Role of prohormone convertases in the tissue-specific processing of proglucagon.

Tissue and Plasma Concentrations of Amidated and Glycine-Extended Glucagon-Like Peptide I in Humans

1994 • 868 citations

Antidiabetogenic Effect of Glucagon-like Peptide-1 (7–36)amide in Normal Subjects and Patients with Diabetes Mellitus

1992 • 858 citations

Glucagon‐like peptide‐1 cells in the gastrointestinal tract and pancreas of rat, pig and man

1992 • 620 citations

Identification of a human insulinoma cDNA encoding a novel mammalian protein structurally related to the yeast dibasic processing protease Kex2.

1990 • 579 citations

Identification of a cDNA encoding a second putative prohormone convertase related to PC2 in AtT20 cells and islets of Langerhans.

1991 • 449 citations

Identification in pituitary tissue of a peptide alpha-amidation activity that acts on glycine-extended peptides and requires molecular oxygen, copper, and ascorbic acid.

1983 • 363 citations

Biological Effects and Metabolic Rates of Glucagonlike Peptide-1 7–36 Amide and Glucagonlike Peptide-1 7–37 in Healthy Subjects Are Indistinguishable

1993 • 311 citations

Sorting and processing of secretory proteins

1994 • 306 citations

Enkephalin convertase: purification and characterization of a specific enkephalin-synthesizing carboxypeptidase localized to adrenal chromaffin granules.

1982 • 283 citations

Insulinotropic Action of Glucagonlike Peptide-I-(7–37) in Diabetic and Nondiabetic Subjects

1992 • 282 citations

Identification of a Second Human Subtilisin-Like Protease Gene in thefes/fpsRegion of Chromosome 15

1991 • 268 citations

Differential Processing of Proglucagon by the Subtilisin-like Prohormone Convertases PC2 and PC3 to Generate either Glucagon or Glucagon-like Peptide

1995 • 228 citations

cDNA structure of the mouse and rat subtilisin/kexin-like PC5: a candidate proprotein convertase expressed in endocrine and nonendocrine cells.

1993 • 223 citations

Evolutionary conserved close linkage of the c-fes/fps proto-oncogene and genetic sequences encoding a receptor-like protein.

1986 • 207 citations

Testicular expression of PC4 in the rat: molecular diversity of a novel germ cell-specific Kex2/subtilisin-like proprotein convertase.

1992 • 203 citations

Both amidated and nonamidated forms of glucagon-like peptide I are synthesized in the rat intestine and the pancreas.

1990 • 154 citations

Identification and processing of proglucagon in pancreatic islets

1979 • 142 citations

Proprotein convertases (PC1/PC3 and PC2) in normal and neoplastic human tissues: their use as markers of neuroendocrine differentiation.

1995 • 133 citations

Identification of an isoform with an extremely large Cys‐rich region of PC6, a Kex2‐like processing endoprotease

1993 • 123 citations

Heterologous processing of prosomatostatin in constitutive and regulated secretory pathways. Putative role of the endoproteases furin, PC1, and PC2.

1993 • 98 citations

The neuroendocrine precursor 7B2 is a sulfated protein proteolytically processed by a ubiquitous furin-like convertase.

1994 • 86 citations

Enzymatic properties of carboxyl-terminally truncated prohormone convertase 1 (PC1/SPC3) and evidence for autocatalytic conversion

1994 • 85 citations

Comparative proteolytic processing of rat prosomatostatin by the convertases PC1, PC2, furin, PACE4 and PC5 in constitutive and regulated secretory pathways

1995 • 80 citations

Fetal Rat Intestinal Cells in Monolayer Culture: A Newin VitroSystem to Study the Glucagon-Like Immunoreactive Peptides*

1987 • 73 citations

Naturally occurring products of proglucagon 111-160 in the porcine and human small intestine.

1988 • 70 citations

Calcium- and pH-dependent aggregation and membrane association of the precursor of the prohormone convertase PC2

1994 • 67 citations

Peptideα-Amidation Activity in Mouse Anterior Pituitary AtT-20 Cell Granules: Properties and Secretion*

1984 • 66 citations

Tissue distribution and characterization of peptide C-terminal α-amidating activity in rat

1986 • 61 citations

Levels of the conversion endoproteases PC1 (PC3) and PC2 distinguish between insulin-producing pancreatic islet β cells and non-β cells

1994 • 52 citations

Alterations in proglucagon processing and inhibition of proglucagon gene expression in transgenic mice which contain a chimeric proglucagon-SV40 T antigen gene.

1992 • 45 citations

Inhibition of pancreatic glucagon gene expression in mice bearing a subcutaneous glucagon-producing GLUTag transplantable tumor.

1992 • 38 citations

Expression of Mouse Proopiomelanocortin in an Insulinoma Cell Line

1989 • 38 citations

Synthesis and secretion of glucagon-like peptide-1 by fetal rat intestinal cells in culture

1995 • 37 citations

Localization of amidating enzymes (PAM) in rat gastrointestinal tract.

1993 • 23 citations

Expression of human pancreatic polypeptide in heterologous cell lines.

1991 • 10 citations