Molecular mechanism and function of CD40/CD40L engagement in the immune system

Dendritic cells and the control of immunity

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Akt Phosphorylation of BAD Couples Survival Signals to the Cell-Intrinsic Death Machinery

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Regulation of Cell Death Protease Caspase-9 by Phosphorylation

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The two NF-κB activation pathways and their role in innate and adaptive immunity

2004 • 2,476 citations

Germinal Centers

1994 • 1,680 citations

Antigen-specific interaction between T and B cells

1985 • 1,396 citations

Follicular B Helper T Cells Express Cxc Chemokine Receptor 5, Localize to B Cell Follicles, and Support Immunoglobulin Production

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CD40-CD40 ligand

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The CD40 Antigen and its Ligand

1994 • 1,259 citations

A chemokine-driven positive feedback loop organizes lymphoid follicles

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Cxc Chemokine Receptor 5 Expression Defines Follicular Homing T Cells with B Cell Helper Function

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Long-Term Survival of Xenogeneic Pancreatic Islet Grafts Induced by CTLA4lg

1992 • 1,156 citations

CTLA-4–Ig regulates tryptophan catabolism in vivo

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A Putative Chemokine Receptor, BLR1, Directs B Cell Migration to Defined Lymphoid Organs and Specific Anatomic Compartments of the Spleen

1996 • 1,125 citations

Mechanism of antigen-driven selection in germinal centres

1989 • 1,097 citations

Molecular and biological characterization of a murine ligand for CD40

1992 • 1,029 citations

IAP Antagonists Target cIAP1 to Induce TNFα-Dependent Apoptosis

2007 • 1,028 citations

Mechanisms of suppression by suppressor T cells

2005 • 1,023 citations

Human B7-1 (CD80) and B7-2 (CD86) bind with similar avidities but distinct kinetics to CD28 and CTLA-4 receptors

1994 • 950 citations

TRANCE (Tumor Necrosis Factor [TNF]-related Activation-induced Cytokine), a New TNF Family Member Predominantly Expressed in T cells, Is a Dendritic Cell–specific Survival Factor

1997 • 869 citations

Immunosuppression in Vivo by a Soluble Form of the CTLA-4 T Cell Activation Molecule

1992 • 820 citations

A 39-kDa protein on activated helper T cells binds CD40 and transduces the signal for cognate activation of B cells.

1992 • 818 citations

All-trans retinoic acid mediates enhanced T reg cell growth, differentiation, and gut homing in the face of high levels of co-stimulation

2007 • 813 citations

A B-cell-homing chemokine made in lymphoid follicles activates Burkitt's lymphoma receptor-1

1998 • 810 citations

B Cell–attracting Chemokine 1, a Human CXC Chemokine Expressed in Lymphoid Tissues, Selectively Attracts B Lymphocytes via BLR1/CXCR5

1998 • 807 citations

Early Lethality, Functional NF-κB Activation, and Increased Sensitivity to TNF-Induced Cell Death in TRAF2-Deficient Mice

1997 • 791 citations

Blocking both signal 1 and signal 2 of T-cell activation prevents apoptosis of alloreactive T cells and induction of peripheral allograft tolerance

1999 • 762 citations

Visualization of Specific B and T Lymphocyte Interactions in the Lymph Node

1998 • 762 citations

Imaging of Germinal Center Selection Events During Affinity Maturation

2006 • 760 citations

Mice deficient for the CD40 ligand

1994 • 753 citations

Germinal center dark and light zone organization is mediated by CXCR4 and CXCR5

2004 • 731 citations

In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. I. The architecture and dynamics of responding cell populations.

1991 • 683 citations

CD40/CD154 Interactions at the Interface of Tolerance and Immunity

2004 • 673 citations

A Role for CD40 Expression on CD8 ⁺ T Cells in the Generation of CD8 ⁺ T Cell Memory

2002 • 629 citations

Activated T cells induce expression of B7/BB1 on normal or leukemic B cells through a CD40-dependent signal.

