The caudal-related Homeodomain Protein Cdx-2/3 Regulates Glucagon Gene Expression in Islet Cells

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Molecular cloning: A laboratory manual

1990 • 85,659 citations

Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.

1979 • 54,907 citations

A new technique for the assay of infectivity of human adenovirus 5 DNA

1973 • 9,740 citations

Point mutations define a sequence flanking the AUG initiator codon that modulates translation by eukaryotic ribosomes

1986 • 4,785 citations

Insulin-promoter-factor 1 is required for pancreas development in mice

1994 • 1,789 citations

Establishment of a Pancreatic β Cell Line That Retains Glucose-Inducible Insulin Secretion: Special Reference to Expression of Glucose Transporter Isoforms*

1990 • 1,212 citations

Establishment of 2-mercaptoethanol-dependent differentiated insulin-secreting cell lines.

1992 • 1,128 citations

IPF1, a homeodomain-containing transactivator of the insulin gene.

1993 • 882 citations

HOMEODOMAIN PROTEINS

1994 • 828 citations

Preproglucagon gene expression in pancreas and intestine diversifies at the level of post-translational processing.

1986 • 686 citations

Insulin gene enhancer binding protein Isl-1 is a member of a novel class of proteins containing both a homeo-and a Cys–His domain

1990 • 684 citations

Multiple hepatocyte-enriched nuclear factors function in the regulation of transthyretin and alpha 1-antitrypsin genes.

1989 • 545 citations

Beta-cell lines derived from transgenic mice expressing a hybrid insulin gene-oncogene.

1988 • 523 citations

An Intestine-Specific Homeobox Gene Regulates Proliferation and Differentiation

1996 • 508 citations

The sequence specificity of homeodomain-DNA interaction

1988 • 501 citations

IDX-1: a new homeodomain transcription factor expressed in rat pancreatic islets and duodenum that transactivates the somatostatin gene.

1994 • 427 citations

A Homeodomain Protein Related to caudal Regulates Intestine-Specific Gene Transcription

1994 • 399 citations

Synergistic activation of the insulin gene by a LIM-homeo domain protein and a basic helix-loop-helix protein: building a functional insulin minienhancer complex.

1992 • 396 citations

Expression of the homeobox Hox-4 genes and the specification of position in chick wing development

1991 • 394 citations

Insulin synthesis in a clonal cell line of simian virus 40-transformed hamster pancreatic beta cells.

1981 • 381 citations

Characterization of somatostatin transactivating factor-1, a novel homeobox factor that stimulates somatostatin expression in pancreatic islet cells.

1993 • 332 citations

Identification of a novel lymphoid specific octamer binding protein (OTF-2B) by proteolytic clipping bandshift assay (PCBA).

1988 • 284 citations

Structure of the murine homeobox gene cdx-2. Expression in embryonic and adult intestinal epithelium.

1994 • 270 citations

Glucagon gene expression in vertebrate brain.

1988 • 252 citations

Isolation of caudal , a Drosophila homeo box-containing gene with maternal expression, whose transcripts form a concentration gradient at the pre-blastoderm stage

1985 • 238 citations

Regulation of transcription and cell identity by POU domain proteins

1991 • 233 citations

Expression of T Cell Antigen Receptor Heterodimers in a Lipid-Linked Form

1990 • 224 citations

Transcriptional regulation of the human insulin gene is dependent on the homeodomain protein STF1/IPF1 acting through the CT boxes.

1994 • 207 citations

Caenorhabditis elegans has scores of homoeobox-containing genes

1989 • 197 citations

CAT vectors for analysis of eukaryotic promoters and enhancers

1986 • 184 citations

Murine Cdx-4 bears striking similarities to the Drosophila caudal gene in its homeodomain sequence and early expression pattern

1993 • 169 citations

Glucagon gene regulatory region directs oncoprotein expression to neurons and pancreatic a cells

1988 • 161 citations

Pancreatic beta cells express a diverse set of homeobox genes.

1994 • 156 citations

Glucagon gene 5'-flanking sequences direct expression of simian virus 40 large T antigen to the intestine, producing carcinoma of the large bowel in transgenic mice.

1992 • 143 citations

Alpha-cell-specific expression of the glucagon gene is conferred to the glucagon promoter element by the interactions of DNA-binding proteins.

1988 • 142 citations

Hepatocyte nuclear factor 1 alpha is expressed in a hamster insulinoma line and transactivates the rat insulin I gene.

