Glucagon-like peptide-1, a new hormone of the entero-insular axis

A new method for predicting signal sequence cleavage sites

1986 • 4,629 citations

GLUCAGON-LIKE PEPTIDE-1 7-36: A PHYSIOLOGICAL INCRETIN IN MAN

1987 • 1,845 citations

Glucagon-like peptide I stimulates insulin gene expression and increases cyclic AMP levels in a rat islet cell line.

1987 • 830 citations

Insulinotropin: glucagon-like peptide I (7-37) co-encoded in the glucagon gene is a potent stimulator of insulin release in the perfused rat pancreas.

1987 • 814 citations

NEW INTERPRETATION OF ORAL GLUCOSE TOLERANCE

1964 • 693 citations

Preproglucagon gene expression in pancreas and intestine diversifies at the level of post-translational processing.

1986 • 686 citations

Hamster preproglucagon contains the sequence of glucagon and two related peptides

1983 • 602 citations

Truncated glucagon‐like peptide I, an insulin‐releasing hormone from the distal gut

1987 • 566 citations

Exon duplication and divergence in the human preproglucagon gene

1983 • 558 citations

Glucagon-Like Peptides GLP-1 and GLP-2, Predicted Products of the Glucagon Gene, Are Secreted Separately from Pig Small Intestine but Not Pancreas*

1986 • 475 citations

Handbook of Experimental Pharmacology, vol 14.

1972 • 446 citations

Effect of Truncated Glucagon-Like Peptide-1 [Proglucagon-(78–107) amide] on Endocrine Secretion from Pig Pancreas, Antrum, and Nonantral Stomach

1988 • 391 citations

Proglucagon products in plasma of noninsulin-dependent diabetics and nondiabetic controls in the fasting state and after oral glucose and intravenous arginine.

1991 • 371 citations

Distribution of glucagonlike peptide I (GLP‐I), glucagon, and glicentin in the rat brain: An immunocytochemical study

1988 • 325 citations

Glucagon-like peptide-1 but not glucagon-like peptide-2 stimulates insulin release from isolated rat pancreatic islets

1985 • 303 citations

Glucagonlike Peptide I (7–37) Actions on Endocrine Pancreas

1989 • 254 citations

Glucagon gene expression in vertebrate brain.

1988 • 252 citations

Pancreatic preproglucagon cDNA contains two glucagon-related coding sequences arranged in tandem.

1982 • 249 citations

Glucagonostatic and Insulinotropic Action of Glucagonlike Peptide I-(7–36)-Amide

1989 • 222 citations

Mammalian pancreatic preproglucagon contains three glucagon-related peptides.

1983 • 218 citations

Peptide YY (PYY) immunoreactivity is co-stored with glucagon-related immunoreactants in endocrine cells of the gut and pancreas

1984 • 218 citations

Glucagon gene sequence. Four of six exons encode separate functional domains of rat pre-proglucagon.

1984 • 206 citations

Pancreatic and intestinal processing of proglucagon in man

1987 • 203 citations

Complete Sequences of Glucagon-like Peptide-1 from Human and Pig Small Intestine

1989 • 201 citations

Distribution and properties of glucagon immunoreactivity in the digestive tract of various mammals: An immunohistochemical and immunochemical study

1975 • 196 citations

Effect of the entero-pancreatic hormones, gastric inhibitory polypeptide and glucagon-like polypeptide-1(7–36) amide, on fatty acid synthesis in explants of rat adipose tissue

1991 • 186 citations

Coexistence of peptide YY and glicentin immunoreactivity in endocrine cells of the gut

1984 • 183 citations

GLP-1 (glucagon-like peptide 1) and truncated GLP-1, fragments of human proglucagon, inhibit gastric acid secretion in humans

1989 • 176 citations

Identification and Localization of Glucagon-Like Peptide-1 and Its Receptor in Rat Brain*

1987 • 166 citations

Cellular localization of proglucagon/glucagon‐like peptide I messenger RNAs in rat brain

1986 • 165 citations

Both amidated and nonamidated forms of glucagon-like peptide I are synthesized in the rat intestine and the pancreas.

