The Glucagon-Like Peptides

IMMUNOASSAY OF ENDOGENOUS PLASMA INSULIN IN MAN

1960 • 2,983 citations

RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor

1998 • 2,076 citations

A role for glucagon-like peptide-1 in the central regulation of feeding

1996 • 1,880 citations

GLUCAGON-LIKE PEPTIDE-1 7-36: A PHYSIOLOGICAL INCRETIN IN MAN

1987 • 1,845 citations

Stem cells: attributes, cycles, spirals, pitfalls and uncertainties. Lessons for and from the crypt

1990 • 1,793 citations

Preserved incretin activity of glucagon-like peptide 1 [7-36 amide] but not of synthetic human gastric inhibitory polypeptide in patients with type-2 diabetes mellitus.

1993 • 1,579 citations

Glucagon-like peptide 1 promotes satiety and suppresses energy intake in humans.

1998 • 1,338 citations

Reduced incretin effect in Type 2 (non-insulin-dependent) diabetes

1986 • 1,275 citations

A G Protein-Linked Receptor for Parathyroid Hormone and Parathyroid Hormone-Related Peptide

1991 • 1,230 citations

The mechanism of pancreatic secretion

1902 • 1,209 citations

Exendin-4 stimulates both beta-cell replication and neogenesis, resulting in increased beta-cell mass and improved glucose tolerance in diabetic rats.

1999 • 1,207 citations

Differential signal transduction by five splice variants of the PACAP receptor

1993 • 1,185 citations

Dipeptidyl‐peptidase IV hydrolyses gastric inhibitory polypeptide, glucagon‐like peptide‐1(7–36)amide, peptide histidine methionine and is responsible for their degradation in human serum

1993 • 1,119 citations

Degradation of glucose-dependent insulinotropic polypeptide and truncated glucagon-like peptide 1 in vitro and in vivo by dipeptidyl peptidase IV.

1995 • 1,064 citations

Normalization of fasting hyperglycaemia by exogenous glucagon-like peptide 1 (7-36 amide) in Type 2 (non-insulin-dependent) diabetic patients

1993 • 1,064 citations

Developmental biology of the pancreas

1995 • 942 citations

Isolation and characterization of exendin-4, an exendin-3 analogue, from Heloderma suspectum venom. Further evidence for an exendin receptor on dispersed acini from guinea pig pancreas.

1992 • 912 citations

Plasma Insulin Responses to Oral and Intravenous Glucose: Studies in Normal and Diabetic Subjects*

1967 • 908 citations

Expression cloning of the pancreatic beta cell receptor for the gluco-incretin hormone glucagon-like peptide 1.

1992 • 880 citations

Tissue and Plasma Concentrations of Amidated and Glycine-Extended Glucagon-Like Peptide I in Humans

1994 • 868 citations

Antidiabetogenic Effect of Glucagon-like Peptide-1 (7–36)amide in Normal Subjects and Patients with Diabetes Mellitus

1992 • 858 citations

Incretin Effects of Increasing Glucose Loads in Man Calculated from Venous Insulin and C-Peptide Responses*

1986 • 848 citations

Induction of intestinal epithelial proliferation by glucagon-like peptide 2.

1996 • 842 citations

Plasma Insulin Response to Oral and Intravenous Glucose Administration1

1964 • 833 citations

Glucagon-like peptide I stimulates insulin gene expression and increases cyclic AMP levels in a rat islet cell line.

1987 • 830 citations

Signal Sequence Recognition and Protein Targeting to the Endoplasmic Reticulum Membrane

1994 • 821 citations

Insulinotropin: glucagon-like peptide I (7-37) co-encoded in the glucagon gene is a potent stimulator of insulin release in the perfused rat pancreas.

1987 • 814 citations

Exendin-4 is a high potency agonist and truncated exendin-(9-39)-amide an antagonist at the glucagon-like peptide 1-(7-36)-amide receptor of insulin-secreting beta-cells.

1993 • 814 citations

STIMULATION OF INSULIN SECRETION BY GASTRIC INHIBITORY POLYPEPTIDE IN MAN.¹

1973 • 812 citations

Glucagon-like peptide 1 inhibition of gastric emptying outweighs its insulinotropic effects in healthy humans

1997 • 799 citations

The Pax4 gene is essential for differentiation of insulin-producing β cells in the mammalian pancreas

1997 • 779 citations

Pax6 is required for differentiation of glucagon-producing α-cells in mouse pancreas

1997 • 776 citations

Glucose intolerance but normal satiety in mice with a null mutation in the glucagon–like peptide 1 receptor gene

1996 • 771 citations

The biology of leptin: a review.

1998 • 768 citations

Cloning and functional characterization of a family of human and mouse somatostatin receptors expressed in brain, gastrointestinal tract, and kidney.

1992 • 766 citations

Functional expression and tissue distribution of a novel receptor for vasoactive intestinal polypeptide

1992 • 752 citations

Degradation of glucagon-like peptide-1 by human plasma in vitro yields an N-terminally truncated peptide that is a major endogenous metabolite in vivo.

1995 • 741 citations

The incretin concept today

1979 • 730 citations

Both subcutaneously and intravenously administered glucagon-like peptide I are rapidly degraded from the NH2-terminus in type II diabetic patients and in healthy subjects

1995 • 705 citations

NEW INTERPRETATION OF ORAL GLUCOSE TOLERANCE

1964 • 693 citations

Preproglucagon gene expression in pancreas and intestine diversifies at the level of post-translational processing.

1986 • 686 citations

Glucagon-like peptide-1(7–36)amide and glucose-dependent insulinotropic polypeptide secretion in response to nutrient ingestion in man: acute post-prandial and 24-h secretion patterns

1993 • 678 citations

Truncated GLP-1 (proglucagon 78?107-amide) inhibits gastric and pancreatic functions in man

1993 • 661 citations

The proprotein convertases

1998 • 648 citations

Glucagon‐like peptide‐1 cells in the gastrointestinal tract and pancreas of rat, pig and man

1992 • 620 citations

Mice lacking the homeodomain transcription factor Nkx2.2 have diabetes due to arrested differentiation of pancreatic β cells

1998 • 616 citations

Distribution of glucagon-like peptide-1 and other preproglucagon-derived peptides in the rat hypothalamus and brainstem

1997 • 608 citations

Hamster preproglucagon contains the sequence of glucagon and two related peptides

1983 • 602 citations

Central administration of GLP-1-(7-36) amide inhibits food and water intake in rats

1996 • 581 citations

Pancreatic beta-cells are rendered glucose-competent by the insulinotropic hormone glucagon-like peptide-1(7-37)

1993 • 576 citations

Glucagon-Like Peptide-1 and Glucose-Dependent Insulin-Releasing Polypeptide Plasma Levels in Response to Nutrients

1995 • 572 citations

Tissue distribution of messenger ribonucleic acid encoding the rat glucagon-like peptide-1 receptor.

1996 • 569 citations

Genetic analysis reveals that PAX6 is required for normal transcription of pancreatic hormone genes and islet development.

1997 • 567 citations

Truncated glucagon‐like peptide I, an insulin‐releasing hormone from the distal gut

1987 • 566 citations

Exon duplication and divergence in the human preproglucagon gene

1983 • 558 citations

Glucagon-Like Peptides

1998 • 548 citations

Cloning and Functional Expression of the Human Islet GLP-1 Receptor: Demonstration That Exendin-4 Is an Agonist and Exendin-(9–39) an Antagonist of the Receptor

1993 • 533 citations

What’s in a Name? In Search of Leptin’s Physiologic Role¹

1998 • 527 citations

Cell and Molecular Biology of the Incretin Hormones Glucagon-Like Peptide-I and Glucose-Dependent Insulin Releasing Polypeptide

1995 • 519 citations

Glucagon-like peptide-1 promotes satiety and reduces food intake in patients with diabetes mellitus type 2

1999 • 516 citations

A VIEW OF SUR/K_IR6.X, K_ATP CHANNELS

1998 • 514 citations

Endocrine Cells in Human Intestine: An Immunocytochemical Study

1983 • 502 citations

The VIP₂ receptor: Molecular characterisation of a cDNA encoding a novel receptor for vasoactive intestinal peptide

1993 • 496 citations

Gastric inhibitory polypeptide receptor, a member of the secretin-vasoactive intestinal peptide receptor family, is widely distributed in peripheral organs and the brain.

1993 • 485 citations

Oral Hypoglycemic Agents

1989 • 483 citations

Glucagon-Like Peptides GLP-1 and GLP-2, Predicted Products of the Glucagon Gene, Are Secreted Separately from Pig Small Intestine but Not Pancreas*

1986 • 475 citations

Additive insulinotropic effects of exogenous synthetic human gastric inhibitory polypeptide and glucagon-like peptide-1-(7-36) amide infused at near-physiological insulinotropic hormone and glucose concentrations.

1993 • 467 citations

Gastric emptying, glucose responses, and insulin secretion after a liquid test meal: effects of exogenous glucagon-like peptide-1 (GLP-1)-(7-36) amide in type 2 (noninsulin-dependent) diabetic patients.

1996 • 460 citations

Expression Cloning of an Adenylate Cyclase-Coupled Calcitonin Receptor

1991 • 458 citations

Energy intake and appetite are suppressed by glucagon-like peptide-1 (GLP-1) in obese men.

1999 • 454 citations

Distribution of GLP‐1 Binding Sites in the Rat Brain: Evidence that Exendin‐4 is a Ligand of Brain GLP‐1 Binding Sites

1995 • 451 citations

Glucose-lowering and insulin-sensitizing actions of exendin-4: studies in obese diabetic (ob/ob, db/db) mice, diabetic fatty Zucker rats, and diabetic rhesus monkeys (Macaca mulatta).

1999 • 439 citations

The ileal brake--inhibition of jejunal motility after ileal fat perfusion in man.

