Stem cells: attributes, cycles, spirals, pitfalls and uncertainties. Lessons for and from the crypt

Cell cycle analysis of a cell proliferation-associated human nuclear antigen defined by the monoclonal antibody Ki-67.

1984 • 4,180 citations

A Direct Measurement of the Radiation Sensitivity of Normal Mouse Bone Marrow Cells¹

2010 • 4,125 citations

The relationship between the spleen colony-forming cell and the haemopoietic stem cell.

1978 • 2,290 citations

G ₁ Events and Regulation of Cell Proliferation

1989 • 2,203 citations

Origin, differentiation and renewal of the four main epithelial cell types in the mouse small intestine V. Unitarian theory of the origin of the four epithelial cell types

1974 • 1,697 citations

Tissue culture studies of the proliferative capacity of cervical carcinoma and normal epithelium

1952 • 1,001 citations

Autoantibody to a Nuclear Antigen in Proliferating Cells

1978 • 881 citations

Identity of the proliferating cell nuclear antigen and cyclin

1984 • 702 citations

Growth Kinetics of Tumours

1978 • 691 citations

Stem Cell Concepts

1979 • 569 citations

Stem cells: the generation and maintenance of cellular diversity

1989 • 504 citations

A search for differential polypeptide synthesis throughout the cell cycle of HeLa cells.

1980 • 465 citations

Epithelial stem cells in vivo

1988 • 446 citations

THE EPIDERMAL PROLIFERATIVE UNIT: THE POSSIBLE ROLE OF THE CENTRAL BASAL CELL

1974 • 440 citations

The biology of cell reproduction

1985 • 403 citations

Cell proliferation studies in the intestinal epithelium of the rat I. Determination of the kinetic parameters

1965 • 362 citations

Derivation of mouse intestinal crypts from single progenitor cells

1985 • 330 citations

Cyclin/PCNA immunostaining as an alternative to tritiated thymidine pulse labelling for marking S phase cells in paraffin sections from animal and human tissues

1989 • 295 citations

A clonal marker induced by mutation in mouse intestinal epithelium

1988 • 255 citations

The stem‐cell zone of the small intestinal epithelium. I. Evidence from paneth cells in the adult mouse

1981 • 253 citations

Growth fractions in breast cancers determined in situ with monoclonal antibody Ki-67.

1986 • 249 citations

Multiplication and division in mammalian cells

1976 • 242 citations

Development of the pattern of cell renewal in the crypt-villus unit of chimaeric mouse small intestine

1988 • 235 citations

Radiosensitivity and Fractionation Response of Crypt Cells of Mouse Jejunum

1969 • 232 citations

Response of intestinal cells of differing topographical and hierarchical status to ten cytotoxic drugs and five sources of radiation

1983 • 226 citations

Further studies on the response of intestinal crypt cells of different hierarchical status to eighteen different cytotoxic agents

1987 • 186 citations

A comparison of cell replacement in bone marrow, testis and three regions of surface epithelium

1979 • 180 citations

Demonstration of somatic mutation and colonic crypt clonality by X-linked enzyme histochemistry

1988 • 170 citations

A comprehensive model of the crypts of the small intestine of the mouse provides insight into the mechanisms of cell migration and the proliferation hierarchy

1987 • 160 citations

The crypt cycle. Crypt and villus production in the adult intestinal epithelium

1987 • 142 citations

The Temporal and Spatial Changes in Cell Proliferation within the Irradiated Crypts of the Murine Small Intestine

1990 • 125 citations

Effects of radiation on normal tissues: Hypothetical mechanisms and limitations of in situ assays of clonogenicity

1981 • 123 citations

Evidence for discrete cell kinetic subpopulations in mouse epidermis based on mathematical analysis

1982 • 117 citations

Protooncogene expression during the cell cycle.

1986 • 116 citations

Intestinal Cell Proliferation. I. A Comprehensive Model of Steady‐State Proliferation In the Crypt

1986 • 94 citations

Identification of Stem Cells in the Small Intestine of the Mouse

1976 • 88 citations

Molecules involved in proliferation of normal and cancer cells: presidential address.

1987 • 76 citations

Stem cells: Their identification and characterisation

1984 • 68 citations

Cell population kinetics in the mouse jejunal crypt

1975 • 65 citations

The spatial organization of the hierarchical proliferative cells of the crypts of the small intestine into clusters of ‘synchronized’ cells

1982 • 58 citations

Estimates of the number of clonogenic cells in crypts of murine small intestine

1987 • 56 citations

Epidermal cell proliferation. II. A comprehensive mathematical model of cell proliferation and migration in the basal layer predicts some unusual properties of epidermal stem cells.

1987 • 54 citations

A concept of hemopoietic regulation and its biomathematical realization.

1988 • 51 citations

Continuous maturation of proliferating erythroid precursors

1982 • 49 citations

Intestinal Crypt Proliferation. Ii. Computer Modelling of Mitotic Index Data Provides Further Evidence For Lateral and Vertical Cell Migration In the Absence of Mitotic Activity

1988 • 45 citations

THE EFFECT OF A SINGLE INJECTION OF HYDROXYUREA ON CELL POPULATION KINETICS IN THE SMALL BOWEL MUCOSA OF THE RAT

1977 • 42 citations

A stochastic branching model with formation of subunits applied to the growth of intestinal crypts

1991 • 42 citations

Haemopoietic stem cells: concept and definitions.

1979 • 39 citations

Functional gap junctions in mouse small intestinal crypts

1985 • 34 citations

The Doubling Time of Regenerating Clonogenic Cells in the Crypts of the Irradiated Mouse Small Intestine

1988 • 34 citations

Symmetric and asymmetric cell division in rat corneal epithelium

1990 • 34 citations

STEM CELLS VERSUS STEM LINES

1982 • 34 citations

Effect of gamma radiation at high- and low-dose rate on a novel in vivo mutation assay in mouse intestine

1989 • 30 citations

Heterogeneity of keratinocytes in the epidermal basal cell layer

1990 • 29 citations

Crypt base columnar cells in ileum of BDF₁ Male Mice—their numbers and some features of their proliferation

1989 • 26 citations

The effect of a single injection of cytosine arabinoside on cell population kinetics in the mouse jejunal crypt

1980 • 26 citations

The Response of Murine Intestinal Crypts to Short-Range Promethium-147 β Irradiation: Deductions concerning Clonogenic Cell Numbers and Positions

1989 • 23 citations

The role of stem cells in the regeneration of intestinal crypts after cytotoxic exposure.

1991 • 23 citations

Clonogenic, stem and carcinogen-target cells in small intestine.

1984 • 20 citations

Macroscopic intestinal colonies of mice as a tool for studying differentiation of multipotential intestinal stem cells.

1988 • 20 citations

Stem cells and their properties.

1967 • 16 citations

Clonogenic response of cells of murine intestinal crypts to 12 cytotoxic drugs

1985 • 15 citations

Survival of intestinal crypts after treatment by adriamycin alone or with radiation

1980 • 14 citations