Cancer Chemoprevention and Apoptosis Mechanisms Induced by Dietary Polyphenolics

Cancer Chemopreventive Activity of Resveratrol, a Natural Product Derived from Grapes

1997 • 4,867 citations

Triggering and modulation of apoptosis by oxidative stress

2000 • 1,315 citations

Phosphoinositide 3-kinases: A conserved family of signal transducers

1997 • 944 citations

Milk Thistle ( Silybum marianum ) for the Therapy of Liver Disease

1998 • 708 citations

Chemoprevention of colon carcinogenesis by dietary curcumin, a naturally occurring plant phenolic compound.

1995 • 682 citations

Polyphenols as cancer chemopreventive agents

1995 • 603 citations

Inhibitory effects of the tyrosine kinase inhibitor genistein on mammalian DNA topoisomerase II.

1989 • 559 citations

Dietary Fiber, Vegetables, and Colon Cancer: Critical Review and Meta-analyses of the Epidemiologic Evidence

1990 • 558 citations

Potential health impacts of excessive flavonoid intake

2000 • 551 citations

Relationship between flavonoid structure and inhibition of phosphatidylinositol 3-kinase: A comparison with tyrosine kinase and protein kinase C inhibition

1997 • 532 citations

Inhibition of arachidonate 5-lipoxygenase triggers massive apoptosis in human prostate cancer cells

1998 • 498 citations

Inhibition of human breast cancer cell proliferation and delay of mammary tumorigenesis by flavonoids and citrus juices

1996 • 491 citations

Induction of apoptosis by apigenin and related flavonoids through cytochrome c release and activation of caspase-9 and caspase-3 in leukaemia HL-60 cells

1999 • 462 citations

Inhibition of mitochondrial proton F0F1‐ATPase/ATP synthase by polyphenolic phytochemicals

2000 • 439 citations

Bioavailability of rutin and quercetin in rats

1997 • 435 citations

The Mitochondrion in Cell Death Control: Certainties and Incognita

2000 • 404 citations

Mitochondrial respiratory chain inhibitors induce apoptosis

1994 • 403 citations

A Quantum Chemical Explanation of the Antioxidant Activity of Flavonoids

1996 • 401 citations

Resveratrol, a remarkable inhibitor of ribonucleotide reductase

1998 • 387 citations

Inhibitory effects of caffeic acid phenethyl ester on the activity and expression of cyclooxygenase-2 in human oral epithelial cells and in a rat model of inflammation.

1999 • 376 citations

Differential Effects on Growth, Cell Cycle Arrest, and Induction of Apoptosis by Resveratrol in Human Prostate Cancer Cell Lines

1999 • 363 citations

Protective Effects of Silymarin Against Photocarcinogenesis in a Mouse Skin Model

1997 • 354 citations

Protein Complexes Activate Distinct Caspase Cascades in Death Receptor and Stress-Induced Apoptosis

2000 • 332 citations

Growth inhibition and regression of human prostate and breast tumors in athymic mice by tea epigallocatechin gallate

1995 • 330 citations

Induction of apoptosis in breast cancer cells MDA-MB-231 by genistein

1999 • 317 citations

Capsaicin, a double-edged sword: Toxicity, metabolism, and chemopreventive potential

1995 • 311 citations

Chemoprevention of azoxymethane-induced rat colon carcinogenesis by the naturally occurring flavonoids, diosmin and hesperidin

1997 • 301 citations

Nutraceuticals and functional foods: introduction and meaning

2000 • 300 citations

Inhibitory effects of flavonoids on xanthine oxidase.

