Exendin-4 is a high potency agonist and truncated exendin-(9-39)-amide an antagonist at the glucagon-like peptide 1-(7-36)-amide receptor of insulin-secreting beta-cells.

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

Preserved incretin activity of glucagon-like peptide 1 [7-36 amide] but not of synthetic human gastric inhibitory polypeptide in patients with type-2 diabetes mellitus.

1993 • 1,579 citations

Isolation and characterization of exendin-4, an exendin-3 analogue, from Heloderma suspectum venom. Further evidence for an exendin receptor on dispersed acini from guinea pig pancreas.

1992 • 912 citations

Expression cloning of the pancreatic beta cell receptor for the gluco-incretin hormone glucagon-like peptide 1.

1992 • 880 citations

Antidiabetogenic Effect of Glucagon-like Peptide-1 (7–36)amide in Normal Subjects and Patients with Diabetes Mellitus

1992 • 858 citations

The incretin concept today

1979 • 730 citations

Glucagon‐like peptide‐1 cells in the gastrointestinal tract and pancreas of rat, pig and man

1992 • 620 citations

Pancreatic beta-cells are rendered glucose-competent by the insulinotropic hormone glucagon-like peptide-1(7-37)

1993 • 576 citations

AN IMPROVED METHOD FOR ISOLATION OF MOUSE PANCREATIC ISLETS

1985 • 548 citations

Insulinotropic hormone glucagon-like peptide-I(7-37) stimulation of proinsulin gene expression and proinsulin biosynthesis in insulinoma beta TC-1 cells.

1992 • 323 citations

Regulation of immunoreactive-insulin release from a rat cell line (RINm5F)

1983 • 240 citations

Correlation between cytosolic free Ca2+ and insulin release in an insulin-secreting cell line.

1984 • 199 citations

Receptors for glucagon-like peptide-1(7–36) amide on rat insulinoma-derived cells

1988 • 153 citations

Truncated glucagon-like peptide-1 interacts with exendin receptors on dispersed acini from guinea pig pancreas. Identification of a mammalian analogue of the reptilian peptide exendin-4.

1992 • 116 citations

Amino acid sequences of helospectins, new members of the glucagon superfamily, found in Gila monster venom.

1984 • 105 citations

Glucagon‐like peptide‐1(7–36) amide is a new incretin/enterogastrone candidate

1991 • 89 citations

Adaptation of muscle to creatine depletion: effect on GLUT-4 glucose transporter expression

1993 • 88 citations

Purification and structure of exendin-3, a new pancreatic secretagogue isolated from Heloderma horridum venom

1990 • 69 citations

Purification of a novel pancreatic secretory factor (PSF) and a novel peptide with VIP‐ and secretin‐like properties (helodermin) from Gila monster venom

1984 • 68 citations

Glucagon-like peptide-1(7–37)/(7–36)amide is a new incretin

1992 • 65 citations

Exendin-3, a novel peptide from Heloderma horridum venom, interacts with vasoactive intestinal peptide receptors and a newly described receptor on dispersed acini from guinea pig pancreas. Description of exendin-3(9-39) amide, a specific exendin receptor antagonist.

1991 • 64 citations

Characterization of the receptor for glucagon-like peptide-1(7–36)amide on plasma membranes from rat insulinoma-derived cells by covalent cross-linking

1989 • 52 citations

Insulinotropic glucagonlike peptide-I(7–37)/(7–36)amide A new incretin hormone

1992 • 47 citations

Characterization of receptors for glucagon‐like peptide‐1(7–36) amide on rat lung membranes

1990 • 43 citations

Characterization of glucagon‐like peptide‐I(7–36)amide receptors of rat lung membranes by covalent cross‐linking

1991 • 37 citations

CORRELATION OF THE 24-HOUR RADIOIODINE UPTAKE OF THE HUMAN THYROID GLAND WITH THE SIX- AND EIGHT-HOUR UPTAKES AND THE “ACCUMULATION GRADIENT”

1951 • 33 citations

Solubilization of active GLP‐1 (7–36)amide receptors from RINm5F plasma membranes

1992 • 33 citations

Exendin-3 and -4 are insulin secretagogues

1992 • 10 citations

Helodermin and islet hormone release in isolated rat pancreas

1991 • 7 citations