1990 • 154 citations

Emptying of the gastric substitute, glucagon-like peptide-1 (GLP-1), and reactive hypoglycemia after total gastrectomy

1991 • 154 citations

Receptors for glucagon-like peptide-1(7–36) amide on rat insulinoma-derived cells

1988 • 153 citations

Identification and processing of proglucagon in pancreatic islets

1979 • 142 citations

EXTRACTABLE GLUCAGON OF THE HUMAN PANCREAS

1955 • 142 citations

Anglerfish islet pre-proglucagon II. Nucleotide and corresponding amino acid sequence of the cDNA.

1983 • 137 citations

Glucagon and glicentin immunoreactivity are topologically segregated in the α granule of the human pancreatic A cell

1980 • 127 citations

Localization of glucagon-like peptide (GLP) immunoreactants in human gut and pancreas using light and electron microscopic immunocytochemistry.

1985 • 127 citations

Identical mRNA for preproglucagon in pancreas and gut

1987 • 121 citations

Radio-immunoassays for glucagon-like peptides 1 and 2 (GLP-1 and GLP-2)

1987 • 117 citations

Conversion of proglucagon in pancreatic alpha cells: the major endproducts are glucagon and a single peptide, the major proglucagon fragment, that contains two glucagon-like sequences.

1984 • 117 citations

Gut glucagon, enteroglucagon, gut glucagonlike immunoreactivity, glicentin—Current status

1983 • 114 citations

Structure of the human ghicagon gene

1986 • 113 citations

Co-existence of glicentin and peptide YY in colorectal L-cells in cat and man. An electron microscopic study

1986 • 113 citations

Human glucagon‐like peptides 1 and 2 activate rat brain adenylate cyclase

1984 • 111 citations

Identification and characterization of glucagon‐like peptide‐1 7–36 amide‐binding sites in the rat brain and lung

1988 • 110 citations

Comparison of the Effects of Various C-Terminal and NTerminal Fragment Peptides of Glucagon-Like Peptide-1 on Insulin and Glucagon Release from the Isolated Perfused Rat Pancreas*

1989 • 109 citations

Glucagon-Like Peptide-I Analogs: Effects on Insulin Secretion and Adenosine 3′,5′-Monophosphate Formation*

1990 • 106 citations

Characterization of glucagon-like peptide-1-(7–36)amide in the hypothalamus

1989 • 104 citations

Functional receptors for the insulinotropic hormone glucagon‐like peptide‐I(7–37) on a somatostatin secreting cell line

1991 • 98 citations

Radio-immunoassays for glucagon-like peptides 1 and 2 (GLP-1 and GLP-2)

1987 • 91 citations

Glucagon-like peptide-1 (7–36)-NH2: a physiological inhibitor of gastric acid secretion in man

1990 • 89 citations

Comparison of the Effects of Glucagon-Like Peptide-1-( 1-3 7) and -(7-37) and Glucagon on Islet Hormone Release from Isolated Perfused Canine and Rat Pancreases*

1989 • 85 citations

Insulin, Glucagon, and Somatostatin Receptors on Cultured Cells and Clones from Rat Islet Cell Tumor

1982 • 82 citations

Contributions a l’étude des variations physiologiques de la sécrétion interne du pancréas relations entre les sécrétions externe et interne du pancréas

1929 • 75 citations

Gastric Inhibitory Polypeptide (GIP) and Insulin Release after Small-Bowel Resection in Man

1980 • 70 citations

Effect of glucagon-like peptide-1 on insulin secretion

1988 • 70 citations

GLP-1 and GLP-17-36 Amide

1991 • 69 citations

Colchicine-induced redistribution of an apical membrane glycoprotein (gp330) in proximal tubules