1992 • 139 citations

Insulin regulation of the glucagon gene is mediated by an insulin-responsive DNA element.

1991 • 136 citations

Activation of Proglucagon Gene Transcription Through a Novel Promoter Element by the Caudal-Related Homeodomain Protein cdx-2/3

1996 • 134 citations

Glucose modulates the binding activity of the β-cell transcription factor IUF1 in a phosphorylation-dependent manner

1994 • 134 citations

Proglucagon Processing Similar to Normal Islets in Pancreatic α-Like Cell Line Derived From Transgenic Mouse Tumor

1990 • 134 citations

The caudal gene product is a direct activator of fushi tarazu transcription during Drosophila embryogenesis

1989 • 133 citations

Multipotential phenotypic expression of genes encoding peptide hormones in rat insulinoma cell lines.

1987 • 124 citations

Isolation and characterization of target sequences of the chickenCdxAhomeobox gene

1993 • 122 citations

Identical mRNA for preproglucagon in pancreas and gut

1987 • 121 citations

Hox-1.6: a mouse homeo-box-containing gene member of the Hox-1 complex.

1987 • 119 citations

Isolation of glucagon-secreting cell lines by cloning insulinoma cells

1986 • 112 citations

The LIM Domain Homeobox Gene isl-1 Is a Positive Regulator of Islet Cell-specific Proglucagon Gene Transcription

1995 • 110 citations

Checklist: Vertebrate homeo☐ genes

1996 • 100 citations

Sequence analysis of the murine Hox-2.2, −2.3, and −2.4 homeo boxes: Evolutionary and structural comparisons

1987 • 91 citations

The homeodomain protein IPF-1/STF-1 is expressed in a subset of islet cells and promotes rat insulin 1 gene expression dependent on an intact E1 helix-loop-helix factor binding site

1995 • 91 citations

Clonal Analysis of Insulin and Somatostatin Secretionand L-Dopa Decarboxylase Expression by a Rat Islet Cell Tumor*

1983 • 90 citations

Dorsal-Ventral Differences in Xcad-3 Expression in Response to FGF-Mediated Induction in Xenopus

1994 • 78 citations

Cooperative binding of an Ultrabithorax homeodomain protein to nearby and distant DNA sites.

1993 • 75 citations

Murine Hox-1.7 homeo-box gene: cloning, chromosomal location, and expression.

1987 • 74 citations

The Caudal ‐Type Homeobox Protein Cdx‐2 Binds to the Colon Promoter of the Carbonic Anhydrase 1 Gene

1996 • 72 citations

B-cell size influences glucose-stimulated insulin secretion

1993 • 66 citations

Isolation, Characterization, and Precise Physical Localization of Human CDX1, a caudal-Type Homeobox Gene

1995 • 65 citations

Comparison of mouse and human HOX-4 complexes defines conserved sequences involved in the regulation of Hox-4.4.

1992 • 65 citations

Genetic and Biochemical Analysis of Alternative RNA Splicing

1994 • 63 citations

Isolation and characterization of the murine homeobox gene Cdx-1. Regulation of expression in intestinal epithelial cells.

1993 • 58 citations

A maternal homeobox gene, Bombyx caudal, forms both mRNA and protein concentration gradients spanning anteroposterior axis during gastrulation

1994 • 56 citations

Cooperative DNA Binding of the Human HoxB5 (Hox-2.1) Protein Is Under Redox Regulation In Vitro

1993 • 55 citations

The Upstream Promoter Element of the Glucagon Gene, G1, Confers Pancreatic Alpha Cell-specific Expression

1995 • 51 citations

Islet-specific Proteins Interact with the Insulin-response Element of the Glucagon Gene

1995 • 49 citations

A role for CdxA in gut closure and intestinal epithelia differentiation

1994 • 43 citations

Homologous DNA Sequences and Cellular Factors Are Implicated in the Control of Glucagon and Insulin Gene Expression

1995 • 40 citations

Hox-3.6: isolation and characterization of a new murine homeobox gene located in the 5′ region of the Hox-3 cluster

1992 • 32 citations

The group IIB intron from the green alga Scenedesmus obliquus mitochondrion: molecular characterization of the in vitro splicing products

1991 • 21 citations

Insulin Gene Transcription Is Decreased Rapidly by Lowering Glucose Concentrations in Rat Islet Cells

1994 • 20 citations

A Novel Chicken Homeobox-Containing Gene Expressed in Neurulating Embryos

1993 • 13 citations