1984 • 435 citations

Role of the Vagus Nerve in Mediating Proximal Nutrient-Induced Glucagon-Like Peptide-1 Secretion*

1999 • 434 citations

Tissue‐specific expression of the human receptor for glucagon‐like peptide‐I: brain, heart and pancreatic forms have the same deduced amino acid sequences

1995 • 425 citations

The adipoinsular axis: effects of leptin on pancreatic β-cells

2000 • 423 citations

Defective prohormone processing and altered pancreatic islet morphology in mice lacking active SPC2

1997 • 423 citations

Gastric emptying and release of incretin hormones after glucose ingestion in humans.

1996 • 416 citations

Molecular cloning and expression of a cDNA encoding the secretin receptor.

1991 • 415 citations

FUNCTIONAL SUBDIVISION OF ISLETS OF LANGERHANS AND POSSIBLE ROLE OF D CELLS

1975 • 408 citations

Glucagon-like peptide-1 inhibits gastric emptying via vagal afferent-mediated central mechanisms

1997 • 407 citations

Expression cloning and signaling properties of the rat glucagon receptor

1993 • 393 citations

Effect of Truncated Glucagon-Like Peptide-1 [Proglucagon-(78–107) amide] on Endocrine Secretion from Pig Pancreas, Antrum, and Nonantral Stomach

1988 • 391 citations

Leptin Suppression of Insulin Secretion by the Activation of ATP-Sensitive K+ Channels in Pancreatic β-Cells

1997 • 386 citations

Endocrine tumour in kidney affecting small bowel structure, motility, and absorptive function

1971 • 379 citations

Calcium-independent potentiation of insulin release by cyclic AMP in single β-cells

1993 • 377 citations

Attenuated GLP-1 secretion in obesity: cause or consequence?

1996 • 374 citations

Proglucagon products in plasma of noninsulin-dependent diabetics and nondiabetic controls in the fasting state and after oral glucose and intravenous arginine.

1991 • 371 citations

Entero-Insular Axis

1969 • 366 citations

ATP-sensitive K⁺channels in pancreatic, cardiac, and vascular smooth muscle cells

1998 • 349 citations

Continuous subcutaneous infusion of glucagon-like peptide 1 lowers plasma glucose and reduces appetite in type 2 diabetic patients.

1999 • 335 citations

Leptin Receptors Expressed on Pancreatic β-Cells

1996 • 332 citations

Molecular cloning and expression of a pituitary-specific receptor for growth hormone-releasing hormone.

1992 • 327 citations

Glucagonostatic Actions and Reduction of Fasting Hyperglycemia by Exogenous Glucagon-Like Peptide I(7–36) amide in type I diabetic patients

1996 • 326 citations

Distribution of glucagonlike peptide I (GLP‐I), glucagon, and glicentin in the rat brain: An immunocytochemical study

1988 • 325 citations

Prototypic G protein-coupled receptor for the intestinotrophic factor glucagon-like peptide 2

1999 • 324 citations

Insulinotropic hormone glucagon-like peptide-I(7-37) stimulation of proinsulin gene expression and proinsulin biosynthesis in insulinoma beta TC-1 cells.

1992 • 323 citations

A Gastric Inhibitory Polypeptide II: The Complete Amino Acid Sequence

1971 • 323 citations

Effect of infusion of nutrient solutions into the ileum on gastrointestinal transit and plasma levels of neurotensin and enteroglucagon

1984 • 322 citations

Divergent tissue-specific and developmental expression of receptors for glucagon and glucagon-like peptide-1 in the mouse.

1994 • 321 citations

Biological Effects and Metabolic Rates of Glucagonlike Peptide-1 7–36 Amide and Glucagonlike Peptide-1 7–37 in Healthy Subjects Are Indistinguishable

1993 • 311 citations

Intestinal growth-promoting properties of glucagon-like peptide-2 in mice

1997 • 310 citations

The insulinotropic actions of glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (7–37) in normal and diabetic subjects

1994 • 309 citations

Dipeptidyl peptidase IV inhibition potentiates the insulinotropic effect of glucagon-like peptide 1 in the anesthetized pig.

1998 • 309 citations

Glucagon-like peptide-1 but not glucagon-like peptide-2 stimulates insulin release from isolated rat pancreatic islets

1985 • 303 citations

Characterization of the responses of circulating glucagon-like immunoreactivity to intraduodenal and intravenous administration of glucose

1968 • 294 citations

Central Administration of Glucagon-Like Peptide-1 Activates Hypothalamic Neuroendocrine Neurons in the Rat*

1997 • 292 citations

Glucagon-like peptide 1 undergoes differential tissue-specific metabolism in the anesthetized pig

1996 • 291 citations

Glucagon-like peptide-1, a new hormone of the entero-insular axis

1992 • 290 citations

Effects of subcutaneous glucagon-like peptide 1 (GLP-1 [7-36 amide]) in patients with NIDDM

1996 • 286 citations

Glucagon-Like Peptide I Receptors in the Subfornical Organ and the Area Postrema Are Accessible to Circulating Glucagon-Like Peptide I

1996 • 286 citations

DEMENTIA

1982 • 284 citations

Glucagon-like peptide 1 enhances glucose tolerance both by stimulation of insulin release and by increasing insulin-independent glucose disposal.

1994 • 283 citations

Insulinotropic Action of Glucagonlike Peptide-I-(7–37) in Diabetic and Nondiabetic Subjects

1992 • 282 citations

Leptin Suppression of Insulin Secretion and Gene Expression in Human Pancreatic Islets: Implications for the Development of Adipogenic Diabetes Mellitus1

1999 • 282 citations

Activation of proglucagon gene transcription by protein kinase-A in a novel mouse enteroendocrine cell line.

1994 • 279 citations

Dipeptidyl peptidase IV resistant analogues of glucagon-like peptide-1 which have extended metabolic stability and improved biological activity

1998 • 279 citations

Structure-activity studies of glucagon-like peptide-1.

1994 • 272 citations

Near-normalisation of diurnal glucose concentrations by continuous administration of glucagon-like peptide-1 (GLP-1) in subjects with NIDDM

1997 • 272 citations

Degradation of glucagon-like peptide-1 by human plasma in vitro yields an N-terminally truncated peptide that is a major endogenous metabolite in vivo

1995 • 270 citations

Luminal glucose concentrations in the gut under normal conditions

1990 • 269 citations

Development of neuroendocrine tumors in the gastrointestinal tract of transgenic mice. Heterogeneity of hormone expression.

1990 • 265 citations

Regulation of intestinal proglucagon-derived peptide secretion by glucose-dependent insulinotropic peptide in a novel enteroendocrine loop.

1993 • 264 citations

Embryogenesis of the murine endocrine pancreas; early expression of pancreatic polypeptide gene

1991 • 262 citations

Regulation of the biological activity of glucagon-like peptide 2 in vivo by dipeptidyl peptidase IV

1997 • 262 citations

Further purification of a polypeptide demonstrating enterogastrone activity

1970 • 262 citations

Upregulation of SGLT-1 transport activity in rat jejunum induced by GLP-2 infusion in vivo

1997 • 261 citations

Improved Glucose Tolerance in Zucker Fatty Rats by Oral Administration of the Dipeptidyl Peptidase IV Inhibitor Isoleucine Thiazolidide

1998 • 260 citations

Glucagonlike peptide 1: A newly discovered gastrointestinal hormone

1994 • 258 citations

Cellular regulation of islet hormone secretion by the incretin hormone glucagon-like peptide 1

1998 • 258 citations

Glucagonlike Peptide I (7–37) Actions on Endocrine Pancreas

1989 • 254 citations

On the treatment of Diabetus mellitus by acid extract of Duodenal Mucous Membrane

1906 • 253 citations

Glucagon gene expression in vertebrate brain.

1988 • 252 citations

Intestinal function in mice with small bowel growth induced by glucagon-like peptide-2

1997 • 252 citations

Exendin(9-39)amide is an antagonist of glucagon-like peptide-1(7-36)amide in humans.

1998 • 251 citations

Further characterisation of the 'ileal brake' reflex in man--effect of ileal infusion of partial digests of fat, protein, and starch on jejunal motility and release of neurotensin, enteroglucagon, and peptide YY.

1988 • 249 citations

Pancreatic preproglucagon cDNA contains two glucagon-related coding sequences arranged in tandem.

1982 • 249 citations

Glucagon-like peptide-1-(9-36) amide is a major metabolite of glucagon-like peptide-1-(7-36) amide after in vivo administration to dogs, and it acts as an antagonist on the pancreatic receptor

1996 • 248 citations

Gastric Inhibitory Polypeptide: Its Physiologic Release and Insulinotropic Action in the Dog

1975 • 242 citations

Expression and Functional Activity of Glucagon, Glucagon-Like Peptide I, and Glucose-Dependent Insulinotropic Peptide Receptors in Rat Pancreatic Islet Cells

1996 • 241 citations

Radioimmunoassay for Gastric Inhibitory Polypeptide

1974 • 239 citations

Origin of Genes

1997 • 236 citations

Colocalization of Glucagon‐Like Peptide‐1 (GLP‐1) Receptors, Glucose Transporter GLUT‐2, and Glucokinase mRNAs in Rat Hypothalamic Cells: Evidence for a Role of GLP‐1 Receptor Agonists as an Inhibitory Signal for Food and Water Intake

1996 • 232 citations

Differential Processing of Proglucagon by the Subtilisin-like Prohormone Convertases PC2 and PC3 to Generate either Glucagon or Glucagon-like Peptide

1995 • 228 citations

Role of prohormone convertases in the tissue-specific processing of proglucagon.

1996 • 224 citations

Onset of cell-specific gene expression in the developing mouse pancreas.

1992 • 224 citations

Glucagonostatic and Insulinotropic Action of Glucagonlike Peptide I-(7–36)-Amide

1989 • 222 citations

Characterisation of the processing by human neutral endopeptidase 24.11 of GLP-1(7–36) amide and comparison of the substrate specificity of the enzyme for other glucagon-like peptides

1995 • 221 citations

cAMP-dependent Mobilization of Intracellular Ca2+ Stores by Activation of Ryanodine Receptors in Pancreatic β-Cells

1999 • 221 citations

Mammalian pancreatic preproglucagon contains three glucagon-related peptides.