1989 • 69 citations

Characterization of high‐affinity receptors for truncated glucagon‐like peptide‐1 in rat gastric glands

1990 • 67 citations

Mutations in the guinea pig preproglucagon gene are restricted to a specific portion of the prohormone sequence

1986 • 65 citations

Cloning of Complementary DNAs Encoding Islet Amyloid Polypeptide, Insulin, and Glucagon Precursors from a New World Rodent, the Degu,Octodon degus

1990 • 65 citations

Effects of Glucagonlike Peptide l-(7–36) on Release of Insulin, Glucagon, and Somatostatin by Rat Pancreatic Islet Cell Monolayer Cultures

1989 • 65 citations

Molecular forms of glucagon‐like peptides in man

1985 • 64 citations

Immunochemical Studies on Macromolecular Gastrins

1977 • 61 citations

Heterogeneity of somatostatin like immunoreactivity (SLI) in extracts of porcine, canine and human pancreas

1981 • 60 citations

Relationship between molecular structures of sugars and their ability to stimulate the release of glucagon-like peptide-1 from canine ileal loops.

1990 • 60 citations

Immunohistochemical localization of glucagon-like peptide 1

1987 • 59 citations

Synergistic stimulatory effect of glucagon‐like peptide‐1 (7–36) amide and glucose‐dependent insulin‐releasing polypeptide on the endocrine rat pancreas

1989 • 58 citations

Absence of insulinotropic glucagon‐like peptide‐I(7–37) receptors on isolated rat liver hepatocytes

1991 • 57 citations

Signal transmission after GLP-1(7-36)amide binding in RINm5F cells

1989 • 56 citations

Effect of Glucagon-Like Peptide-1 on Gastric Somatostatin and Gastrin Secretion in the Rat

1990 • 55 citations

Nucleotide sequence determination of chicken glucagon precursor cDNA

1990 • 54 citations

Extrapancreatic Glucagons

1978 • 52 citations

Proglucagon Gene Expression and Posttranslational Processing in a Hamster Islet Cell Line*

1988 • 52 citations

Isolation and characterisation of GLP‐1 7–36 amide from rat intestine Elevated levels in diabetic rats

1988 • 52 citations

Characterization of the receptor for glucagon-like peptide-1(7–36)amide on plasma membranes from rat insulinoma-derived cells by covalent cross-linking

1989 • 52 citations

Molecular Forms of Glucagon-Like Peptide-1 in Human Pancreas and Glucagonomas

1985 • 51 citations

All products of proglucagon are elevated in plasma from uremic patients.

1992 • 51 citations

Measurement and Partial Characterization of Immunoreactive Glucagon in Gastrointestinal Tissues of Dogs

1976 • 49 citations

Preserved incretin effect in type 1 diabetic patients with end-stage nephropathy treated by combined heterotopic pancreas and kidney transplantation

1993 • 46 citations

Proglucagon Processing in a Rat Islet Cell Line Resembles Phenotype of Intestine Rather than Pancreas*

1986 • 45 citations

Glucagonlike Peptide-I-(7–36)-Amide Receptors Only in Islets of Langerhans: Autoradiographic Survey of Extracerebral Tissues in Rats

1991 • 45 citations

Molecular Biology of Gastrointestinal Peptides and Growth Factors: Relevance to Intestinal Adaptation

1990 • 44 citations

Effect of truncated glucagon‐like peptide 1 on cAMP in rat gastric glands and HGT‐1 human gastric cancer cells

1988 • 43 citations

Characterization of receptors for glucagon‐like peptide‐1(7–36) amide on rat lung membranes

1990 • 43 citations

Truncated glucagon‐like peptide‐1 (proglucagon 78–107 amide), an intestinal insulin‐releasing peptide, has specific receptors on rat insulinoma cells (RIN 5AH)