1993 • 290 citations

Flavopiridol Induces Apoptosis in Chronic Lymphocytic Leukemia Cells Via Activation of Caspase-3 Without Evidence of bcl-2 Modulation or Dependence on Functional p53

1998 • 290 citations

A comparison of hepatocyte cytotoxic mechanisms for Cu2+ and Cd2+

2000 • 285 citations

Antitumor effects of Scutellariae radix and its components baicalein, baicalin, and wogonin on bladder cancer cell lines

2000 • 284 citations

Chemopreventive effects of carotenoids and curcumins on mouse colon carcinogenesis after 1,2-dimethylhydrazine initiation

1998 • 282 citations

Effects of luteolin and quercetin, inhibitors of tyrosine kinase, on cell growth and metastasis‐associated properties in A431 cells overexpressing epidermal growth factor receptor

1999 • 280 citations

Flavonoids as DNA Topoisomerase Antagonists and Poisons: Structure-Activity Relationships

1995 • 269 citations

Flavonoids and the inhibition of PKC and PI 3-kinase

1999 • 261 citations

Cell-Cycle Arrest at G2/M and Growth Inhibition by Apigenin in Human Colon Carcinoma Cell Lines

2000 • 260 citations

DNA Polymerase and Topoisomerase II Inhibitors from Psoralea corylifolia

1998 • 260 citations

Resveratrol Is a Selective Human Cytochrome P450 1A1 Inhibitor

1999 • 240 citations

Effect of trans‐resveratrol, a natural polyphenolic compound, on human polymorphonuclear leukocyte function

1998 • 239 citations

Flavonoids activate wild-type p53.

1996 • 228 citations

Cancer chemopreventive activity of resveratrol.

1999 • 227 citations

Curcumin mediated apoptosis in AK‐5 tumor cells involves the production of reactive oxygen intermediates

1999 • 218 citations

Regulation of reactive oxygen species-induced apoptosis and necrosis by caspase 3-like proteases

1998 • 216 citations

A flavonoid antioxidant, silymarin, affords exceptionally high protection against tumor promotion in the SENCAR mouse skin tumorigenesis model.

1999 • 215 citations

The effect of flavonoids on aerobic glycolysis and growth of tumor cells.

1975 • 211 citations

Inhibition of tumor promoter-mediated processes in mouse skin and bovine lens by caffeic acid phenethyl ester.

1993 • 201 citations

Resveratrol prevents apoptosis in K562 cells by inhibiting lipoxygenase and cyclooxygenase activity

1999 • 194 citations

Effect of Naturally Occurring Flavonoids on Lipid Peroxidation and Membrane Permeability Transition in Mitochondria

1998 • 193 citations

Prevention of N-nitrosodiethylamine-induced lung tumorigenesis by ellagic acid and quercetin in mice

1999 • 190 citations

Comparative chemopreventive mechanisms of green tea, black tea and selected polyphenol extracts measured by in vitro bioassays

2000 • 185 citations

In vitrobiotransformation of flavonoids by rat liver microsomes

1998 • 182 citations

Role of the Mitochondrial Membrane Permeability Transition (MPT) in Rotenone-Induced Apoptosis in Liver Cells

2000 • 181 citations

Biochemical Targets of the Isoflavone Genistein in Tumor Cell Lines

1995 • 171 citations

Molecular mechanisms in the antiproliferative action of quercetin

1997 • 169 citations

Activation of mitogen-activated protein kinases by green tea polyphenols: potential signaling pathways in the regulation of antioxidant-responsive element-mediated phase II enzyme gene expression

1997 • 167 citations

Tea and Health: The Underlying Mechanisms

1999 • 166 citations

Tea Flavonols in Cardiovascular Disease and Cancer Epidemiology

1999 • 165 citations

Genistein inhibits proliferation similarly in estrogen receptor-positive and negative human breast carcinoma cell lines characterized by P21WAF1/CIP1 induction, G2/M arrest, and apoptosis

1998 • 161 citations

Suppression of protein kinase C and nuclear oncogene expression as possible molecular mechanisms of cancer chemoprevention by apigenin and curcumin

1997 • 155 citations

Active Oxygens Generation by Flavonoids.

1998 • 148 citations

Chemoprevention of 4-nitroquinoline 1-oxide-induced rat oral carcinogenesis by the dietary flavonoids chalcone, 2-hydroxychalcone, and quercetin.