1983 • 218 citations

Ileal release of glucagon-like peptide-1 (GLP-1)

1995 • 216 citations

Functional expression of the rat glucagon-like peptide-I receptor, evidence for coupling to both adenylyl cyclase and phospholipase-C.

1993 • 214 citations

Glucagon-Like Peptide-2 Inhibits Centrally Induced Antral Motility in Pigs

1998 • 212 citations

Proglucagon is processed to glucagon by prohormone convertase PC2 in alpha TC1-6 cells.

1994 • 211 citations

The primary structure of porcine glicentin (proglucagon)

1981 • 206 citations

Pancreatic and intestinal processing of proglucagon in man

1987 • 203 citations

The Insulinotropic Action of Gastric Inhibitory Polypeptide in the Perfused Isolated Rat Pancreas

1976 • 203 citations

Dietary fiber modulates intestinal proglucagon messenger ribonucleic acid and postprandial secretion of glucagon-like peptide-1 and insulin in rats.

1996 • 202 citations

Complete Sequences of Glucagon-like Peptide-1 from Human and Pig Small Intestine

1989 • 201 citations

An enteroglucagon tumour

1972 • 200 citations

Leptin inhibits insulin gene transcription and reverses hyperinsulinemia in leptin-deficient ob/ob mice

1999 • 196 citations

Distribution and properties of glucagon immunoreactivity in the digestive tract of various mammals: An immunohistochemical and immunochemical study

1975 • 196 citations

Characterization of response of circulating glucagon to intraduodenal and intravenous administration of amino acids

1968 • 195 citations

Glucagon-like peptide-1 is a physiological incretin in rat.

1995 • 193 citations

PVN infusion of GLP-1-(7—36) amide suppresses feeding but does not induce aversion or alter locomotion in rats

1998 • 191 citations

Glucagon-like peptide-1 inhibits gastropancreatic function by inhibiting central parasympathetic outflow

1998 • 190 citations

Central infusion of GLP-1, but not leptin, produces conditioned taste aversions in rats

1997 • 188 citations

Effect of the entero-pancreatic hormones, gastric inhibitory polypeptide and glucagon-like polypeptide-1(7–36) amide, on fatty acid synthesis in explants of rat adipose tissue

1991 • 186 citations

Activation of a cAMP-regulated Ca2+-Signaling Pathway in Pancreatic β-Cells by the Insulinotropic Hormone Glucagon-like Peptide-1

1995 • 185 citations

Reduction of the Incretin Effect in Rats by the Glucagon-Like Peptide 1 Receptor Antagonist Exendin (9–39) Amide

1995 • 180 citations

Changes in arterial blood pressure and heart rate induced by glucagon-like peptide-1-(7-36) amide in rats

1994 • 179 citations

Insulinotropic Glucagon-Like Peptide I Receptor Expression in Glucagon-Producing α-Cells of the Rat Endocrine Pancreas

1997 • 177 citations

Preparation of highly active enterogastrone

1969 • 177 citations

GLP-1 (glucagon-like peptide 1) and truncated GLP-1, fragments of human proglucagon, inhibit gastric acid secretion in humans

1989 • 176 citations

Glucagon-like peptide-1 receptor (GLP1-R) mRNA in the rat hypothalamus.

1996 • 174 citations

Glucagon-like peptide-1 can reverse the age-related decline in glucose tolerance in rats.

1997 • 174 citations

High Potency Antagonists of the Pancreatic Glucagon-like Peptide-1 Receptor

1997 • 173 citations

Human [Gly²]GLP-2 reduces the severity of colonic injury in a murine model of experimental colitis

1999 • 170 citations

Proglucagon processing in porcine and human pancreas.

1994 • 167 citations

Regulation of Glucagon-Like Peptide-1 Synthesis and Secretion in the GLUTag Enteroendocrine Cell Line¹

1998 • 166 citations

Identification and Localization of Glucagon-Like Peptide-1 and Its Receptor in Rat Brain*

1987 • 166 citations

Cellular localization of proglucagon/glucagon‐like peptide I messenger RNAs in rat brain

1986 • 165 citations

Molecular Forms of Human Enteroglucagon in Tissue and Plasma: Plasma Responses to Nutrient Stimuli in Health and in Disorders of the Upper Gastrointestinal Tract*

1983 • 165 citations

Tissue-specific Expression of Unique mRNAs That Encode Proglucagon-derived Peptides or Exendin 4 in the Lizard

1997 • 165 citations

Amino acid sequence and heterogeneity of gastric inhibitory polypeptide (GIP)

1981 • 164 citations

Demonstration of the Humoral Agent in Fat Inhibition of Gastric Secretion.

1930 • 164 citations

Peptones stimulate both the secretion of the incretin hormone glucagon-like peptide 1 and the transcription of the proglucagon gene.

1998 • 164 citations

Enhanced glucose-dependent insulinotropic polypeptide secretion and insulinotropic action in glucagon-like peptide 1 receptor -/- mice.

1998 • 161 citations

Cellular localization of gastric inhibitory polypeptide in the duodenum and jejunum

1973 • 159 citations

Regulation of Intestinal Proglucagon- Derived Peptide Secretion by Intestinal Regulatory Peptides*

1991 • 156 citations

Dose-response comparisons of canine plasma gastroenteropancreatic hormone responses to bombesin and the porcine gastrin-releasing peptide (GRP)

1983 • 155 citations

Both amidated and nonamidated forms of glucagon-like peptide I are synthesized in the rat intestine and the pancreas.

1990 • 154 citations

Gut incretin hormones in identical twins discordant for non-insulin-dependent diabetes mellitus (NIDDM)—evidence for decreased glucagon-like peptide 1 secretion during oral glucose ingestion in NIDDM twins

1996 • 154 citations

Emptying of the gastric substitute, glucagon-like peptide-1 (GLP-1), and reactive hypoglycemia after total gastrectomy

1991 • 154 citations

The Sulfonylurea Controversy: More Questions From the Heart 11This study was supported by a Clinician-Investigator Fellowship from General Mills, Rochester, Minnesota; by the American Heart Association, Minnesota Affiliate, Minneapolis; by the Miami Heart Research Institute, Miami, Florida; and by the Bruce and Ruth Rappaport Program in Vascular Biology and Gene Delivery, Geneva, Switzerland.

1998 • 154 citations

Initiation of Increased Pancreatic Islet Growth in Young Normoglycemic Mice (Umeå +/?)*

1999 • 153 citations

Receptors for glucagon-like peptide-1(7–36) amide on rat insulinoma-derived cells

1988 • 153 citations

Investigation of Glucose-dependent Insulinotropic Polypeptide(1-42) and Glucagon-like Peptide-1-(7-36) Degradation by Dipeptidyl Peptidase IV Using Matrix-assisted Laser Desorption/Ionization-Time of Flight Mass Spectrometry

1996 • 153 citations

The cytological characters of the areas of langerhans

1907 • 152 citations

Cloning, Functional Expression, and Chromosomal Localization of the Human Pancreatic Islet Glucose-Dependent Insulinotropic Polypeptide Receptor

1995 • 151 citations

Secretion of Proglucagon-Derived Peptides in Response to Intestinal Luminal Nutrients*

1991 • 151 citations

The inhibitory effect of glucagon-like peptide-1 (GLP-1) 7-36 amide on gastric acid secretion in humans depends on an intact vagal innervation.

1997 • 151 citations

Cloning and functional expression of the human glucagon-like peptide-1 (GLP-1) receptor

1993 • 150 citations

Microcirculation of the Islets of Langerhans: Long Beach Veterans Administration Regional Medical Education Center Symposium

1996 • 150 citations

Glucagon-Like Peptide I Reduces Postprandial Glycemic Excursions in IDDM

1995 • 147 citations

Pre-Proglucagon Messenger Ribonucleic Acid: Nucleotide and Encoded Amino Acid Sequences of the Rat Pancreatic Complementary Deoxyribonucleic Acid*

1984 • 147 citations

The role of the free cytosolic calcium level in beta-cell signal transduction by gastric inhibitory polypeptide and glucagon-like peptide I(7-37).

1993 • 146 citations

GLP-1 stimulates secretion of macromolecules from airways and relaxes pulmonary artery

1993 • 143 citations

Alpha-cell-specific expression of the glucagon gene is conferred to the glucagon promoter element by the interactions of DNA-binding proteins.

1988 • 142 citations

Glucagon-like peptide 1 (GLP-1) as a new therapeutic approach for Type 2-diabetes

2009 • 142 citations

Release of immunoreactive gastric inhibitory polypeptide (IR-GIP) by oral ingestion of food substances

1975 • 139 citations

Subcutaneous Injection of the Incretin Hormone Glucagon-Like Peptide 1 Abolishes Postprandial Glycemia in NIDDM

1994 • 138 citations

Anglerfish islet pre-proglucagon II. Nucleotide and corresponding amino acid sequence of the cDNA.

1983 • 137 citations

Glucagon and Glucagon-like Peptides in Fishes

1996 • 136 citations

GLP-1 action in L6 myotubes is via a receptor different from the pancreatic GLP-1 receptor

1998 • 136 citations

Agonist-induced internalization and recycling of the glucagon-like peptide-1 receptor in transfected fibroblasts and in insulinomas

1995 • 136 citations

Clinical Aspects of Leptin

1998 • 136 citations

Immunofluorescent localization of enteroglucagon cells in the gastrointestinal tract of the dog

1971 • 135 citations

Activation of Proglucagon Gene Transcription Through a Novel Promoter Element by the Caudal-Related Homeodomain Protein cdx-2/3

1996 • 134 citations

Leptin interacts with glucagon‐like peptide‐1 neurons to reduce food intake and body weight in rodents

1997 • 134 citations

Glucagon‐like peptide 1: A potent glycogenic hormone

1994 • 133 citations

Potent glycogenic effect of GLP-1(7?36)amide in rat skeletal muscle

1994 • 133 citations

Prevention of parenteral nutrition-induced gut hypoplasia by coinfusion of glucagon-like peptide-2

1997 • 132 citations

Circulating and Tissue Forms of the Intestinal Growth Factor, Glucagon-Like Peptide-2*

1997 • 131 citations

Leptin Suppression of Insulin Secretion and Gene Expression in Human Pancreatic Islets: Implications for the Development of Adipogenic Diabetes Mellitus

1999 • 131 citations

Proglucagon gene expression is regulated by a cyclic AMP-dependent pathway in rat intestine.