1993 • 622 citations

Requirement for T-cell apoptosis in the induction of peripheral transplantation tolerance

1999 • 621 citations

T Follicular Helper (T_FH) Cells in Normal and Dysregulated Immune Responses

2008 • 611 citations

Nonredundant and complementary functions of TRAF2 and TRAF3 in a ubiquitination cascade that activates NIK-dependent alternative NF-κB signaling

2008 • 580 citations

Noncanonical NF-κB activation requires coordinated assembly of a regulatory complex of the adaptors cIAP1, cIAP2, TRAF2 and TRAF3 and the kinase NIK

2008 • 575 citations

NF-κB-mediated up-regulation of Bcl-x and Bfl-1/A1 is required for CD40 survival signaling in B lymphocytes

1999 • 526 citations

Antigen recognition strength regulates the choice between extrafollicular plasma cell and germinal center B cell differentiation

2006 • 511 citations

Functions of CD40 on B cells, dendritic cells and other cells

1997 • 490 citations

In Vivo–Activated Cd4 T Cells Upregulate Cxc Chemokine Receptor 5 and Reprogram Their Response to Lymphoid Chemokines

1999 • 482 citations

Clinical Activity and Immune Modulation in Cancer Patients Treated With CP-870,893, a Novel CD40 Agonist Monoclonal Antibody

2007 • 471 citations

Immune Tolerance After Delivery of Dying Cells to Dendritic Cells In Situ

2002 • 466 citations

CD40 activation in vivo overcomes peptide-induced peripheral cytotoxic T-lymphocyte tolerance and augments anti-tumor vaccine efficacy

1999 • 463 citations

In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. II. A common clonal origin for periarteriolar lymphoid sheath-associated foci and germinal centers.

1992 • 456 citations

Involvement of CRAF1, a relative of TRAF, in CD40 signaling

1995 • 454 citations

Dendritic Cells Interact Directly with Naive B Lymphocytes to Transfer Antigen and Initiate Class Switching in a Primary T-Dependent Response

1998 • 454 citations

CD40 and IgE: synergism between anti-CD40 monoclonal antibody and interleukin 4 in the induction of IgE synthesis by highly purified human B cells.

1990 • 453 citations

TRAF2 Is Essential for JNK but Not NF-κB Activation and Regulates Lymphocyte Proliferation and Survival

1997 • 449 citations

Activation of human B cells mediated through two distinct cell surface differentiation antigens, Bp35 and Bp50.

1986 • 439 citations

Increased expression of Ia antigens on resting B cells: an additional role for B-cell growth factor.

1984 • 438 citations

gp39-CD40 interactions are essential for germinal center formation and the development of B cell memory.

1994 • 431 citations

Survival of mouse pancreatic islet allografts in recipients treated with allogeneic small lymphocytes and antibody to CD40 ligand.

1995 • 426 citations

CD40 antibody evokes a cytotoxic T-cell response that eradicates lymphoma and bypasses T-cell help

1999 • 423 citations

Antigen presentation by hapten-specific B lymphocytes. I. Role of surface immunoglobulin receptors.

1984 • 422 citations

Conversion of tumor-specific CD4+ T-cell tolerance to T-cell priming through in vivo ligation of CD40

1999 • 409 citations

Synergy between chemotherapy and immunotherapy in the treatment of established murine solid tumors.

2003 • 401 citations

OX40 costimulation turns off Foxp3+ Tregs

2007 • 398 citations

Dendritic Cell Development and Survival Require Distinct NF-κB Subunits

2002 • 395 citations

Cell Surface Recycling of Internalized Antigen Permits Dendritic Cell Priming of B Cells

2005 • 386 citations

The Humoral Immune Response Is Initiated in Lymph Nodes by B Cells that Acquire Soluble Antigen Directly in the Follicles

2007 • 373 citations

Programmed death 1 ligand signaling regulates the generation of adaptive Foxp3 ⁺ CD4 ⁺ regulatory T cells

2008 • 370 citations

Tyrosine phosphorylated p91 binds to a single element in the ISGF2/IRF-1 promoter to mediate induction by IFN alpha and IFN gamma, and is likely to autoregulate the p91 gene.

