Heterologous Desensitization of the Glucagon-like Peptide-1 Receptor by Phorbol Esters Requires Phosphorylation of the Cytoplasmic Tail at Four Different Sites

THE ATTRACTIONS OF PROTEINS FOR SMALL MOLECULES AND IONS

1949 • 19,979 citations

Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase

1988 • 6,107 citations

[42] Detection and quantification of phosphotyrosine in proteins

1983 • 1,184 citations

β-Arrestin: a Protein that Regulates β-adrenergic Receptor Function

1990 • 1,162 citations

Expression cloning of the pancreatic beta cell receptor for the gluco-incretin hormone glucagon-like peptide 1.

1992 • 880 citations

Beta-adrenergic receptor kinase: identification of a novel protein kinase that phosphorylates the agonist-occupied form of the receptor.

1986 • 650 citations

Truncated glucagon‐like peptide I, an insulin‐releasing hormone from the distal gut

1987 • 566 citations

Beta-arrestin2, a novel member of the arrestin/beta-arrestin gene family.

1992 • 531 citations

Structure and mechanism of the G protein-coupled receptor kinases.

1993 • 480 citations

Removal of phosphorylation sites from the β2-adrenergic receptor delays onset of agonist-promoted desensitization

1988 • 429 citations

Multisite and hierarchal protein phosphorylation

1991 • 419 citations

Multiple pathways of rapid beta 2-adrenergic receptor desensitization. Delineation with specific inhibitors.

1990 • 393 citations

Receptor-specific desensitization with purified proteins. Kinase dependence and receptor specificity of beta-arrestin and arrestin in the beta 2-adrenergic receptor and rhodopsin systems.

1992 • 330 citations

A general method of site-specific mutagenesis using a modification of the Thermus aquaticus polymerase chain reaction

1989 • 321 citations

Glucagonlike Peptide I (7–37) Actions on Endocrine Pancreas

1989 • 254 citations

Overexpression of beta-arrestin and beta-adrenergic receptor kinase augment desensitization of beta 2-adrenergic receptors.

1993 • 234 citations

The receptor kinase family: primary structure of rhodopsin kinase reveals similarities to the beta-adrenergic receptor kinase.

1991 • 189 citations

Gut hormones and diabetes mellitus

1992 • 182 citations

Phosphorylation of the Na,K-ATPase alpha-subunit by protein kinase A and C in vitro and in intact cells. Identification of a novel motif for PKC-mediated phosphorylation.

1994 • 172 citations

Phosphorylation and Activation of β-Adrenergic Receptor Kinase by Protein Kinase C

1995 • 160 citations

Agonist-induced internalization and recycling of the glucagon-like peptide-1 receptor in transfected fibroblasts and in insulinomas

1995 • 136 citations

Differential expression of the beta-adrenergic receptor modifies agonist stimulation of adenylyl cyclase: a quantitative evaluation.

1994 • 107 citations

cAMP-dependent protein kinase and protein kinase C consensus site mutations of the beta-adrenergic receptor. Effect on desensitization and stimulation of adenylylcyclase.

1994 • 87 citations

Signal transduction by the cloned glucagon-like peptide-1 receptor: comparison with signaling by the endogenous receptors of beta cell lines.

1994 • 78 citations

Desensitization and phosphorylation of the glucagon-like peptide-1 (GLP-1) receptor by GLP-1 and 4-phorbol 12-myristate 13-acetate.

1996 • 75 citations

Molecular Biology of Diabetes

1994 • 69 citations

Identification of a specific domain in the beta-adrenergic receptor required for phorbol ester-induced inhibition of catecholamine-stimulated adenylyl cyclase.

1990 • 44 citations