1989 • 131 citations

Rapid Oscillations in Plasma Glucagon-Like Peptide-1 (GLP-1) in Humans: Cholinergic Control of GLP-1 Secretion via Muscarinic Receptors1

1997 • 131 citations

Human pancreatic secretion and intestinal motility: effects of ileal nutrient perfusion

1990 • 130 citations

Glucose and glucoincretin peptides synergize to induce c-fos, c-jun, junB, zif-268, and nur-77 gene expression in pancreatic beta(INS-1) cells.

1998 • 130 citations

Oxyntomodulin: a potential hormone from the distal gut. Pharmacokinetics and effects on gastric acid and insulin secretion in man

1988 • 130 citations

Effects of Glucagon-Like Peptide-1 on Islet Function and Insulin Sensitivity in Noninsulin-Dependent Diabetes Mellitus¹

1997 • 129 citations

A newly discovered role of transcription factors involved in pancreas development and the pathogenesis of diabetes mellitus.

1998 • 129 citations

Glucagon-Like Peptide-1 7-36 Amide and Peptide YY from the L-Cell of the Ileal Mucosa Are Potent Inhibitors of Vagally Induced Gastric Acid Secretion in Man

1994 • 128 citations

Glucagon-Like Peptide I Increases Cytoplasmic Calcium in Insulin-Secreting βTC3-Cells by Enhancement of Intracellular Calcium Mobilization

1995 • 128 citations

Glucagon Gene Transcription Activation Mediated by Synergistic Interactions of pax-6 and cdx-2 with the p300 Co-activator

1999 • 127 citations

Functional expression of the rat pancreatic islet glucose-dependent insulinotropic polypeptide receptor: ligand binding and intracellular signaling properties.

1995 • 125 citations

Effects of an elemental diet, inert bulk and different types of dietary fibre on the response of the intestinal epithelium to refeeding in the rat and relationship to plasma gastrin, enteroglucagon, and PYY concentrations.

1987 • 124 citations

Glucagon-like peptide-1 (GLP-1): A gut hormone of potential interest in the treatment of diabetes

1998 • 124 citations

Glucagon-like peptide-1 stimulates luteinizing hormone-releasing hormone secretion in a rodent hypothalamic neuronal cell line.

1998 • 124 citations

Regulation of glucagon-like peptide-1 secretion from rat ileum by neurotransmitters and peptides

1995 • 124 citations

Evolution of the growth hormone-releasing factor (GRF) family of peptides.

1992 • 123 citations

Intraventricular GLP-1 reduces short- but not long-term food intake or body weight in lean and obese rats

1998 • 122 citations

Intestinal response to growth factors administered alone or in combination with human [Gly²]glucagon-like peptide 2

1997 • 122 citations

Elimination of the action of glucagon-like peptide 1 causes an impairment of glucose tolerance after nutrient ingestion by healthy baboons.

1996 • 122 citations

Identical mRNA for preproglucagon in pancreas and gut

1987 • 121 citations

Glucagon-like peptide 1(7-36) amide's central inhibition of feeding and peripheral inhibition of drinking are abolished by neonatal monosodium glutamate treatment.

1998 • 121 citations

The hormonal pattern of intestinal adaptation. A major role for enteroglucagon.

1982 • 120 citations

Enteral Enhancement of Glucose Disposition by Both Insulin-Dependent and Insulin-Independent Processes: A Physiological Role of Glucagon-Like Peptide I

1995 • 120 citations

Radio-immunoassays for glucagon-like peptides 1 and 2 (GLP-1 and GLP-2)

1987 • 117 citations

The effect of GIP and glucagon-like peptides on intestinal basolateral membrane hexose transport

1996 • 117 citations

Glucagon-like peptide-1-(7-36)amide and a rise in cyclic adenosine 3',5'-monophosphate increase cytosolic free Ca2+ in rat pancreatic beta-cells by enhancing Ca2+ channel activity.

1993 • 117 citations

Interactions of exendin-(9–39) with the effects of glucagon-like peptide-1-(7–36) amide and of exendin-4 on arterial blood pressure and heart rate in rats

1996 • 116 citations

Truncated glucagon-like peptide-1 interacts with exendin receptors on dispersed acini from guinea pig pancreas. Identification of a mammalian analogue of the reptilian peptide exendin-4.

1992 • 116 citations

A Gastric Inhibitory Polypeptide. I. The Amino Acid Composition and the Tryptic Peptides

1971 • 116 citations

Normalization of Insulin Responses to Glucose by Overnight Infusion of Glucagon-Like Peptide 1 (7–36) Amide in Patients With NIDDM

1996 • 115 citations

Glucagon-like peptide-1(7-36) amide (GLP-1) enhances insulin-stimulated glucose metabolism in 3T3-L1 adipocytes: one of several potential extrapancreatic sites of GLP-1 action.

1994 • 114 citations

Glucagon-like peptide 1 increases insulin sensitivity in depancreatized dogs.

1999 • 114 citations

Glucagon-Like Peptide-I and the Control of Insulin Secretion in the Normal State and in NIDDM

1993 • 114 citations

Glucagon and its Family Revisited

1995 • 114 citations

GLP-1 does not acutely affect insulin sensitivity in healthy man

1996 • 113 citations

Glucagon-Like Peptide I and Glucose-Dependent Insulinotropic Polypeptide Stimulate Ca2+-Induced Secretion in Rat α-Cells by a Protein Kinase A–Mediated Mechanism

1997 • 113 citations

Membrane depolarization and calcium influx induce glucagon gene transcription in pancreatic islet cells through the cyclic AMP-responsive element.

1993 • 112 citations

cAMP enhances insulin secretion by an action on the ATP-sensitive K+ channel-independent pathway of glucose signaling in rat pancreatic islets.

1999 • 112 citations

Comparison of Fos induced in rat brain by GLP-1 and amylin

1997 • 111 citations

Human glucagon‐like peptides 1 and 2 activate rat brain adenylate cyclase

1984 • 111 citations

Preservation of incretin activity after removal of gastric inhibitory polypeptide (GIP) from rat gut extracts by immunoadsorption

1983 • 110 citations

Identification of the intestinal cell storing gastric inhibitory peptide

1975 • 110 citations

Identification and characterization of glucagon‐like peptide‐1 7–36 amide‐binding sites in the rat brain and lung

1988 • 110 citations

Deoxycholate is an important releaser of peptide YY and enteroglucagon from the human colon.

1993 • 110 citations

Comparison of the Effects of Various C-Terminal and NTerminal Fragment Peptides of Glucagon-Like Peptide-1 on Insulin and Glucagon Release from the Isolated Perfused Rat Pancreas*

1989 • 109 citations

Identification of glucagon-like peptide 1 (GLP-1) actions essential for glucose homeostasis in mice with disruption of GLP-1 receptor signaling.

1998 • 109 citations

Role of the Prohormone Convertase PC3 in the Processing of Proglucagon to Glucagon-like Peptide 1

1997 • 109 citations

Stereospecific effects of fatty acids on proglucagon-derived peptide secretion in fetal rat intestinal cultures.

1995 • 108 citations

Gastrin-releasing peptide is a novel mediator of proximal nutrient-induced proglucagon-derived peptide secretion from the distal gut.

1996 • 108 citations

Effects of Ingestion of Triglyceride or Galactose on Secretion of Gastric Inhibitory Polypeptide and on Responses to Intravenous Glucose in Normal and Diabetic Subjects

1978 • 107 citations

Glucagon-Like Peptide-I Analogs: Effects on Insulin Secretion and Adenosine 3′,5′-Monophosphate Formation*

1990 • 106 citations

Release of Gastric Inhibitory Polypeptide (GIP) by Intraduodenal Acidification in Rats and Humans and Abolishment of the Incretin Effect of Acid by GIP-Antiserum in Rats

1979 • 105 citations

Characterization of glucagon-like peptide-1-(7–36)amide in the hypothalamus

1989 • 104 citations

Improved glucose tolerance in rats treated with the dipeptidyl peptidase IV (CD26) inhibitor Ile-thiazolidide

1999 • 104 citations

Is glucagon-like peptide 1 an incretin hormone?

1999 • 103 citations

Structure of Glucagon-Like Peptide(7-36) Amide in a Dodecylphosphocholine Micelle as Determined by 2D NMR

1994 • 102 citations

Identification and localization of glucagon-related peptides in rat brain.

1980 • 101 citations

The glucagon superfamily: Precursor structure and gene organization

1986 • 100 citations

Effect of total parenteral nutrition on gut hormone release in humans

1981 • 100 citations

Identification of Glucagon-like Peptide-2 (GLP-2)-activated Signaling Pathways in Baby Hamster Kidney Fibroblasts Expressing the Rat GLP-2 Receptor

1999 • 100 citations

Cell-specific post-translational processing of preproglucagon expressed from a metallothionein-glucagon fusion gene.

1986 • 100 citations

Regulation of glucagon-like peptide-1-(7-36) amide, peptide YY, and neurotensin secretion by neurotransmitters and gut hormones in the isolated vascularly perfused rat ileum.

1995 • 99 citations

Release of glucagon-like peptide-1 (GLP-1) by carbohydrates in the perfused rat ileum

1997 • 99 citations

Differential effects of subcutaneous GLP-1 on gastric emptying, antroduodenal motility, and pancreatic function in men.