1994 • 359 citations

High affinity germinal center B cells are actively selected into the plasma cell compartment

2006 • 358 citations

A two-step, two-signal model for the primary activation of precursor helper T cells

1999 • 356 citations

In vivo CD40-gp39 interactions are essential for thymus-dependent humoral immunity. II. Prolonged suppression of the humoral immune response by an antibody to the ligand for CD40, gp39.

1993 • 354 citations

Asialo GM1+ CD8+ T cells play a critical role in costimulation blockade–resistant allograft rejection

1999 • 351 citations

In Situ Studies of the Primary Immune Response to (4-Hydroxy-3-Nitrophenyl)Acetyl. V. Affinity Maturation Develops in Two Stages of Clonal Selection

1998 • 349 citations

CD40-ligand (CD154) gene therapy for chronic lymphocytic leukemia

2000 • 345 citations

CD40-gp39 INTERACTIONS PLAY A CRITICAL ROLE DURING ALLOGRAFT REJECTION

1996 • 331 citations

The immunological synapse and CD28-CD80 interactions

2001 • 303 citations

Long-term survival of skin allografts induced by donor splenocytes and anti-CD154 antibody in thymectomized mice requires CD4(+) T cells, interferon-gamma, and CTLA4.

1998 • 297 citations

Modulation of NF-κB Activity and Apoptosis in Chronic Lymphocytic Leukemia B Cells

2000 • 278 citations

A soluble form of TRAP (CD40 ligand) is rapidly released after T cell activation

1995 • 252 citations

CD40 Ligand Blockade Induces CD4+ T Cell Tolerance and Linked Suppression

1999 • 251 citations

In vivo CD40-gp39 interactions are essential for thymus-dependent humoral immunity. I. In vivo expression of CD40 ligand, cytokines, and antibody production delineates sites of cognate T-B cell interactions.

1993 • 250 citations

CD40−Tumor Necrosis Factor Receptor-Associated Factor (TRAF) Interactions: Regulation of CD40 Signaling through Multiple TRAF Binding Sites and TRAF Hetero-Oligomerization

1998 • 248 citations

Gene transfer of CD40-ligand induces autologous immune recognition of chronic lymphocytic leukemia B cells.

1998 • 247 citations

A New Mechanism of NK Cell Cytotoxicity Activation: The CD40–CD40 Ligand Interaction

1997 • 244 citations

2 å crystal structure of an extracellular fragment of human CD40 ligand

1995 • 240 citations

Inhibition of human B-cell lymphoma growth by CD40 stimulation

1994 • 232 citations

TNF receptor (TNFR)-associated factor (TRAF) 3 serves as an inhibitor of TRAF2/5-mediated activation of the noncanonical NF-κB pathway by TRAF-binding TNFRs

2005 • 232 citations

TRAF2 and TRAF3 Signal Adapters Act Cooperatively to Control the Maturation and Survival Signals Delivered to B Cells by the BAFF Receptor

2008 • 232 citations

CD40 stimulation leads to effective therapy of CD40⁻tumors through induction of strong systemic cytotoxic T lymphocyte immunity

2002 • 224 citations

Developmental Switches in Chemokine Response Profiles during B Cell Differentiation and Maturation

2000 • 222 citations

Phase I Study of Recombinant Human CD40 Ligand in Cancer Patients

2001 • 221 citations

Jak3 Is Associated with CD40 and Is Critical for CD40 Induction of Gene Expression in B Cells

1997 • 207 citations

Activation of the B-cell Surface Receptor CD40 Induces A20, a Novel Zinc Finger Protein That Inhibits Apoptosis

1995 • 205 citations

A novel function of CD40: induction of cell death in transformed cells.

1996 • 202 citations

Crystallographic analysis of CD40 recognition and signaling by human TRAF2

1999 • 200 citations

CD40-induced growth inhibition in epithelial cells is mimicked by Epstein-Barr Virus-encoded LMP1: involvement of TRAF3 as a common mediator.

1996 • 200 citations

T-cell–B-cell cooperation

2004 • 186 citations

Targeted disruption ofTraf5gene causes defects in CD40- and CD27-mediated lymphocyte activation

1999 • 185 citations

CD40 signaling activates CD11a/CD18 (LFA-1)-mediated adhesion in B cells.

