chimeric peptides define the structural requirements for specific ligand-receptor interaction of GLP-1

Preserved incretin activity of glucagon-like peptide 1 [7-36 amide] but not of synthetic human gastric inhibitory polypeptide in patients with type-2 diabetes mellitus.

1993 • 1,579 citations

Expression cloning of the pancreatic beta cell receptor for the gluco-incretin hormone glucagon-like peptide 1.

1992 • 880 citations

Antidiabetogenic Effect of Glucagon-like Peptide-1 (7–36)amide in Normal Subjects and Patients with Diabetes Mellitus

1992 • 858 citations

The incretin concept today

1979 • 730 citations

Gastric inhibitory polypeptide receptor, a member of the secretin-vasoactive intestinal peptide receptor family, is widely distributed in peripheral organs and the brain.

1993 • 485 citations

Glucagon-Like Peptides GLP-1 and GLP-2, Predicted Products of the Glucagon Gene, Are Secreted Separately from Pig Small Intestine but Not Pancreas*

1986 • 475 citations

Additive insulinotropic effects of exogenous synthetic human gastric inhibitory polypeptide and glucagon-like peptide-1-(7-36) amide infused at near-physiological insulinotropic hormone and glucose concentrations.

1993 • 467 citations

Glucagon-like peptide-1 but not glucagon-like peptide-2 stimulates insulin release from isolated rat pancreatic islets

1985 • 303 citations

Glucagon-like peptide-1, a new hormone of the entero-insular axis

1992 • 290 citations

Structure-activity studies of glucagon-like peptide-1.

1994 • 272 citations

Further purification of a polypeptide demonstrating enterogastrone activity

1970 • 262 citations

Regulation of immunoreactive-insulin release from a rat cell line (RINm5F)

1983 • 240 citations

Additive insulinotropic effects of exogenous synthetic human gastric inhibitory polypeptide and glucagon-like peptide-1-(7-36) amide infused at near-physiological insulinotropic hormone and glucose concentrations

1993 • 146 citations

Comparison of the Effects of Various C-Terminal and NTerminal Fragment Peptides of Glucagon-Like Peptide-1 on Insulin and Glucagon Release from the Isolated Perfused Rat Pancreas*

1989 • 109 citations

Gastric inhibitory polypeptide receptor, a member of the secretin- vasoactive intestinal peptide receptor family, is widely distributed in peripheral organs and the brain

1993 • 104 citations

Structure/Activity Characterization of Glucagon‐Like Peptide‐1

1994 • 94 citations

Isolation and primary structure of pituitary human galanin, a 30-residue nonamidated neuropeptide.

1991 • 73 citations

Functional GIP receptors in a hamster pancreatic beta cell line, In 111: Specific binding and biological effects

1984 • 60 citations

Binding specificity and signal transduction of receptors for glucagon-like peptide-1(7–36)amide and gastric inhibitory polypeptide on RINm5F insulinoma cells

1993 • 57 citations

Isolation and primary structure of tumor-derived peptides related to human pancreastatin and chromogranin A.

1988 • 55 citations

Characterization of the receptor for glucagon-like peptide-1(7–36)amide on plasma membranes from rat insulinoma-derived cells by covalent cross-linking

1989 • 52 citations

Comparison of the effect of GIP and GLP‐1 (7–36amide) on insulin release from rat pancreatic islets

1992 • 39 citations

Glucagon-like peptide-1(7–36)amide: characterization of the domain responsible for binding to its receptor on rat insulinoma RINm5F cells

1990 • 33 citations

Gastric inhibitory polypeptide receptor in hamster pancreatic beta cells. Direct cross-linking, solubilization and characterization as a glycoprotein

1986 • 26 citations

Structural requirements for gastric inhibitory polypeptide (GIP) receptor binding and stimulation of insulin release

1986 • 24 citations