1997 • 99 citations

Effects of Glucagon-Like Peptide-1 on Islet Function and Insulin Sensitivity in Noninsulin-Dependent Diabetes Mellitus

1997 • 98 citations

Functional receptors for the insulinotropic hormone glucagon‐like peptide‐I(7–37) on a somatostatin secreting cell line

1991 • 98 citations

The Effect of Glucagon-Like Peptide I (GLP-I) on Glucose Elimination in Healthy Subjects Depends on the Pancreatic Glucoregulatory Hormones

1996 • 98 citations

Glucose and glucoincretin peptides synergize to induce c‐fos, c‐jun,junB,zif‐268, and nur‐77gene expression in pancreatic β(INS‐1) cells

1998 • 97 citations

Localization of glucagon in the alpha cells in the pancreatic islet by immunofluorescent technics.

1962 • 97 citations

Glicentin Immunoreactive Cells: Their Relationship to Glucagon-Producing Cells*

1979 • 97 citations

Potential Therapeutic Levels of Glucagon-Like Peptide I Achieved in Humans by a Buccal Tablet

1996 • 95 citations

Trout and chicken proglucagon: alternative splicing generates mRNA transcripts encoding glucagon-like peptide 2.

1995 • 95 citations

Structure/Activity Characterization of Glucagon‐Like Peptide‐1

1994 • 94 citations

POU Domain Transcription Factor brain 4 Confers Pancreatic α-Cell-Specific Expression of the Proglucagon Gene Through Interaction with a Novel Proximal Promoter G1 Element

1997 • 94 citations

Stimulation of Release of Insulin by an Extract of Intestinal Mucosa

1966 • 94 citations

The Effects of Triglyceride Absorption upon Glucagon, Insulin, and Gut Glucagon-Like Immunoreactivity

1973 • 92 citations

Influence of Gastric Inhibitory Polypeptide Antiserum on Glucose-Induced Insulin Secretion in Rats

1982 • 91 citations

Cytochemical and ultrastructural differentiation of enteroglucagon and pancreatic-type glucagon cells of the gastrointestinal tract

1976 • 90 citations

Glucagon‐like peptide‐1(7–36) amide is a new incretin/enterogastrone candidate

1991 • 89 citations

Dual Glucagon Recognition by Pancreatic β-Cells via Glucagon and Glucagon-Like Peptide 1 Receptors

1998 • 89 citations

Glucagon-like peptide-1 (7–36)-NH2: a physiological inhibitor of gastric acid secretion in man

1990 • 89 citations

Transcriptional activation of the rat glucagon gene by the cyclic AMP-responsive element in pancreatic islet cells.

1990 • 88 citations

Distribution of Oxyntomodulin and Glucagon in the Gastrointestinal Tract and the Plasma of the Rat*

1987 • 88 citations

Effects of Aging and a High Fat Diet on Body Weight and Glucose Tolerance in Glucagon-Like Peptide-1 Receptor−/− Mice*

1998 • 87 citations

The microanatomy of the islets of langerhans

1976 • 87 citations

Isolation and structures of coho salmon (Oncorhynchus kisutch) glucagon and glucagon-like peptide

1986 • 87 citations

NEURONAL PEPTIDES IN THE INTESTINE

1982 • 87 citations

Lipolytic action of glucagon-like peptides in isolated rat adipocytes

1992 • 86 citations

Presence and characterization of glucagon-like peptide-1(7-36) amide receptors in solubilized membranes of rat adipose tissue.

1993 • 86 citations

Autoradiographic localization of receptors for glucagon-like peptide-1(7–36) amide in rat brain

1992 • 86 citations

Glucagon‐like peptide‐1 (GLP‐1): a trial of treatment in non‐insulin‐dependent diabetes mellitus

1997 • 86 citations

Nutrient-independent increases in proglucagon and ornithine decarboxylase messenger RNAs after jejunoileal resection

1992 • 85 citations

Comparison of the Effects of Glucagon-Like Peptide-1-( 1-3 7) and -(7-37) and Glucagon on Islet Hormone Release from Isolated Perfused Canine and Rat Pancreases*

1989 • 85 citations

Biological activity of GLP-1-analogues with N-terminal modifications

1999 • 85 citations

Distribution of glucagon receptors on hormone-specific endocrine cells of rat pancreatic islets.

1996 • 85 citations

Glucagon and glucagon-like peptide 1: selective receptor recognition via distinct peptide epitopes.

1994 • 84 citations

Proglucagon processing in islet and intestinal cell lines

1996 • 84 citations

Glucagonoma syndrome demonstrating giant duodenal villi.

1984 • 84 citations

The amino acid sequence of human glucagon

1972 • 83 citations

Isolation and characterization of reptilian insulin, glucagon, and pancreatic polypeptide: Complete amino acid sequence of alligator (Alligator mississippiensis) insulin and pancreatic polypeptide

1984 • 83 citations

A Multiparameter Study on the Action of Preparations Containing Cholecystokinin-Pancreozymin

1970 • 81 citations

Ileal glucagon gene expression: Ontogeny and response to massive small bowel resection

1990 • 81 citations

Insulinotropic Hormone Glucagon-Like Peptide-1-(7–37) Appears Not to Augment Insulin-Mediated Glucose Uptake in Young Men during Euglycemia¹

1998 • 81 citations

GLP-1 Tablet in Type 2 Diabetes in Fasting and Postprandial Conditions

1997 • 80 citations

Isolation and structures of glucagon and glucagon-like peptide from catfish pancreas.

1985 • 80 citations

Physiological Effect of Glucagon in Human Isolated Adipocytes

1995 • 79 citations

Leptin constrains acetylcholine-induced insulin secretion from pancreatic islets of ob/ob mice.

1997 • 79 citations

Regulation of glucagon-like peptide-1-(7-36) amide secretion by intestinal neurotransmitters and hormones in the isolated vascularly perfused rat colon.

1994 • 79 citations

Novel signal transduction and peptide specificity of glucagon-like peptide receptor in 3T3-L1 adipocytes

1997 • 79 citations

Glucagon-like peptide-1 binding to rat hepatic membranes

1995 • 79 citations

Exendin-4 Agonist and Exendin(9-39)amide Antagonist of the GLP-1(7-36)amide Effects in Liver and Muscle

1997 • 79 citations

Insulinotropic Glucagon-like Peptide-1-mediated Activation of Non-selective Cation Currents in Insulinoma Cells Is Mimicked by Maitotoxin

1997 • 78 citations

Processing of Mouse Proglucagon by Recombinant Prohormone Convertase 1 and Immunopurified Prohormone Convertase 2 in Vitro

1995 • 78 citations

Stimulation of glucagon-like peptide-1 secretion by muscarinic agonist in a murine intestinal endocrine cell line.

1994 • 78 citations

Control of Glucagon-Like Immunoreactive Peptide Secretion from Fetal Rat Intestinal Cultures*

1988 • 78 citations

Regional Expression of Epithelial Dipeptidyl Peptidase IV in the Human Intestines

1994 • 77 citations

Glucagon-like Polypeptides in Canine Brain

1979 • 76 citations

Desensitization and phosphorylation of the glucagon-like peptide-1 (GLP-1) receptor by GLP-1 and 4-phorbol 12-myristate 13-acetate.

1996 • 75 citations

Luminal glucagon-like peptide-1(7–36) amide-releasing factors in the isolated vascularly perfused rat colon

1995 • 75 citations

Intestinal growth is associated with elevated levels of glucagon-like peptide 2 in diabetic rats

1997 • 74 citations

Homologous Desensitization of the Insulinotropic Glucagon-Like Peptide-I(7–37) Receptor on Insulinoma (HIT-T15) Cells*

1991 • 74 citations

Glucagon-Like Peptide I Enhances the Insulinotropic Effect of Glibenclamide in NIDDM Patients and in the Perfused Rat Pancreas

1996 • 74 citations

Differential Regulation of the Glucagon and Insulin I Gene Promoters by the Basic Helix-Loop-Helix Transcription Factors E47 and BETA2

1998 • 73 citations

Fetal Rat Intestinal Cells in Monolayer Culture: A Newin VitroSystem to Study the Glucagon-Like Immunoreactive Peptides*

1987 • 73 citations

Glucagon-Like-Peptide-1 Secretion from Canine L-Cells Is Increased by Glucose-Dependent-Insulinotropic Peptide but Unaffected by Glucose

1998 • 73 citations

Amino Acid Sequence of Bovine Glucagon

1971 • 72 citations

Intra-islet regulation of hormone secretion by glucagon-like peptide-1-(7--36) amide

1995 • 72 citations

Glucagon-like peptide-1 binding to rat skeletal muscle

1995 • 72 citations

Mouse pancreatic beta-cells exhibit preserved glucose competence after disruption of the glucagon-like peptide-1 receptor gene.

1998 • 72 citations

The Xenopus proglucagon gene encodes novel GLP-1-like peptides with insulinotropic properties

1997 • 72 citations

Bioactive peptides from lizard venoms

1996 • 72 citations

Naturally occurring products of proglucagon 111-160 in the porcine and human small intestine.

1988 • 70 citations

Gastric Inhibitory Polypeptide (GIP) and Insulin Release after Small-Bowel Resection in Man

1980 • 70 citations

Hypersecretion of Truncated Glucagon‐like Peptide‐1 and Gastric Inhibitory Polypeptide in Obese Patients

1993 • 69 citations

Glucagon·Glucagon-like Peptide I Receptor Chimeras Reveal Domains That Determine Specificity of Glucagon Binding

1995 • 69 citations

Internalization and Homologous Desensitization of the GLP-1 Receptor Depend on Phosphorylation of the Receptor Carboxyl Tail at the Same Three Sites

1997 • 69 citations

Intestinal transit is more potently inhibited by fat in the distal (ileal brake) than in the proximal (jejunal brake) gut.