1991 • 184 citations

CD40 Signaling through Tumor Necrosis Factor Receptor-associated Factors (TRAFs)

1999 • 184 citations

Suppression of apoptosis in normal and neoplastic human B lymphocytes by CD40 ligand is independent of Bcl‐2 induction

1993 • 180 citations

Recombinant Soluble Trimeric CD40 Ligand Is Biologically Active

1995 • 176 citations

Germinal Center Initiation, Variable Gene Region Hypermutation, and Mutant B Cell Selection without Detectable Immune Complexes on Follicular Dendritic Cells

2000 • 174 citations

The Human Tumor Necrosis Factor (TNF) Receptor-associated Factor 1 Gene (TRAF1) Is Up-regulated by Cytokines of the TNF Ligand Family and Modulates TNF-induced Activation of NF-κB and c-Jun N-terminal Kinase

1999 • 169 citations

Prospects for CD40-directed experimental therapy of human cancer

2002 • 168 citations

CD40 Induces Apoptosis in Carcinoma Cells through Activation of Cytotoxic Ligands of the Tumor Necrosis Factor Superfamily

2000 • 168 citations

Prospect of Targeting the CD40 Pathway for Cancer Therapy

2007 • 167 citations

TRAF Proteins in CD40 Signaling

2007 • 166 citations

The Role of CD40–CD154 Interactions in Autoimmunity and the Benefit of Disrupting this Pathway

2004 • 161 citations

The CD40/CD40L costimulatory pathway in inflammatory bowel disease

2004 • 155 citations

The role of bcl‐x_L in CD40‐mediated rescue from anti‐μ‐induced apoptosis in WEHI‐231 B lymphoma cells

1995 • 154 citations

IFN-γ mediates CD4+ T-cell loss and impairs secondary antitumor responses after successful initial immunotherapy

2007 • 154 citations

High-Affinity Interactions of Tumor Necrosis Factor Receptor-Associated Factors (TRAFs) and CD40 Require TRAF Trimerization and CD40 Multimerization

1999 • 154 citations

CD40-CD40 Ligand-Independent Activation of CD8+ T Cells Can Trigger Allograft Rejection

2000 • 153 citations

Separation of events mediating B cell proliferation and Ig production by using T cell membranes and lymphokines.

1990 • 150 citations

Identification of a human epithelial cell surface protein sharing an epitope with the C3d/epstein‐barr virus receptor molecule of B lymphocytes

1989 • 149 citations

The CD40-TRAF6 axis controls affinity maturation and the generation of long-lived plasma cells

2002 • 147 citations

TNFR-Associated Factor Family Protein Expression in Normal Tissues and Lymphoid Malignancies

2000 • 143 citations

Regulation of the Subcellular Localization of Tumor Necrosis Factor Receptor–associated Factor (TRAF)2 by TRAF1 Reveals Mechanisms of TRAF2 Signaling

2002 • 142 citations

Dendritic cells modified to express CD40 ligand elicit therapeutic immunity against preexisting murine tumors

2000 • 142 citations

COMBINED COSTIMULATION BLOCKADE PLUS RAPAMYCIN BUT NOT CYCLOSPORINE PRODUCES PERMANENT ENGRAFTMENT1

1998 • 140 citations

Inhibition of Human Breast Carcinoma Growth by a Soluble Recombinant Human CD40 Ligand

1999 • 140 citations

Genetic Characterization of Strain Differences in the Ability to Mediate CD40/CD28-Independent Rejection of Skin Allografts

2000 • 137 citations

Follicular Dendritic Cells Specifically Express the Long CR2/CD21 Isoform

1997 • 136 citations

Requirement for TRAF3 in Signaling by LMP1 But Not CD40 in B Lymphocytes

2004 • 131 citations

Flice-Inhibitory Protein Is a Key Regulator of Germinal Center B Cell Apoptosis

2001 • 129 citations

Expression of immune regulatory molecules in Epstein-Barr virus-associated nasopharyngeal carcinomas with prominent lymphoid stroma. Evidence for a functional interaction between epithelial tumor cells and infiltrating lymphoid cells.

