Evidence of active nerve cell degeneration in the substantia nigra of humans years after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine exposure

Chronic Parkinsonism in Humans Due to a Product of Meperidine-Analog Synthesis

1983 • 4,822 citations

Reactive microglia are positive for HLA‐DR in the substantia nigra of Parkinson's and Alzheimer's disease brains

1988 • 2,754 citations

A primate model of parkinsonism: selective destruction of dopaminergic neurons in the pars compacta of the substantia nigra by N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.

1983 • 2,149 citations

Chronic parkinsonism secondary to intravenous injection of meperidine analogues

1979 • 1,356 citations

Parkinsonism-inducing neurotoxin, N-methyl-4-phenyl-1,2,3,6 -tetrahydropyridine: uptake of the metabolite N-methyl-4-phenylpyridine by dopamine neurons explains selective toxicity.

1985 • 1,253 citations

Inhibition of NADH-linked oxidation in brain mitochondria by 1-methyl-4-phenyl-pyridine, a metabolite of the neurotoxin, 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine

1985 • 1,236 citations

Metabolism of the neurotoxic tertiary amine, MPTP, by brain monoamine oxidase

1984 • 1,092 citations

Dopaminergic Neurotoxicity of 1-Methyl-4-Phenyl-1,2,5,6-Tetrahydropyridine in Mice

1984 • 1,005 citations

Tumor necrosis factor-α (TNF-α) increases both in the brain and in the cerebrospinal fluid from parkinsonian patients

1994 • 923 citations

Selective nigral toxicity after systemic administration of 1-methyl-4-phenyl-1,2,5,6-tetrahydropyrine (MPTP) in the squirrel monkey

1984 • 913 citations

Parkinson Disease in Twins<SUBTITLE>An Etiologic Study</SUBTITLE>

1999 • 861 citations

Interleukin-1β, interleukin-6, epidermal growth factor and transforming growth factor-α are elevated in the brain from parkinsonian patients

1994 • 788 citations

Intraneuronal generation of a pyridinium metabolite may cause drug-induced parkinsonism

1984 • 772 citations

Interleukin-1β and interleukin-6 are elevated in the cerebrospinal fluid of Alzheimer's and de novo Parkinson's disease patients

1995 • 758 citations

A radical hypothesis for neurodegeneration

1993 • 727 citations

Permanent human parkinsonism due to 1‐methy 1–4‐phenyl‐1,2,3,6‐tetrahydropyridine (MPTP)

1985 • 620 citations

Immunocytochemical analysis of tumor necrosis factor and its receptors in Parkinson's disease

1994 • 576 citations

Interleukin (IL)-1β, IL-2, IL-4, IL-6 and transforming growth factor-α levels are elevated in ventricular cerebrospinal fluid in juvenile parkinsonism and Parkinson's disease

1996 • 518 citations

Glial pathology but absence of apoptotic nigral neurons in long‐standing Parkinson's disease

1998 • 426 citations

1-Methyl-4-phenylpyridinium ion (MPP+): Identification of a metabolite of MPTP, a toxin selective to the substantia nigra

1984 • 423 citations

Subthalamic nucleus‐mediated excitotoxicity in parkinson's disease: A target for neuroprotection

1998 • 395 citations

Is Parkinson's disease a progressive siderosis of substantia nigra resulting in iron and melanin induced neurodegeneration?

1989 • 290 citations

Selectivity of the Parkinsonian Neurotoxin MPTP: Toxic Metabolite MPP ⁺ Binds to Neuromelanin

1986 • 289 citations

Parkinsonism Induced By 1-Methyl-4-Phenyl-1, 2, 3, 6-Tetrahydropyridine (MPTP): Implications for Treatment and the Pathogenesis of Parkinson’s Disease

1984 • 277 citations

Uptake of the neurotoxin 1-methyl-4-phenylpyridine (MPP+) by mitochondria and its relation to the inhibition of the mitochondrial oxidation of NAD+-linked substrates by MPP+

1986 • 267 citations

Similarities and differences between MPTP-induced parkinsonsim and Parkinson's disease. Neuropathologic considerations.

1993 • 209 citations

The Impact of Microglia-Derived Cytokines upon Gliosis in the CNS

1994 • 195 citations

Positron emission tomographic evidence for progression of human MPTP‐induced dopaminergic lesions

1994 • 153 citations

TGFβ1 and TGFβ2 Concentrations Are Elevated in Parkinson's Disease in Ventricular Cerebrospinal Fluid

1996 • 151 citations

MPTP: A neurotoxin producing a parkinsonian syndrome

1987 • 133 citations

Amyotrophic lateral sclerosis among chamorro migrants from guam

1980 • 121 citations

MPTP, a neurotoxin producing a Parkinsonian syndrome

1986 • 90 citations

Slow toxins, biologic markers, and long‐latency neurodegenerative disease in the western Pacific region

1991 • 81 citations

The free radical hypothesis in idiopathic parkinsonism: Evidence against it

1992 • 68 citations

Motor neuron disease on Guam: geographic and familial Occurrence, 1956-85

1996 • 63 citations

Guam: Deadly Disease Dying Out

1993 • 36 citations

The Neuropathology of Dementia

1998 • 24 citations