1997 • 69 citations

Renal Catabolism of Truncated Glucagon-Like Peptide 1

1993 • 69 citations

Endoproteolysis of Glucagon-like Peptide (GLP)-1(7–36) amide by Ectopeptidases in RINm5F Cells

1997 • 69 citations

GLP-1 and GLP-17-36 Amide

1991 • 69 citations

Human Glucagon-Like Peptide-1 Receptor Gene: Localization to Chromosome Band 6p21 by Fluorescence In Situ Hybridization and Linkage of a Highly Polymorphic Simple Tandem Repeat DNA Polymorphism to Other Markers on Chromosome 6

1993 • 68 citations

STUDIES ON THE PHYSIOLOGY OF SECRETIN

1930 • 68 citations

Stimulation of cloned human glucagon‐like peptide 1 receptor expressed in HEK 293 cells induces cAMP‐dependent activation of calcium‐induced calcium release

1995 • 67 citations

Characterization of high‐affinity receptors for truncated glucagon‐like peptide‐1 in rat gastric glands

1990 • 67 citations

The caudal-related Homeodomain Protein Cdx-2/3 Regulates Glucagon Gene Expression in Islet Cells

1996 • 66 citations

Insulinotropic Hormone Glucagon-Like Peptide-1-(7-37) Appears Not to Augment Insulin-Mediated Glucose Uptake in Young Men during Euglycemia

1998 • 66 citations

The Inhibitory Effect of Glucagon-Like Peptide-1 (7-36)amide on Antral Motility is Antagonized by Its N-Terminally Truncated Primary Metabolite GLP-1 (9-36)amide

1998 • 66 citations

Glucagon-like peptide-1 (GLP-1) releases thyrotropin (TSH): characterization of binding sites for GLP-1 on alpha-TSH cells.

1996 • 66 citations

A role for Ca2+-sensitive nonselective cation channels in regulating the membrane potential of pancreatic beta-cells.

1998 • 66 citations

Gut-type glucagon immunoreactivity in nerves of the rat brain

1979 • 65 citations

Somatostatin-related and glucagon-related peptides with unusual structural features from the European eel (Anguilla anguilla)

1988 • 65 citations

Mutations in the guinea pig preproglucagon gene are restricted to a specific portion of the prohormone sequence

1986 • 65 citations

Glucagon-like peptide-1(7–37)/(7–36)amide is a new incretin

1992 • 65 citations

Cloning of Complementary DNAs Encoding Islet Amyloid Polypeptide, Insulin, and Glucagon Precursors from a New World Rodent, the Degu,Octodon degus

1990 • 65 citations

Molecular forms of glucagon‐like peptides in man

1985 • 64 citations

Cloning and Functional Expression of a Human Glucagon-like Peptide-1 Receptor

1993 • 64 citations

Molecular pharmacology of somatostatin receptors

1995 • 64 citations

The Antidiabetogenic Effect of GLP-1 Is Maintained During a 7-Day Treatment Period and Improves Diabetic Dyslipoproteinemia in NIDDM Patients

1996 • 64 citations

Scanning of the Glucagon-Like Peptide-1 Receptor Localizes G Protein-Activating Determinants Primarily to the N Terminus of the Third Intracellular Loop

1997 • 64 citations

The third cytoplasmic domain of the GLP-1[7-36 amide] receptor is required for coupling to the adenylyl cyclase system.

1996 • 64 citations

GIP regulates glucose transporters, hexokinases, and glucose-induced insulin secretion in RIN 1046-38 cells

1996 • 63 citations

Influence of somatostatin and bombesin on plasma enteroglucagon and cell proliferation after intestinal resection in the rat.

1985 • 62 citations

NH2-terminally modified gastric inhibitory polypeptide exhibits amino-peptidase resistance and enhanced antihyperglycemic activity.

1999 • 62 citations

Intestinal control of human postprandial gastric function: The role of components of jejunoileal chyme in regulating gastric secretion and gastric emptying

1981 • 61 citations

Mechanisms of the antidiabetic action of subcutaneous glucagon-like peptide-1(7-36)amide in non-insulin dependent diabetes mellitus

1998 • 61 citations

Rapid Oscillations in Plasma Glucagon-Like Peptide-1 (GLP-1) in Humans: Cholinergic Control of GLP-1 Secretion via Muscarinic Receptors

1997 • 61 citations

Secretion of Glucagon-Like Peptide-1 and Reactive Hypoglycemia after Partial Gastrectomy

1994 • 61 citations

Glucagon-like peptide-1 (7–36 amide): a potent glucagonostatic and insulinotropic hormone

1988 • 61 citations

Identification of Specific Binding Sites for Glucagon-Like Peptide-1 on the Posterior Lobe of the Rat Pituitary

1995 • 60 citations

Relationship between molecular structures of sugars and their ability to stimulate the release of glucagon-like peptide-1 from canine ileal loops.

1990 • 60 citations

Glucagon gene transcription in an islet cell line is regulated via a protein kinase C-activated pathway.

1987 • 60 citations

The Mechanism of Pancreatic Secretion

1968 • 60 citations

Effect of Bombesin on Plasma Insulin, Pancreatic Glucagon, and Gut Glucagon in Man*

1983 • 59 citations

The effect of somatostatin on the response of GLI to the intraduodenal administration of glucose, protein, and fat

1975 • 59 citations

Effects of glucagon and glucagon-like peptide-1-(7-36) amide on C cells from rat thyroid and medullary thyroid carcinoma CA-77 cell line.

1996 • 59 citations

Point Mutations in the First and Third Intracellular Loops of the Glucagon-like Peptide-1 Receptor Alter Intracellular Signaling

1996 • 59 citations

Immunohistochemical localization of glucagon-like peptide 1

1987 • 59 citations

Molecular Cloning of the Helodermin and Exendin-4 cDNAs in the Lizard

1998 • 58 citations

Binding specificity and signal transduction of receptors for glucagon-like peptide-1(7–36)amide and gastric inhibitory polypeptide on RINm5F insulinoma cells

1993 • 57 citations

Failure of GLP-l(7–36)amide to affect glycogenesis in rat skeletal muscle

1995 • 57 citations

Absence of insulinotropic glucagon‐like peptide‐I(7–37) receptors on isolated rat liver hepatocytes

1991 • 57 citations

Glicentin and gastric inhibitory polypeptide immunoreactivity in endocrine cells of the gut and pancreas.

1980 • 56 citations

Glucagon-Like Peptide 1 Improves the Ability of the β-Cell to Sense and Respond to Glucose in Subjects With Impaired Glucose Tolerance

1998 • 55 citations

Effect of Glucagon-Like Peptide-1 on Gastric Somatostatin and Gastrin Secretion in the Rat

1990 • 55 citations

Reduced gastric inhibitory polypeptide but normal glucagon-like peptide 1 response to oral glucose in postmenopausal women with impaired glucose tolerance

1997 • 55 citations

Orexins: A Newly Discovered Family of Hypothalamic Regulators of Food Intake

2009 • 55 citations

Developmental and Tissue-Specific Regulation of Proglucagon Gene Expression*

1990 • 54 citations

Nucleotide sequence determination of chicken glucagon precursor cDNA

1990 • 54 citations

Stimulation of Truncated Glucagon-Like Peptide-1 Release from the Isolated Perfused Canine Ileum by Glucose Absorption

1994 • 53 citations

GLP-1 (7 - 36) Amide: Effects on Glucose Transport and Metabolism in Rat Adipose Tissue

1997 • 53 citations

Characterization of the receptor for glucagon-like peptide-1(7–36)amide on plasma membranes from rat insulinoma-derived cells by covalent cross-linking

1989 • 52 citations

Rat parietal cell receptors for GLP-1-(7-36) amide: northern blot, cross-linking, and radioligand binding

1994 • 52 citations

The isolated N‐terminal extracellular domain of the glucagon‐like peptide‐1 (GLP)‐1 receptor has intrinsic binding activity

1996 • 52 citations

Gastrin-releasing peptide (GRP) in neurones of the mammalian gut

1983 • 51 citations

The Upstream Promoter Element of the Glucagon Gene, G1, Confers Pancreatic Alpha Cell-specific Expression

1995 • 51 citations

Subcutaneous glucagon-like peptide-1 improves postprandial glycaemic control over a 3-week period in patients with early Type 2 diabetes

1998 • 51 citations

Tissue-Specific and Glucose-Dependent Expression of Receptor Genes for Glucagon and Glucagon-Like Peptide-1 (GLP-1)

1997 • 51 citations

All products of proglucagon are elevated in plasma from uremic patients.

1992 • 51 citations

Molecular cloning of a cDNA encoding for the GLP-1 receptor expressed in rat lung

2009 • 50 citations

Regulation of glucagon and glucagon-like peptide-1 receptor messenger ribonucleic acid expression in cultured rat pancreatic islets by glucose, cyclic adenosine 3',5'-monophosphate, and glucocorticoids.

1995 • 50 citations

Localization of the Domains Involved in Ligand Binding and Activation of the Glucose-Dependent Insulinotropic Polypeptide Receptor

1997 • 50 citations

Measurement of gut hormonal peptides in biopsies from human stomach and proximal small intestine.

1983 • 50 citations

Islet-specific Proteins Interact with the Insulin-response Element of the Glucagon Gene

1995 • 49 citations

Plasma Glucagon-Like Peptide-1 (7-36) Amide (GLP-1) Response to Liquid Phase, Solid Phase, and Meals of Differing Lipid Composition

1998 • 49 citations

Gene-specific Transcriptional Activity of the Insulin cAMP-responsive Element Is Conferred by NF-Y in Combination with cAMP Response Element-binding Protein

1998 • 48 citations

Release of gastric inhibitory polypeptide from cultured canine endocrine cells

1994 • 48 citations

Characterization of GIP(1–30) and GIP(1–42) as stimulators of proinsulin gene transcription

1995 • 48 citations

A role for central glucagon-like peptide-1 in temperature regulation

1996 • 48 citations

Five Out of Six Tryptophan Residues in the N -Terminal Extracellular Domain of the Rat GLP-1 Receptor Are Essential for its Ability to Bind GLP-1

1997 • 48 citations

Regulation of glucose transporters and hexose uptake in 3T3-L1 adipocytes: glucagon-like peptide-1 and insulin interactions

1997 • 48 citations

Primary structure of glucagon from an elasmobranchian fish, Torpedo marmorata

1985 • 47 citations

The Caudal Homeobox Protein cdx-2/3 Activates Endogenous Proglucagon Gene Expression in InR1-G9 Islet Cells

1997 • 47 citations

Insulinotropic glucagonlike peptide-I(7–37)/(7–36)amide A new incretin hormone

1992 • 47 citations

IS A DUODENAL HORMONE INVOLVED IN CARBOHYDRATE METABOLISM?