1995 • 127 citations

A Positive Regulatory Role for Cbl Family Proteins in Tumor Necrosis Factor-related Activation-induced Cytokine (TRANCE) and CD40L-mediated Akt Activation

2001 • 123 citations

Critical, but Conditional, Role of OX40 in Memory T Cell-Mediated Rejection

2006 • 122 citations

A CD40 Signalosome Anchored in Lipid Rafts Leads to Constitutive Activation of NF-κB and Autonomous Cell Growth in B Cell Lymphomas

2002 • 121 citations

Growth-inhibitory effects of CD40 ligand (CD154) and its endogenous expression in human breast cancer.

2001 • 120 citations

The Binding Site for TRAF2 and TRAF3 but Not for TRAF6 Is Essential for CD40-Mediated Immunoglobulin Class Switching

2002 • 120 citations

CD40 is expressed and functional on neuronal cells

2002 • 119 citations

Tumor Necrosis Factor Receptor-associated Factor 2 (TRAF2)-deficient B Lymphocytes Reveal Novel Roles for TRAF2 in CD40 Signaling

2003 • 118 citations

B-cell growth factor (B-cell growth factor I or B-cell-stimulating factor, provisional 1) is a differentiation factor for resting B cells and may not induce cell growth.

1985 • 118 citations

Peripheral Deletion After Bone Marrow Transplantation with Costimulatory Blockade Has Features of Both Activation-Induced Cell Death and Passive Cell Death

2001 • 117 citations

Costimulation blockade in autoimmunity and transplantation

2008 • 110 citations

Cooperation between TNF Receptor-Associated Factors 1 and 2 in CD40 Signaling

2006 • 109 citations

Protective immunity induced by tumor vaccines requires interaction between CD40 and its ligand, CD154.

1997 • 106 citations

Regulation of TRAF2 Signaling by Self-induced Degradation

2002 • 104 citations

Kinase MEKK1 is required for CD40-dependent activation of the kinases Jnk and p38, germinal center formation, B cell proliferation and antibody production

2006 • 104 citations

The antileukemia activity of a human anti-CD40 antagonist antibody, HCD122, on human chronic lymphocytic leukemia cells

2008 • 102 citations

Analysis of the oligomeric requirement for signaling by CD40 using soluble multimeric forms of its ligand, CD154

2001 • 102 citations

Critical Role of OX40 in CD28 and CD154-Independent Rejection

2004 • 102 citations

The Role of the p38 Mitogen-Activated Protein Kinase, Extracellular Signal-Regulated Kinase, and Phosphoinositide-3-OH Kinase Signal Transduction Pathways in CD40 Ligand-Induced Dendritic Cell Activation and Expansion of Virus-Specific CD8+ T Cell Memory Responses

2004 • 101 citations

Imprinting the Fate of Antigen-Reactive B Cells through the Affinity of the B Cell Receptor

2006 • 100 citations

Bcl-x rather than Bcl-2 mediates CD40-dependent centrocyte survival in the germinal center

1996 • 99 citations

Stimulation of B-cell proliferation by membrane-associated molecules from activated T cells.

1988 • 98 citations

Mechanisms of donor-specific transfusion tolerance: preemptive induction of clonal T-cell exhaustion via indirect presentation

2003 • 95 citations

Short-circuiting long-lived humoral immunity by the heightened engagement of CD40

2002 • 95 citations

CTLA4Ig PROLONGS ALLOGRAFT SURVIVAL WHILE SUPPRESSING CELL-MEDIATED IMMUNITY

1994 • 94 citations

Anti-Tumor Immunity Induced by in Vivo Adenovirus Vector-Mediated Expression of CD40 Ligand in Tumor Cells

1999 • 91 citations

CD4-Dependent Generation of Dominant Transplantation Tolerance Induced by Simultaneous Perturbation of CD154 and LFA-1 Pathways

2002 • 90 citations

CTLA4Ig PROLONGS ALLOGRAFT SURVIVAL WHILE SUPPRESSING CELL-MEDIATED IMMUNITY

1994 • 88 citations

Specificities of CD40 signaling: Involvement of TRAF2 in CD40-induced NF-κB activation and intercellular adhesion molecule-1 up-regulation

