human α-Synucleins Assemble into Elongated Filaments with Distinct Morphologies in Vitro

1999 • 510 citations

Electrochemical Analysis of Protein Nitrotyrosine and Dityrosine in the Alzheimer Brain Indicates Region-Specific Accumulation

1998 • 507 citations

Peroxynitrite-Mediated Inactivation of Manganese Superoxide Dismutase Involves Nitration and Oxidation of Critical Tyrosine Residues

1998 • 506 citations

Activation of the inducible form of nitric oxide synthase in the brains of patients with multiple sclerosis.

1995 • 464 citations

Oxidative stress induces amyloid-like aggregate formation of NACP/α-synuclein in vitro

1999 • 421 citations

Abnormal accumulation of NACP/alpha-synuclein in neurodegenerative disorders.

1998 • 403 citations

Nigral and Cortical Lewy Bodies and Dystrophic Nigral Neurites in Parkinsonʼs Disease and Cortical Lewy Body Disease Contain α-synuclein Immunoreactivity

1998 • 393 citations

Aggregates from mutant and wild‐type α‐synuclein proteins and NAC peptide induce apoptotic cell death in human neuroblastoma cells by formation of β‐sheet and amyloid‐like filaments

1998 • 357 citations

Accumulation of α-synuclein/NACP is a cytopathological feature common to Lewy body disease and multiple system atrophy

1998 • 350 citations

NACP, a presynaptic protein, immunoreactivity in Lewy bodies in Parkinson's disease

1997 • 322 citations

Factors Determining the Selectivity of Protein Tyrosine Nitration

1999 • 313 citations

Fatal attractions: abnormal protein aggregation and neuron death in Parkinson's disease and Lewy body dementia

1998 • 297 citations

Widespread Alterations of α-Synuclein in Multiple System Atrophy

1999 • 296 citations

Hallervorden-Spatz Syndrome

1974 • 274 citations

Induction of nitrotyrosine-like immunoreactivity in the lower motor neuron of amyotrophic lateral sclerosis

1995 • 266 citations

Mass Spectrometric Quantification of 3-Nitrotyrosine, ortho-Tyrosine, and o,o′-Dityrosine in Brain Tissue of 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated Mice, a Model of Oxidative Stress in Parkinson's Disease

1999 • 264 citations

Filamentous nerve cell inclusions in neurodegenerative diseases

1998 • 261 citations

Immunoelectron-microscopic demonstration of NACP/α-synuclein-epitopes on the filamentous component of Lewy bodies in Parkinson's disease and in dementia with Lewy bodies

1998 • 242 citations

NACP/α-synuclein immunoreactivity in fibrillary components of neuronal and oligodendroglial cytoplasmic inclusions in the pontine nuclei in multiple system atrophy

1998 • 240 citations

Role of Cytochrome c as a Stimulator of α-Synuclein Aggregation in Lewy Body Disease

1999 • 229 citations

A panel of epitope-specific antibodies detects protein domains distributed throughout human ?-synuclein in lewy bodies of Parkinson's disease

2000 • 219 citations

Human Phagocytes Employ the Myeloperoxidase-Hydrogen Peroxide System to Synthesize Dityrosine, Trityrosine, Pulcherosine, and Isodityrosine by a Tyrosyl Radical-dependent Pathway

1996 • 147 citations

Mutated -synuclein gene in two Greek kindreds with familial PD: Incomplete penetrance?

1999 • 130 citations

Oxidative Damage to Proteins, Lipids, and DNA in Cortical Brain Regions from Patients with Dementia with Lewy Bodies

1998 • 122 citations

Peroxynitrite Induces Covalent Dimerization of Epidermal Growth Factor Receptors in A431 Epidermoid Carcinoma Cells

1998 • 100 citations

Experimental developments in movement disorders: update on proposed free radical mechanisms

1998 • 48 citations