1940 • 46 citations

Crystallization and amino acid sequence of duck glucagon

1972 • 46 citations

Chicken glucagon. Isolation and amino acid sequence studies.

1975 • 46 citations

Alterations in proglucagon processing and inhibition of proglucagon gene expression in transgenic mice which contain a chimeric proglucagon-SV40 T antigen gene.

1992 • 45 citations

Desensitization and phosphorylation of the glucagon-like peptide-1 (GLP- 1) receptor by GLP-1 and 4-phorbol 12-myristate 13-acetate

1996 • 45 citations

Oxyntomodulin and Glicentin: Brain-Gut Peptides in the Rat*

1988 • 45 citations

The proglucagon gene upstream enhancer contains positive and negative domains important for tissue-specific proglucagon gene transcription.

1995 • 45 citations

Glucagonlike Peptide-I-(7–36)-Amide Receptors Only in Islets of Langerhans: Autoradiographic Survey of Extracerebral Tissues in Rats

1991 • 45 citations

Proglucagon Processing in an Islet Cell Line: Effects of PC1 Overexpression and PC2 Depletion¹

1998 • 44 citations

Heterologous Desensitization of the Glucagon-like Peptide-1 Receptor by Phorbol Esters Requires Phosphorylation of the Cytoplasmic Tail at Four Different Sites

1996 • 44 citations

Morphologic and physiologic studies of canine ileal enteroglucagon-containing cells in short-term culture

1987 • 43 citations

Isolation and structural characterization of insulin, glucagon and somatostatin from the turtle, Pseudemys scripta

1990 • 43 citations

Effect of truncated glucagon‐like peptide 1 on cAMP in rat gastric glands and HGT‐1 human gastric cancer cells

1988 • 43 citations

Characterization of receptors for glucagon‐like peptide‐1(7–36) amide on rat lung membranes

1990 • 43 citations

Glucagon and Related Peptides in Fetal Rat Hypothalamusin Vivoandin Vitro*

1990 • 43 citations

chimeric peptides define the structural requirements for specific ligand-receptor interaction of GLP-1

1996 • 42 citations

Transcription of the Rat Glucagon Gene by the Cyclic AMP Response Element-Binding Protein CREB Is Modulated by Adjacent CREB-Associated Proteins

1993 • 42 citations

Truncated glucagon‐like peptide‐1 (proglucagon 78–107 amide), an intestinal insulin‐releasing peptide, has specific receptors on rat insulinoma cells (RIN 5AH)

1988 • 41 citations

Evolution of glucagon genes.

1984 • 41 citations

A comparison of the ability of serum and monoclonal antibodies to gastric inhibitory polypeptide to detect immunoreactive cells in the gastroenteropancreatic system of mammals and reptiles

1982 • 41 citations

How glucagon-like is glucagon-like peptide-1?

1984 • 41 citations

Glucagon-Like Peptide-1-(7–36)Amide Increases Pulmonary Surfactant Secretion through a Cyclic Adenosine 3′,5′-Monophosphate-Dependent Protein Kinase Mechanism in Rat Type II Pneumocytes*

1998 • 40 citations

Effects of Glucagon-Like Peptide 1 on the Kinetics of Glycogen Synthase a in Hepatocytes from Normal and Diabetic Rats*

1998 • 40 citations

Homologous DNA Sequences and Cellular Factors Are Implicated in the Control of Glucagon and Insulin Gene Expression

1995 • 40 citations

Multiple molecular forms of insulin and glucagon-like peptide from the pacific ratfish (Hydrolagus colliei)

1989 • 39 citations

Characterization of insulins and proglucagon-derived peptides from a phylogenetically ancient fish, the paddlefish (Polyodon spathula)

1994 • 39 citations

The Positive Charge of the Imidazole Side Chain of Histidine7 Is Crucial for GLP-1 Action.

1997 • 39 citations

Preserved GLP-I Effects on Glycogen Synthase a Activity and Glucose Metabolism in Isolated Hepatocytes and Skeletal Muscle From Diabetic Rats

1997 • 39 citations

Glucose, Insulin, Pancreatic Glucagon and Glucagon-like Immunoreactive Materials in the Plasma of Normal and Diabetic Children. Effect of the Initial Insulin Treatment

1975 • 39 citations

Glucagon-like peptide-1 does not have a role in hepatic carbohydrate metabolism

1985 • 39 citations

Multiple cis-acting domains mediate basal and adenosine 3',5'-monophosphate-dependent glucagon gene transcription in a mouse neuroendocrine cell line.

1993 • 39 citations

Inhibition of pancreatic glucagon gene expression in mice bearing a subcutaneous glucagon-producing GLUTag transplantable tumor.

1992 • 38 citations

GIP and GLP-1(7–36)amide secretion in response to intraduodenal infusions of nutrients in pigs

1995 • 38 citations

Primary structures of three fragments of proglucagon from the pancreatic islets of the daddy Sculpin (Cottus scorpius)

1987 • 38 citations

Structure–activity relationships of glucagon-like peptide-1(7–36)amide: insulinotropic activities in perfused rat pancreases, and receptor binding and cyclic AMP production in RINm5F cells

1994 • 38 citations

Reduced Insulinotropic Effects of Glucagonlike Peptide I-(7–36)-Amide and Gastric Inhibitory Polypeptide in Isolated Perfused Diabetic Rat Pancreas

1990 • 38 citations

Synthesis and secretion of glucagon-like peptide-1 by fetal rat intestinal cells in culture

1995 • 37 citations

Characterization of glucagon‐like peptide‐I(7–36)amide receptors of rat lung membranes by covalent cross‐linking

1991 • 37 citations

The amino terminal domain of the glucagon-like peptide-1 receptor is a critical determinant of subtype specificity.

1996 • 37 citations

Turkey Glucagon: Crystallization, Amino Acid Composition and Immunology

2009 • 37 citations

Glucagon-like peptide-1(7–37) has a larger volume of distribution than glucagon-like peptide-1(7–36)amide in dogs and is degraded more quickly in vitro by dog plasma

1996 • 36 citations

Isolation of alligator gar (Lepisosteus spatula) glucagon, oxyntomodulin, and glucagon-like peptide: Amino acid sequences of oxyntomodulin and glucagon-like peptide

1988 • 36 citations

Glucagon-like peptide-1(7-36) amide enhances insulin-stimulated glucose uptake and decreases intracellular cAMP content in isolated rat adipocytes

1996 • 36 citations

Gastric inhibitory polypeptide release from a tumor-derived cell line

1995 • 36 citations

The relation of the duodenal mucosa to the internal secretion of the pancreas

1932 • 35 citations

Response of truncated glucagon-like peptide-1 and gastric inhibitory polypeptide to glucose ingestion in non-insulin dependent diabetes mellitus

1995 • 34 citations

Human Glucagon-Like Peptide-1 Receptor Gene in NIDDM: Identification and Use of Simple Sequence Repeat Polymorphisms in Genetic Analysis

1994 • 34 citations

Inositolphosphoglycans possibly mediate the effects of glucagon-like peptide-1(7-36)amide on rat liver and adipose tissue

1998 • 34 citations

Tissue-Specific Differences in the Levels of Proglucagon-Derived Peptides in Streptozotocin-Induced Diabetes*

1989 • 34 citations

Immunoassayable Gastric Inhibitory Polypeptide: Investigations into its Role in Carbohydrate Metabolism

1979 • 34 citations

Sympathetic pathways mediate GLP-1 actions in the gastrointestinal tract of the rat

1998 • 34 citations

Subcutaneous Glucagon-Like Peptide I Combined With Insulin Normalizes Postcibal Glycemic Excursions in IDDM

1997 • 34 citations

Glucagon-like peptide-1(7–36)amide: characterization of the domain responsible for binding to its receptor on rat insulinoma RINm5F cells

1990 • 33 citations

Ligand-specificity of the rat GLP-I receptor recombinantly expressed in Chinese hamster ovary (CHO-) cells.

1994 • 32 citations

Therapeutic potential of glucagon-like peptide 1 in type 2 diabetes.

1996 • 32 citations

Characterization of a Novel Protein Kinase C Response Element in the Glucagon Gene

1997 • 31 citations

Comparison of GLP-1 (7-36amide) and GIP on release of somatostatin-like immunoreactivity and insulin from the isolated rat pancreas.

1990 • 31 citations

Hepatocyte-nuclear factor 3 beta gene transcripts generate protein isoforms with different transactivation properties on the glucagon gene.

1995 • 31 citations

Extrapancreatic action of truncated glucagon-like peptide-I in otsuka long-evans tokushima fatty rats, an animal model for non—insulin-dependent diabetes mellitus

1997 • 31 citations

Structural requirements for biological activity of glucagon‐like peptide‐I

1992 • 31 citations

Evidence for redundancy in propeptide/prohormone convertase activities in processing proglucagon: an antisense study.

1996 • 31 citations

New treatments for patients with type 2 diabetes mellitus

1996 • 31 citations

Isolation and Structural Characterization of Proglucagon-Derived Peptides, Pancreatic Polypeptide, and Somatostatin from the UrodeleAmphiuma tridactylum

1996 • 31 citations

Gene Expression of the Human Glucagon-Like Peptide-1 Receptor Is Regulated by Sp1 and Sp3¹

1999 • 30 citations

Fatty acids stereospecifically stimulate neurotensin release and increase [Ca2+]i in enteric endocrine cells

1991 • 30 citations

Über das insulotrope Hormon der Darmschleimhaut (Duodenin)

1934 • 30 citations

Ontogeny of immunoreactive glicentin in the human gastrointestinal tract and endocrine pancreas

1982 • 30 citations

Transcription of the rat glucagon gene by the cyclic AMP response element-binding protein CREB is modulated by adjacent CREB-associated proteins.