1996 • 146 citations

cAMP-Mediated Signals as Determinants for Apoptosis in Primary Granulosa Cells

1995 • 145 citations

The flavonoid galangin is an inhibitor of CYP1A1 activity and an agonist/antagonist of the aryl hydrocarbon receptor

1999 • 144 citations

Chemoprotective effects of capsaicin and diallyl sulfide against mutagenesis or tumorigenesis by vinyl carbamate and N-nitrosodiinethylamine

1995 • 144 citations

Rotenoids mediate potent cancer chemopreventive activity through transcriptional regulation of ornithine decarboxylase

1995 • 139 citations

Studies on the inhibitory effects of quercetin on the growth of HL-60 leukemia cells

1997 • 137 citations

Inhibitory effects of caffeic acid phenethyl ester (CAPE) on 12-O-tetradecanoylphorbol-13-acetate-induced tumor promotion in mouse skin and the synthesis of DNA, RNA and protein in HeLa cells

1996 • 135 citations

Lipoxygenase Inhibition Induced Apoptosis, Morphological Changes, and Carbonic Anhydrase Expression in Human Pancreatic Cancer Cells

1999 • 134 citations

Chemopreventive effects of ferulic acid on oral and rice germ on large bowel carcinogenesis.

2000 • 133 citations

The effects of dietary ellagic acid on rat hepatic and esophageal mucosal cytochromes P450 and phase II enzymes

1996 • 131 citations

Genistein induces apoptosis and topoisomerase II-mediated DNA breakage in colon cancer cells

2000 • 129 citations

Cancer chemopreventive activity mediated by 4'-bromoflavone, a potent inducer of phase II detoxification enzymes.

1999 • 122 citations

Induction of the anticarcinogenic marker enzyme, quinone reductase, in murine hepatoma cells in vitro by flavonoids

1997 • 115 citations

Cell Death Induced by Baicalein in Human Hepatocellular Carcinoma Cell Lines

1996 • 113 citations

Chemoprevention of 4-nitroquinoline 1-oxide-induced oral carcinogenesis in rats by flavonoids diosmin and hesperidin, each alone and in combination.

1997 • 112 citations

p53-Independent Apoptosis Induced by Genistein in Lung Cancer Cells

1999 • 109 citations

Effects of Oral Administration of Tea, Decaffeinated Tea, and Caffeine on the Formation and Growth of Tumors in High-Risk SKH-1 Mice Previously Treated With Ultraviolet B Light

1999 • 109 citations

Skin Cancer Chemopreventive Effects of a Flavonoid Antioxidant Silymarin Are Mediated via Impairment of Receptor Tyrosine Kinase Signaling and Perturbation in Cell Cycle Progression

1998 • 108 citations

Capsaicin inhibits plasma membrane NADH oxidase and growth of human and mouse melanoma lines

1996 • 106 citations

Flavopiridol binds to duplex DNA.

2000 • 104 citations

Inhibitory effect of silymarin, an anti-hepatotoxic flavonoid, on 12-O-tetradecanoylphorbol-13-acetate-induced epidermal ornithine decarboxylase activity and mRNA in SENCAR mice

1994 • 99 citations

Structural Studies on Bioactive Compounds. 23. Synthesis of Polyhydroxylated 2-Phenylbenzothiazoles and a Comparison of their Cytotoxicities and Pharmacological Properties with Genistein and Quercetin

1994 • 98 citations

Inhibition of Benzoyl Peroxide-Mediated Tumor Promotion in 7,12-Dimethylbenz(a)anthracene-Initiated Skin of Sencar Mice by Antioxidants Nordihydroguaiaretic Acid and Diallyl Sulfide

1990 • 92 citations

Chemoprevention of colon carcinogenesis by phenylethyl-3-methylcaffeate.

1995 • 87 citations

Bioavailability of Flavonoids and Potential Bioactive Forms in Vivo

2000 • 87 citations

Site-Selective 8 -Chloro- Cyclic Adenosine 3′,5′-Monophosphate as a Biologic Modulator of Cancer: Restoration of Normal Control Mechanisms

1989 • 81 citations

Induction of Apoptosis by Arachidonic Acid in Human Retinoblastoma Y79 Cells: Involvement of Oxidative Stress

2000 • 78 citations

Rosemary extract and carnosol stimulate rat liver glutathione-S-transferase and quinone reductase activities

1996 • 77 citations

Chemoprevention of digestive organs carcinogenesis by natural product protocatechuic acid

1995 • 75 citations

Structure-activity relationship of caffeic acid analogues on xanthine oxidase inhibition.