1999 • 87 citations

Enhanced efficacy and reduced toxicity of multifactorial adjuvants compared with unitary adjuvants as cancer vaccines

2008 • 85 citations

Upregulation of TRAF-3 by shear stress blocks CD40-mediated endothelial activation

2001 • 85 citations

Interleukins 4 and 5 control expression of IL-2 receptor on murine B cells through independent induction of its two chains

1989 • 83 citations

Anti-CD40 monoclonal antibody therapy in combination with irradiation results in a CD8 T-cell–dependent immunity to B-cell lymphoma

2003 • 83 citations

CD40 stimulation accelerates deletion of tumor-specific CD8⁺T cells in the absence of tumor-antigen vaccination

2001 • 81 citations

Short-circuiting long-lived humoral immunity by the heightened engagement of CD40

2002 • 80 citations

Tumor Necrosis Factor-α Facilitates Induction of CD80 (B7-1) and CD54 on Human B Cells by Activated T Cells: Complex Regulation by IL-4, IL-10, and CD40L

1995 • 79 citations

Role for CD40–CD40 ligand interactions in the immune response to solid tumours

2000 • 76 citations

Immunotherapy of high-risk acute leukemia with a recipient (autologous) vaccine expressing transgenic human CD40L and IL-2 after chemotherapy and allogeneic stem cell transplantation

2005 • 75 citations

Affinity of antigen encounter and other early B-cell signals determine B-cell fate

2007 • 74 citations

T-cell-replacing factor (interleukin 5) induces expression of interleukin 2 receptors on murine splenic B cells.

1987 • 73 citations

Mechanism for fetal hemoglobin induction by histone deacetylase inhibitors involves γ-globin activation by CREB1 and ATF-2

2006 • 72 citations

Inhibition of Phosphatidylinositol 3-Kinase- and ERK MAPK-regulated Protein Synthesis Reveals the Pro-apoptotic Properties of CD40 Ligation in Carcinoma Cells

2004 • 71 citations

CD40 is functionally expressed on human breast carcinomas: Variable inducibility by cytokines and enhancement of Fas-mediated apoptosis

1998 • 70 citations

Mutation pattern of immunoglobulin transgenes is compatible with a model of somatic hypermutation in which targeting of the mutator is linked to the direction of DNA replication.

1991 • 69 citations

Antitumor Responses Induced by Transgenic Expression of CD40 Ligand

1997 • 66 citations

A Novel Mechanism for TNFR-Associated Factor 6-Dependent CD40 Signaling

2007 • 66 citations

CD40 activation in epithelial ovarian carcinoma cells modulates growth, apoptosis, and cytokine secretion

2002 • 66 citations

Effects of Cyclosporine on Transplant Tolerance: The Role of IL‐2

2007 • 65 citations

Physiological Roles and Mechanisms of Signaling by TRAF2 and TRAF5

2007 • 64 citations

CD40 activation mediates p53-dependent cell cycle regulation in human multiple myeloma cell lines

2000 • 63 citations

CD40 ligand-CD40 interaction induces chemokines in cervical carcinoma cells in synergism with IFN-gamma.

1999 • 63 citations

TRAF6 Is Required for TRAF2-Dependent CD40 Signal Transduction in Nonhemopoietic Cells

2005 • 61 citations

Constitutive activation of the CD40 pathway promotes cell transformation and neoplastic growth

2005 • 60 citations

Up-Regulation of Bcl-xLExpression Protects CD40-Activated Human B Cells from Fas-Mediated Apoptosis

1996 • 60 citations

TRAF3 and Its Biological Function

2007 • 59 citations

CD154 on the surface of CD4+CD25+ regulatory t cells contributes to skin transplant tolerance

2003 • 58 citations

TNF受容体(TNFR)関連因子(TRAF)3はTRAF結合性TNFRによる非定型的NFκB経路のTRAF2/5介在性活性化の阻害物質として働く

2005 • 58 citations

CD40 Ligand-CD40 Interaction Induces Chemokines in Cervical Carcinoma Cells in Synergism with IFN-γ

1999 • 57 citations

CD11a-CD18 and CD102 interactions mediate human myeloma cell growth arrest induced by CD40 stimulation.

