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α-Synuclein in filamentous inclusions of Lewy bodies from Parkinson’s disease and dementia with Lewy bodies

1998 • 2,898 citations

A Drosophila model of Parkinson's disease

2000 • 2,062 citations

Dopaminergic Loss and Inclusion Body Formation in α-Synuclein Mice: Implications for Neurodegenerative Disorders

2000 • 1,729 citations

Aggregation of alpha-synuclein in Lewy bodies of sporadic Parkinson's disease and dementia with Lewy bodies.

1998 • 1,546 citations

Acceleration of oligomerization, not fibrillization, is a shared property of both α-synuclein mutations linked to early-onset Parkinson's disease: Implications for pathogenesis and therapy

2000 • 1,497 citations

Accelerated in vitro fibril formation by a mutant α-synuclein linked to early-onset Parkinson disease

1998 • 1,460 citations

Neuropathology of Parkinsonʼs Disease

1996 • 1,457 citations

Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology

1997 • 1,438 citations

Dementia with Lewy bodies.

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Both Familial Parkinson's Disease Mutations Accelerate α-Synuclein Aggregation

1999 • 695 citations

α-Synuclein Fibrillogenesis Is Nucleation-dependent

1999 • 686 citations

Subcellular Localization of Wild-Type and Parkinson's Disease-Associated Mutant α-Synuclein in Human and Transgenic Mouse Brain

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Overexpression of the neural growth-associated protein GAP-43 induces nerve sprouting in the adult nervous system of transgenic mice

1995 • 612 citations

Mutant and Wild Type Human α-Synucleins Assemble into Elongated Filaments with Distinct Morphologies in Vitro

1999 • 510 citations

Synthetic filaments assembled from C‐terminally truncated α‐synuclein

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Degradation of α-Synuclein by Proteasome

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1998 • 403 citations

Pathology and Biology of the Lewy Body

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Nigral and Cortical Lewy Bodies and Dystrophic Nigral Neurites in Parkinsonʼs Disease and Cortical Lewy Body Disease Contain α-synuclein Immunoreactivity

1998 • 393 citations

α‐Synuclein Up‐Regulation in Substantia Nigra Dopaminergic Neurons Following Administration of the Parkinsonian Toxin MPTP

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Ubiquitin carboxyl‐terminal hydrolase (PGP 9.5) is selectively present in ubiquitinated inclusion bodies characteristic of human neurodegenerative diseases

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Accumulation of α-synuclein/NACP is a cytopathological feature common to Lewy body disease and multiple system atrophy

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Pattern of brain destruction in Parkinson's and Alzheimer's diseases

1996 • 325 citations

NACP, a presynaptic protein, immunoreactivity in Lewy bodies in Parkinson's disease

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The Synuclein Family

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THE DISTRIBUTION OF LEWY BODIES IN THE CENTRAL AND AUTONOMIC NERVOUS SYSTEMS IN IDIOPATHIC PARALYSIS AGITANS

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MPTP induces alpha-synuclein aggregation in the substantia nigra of baboons

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Effects of the mutations Ala³⁰ to Pro and Ala⁵³ to Thr on the physical and morphological properties of α‐synuclein protein implicated in Parkinson's disease

1998 • 263 citations

Filamentous nerve cell inclusions in neurodegenerative diseases

1998 • 261 citations

Immunoelectron-microscopic demonstration of NACP/α-synuclein-epitopes on the filamentous component of Lewy bodies in Parkinson's disease and in dementia with Lewy bodies

1998 • 242 citations

Extensive axonal Lewy neurites in Parkinson's disease: a novel pathological feature revealed by α-synuclein immunocytochemistry

1999 • 239 citations

A panel of epitope-specific antibodies detects protein domains distributed throughout human ?-synuclein in lewy bodies of Parkinson's disease

2000 • 219 citations

Immunocytochemical Co-localization of the Proteasome in Ubiquitinated Structures in Neurodegenerative Diseases and the Elderly

1997 • 214 citations

Silver staining of nerve axons in paraffin sections

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Endogenous Serine Protease Inhibitor Modulates Epileptic Activity and Hippocampal Long-Term Potentiation

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A new stain for quantitative measurement of sprouting at neuromuscular junctions

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α-Synuclein immunoreactivity in dementia with Lewy bodies: morphological staging and comparison with ubiquitin immunostaining

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Parkinson's disease: affection of brain stem nuclei controlling premotor and motor neurons of the somatomotor system

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Low frequency of α‐synuclein mutations in familial Parkinson's disease

1998 • 137 citations

Alpha synuclein is present in Lewy bodies in sporadic Parkinson's disease

1998 • 131 citations

Dementia with Lewy Bodies. A Distinct Non‐Alzheimer Dementia Syndrome?

1998 • 118 citations

Relationships between Lewy bodies and pale bodies in Parkinson's disease

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Axonal transport of synucleins is mediated by all rate components

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Epitope mapping of LB509, a monoclonal antibody directed against human α-synuclein

1999 • 101 citations

Ubiquitin-positive degenerating neurites in the brainstem in Parkinson's disease

1995 • 99 citations

Neuron-specific transgene expression of Bcl-XL but not Bcl-2 genes reduced lesion size after permanent middle cerebral artery occlusion in mice

1999 • 97 citations

Failure to find the a‐synuclein gene missense mutation (G ²⁰⁹ A) in 100 patients with younger onset Parkinson's disease

1998 • 95 citations

The α‐synuclein Ala53Thr mutation is not a common cause of familial Parkinson's disease: A study of 230 European cases

1998 • 81 citations

Argyrophilic glial inclusions in the midbrain of patients with Parkinson's disease and diffuse Lewy body disease are immunopositive for NACP/α-synuclein

1999 • 79 citations

Alpha-synuclein immunoreactive Lewy bodies and Lewy neurites in Parkinson's disease are detectable by an advanced silver-staining technique

1999 • 41 citations

Silver staining method for demonstrating Lewy bodies in Parkinson’s disease and argyrophilic oligodendrocytes in multiple system atrophy

1999 • 34 citations