Effects of an Inhibitor of Poly(ADP-Ribose) Polymerase, Desmethylselegiline, Trientine, and Lipoic Acid in Transgenic ALS Mice

Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis

1993 • 6,762 citations

Motor Neuron Degeneration in Mice that Express a Human Cu,Zn Superoxide Dismutase Mutation

1994 • 3,959 citations

An adverse property of a familial ALS-linked SOD1 mutation causes motor neuron disease characterized by vacuolar degeneration of mitochondria

1995 • 1,424 citations

ALS-Linked SOD1 Mutant G85R Mediates Damage to Astrocytes and Promotes Rapidly Progressive Disease with SOD1-Containing Inclusions

1997 • 1,313 citations

Aggregation and Motor Neuron Toxicity of an ALS-Linked SOD1 Mutant Independent from Wild-Type SOD1

1998 • 1,207 citations

Poly(ADP-ribose) polymerase gene disruption renders mice resistant to cerebral ischemia

1997 • 1,020 citations

Altered Reactivity of Superoxide Dismutase in Familial Amyotrophic Lateral Sclerosis

1996 • 718 citations

Functional Role of Caspase-1 and Caspase-3 in an ALS Transgenic Mouse Model

2000 • 700 citations

Benefit of vitamin E, riluzole, and gababapentin in a transgenic model of familial amyotrophic lateral sclerosis

1996 • 654 citations

Poly(ADP-ribose) polymerase activation mediates 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced parkinsonism

1999 • 372 citations

Amyotrophic lateral sclerosis: Recent insights from genetics and transgenic mice

1995 • 353 citations

Glyceraldehyde-3-phosphate dehydrogenase: Nuclear translocation participates in neuronal and nonneuronal cell death

1997 • 325 citations

(R)‐α‐Lipoic acid‐supplemented old rats have improved mitochondrial function, decreased oxidative damage, and increased metabolic rate

1999 • 297 citations

Protection against peroxynitrite-induced fibroblast injury and arthritis development by inhibition of poly(ADP-ribose) synthase

1998 • 268 citations

Glyceraldehyde-3-phosphate Dehydrogenase, the Putative Target of the Antiapoptotic Compounds CGP 3466 and R-(−)-Deprenyl

1998 • 213 citations

Comparison of the effect of α-lipoic acid and α-tocopherol supplementation on measures of oxidative stress

1999 • 184 citations

Hydroxyl Radical Formation from Cuprous Ion and Hydrogen Peroxide: A Spin-Trapping Study

1995 • 182 citations

The Copper Chelator d‐Penicillamine Delays Onset of Disease and Extends Survival in a Transgenic Mouse Model of Familial Amyotrophic Lateral Sclerosis

1997 • 179 citations

α-Lipoic acid protects against reperfusion injury following cerebral ischemia in rats

1996 • 179 citations

Reduced apoptosis after nerve growth factor and serum withdrawal: conversion of tetrameric glyceraldehyde-3-phosphate dehydrogenase to a dimer.

2000 • 162 citations

Nuclear Localization of Overexpressed Glyceraldehyde-3-Phosphate Dehydrogenase in Cultured Cerebellar Neurons Undergoing Apoptosis

1998 • 155 citations

Involvement of Glyceraldehyde-3-Phosphate Dehydrogenase (GAPDH) and p53 in Neuronal Apoptosis: Evidence That GAPDH Is Upregulated by p53

1999 • 124 citations

Neuroprotective effects of α-lipoic acid and its enantiomers demonstrated in rodent models of focal cerebral ischemia

1996 • 92 citations

Protection against peroxynitrite‐dependent tyrosine nitration and α₁‐antiproteinase inactivation by oxidized and reduced lipoic acid

1996 • 83 citations

Age-related changes in LTP and antioxidant defenses are reversed by an α-lipoic acid-enriched diet

1999 • 81 citations

Benefit of a combined treatment with trientine and ascorbate in familial amyotrophic lateral sclerosis model mice

1999 • 79 citations

Deprenyl and desmethylselegiline protect mesencephalic neurons from toxicity induced by glutathione depletion.

1998 • 79 citations

Selegiline Is Ineffective in a Collaborative Double-blind, Placebo-Controlled Trial for Treatment of Amyotrophic Lateral Sclerosis

1998 • 74 citations

<scp>l</scp>‐(−)‐Desmethylselegiline, a Metabolite of Selegiline [<scp>l</scp>‐(−)‐Deprenyl], Protects Mesencephalic Dopamine Neurons from Excitotoxicity In Vitro

1997 • 71 citations

Protective effects of 5-iodo-6-amino-1,2-benzopyrone, an inhibitor of poly(ADP-ribose) synthetase against peroxynitrite-induced glial damage and stroke development

1998 • 48 citations

Prevention of mutant SOD1 motoneuron degeneration by copper chelatorsin vitro

2000 • 44 citations

SUPPRESSION OF EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS BY ADMINISTRATION OF 5-IODO-6-AMINO-1,2,BENZOPYRONE, A NOVEL INHIBITOR OF POLY (ADP-RIBOSE) SYNTHETASE

1998 • 6 citations