1996 • 55 citations

Functional CD40 Antigen on B Cells, Dendritic Cells and Fibroblasts

1995 • 54 citations

CD40 expression in bladder cancer

1999 • 54 citations

Centrocytes rapidly adopt a memory B cell phenotype on co-culture with autologous germinal centre T cell-enriched preparations

1996 • 53 citations

Indefinite Survival of Neonatal Porcine Islet Xenografts by Simultaneous Targeting of LFA-1 and CD154 or CD45RB

2005 • 48 citations

The effect of simultaneous CD154 and LFA-1 blockade on the survival of allogeneic islet grafts in nonobese diabetic mice1

2003 • 47 citations

CD40 Signaling through a Newly Identified Tumor Necrosis Factor Receptor-associated Factor 2 (TRAF2) Binding Site

2003 • 44 citations

Cognate interactions between helper T cells and B cells. II. Dissection of cognate help by using a class II-restricted, antigen-specific, IL-2-dependent helper T cell clone.

1989 • 44 citations

CD40 cross-linking bypasses the absolute requirement for CD4 T cells during immunization with melanoma antigen gene-modified dendritic cells.

2001 • 42 citations

Cellular responses to murine CD40 in a mouse B cell line may be TRAF dependent or independent

2002 • 40 citations

OX40 Controls Islet Allograft Tolerance in CD154 Deficient Mice by Regulating FOXP3+ Tregs

2008 • 39 citations

The expansive role of CD40 and its ligand, gp39, in immunity

1994 • 39 citations

Prevention of CD40-Triggered Dendritic Cell Maturation and Induction of T-Cell Hyporeactivity by Targeting of Janus Kinase 3

2003 • 39 citations

Activation of the Janus Kinase 3-STAT5a Pathway After CD40 Triggering of Human Monocytes But Not of Resting B Cells

1999 • 39 citations

Dissection of B cell differentiation during primary immune responses in mice with altered CD40 signals

2002 • 38 citations

Negative Regulation of CD40-Mediated B Cell Responses by E3 Ubiquitin Ligase Casitas-B-Lineage Lymphoma Protein-B

2007 • 38 citations

Functional activity of CD40 antibodies correlates to the position of binding relative to CD154

2001 • 37 citations

A pilot study of combined immunotherapy with autologous adoptive tumour‐specific T‐cell transfer, vaccination with CD40‐activated malignant B cells and interleukin 2

2001 • 36 citations

Targeting LFA-1 Synergizes with CD40/CD40L Blockade for Suppression of Both CD4-Dependent and CD8-Dependent Rejection

2003 • 35 citations

The role of CD40L (gp39)/CD40 in T/B cell interaction and primary immunodeficiency

1994 • 35 citations

Regulation of Skin and Islet Allograft Survival in Mice Treated With Costimulation Blockade is Mediated by Different CD4+ Cell Subsets and Different Mechanisms

2004 • 34 citations

Population depletion activates autonomous CD154-dependent survival in biopsylike Burkitt lymphoma cells

2002 • 34 citations

Targeting LFA-1 and CD154 Suppresses the In Vivo Activation and Development of Cytolytic (CD4-Independent) CD8+ T Cells

2005 • 33 citations

CD40L induces proliferation, self-renewal, rescue from apoptosis, and production of cytokines by CD40-expressing AML blasts

2002 • 33 citations

Blockade of the CD28 and CD40 pathways result in the acceptance of pig and rat islet xenografts but not rat cardiac grafts in mice

2001 • 32 citations

Anti-CD28 Antibodies Modify Regulatory Mechanisms and Reinforce Tolerance in CD40Ig-Treated Heart Allograft Recipients

2007 • 32 citations

Tolerance to Antigen-Presenting Cell-Depleted Islet Allografts Is CD4 T Cell Dependent