1995 • 71 citations

Growth inhibitory effects of bioflavonoids and related compounds on human leukemic CEM-C1 and CEM-C7 cells

1992 • 70 citations

Protection against induction of mouse skin papillomas with low and high risk of conversion to malignancy by green tea polyphenols

1997 • 70 citations

Syk Activation Is Required for Spreading and H2O2 Release in Adherent Human Neutrophils

1998 • 69 citations

Contribution of Caffeine and Flavanols in the Induction of Hepatic Phase II Activities by Green Tea

1998 • 68 citations

Flavonoids of honey and propolis : characterization and effects on hepatic drug-metabolizing enzymes and benzo(a)pyrene-DNA binding in rats

1996 • 64 citations

Induction of apoptosis by arachidonic acid in chronic myeloid leukemia cells.

1999 • 63 citations

Caffeic acid phenethyl ester stimulates human antioxidant response element-mediated expression of the NAD(P)H:quinone oxidoreductase (NQO1) gene.

1997 • 58 citations

Cytotoxicity of plant flavonoids against HeLa cells

1988 • 58 citations

Flavonoids of Honey and Propolis: Characterization and Effects on Hepatic Drug-Metabolizing Enzymes and Benzo[a]pyrene−DNA Binding in Rats

1996 • 57 citations

Inhibition of 1,2,4-benzenetriol-generated active oxygen species and induction of phase II enzymes by green tea polyphenols

1995 • 56 citations

Endothelium-dependent relaxation of rat aorta by butein, a novel cyclic AMP-specific phosphodiesterase inhibitor

1995 • 53 citations

Anticlastogenic effect of flavonoids against mutagen-induced micronuclei in mice

1992 • 52 citations

Cancer Chemopreventive Mechanisms of Tea Against Heterocyclic Amine Mutagens from Cooked Meat

1999 • 50 citations

Inhibition of mitochondrial electron transport by nor-dihydroguaiaretic acid (NDGA)

1970 • 47 citations

Ellagic acid induces transcription of the rat glutathione S-transferase-Ya gene

1995 • 44 citations

Chemoprevention for colorectal cancer

2000 • 43 citations

Inhibition of Rat Liver Cyclic AMP-Dependent Protein Kinase by Flavonoids

1992 • 43 citations

Structural requirements for differentiation-induction and growth-inhibition of mouse erythroleukemia cells by isoflavones.

1995 • 38 citations

Inhibition of tumoral cell respiration and growth by nordihydroguaiaretic acid

1994 • 37 citations

Inhibition of WY-14,643 induced hepatic lesion growth in mice by rotenone

1997 • 35 citations

Tyrosine Kinase-Independent Inhibition of Cyclic-AMP Phosphodiesterase by Genistein and Tyrphostin 51

1999 • 34 citations

NADH: Ubiquinone Oxidoreductase Inhibitors Block Induction of Ornithine Decarboxylase Activity in MCF‐7 Human Breast Cancer Cells*

1998 • 34 citations

Uncoupling activity of a series of flavones and flavonols on isolated plant mitochondria

1986 • 32 citations

Antigenotoxicity of galangin against N-methyl-N-nitrosourea

1998 • 28 citations

Mechanism of the inhibitory action of capsaicin on energy metabolism by rat liver mitochondria

1981 • 24 citations

Biodistribution of, Antimutagenic Efficacies in Salmonella typhimurium of, and Inhibition of P450 Activities by Ellagic Acid and One Analogue

1998 • 20 citations

Crystal structure of phlorizin and the iodothyronine deiodinase inhibitory activity of phloretin analogues

1986 • 20 citations

Modulation of cyclic AMP levels in a clonal neural cell line by inhibitors of tyrosine phosphorylation

1997 • 19 citations

Inhibitory effects of semisynthetic flavonoid derivatives on the biochemical markers of tumor promotion in mouse epidermis in vivo

1993 • 10 citations

Uncoupling and inhibition of the respiratory chain in rat liver mitochondria by some naturally occurring estrogens and their metabolites

1991 • 8 citations