Activation of a cAMP-regulated Ca2+-Signaling Pathway in Pancreatic β-Cells by the Insulinotropic Hormone Glucagon-like Peptide-1

A new generation of Ca2+ indicators with greatly improved fluorescence properties.

1985 • 21,873 citations

Copper-Zinc Superoxide Dismutase (SOD1) Is Released by Microglial Cells and Confers Neuroprotection against 6-OHDA Neurotoxicity

2012 • 8,865 citations

GLUCAGON-LIKE PEPTIDE-1 7-36: A PHYSIOLOGICAL INCRETIN IN MAN

1987 • 1,845 citations

Muscarinic activation of ionic currents measured by a new whole-cell recording method.

1988 • 1,777 citations

Preserved incretin activity of glucagon-like peptide 1 [7-36 amide] but not of synthetic human gastric inhibitory polypeptide in patients with type-2 diabetes mellitus.

1993 • 1,579 citations

Normalization of fasting hyperglycaemia by exogenous glucagon-like peptide 1 (7-36 amide) in Type 2 (non-insulin-dependent) diabetic patients

1993 • 1,064 citations

Expression cloning of the pancreatic beta cell receptor for the gluco-incretin hormone glucagon-like peptide 1.

1992 • 880 citations

Regulation of insulin release by calcium.

1981 • 866 citations

Antidiabetogenic Effect of Glucagon-like Peptide-1 (7–36)amide in Normal Subjects and Patients with Diabetes Mellitus

1992 • 858 citations

Glucagon-like peptide I stimulates insulin gene expression and increases cyclic AMP levels in a rat islet cell line.

1987 • 830 citations

Insulinotropin: glucagon-like peptide I (7-37) co-encoded in the glucagon gene is a potent stimulator of insulin release in the perfused rat pancreas.

1987 • 814 citations

The incretin concept today

1979 • 730 citations

Preproglucagon gene expression in pancreas and intestine diversifies at the level of post-translational processing.

1986 • 686 citations

Hamster preproglucagon contains the sequence of glucagon and two related peptides

1983 • 602 citations

Pancreatic beta-cells are rendered glucose-competent by the insulinotropic hormone glucagon-like peptide-1(7-37)

1993 • 576 citations

Truncated glucagon‐like peptide I, an insulin‐releasing hormone from the distal gut

1987 • 566 citations

Cloning and Functional Expression of the Human Islet GLP-1 Receptor: Demonstration That Exendin-4 Is an Agonist and Exendin-(9–39) an Antagonist of the Receptor

1993 • 533 citations

Beta-cell lines derived from transgenic mice expressing a hybrid insulin gene-oncogene.

1988 • 523 citations

Oral Hypoglycemic Agents

1989 • 483 citations

Effect of Truncated Glucagon-Like Peptide-1 [Proglucagon-(78–107) amide] on Endocrine Secretion from Pig Pancreas, Antrum, and Nonantral Stomach

1988 • 391 citations

Insulin synthesis in a clonal cell line of simian virus 40-transformed hamster pancreatic beta cells.

1981 • 381 citations

Calcium-independent potentiation of insulin release by cyclic AMP in single β-cells

1993 • 377 citations

Insulinotropic hormone glucagon-like peptide-I(7-37) stimulation of proinsulin gene expression and proinsulin biosynthesis in insulinoma beta TC-1 cells.

1992 • 323 citations

Glucagon-like peptide-1, a new hormone of the entero-insular axis

1992 • 290 citations

Insulinotropic Action of Glucagonlike Peptide-I-(7–37) in Diabetic and Nondiabetic Subjects

1992 • 282 citations

Functional expression of the rat glucagon-like peptide-I receptor, evidence for coupling to both adenylyl cyclase and phospholipase-C.

1993 • 214 citations

Coupling of opiate receptors to adenylate cyclase: requirement for Na+ and GTP.

1979 • 200 citations

Bimodal regulation of adenylate cyclase

1982 • 161 citations

Cloning and functional expression of the human glucagon-like peptide-1 (GLP-1) receptor

1993 • 150 citations

Ion Channels and Insulin Secretion

1990 • 147 citations

The role of the free cytosolic calcium level in beta-cell signal transduction by gastric inhibitory polypeptide and glucagon-like peptide I(7-37).

1993 • 146 citations

Modulation of sodium-sensitive GTPase by partial opiate agonists. An explanation for the dual requirement for Na+ and GTP in inhibitory regulation of adenylate cyclase.

1982 • 125 citations

Signal transduction crosstalk in the endocrine system: pancreatic β-cells and the glucose competence concept

1992 • 125 citations

Glucagon-like peptide-1-(7-36)amide and a rise in cyclic adenosine 3',5'-monophosphate increase cytosolic free Ca2+ in rat pancreatic beta-cells by enhancing Ca2+ channel activity.