1999 • 31 citations

Prolonged Survival of Microencapsulated Neonatal Porcine Islets in Mice Treated with a Combination of Anti-CD154 and Anti-LFA-1 Monoclonal Antibodies

2005 • 30 citations

The role of positive costimulatory molecules in transplantation and tolerance

2008 • 27 citations

Antibody-Induced Transplantation Tolerance: The Role of Dominant Regulation

2003 • 27 citations

Neutralizing IL-7 Promotes Long-Term Allograft Survival Induced by CD40/CD40L Costimulatory Blockade

2006 • 26 citations

The in vivo function of a noncanonical TRAF2-binding domain in the C-terminus of CD40 in driving B-cell growth and differentiation

2007 • 26 citations

Cognate interactions between helper T cells and B cells. IV. Requirements for the expression of effector phase activity by helper T cells.

1990 • 24 citations

A Phase 1 Dose Escalation Study of a Fully Human, Antagonist Anti-CD40 Antibody, HCD122 (Formerly CHIR-12.12) in Patients with Relapsed and Refractory Multiple Myeloma.

2006 • 24 citations

Blockade of CD40L/CD40 costimulatory pathway in a DST presensitization model of islet allograft leads to a state of Allo-Ag specific tolerance and permits subsequent engraftment of donor strain islet or heart allografts

1999 • 24 citations

Outside inside signalling in CD40-mediated B cell activation.

2007 • 24 citations

CD40 triggered human monocyte-derived dendritic cells convert to tolerogenic dendritic cells when JAK3 activity is inhibited

2002 • 23 citations

Comparison of immune responsiveness in mice after single or multiple donor-specific transfusions.

1984 • 22 citations

Immunogenetic therapy for B-cell malignancies.

2000 • 22 citations

CD40-mediated Activation of NF-κB in Airway Epithelial Cells

2002 • 21 citations

A humanized antibody against CD40 (SGN-40) is well tolerated and active in non-Hodgkin’s lymphoma (NHL): Results of a phase I study

2006 • 21 citations

PD-1–PD-L1 Pathway Is Involved in Suppressing Alloreactivity of Heart Infiltrating T Cells During Murine GVHD Across Minor Histocompatibility Antigen Barriers

2007 • 20 citations

Distinctive maturation of in vitro versus in vivo anti-CD40 mAb-matured dendritic cells in mice.

2003 • 18 citations

Pharmacokinetics and Pharmacodynamics from a First-in-Human Phase 1 Dose Escalation Study with Antagonist Anti-CD40 Antibody, HCD122 (Formerly CHIR-12.12), in Patients with Relapsed and Refractory Chronic Lymphocytic Leukemia.

2006 • 18 citations

Islet Allograft Rejection in Nonobese Diabetic Mice Involves the Common γ-Chain and CD28/CD154-Dependent and -Independent Mechanisms

2003 • 17 citations

New Insights in CD28‐Independent Allograft Rejection

2007 • 15 citations

A Phase I Humanized Anti-CD40 Monoclonal Antibody (SGN-40) in Patients with Multiple Myeloma.

2005 • 15 citations

Combined donor specific transfusion and anti-CD154 therapy achieves airway allograft tolerance

2005 • 15 citations

Blockade of the PD-1/PD-1L pathway reverses the protective effect of anti-CD40L therapy in a rat to mouse concordant islet xenotransplantation model

2007 • 14 citations

Anti-CD25 mAb, Anti-IL2 mAb, and IL2 Block Tolerance Induction Through Anti-CD154 mAb and Rapamycin in Xenogeneic Islet Transplantation

2007 • 11 citations

The role of CD40L (gp39)/CD40 in T/B cell interaction and primary immunodeficiency

1994 • 11 citations

In vitro characterization and pre-clinical pharmacokinetics of CP-870,893, a human anti-CD40 agonist antibody

2006 • 10 citations

IL-2 Pathway Blocking in Combination with Anti-CD154 Synergistically Establishes Mixed Macrochimerism with Limited Dose of Bone Marrow Cells and Prolongs Skin Graft Survival in Mice

2006 • 8 citations

Role of Lipid Rafts in GPVI Agonist-Induced Platelet Signaling.

2005 • 3 citations