1988 • 41 citations

Glucagon-like peptide-1 does not have a role in hepatic carbohydrate metabolism

1985 • 39 citations

Reduced Insulinotropic Effects of Glucagonlike Peptide I-(7–36)-Amide and Gastric Inhibitory Polypeptide in Isolated Perfused Diabetic Rat Pancreas

1990 • 38 citations

GLP-1-(7-36) amide, -(1-37), and -(1-36) amide: potent cAMP-dependent stimuli of rat parietal cell function

1991 • 37 citations

Characterization of glucagon‐like peptide‐I(7–36)amide receptors of rat lung membranes by covalent cross‐linking

1991 • 37 citations

Depression of Insulin Release by Anti-GIP Serum after Oral Glucose in Rats

1981 • 35 citations

Light and electron microscopical immunocytochemical localization of pancreastatin-like immunoreactivity in porcine tissues

1990 • 33 citations

Glucagon-like peptide-1(7–36)amide: characterization of the domain responsible for binding to its receptor on rat insulinoma RINm5F cells

1990 • 33 citations

Early O-glycosidic glycosylation of proglucagon in pancreatic islets: an unusual type of prohormonal modification.

1986 • 32 citations

The Role of Gut-Glucagon-Like Immunoreactants in the Control of Gastrointestinal Epithelial Cell Renewal

1990 • 31 citations

Distribution of glucagon-like peptide I in canine and feline pancreas and gastrointestinal tract.

1986 • 31 citations

Comparison of half-disappearance times, distribution volumes and metabolic clearance rates of exogenous glucagon-like peptide 1 and glucagon in rats

1988 • 28 citations

The major proglucagon fragment: An abundant islet protein and secretory product

1981 • 25 citations

Distribution and molecular forms of glucagon-like peptide in the dog

1989 • 24 citations

Serially Transplantable Chemically Induced Rat Islet Cell Tumor*

1980 • 23 citations

Alterations of plasma immunoreactive glucagon-like peptide-1 behavior in non-insulin-dependent diabetics

1990 • 21 citations

Interference of immunoglobulins in two glucagon radioimmunoassays.

1982 • 20 citations

Identification of Glucagon-Like Peptide-1(7–36) Amide in Rat Brain

1989 • 20 citations

Effects of truncated glucagon-like peptide-1 on pancreatic hormone release in normal conscious dogs

1990 • 20 citations

Release of glucagon-like peptide 1 immunoreactivity from the perfused rat pancreas

1987 • 20 citations

A large molecular form of glucagon-like peptide-1(GLP-1) immunoreactivity is co-released with glucagon from pancreas by arginine in normal subjects

1987 • 18 citations

Glucagon-like immunoreactivity in hypothalamic neurons of the rat

1990 • 18 citations

<b>EFFECT OF GLUCAGON-LIKE PEPTIDE-1 AND -2 ON GLYCOGENOLYSIS IN CULTURED RAT </b><b>HEPATOCYTES </b>

1986 • 18 citations

Inhibition of Meal-stimulated Gastric Acid Secretion in Man by Exogenous and Endogenous Pancreatic Glucagon

1978 • 16 citations

Effects of truncated glucagon-like peptide-1 on the responses of starved sheep to glucose

1991 • 15 citations

<b>MULTIPLE FORMS OF GLUCAGON-LIKE PEPTIDE-1 AND GLUCAGON-LIKE IMMUNOREACTIVITIES IN CANINE GASTROINTESTINAL TRACT AND THEIR RELEASE INTO </b><b>CIRCULATION </b>

1990 • 9 citations

Proceedings: Characterization of the new gastrointestinal hormones.

1975 • 9 citations

Effect of glucagon on vagally induced gastric acid secretion in humans

1988 • 9 citations

<b>GLUCAGON-LIKE PEPTIDE-1 IN THE RAT </b><b>PANCREAS </b>

1987 • 8 citations

Glucagon like peptides and lipolysis in isolated rat adipocytes

1988 • 2 citations