Agonist-induced internalization and recycling of the glucagon-like peptide-1 receptor in transfected fibroblasts and in insulinomas

Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase

1988 • 6,107 citations

ASSEMBLY OF ASPARAGINE-LINKED OLIGOSACCHARIDES

1985 • 4,790 citations

GLUCAGON-LIKE PEPTIDE-1 7-36: A PHYSIOLOGICAL INCRETIN IN MAN

1987 • 1,845 citations

Receptor-Mediated Endocytosis: Concepts Emerging from the LDL Receptor System

1985 • 1,585 citations

Binding and Degradation of Low Density Lipoproteins by Cultured Human Fibroblasts

1974 • 1,481 citations

pH and the recycling of transferrin during receptor-mediated endocytosis.

1983 • 1,165 citations

Expression cloning of the pancreatic beta cell receptor for the gluco-incretin hormone glucagon-like peptide 1.

1992 • 880 citations

Neurotransmitter receptor binding

1978 • 822 citations

Intracellular site of asialoglycoprotein receptor-ligand uncoupling: Double-label immunoelectron microscopy during receptor-mediated endocytosis

1983 • 816 citations

Exendin-4 is a high potency agonist and truncated exendin-(9-39)-amide an antagonist at the glucagon-like peptide 1-(7-36)-amide receptor of insulin-secreting beta-cells.

1993 • 814 citations

Clathrin, Adaptors, and Sorting

1990 • 704 citations

Preproglucagon gene expression in pancreas and intestine diversifies at the level of post-translational processing.

1986 • 686 citations

Internalization and processing of transferrin and the transferrin receptor in human carcinoma A431 cells.

1983 • 636 citations

Truncated glucagon‐like peptide I, an insulin‐releasing hormone from the distal gut

1987 • 566 citations

Cloning and Functional Expression of the Human Islet GLP-1 Receptor: Demonstration That Exendin-4 Is an Agonist and Exendin-(9–39) an Antagonist of the Receptor

1993 • 533 citations

ADENYLATE CYCLASE-COUPLED BETA-ADRENERGIC RECEPTORS: Structure and Mechanisms of Activation and Desensitization

1983 • 486 citations

Structure and mechanism of the G protein-coupled receptor kinases.

1993 • 480 citations

Kinase activity controls the sorting of the epidermal growth factor receptor within the multivesicular body

1990 • 452 citations

Ligand-regulated internalization and recycling of human beta 2-adrenergic receptors between the plasma membrane and endosomes containing transferrin receptors.

1992 • 445 citations

Agonist-induced desensitization of the beta-adrenergic receptor-linked adenylate cyclase.

1983 • 441 citations

Removal of phosphorylation sites from the β2-adrenergic receptor delays onset of agonist-promoted desensitization

1988 • 429 citations

Phosphorylation Sites on Two Domains of the β2-Adrenergic Receptor Are Involved in Distinct Pathways of Receptor Desensitization

1989 • 415 citations

Beta-adrenergic receptor sequestration. A potential mechanism of receptor resensitization.

1993 • 387 citations

Membrane Traffic in Endocytosis: Insights from Cell-Free Assays

1989 • 369 citations

A highly conserved tyrosine residue in G protein-coupled receptors is required for agonist-mediated beta 2-adrenergic receptor sequestration.

1994 • 361 citations

Kinetics of internalization and recycling of the asialoglycoprotein receptor in a hepatoma cell line.

1982 • 357 citations

Clathrin and HA2 adaptors: effects of potassium depletion, hypertonic medium, and cytosol acidification.

1993 • 349 citations

The Structure and Insertion of Integral Proteins in Membranes

1990 • 304 citations

Lateral Diffusion of Proteins in Membranes

1987 • 268 citations

BiP (GRP78), an essential hsp70 resident protein in the endoplasmic reticulum

1994 • 227 citations

Phosphorylation/dephosphorylation of the beta-adrenergic receptor regulates its functional coupling to adenylate cyclase and subcellular distribution.

1986 • 221 citations

Characterization of an altered membrane form of the beta-adrenergic receptor produced during agonist-induced desensitization.

1983 • 206 citations

Transferrin receptor and its recycling in HeLa cells.

1982 • 206 citations

Desensitization of the beta-adrenergic receptor of frog erythrocytes. Recovery and characterization of the down-regulated receptors in sequestered vesicles.

1983 • 191 citations

Evidence for recycling of insulin receptors in isolated rat adipocytes.

1981 • 165 citations

Principles of Drug Action. The Basis of Pharmacology

1991 • 158 citations

A comparison of catecholamine-induced internalization of beta-adrenergic receptors and receptor-mediated endocytosis of epidermal growth factor in human astrocytoma cells. Inhibition by phenylarsine oxide.

1985 • 151 citations

Clathrin facilitates the internalization of seven transmembrane segment receptors for mating pheromones in yeast.

1993 • 151 citations

Agonist-induced internalization of the substance P (NK1) receptor expressed in epithelial cells

1994 • 144 citations

Mutations of the human beta 2-adrenergic receptor that impair coupling to Gs interfere with receptor down-regulation but not sequestration.

1991 • 136 citations

The Liver: Biology and Pathobiology

1994 • 125 citations

Multipotential phenotypic expression of genes encoding peptide hormones in rat insulinoma cell lines.

1987 • 124 citations

Glucagon-Like Peptide-I and the Control of Insulin Secretion in the Normal State and in NIDDM

1993 • 114 citations

Involvement of tyrosine residues located in the carboxyl tail of the human beta 2-adrenergic receptor in agonist-induced down-regulation of the receptor.

1990 • 109 citations

Genetic analysis of beta-adrenergic receptor internalization and down-regulation.

1985 • 102 citations

Relationship between an altered membrane form and a low affinity form of the beta-adrenergic receptor occurring during catecholamine-induced desensitization. Evidence for receptor internalization.

1984 • 86 citations

Signal transduction by the cloned glucagon-like peptide-1 receptor: comparison with signaling by the endogenous receptors of beta cell lines.

1994 • 78 citations

Separation of the structural requirements for agonist-promoted activation and sequestration of the beta-adrenergic receptor.

1990 • 64 citations

Signal transmission after GLP-1(7-36)amide binding in RINm5F cells

1989 • 56 citations

Isoproterenol-initiated beta-adrenergic receptor diacytosis in cultured cells.

1992 • 34 citations

Comparison of binding of 125I-iodopindolol to control and desensitized cells at 37 degrees and on ice.

1986 • 9 citations