1993 • 117 citations

Control of insulin secretion: a model involving Ca2+, cAMP and diacylglycerol

1990 • 115 citations

The Ionic, Electrical, and Secretory Effects of Endogenous Cyclic Adenosine Monophosphate in Mouse Pancreatic B Cells: Studies with Forskolin*

1984 • 110 citations

Cyclic nucleotide-gated channels: an expanding new family of ion channels.

1994 • 108 citations

Glucagon-Like Peptide-I Analogs: Effects on Insulin Secretion and Adenosine 3′,5′-Monophosphate Formation*

1990 • 106 citations

The pancreatic β-cell glucose sensor

1994 • 103 citations

Regulation of Insulin Secretion from β-Cell Lines Derived from Transgenic Mice Insulinomas Resembles that of Normal β-Cells*

1990 • 99 citations

Murine Insulinoma Cell Line With Normal Glucose-Regulated Insulin Secretion

1993 • 88 citations

Comparison of the Effects of Glucagon-Like Peptide-1-( 1-3 7) and -(7-37) and Glucagon on Islet Hormone Release from Isolated Perfused Canine and Rat Pancreases*

1989 • 85 citations

The Incretin Notion and its Relevance to Diabetes

1993 • 82 citations

Stimulus-response coupling in insulin-secreting HIT cells. Effects of secretagogues on cytosolic Ca2+, diacylglycerol, and protein kinase C activity.

1990 • 76 citations

Cyclic AMP as a determinant for glucose induction of fast Ca2+ oscillations in isolated pancreatic beta-cells

1991 • 75 citations

Homologous Desensitization of the Insulinotropic Glucagon-Like Peptide-I(7–37) Receptor on Insulinoma (HIT-T15) Cells*

1991 • 74 citations

Inhibition of adenylate cyclase by hormones and neurotransmitters.

1981 • 73 citations

Inhibition of a calcium‐activated, non‐selective cation channel, in a rat insulinoma cell line, by adenine derivatives

1986 • 67 citations

Effects of Glucagonlike Peptide l-(7–36) on Release of Insulin, Glucagon, and Somatostatin by Rat Pancreatic Islet Cell Monolayer Cultures

1989 • 65 citations

Forskolin-Induced Activation of Adenylate Cyclase, Cyclic Adenosine Monophosphate Production and Insulin Release in Rat Pancreatic Islets^*

1984 • 65 citations

Enhancers of cytosolic cAMP augment depolarization-induced exocytosis from pancreatic B-cells: evidence for effects distal to Ca2+ entry

1993 • 60 citations

Glucose-induced insulin secretion from purified beta-cells. A role for modulation of Ca2+ influx by cAMP- and protein kinase C-dependent signal transduction pathways.

1993 • 57 citations

Mechanisms and components involved in adenylate cyclase inhibition by hormones.

1984 • 55 citations

Electrical activity, cAMP concentration, and insulin release in mouse islets of Langerhans

1985 • 51 citations

Cyclic AMP raises cytosolic Ca²⁺ and promotes Ca²⁺ influx in a clonal pancreatic β‐cell line (HIT T‐15)

1987 • 48 citations

Insulinotropic glucagonlike peptide-I(7–37)/(7–36)amide A new incretin hormone

1992 • 47 citations

Voltage-independent calcium channels mediate slow oscillations of cytosolic calcium that are glucose dependent in pancreatic beta-cells.

1994 • 45 citations

Calcium and pancreatic β-cell function 7. Evidence for cyclic AMP-induced translocation of intracellular calcium

1980 • 32 citations

Glucagon and forskolin have dual effects upon islet cell electrical activity

1984 • 32 citations

Effects of glucagon like-1(7–36)amide on the ctoplasmic Ca2+-concentration in rat islet cells

1993 • 29 citations

Nucleotide regulation of a calcium-activated cation channel in the rat insulinoma cell line, CRI-G1

1994 • 22 citations

Analysis and use of the perforated patch technique for recording ionic currents in pancreaticβ-cells

1991 • 20 citations

Inhibitory Coupling of Hormone and Neurotransmitter Receptors to Adenylate Cyclase

1983 • 17 citations

Cyclic AMP triggers large [Ca2+]i oscillations in glucose-stimulated beta-cells from ob/ob mice.

1994 • 16 citations

Stimulation of rat parietal cell function by histamine and GLP-1-(7-36) amide is mediated by Gs alpha

1994 • 16 citations

GLP-1(7–36)amide-stimulated insulin secretion in rat islets is sodium-dependent

1991 • 14 citations

On the mechanism of receptor-mediated inhibition of adenylate cyclase.

1984 • 11 citations

Monovalent ion enhancement of β-adrenergic-stimulated adenylate cyclase activity in mouse parotid gland

1989 • 10 citations