1993 • 30 citations

LOCALIZATION OF REGULATORY PEPTIDES IN THE GUT

1982 • 30 citations

Primary Structures of Glucagon and Glucagon-like Peptide Isolated from the Intestine of the Parasitic Phase Lamprey Petromyzon marinus

1993 • 29 citations

Participation of the Jejunum and Ileum in Postprandial Gastric Secretion in Man

1977 • 29 citations

Galanin is a potent inhibitor of glucagon-like peptide-1 secretion from rat ileum

1996 • 29 citations

The distribution of endocrine cells along the mouse intestine: A quantitative immunocytochemical study

1988 • 29 citations

Glucagon-like peptide-I-(7–37) suppresses hyperglycemia in rats

1993 • 29 citations

Effects of glucagon like-1(7–36)amide on the ctoplasmic Ca2+-concentration in rat islet cells

1993 • 29 citations

Non-linkage of the glucagon-like peptide 1 receptor gene with maturity onset diabetes of the young

1994 • 29 citations

Exchange of W39 by A within the N-terminal extracellular domain of the GLP-1 receptor results in a loss of receptor function

1996 • 28 citations

Cloning and Characterization of the 5′ Flanking Sequences (Promoter Region) of the Human GLP-1 Receptor Gene

1997 • 28 citations

Drugs on the Horizon for Treatment of Type 2 Diabetes

1995 • 27 citations

The Use of Perfused Rat Intestine to Characterise the Glucagon-Like Immunoreactivity Released into Serosal Secretions Following Stimulation by Glucose

1979 • 27 citations

Somatostatin and muscarinic inhibition of canine enteric endocrine cells: cellular mechanisms

1987 • 27 citations

Insulin Response and Glucose-C14 Disappearance Rate During the Glucose Tolerance Test in the Unanesthetized Dog

1963 • 27 citations

Gastric inhibitory polypeptide and glucagon-like peptide-1(7–36) amide exert similar effects on somatostatin secretion but opposite effects on gastrin secretion from the rat stomach

1994 • 27 citations

Inositolphosphoglycans and diacylglycerol are possible mediators in the glycogenic effect of GLP‐1(7‐36)amide in BC3H‐1 myocytes

1996 • 27 citations

Primary structures of peptides derived from proglucagon isolated from the pancreas of the elasmobranch fish, Scyliorhinus canicula

1994 • 26 citations

Primary structure of insulin and glucagon from the flounder (Platichthys flesus)

1987 • 26 citations

Inositolphosphoglycans are possible mediators of the glucagon-like peptide 1 (7–36)amide action in the liver

1996 • 26 citations

Influence of vagal integrity on gastrin and somatostatin release in dogs

1987 • 24 citations

The Structure-Function Relationship of GLP-1 Related Peptides in the Endocrine Function of the Canine Pancreas.

1991 • 24 citations

Dipeptidyl peptidase IV expression in rat jejunal crypt-villus axis is controlled at mRNA level

1991 • 24 citations

Primary structure of glucagon from the gut of the common dogfish (Scyliorhinus canicula)

1987 • 23 citations

Structure and biological activity of glucagon and glucagon-like peptide from a primitive bony fish, the bowfin (Amia calva)

1993 • 22 citations

Pituitary adenylate cyclase-activating polypeptide receptors of types I and II and glucagon-like peptide-I receptors are expressed in the rat medullary carcinoma of the thyroid cell line 6/23.

1994 • 22 citations

Blood Glucose Lowering and Glucagonostatic Effects of Glucagon-Like Peptide I in Insulin-Deprived Diabetic Dogs

1997 • 22 citations

Carboxypeptidase‐B‐like processing of the C‐terminus of glucagon‐like peptide‐2 in pig and human small intestine

1989 • 22 citations

Über den blutzuckerwirksamen Stoff in Sekretinextrakten

1929 • 22 citations

Alterations of plasma immunoreactive glucagon-like peptide-1 behavior in non-insulin-dependent diabetics

1990 • 21 citations

Comparative effects of GLP-1-(7-36) amide, oxyntomodulin and glucagon on rabbit gastric parietal cell function

1995 • 21 citations

Overnight GLP-1 normalizes fasting but not daytime plasma glucose levels in NIDDM patients

2009 • 20 citations

Identification of Glucagon-Like Peptide-1(7–36) Amide in Rat Brain

1989 • 20 citations

Rabbit Glucagon: Isolation, Crystallization and Amino Acid Composition

1972 • 20 citations

Intestinal glucagon mRNA identified by hybridization to a cloned islet cDNA encoding a precursor

1981 • 20 citations

Release of glucagon-like peptide 1 immunoreactivity from the perfused rat pancreas

1987 • 20 citations

Camel Glucagon: Isolation, Crystallization and Amino Acid Composition

1974 • 19 citations

Gut glucagon-like immunoreactants.

1980 • 19 citations

Increased ileal proglucagon expression after jejunectomy is not suppressed by inhibition of bowel growth

1996 • 19 citations

Evidence for redundancy in propeptide/prohormone convertase activities in processing proglucagon: an antisense study

1996 • 19 citations

Chromatographic pattern of extrapancreatic glucagon and glucagon-like immunoreactivity before and during stimulation by epinephrine and participation of glucagon in epinephrine-induced hepatic glucose overproduction.

1981 • 18 citations

Glucagon-like immunoreactivity in hypothalamic neurons of the rat

1990 • 18 citations

Ligand-Induced Regulation of Glucagon-like Peptide-I Receptor Function and Expression in Insulin-Secreting β Cells

1996 • 18 citations

Glucose-dependent stimulatory effect of glucagon-like peptide 1(7-36) amide on the electrical activity of pancreatic beta-cells recorded in vivo.

1999 • 18 citations

Isolation and structural characterization of insulin and glucagon from the holocephalan species Callorhynchus milii (elephantfish)

1989 • 18 citations

Elevated gut glucagon-like immunoreactive material in human and experimental diabetes and its suppression by somatostatin

1976 • 18 citations

Leptin Sensitivity in Nonobese Glucagon-Like Peptide I Receptor −/− Mice

1997 • 17 citations

Untitled

1997 • 17 citations

Altered Glucose Dependence of Glucagon-Like Peptide I(7–36)–Induced Insulin Secretion from the Zucker (fa/fa) Rat Pancreas

1995 • 17 citations

Gut Glucagon-like Immunoreactants

1980 • 17 citations

The newly developed sulfonylurea glimepiride: a new ingredient, an old recipe

1998 • 17 citations

Decrease in Blood Glucose and Release of Gut Glucagon-like Immunoreactive Materials by Bombesin Infusion in the Dog

1980 • 17 citations

Highly Increased Insulin Secretion in a Patient with Postprandial Hypoglycemia: Role of Glucagon-Like Peptlde-1 (7-36) Amide.

1995 • 17 citations

Response of plasma glicentin to fat ingestion in piglets

1987 • 17 citations

Hyperglycaemia but not hyperinsulinaemia prevents the secretion of glucagon-like peptide-1 (7-36 amide) stimulated by fat ingestion

1991 • 17 citations

Galanin inhibits glucagon-like peptide-1 secretion through pertussis toxin-sensitive G protein and ATP-dependent potassium channels in rat ileal L-cells

1998 • 16 citations

The proglucagon gene upstream enhancer contains positive and negative domains important for tissue-specific proglucagon gene transcription

1995 • 16 citations

Chromatographic Pattern of Gut Glucagon-Like Immunoreactivity (GLI) in Plasma before and during Glucose Absorption

1979 • 15 citations

The Action of Intestinal Extracts

1926 • 15 citations

Glucagon-like peptide 1 immunoreactivity in gastroentero-pancreatic endocrine tumors: a light- and electron-microscopic study

1994 • 15 citations

Inhibition of pancreatic exocrine secretion and augmentation of the release of gut glucagon-like immunoreactive materials by intraileal administration of bile in the dog

1983 • 15 citations

Glucagon-related peptides in the rat hypothalamus

1986 • 14 citations

Glucagon Gene G3 Enhancer: Evidence that Activity Depends on Combination of an Islet-Specific Factor and a Winged Helix Protein

1997 • 13 citations

IMMUNOCYTOCHEMICAL LOCALIZATION OF GASTRIC INHIBITORY PEPTIDE AND GLUCAGON IN THE ALIMENTARY TRACT OF RUMINANTS

1986 • 13 citations

Diurnal Profile of Oxyntomodulin-like Immunoreactivity in Duodenal Ulcer Patients

1993 • 11 citations

Identification of amidated forms of GLP-1 in rat tissues using a highly sensitive radioimmunoassay

1997 • 11 citations

Opossum insulin, glucagon and pancreatic polypeptide: Amino acid sequences

1989 • 11 citations

The Glucagon/Glucagon-Like lmmunoreactivities in Neurons of the Human Brain⁴)

2009 • 11 citations

Response of gut glucagon-like immunoreactivity to hypoglycemia in dogs

1989 • 10 citations

<b>FIVE pS ANION CHANNELS IN HUMAN AIRWAY EPITHELIAL CELLS </b>

1992 • 10 citations

Rhesus monkey gastroenteropancreatic hormones: relationship to human sequences

1991 • 8 citations

Contribution of a PS1‐like element to the tissue‐ and cell‐specific expression of the human GLP‐1 receptor gene

1998 • 8 citations

Release of Glucagon-Like Immunoreactive Material (GLI) from the Isolated Perfused Jejunum of Normal and Diabetic Rats

1985 • 7 citations

Purification and primary structure of glucagon from ostrich pancreas splenic lobes

1991 • 7 citations

Regulation of glucagon-like peptide-I receptor expression and transcription by the protein kinase C pathway

1996 • 4 citations

Deleted Work

1955 • 0 citations