CD40-CD40 Ligand-Independent Activation of CD8+ T Cells Can Trigger Allograft Rejection

CD28/B7 SYSTEM OF T CELL COSTIMULATION

1996 • 2,726 citations

T-cell help for cytotoxic T lymphocytes is mediated by CD40–CD40L interactions

1998 • 2,615 citations

A conditioned dendritic cell can be a temporal bridge between a CD4+ T-helper and a T-killer cell

1998 • 2,373 citations

Help for cytotoxic-T-cell responses is mediated by CD40 signalling

1998 • 2,106 citations

Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation.

1996 • 2,032 citations

Natural adjuvants: Endogenous activators of dendritic cells

1999 • 1,611 citations

Acquisition of Lymphokine-Producing Phenotype by CD4+ T Cells

1994 • 1,573 citations

CD40 AND CD154 IN CELL-MEDIATED IMMUNITY

1998 • 1,546 citations

Long-term acceptance of skin and cardiac allografts after blocking CD40 and CD28 pathways

1996 • 1,457 citations

ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28

1999 • 1,418 citations

Activation of human dendritic cells through CD40 cross-linking.

1994 • 1,351 citations

The immune responses in CD40-deficient mice: Impaired immunoglobulin class switching and germinal center formation

1994 • 1,099 citations

Molecular and biological characterization of a murine ligand for CD40

1992 • 1,029 citations

CTLA4-Ig and anti-CD40 ligand prevent renal allograft rejection in primates

1997 • 936 citations

Treatment with humanized monoclonal antibody against CD154 prevents acute renal allograft rejection in nonhuman primates

1999 • 824 citations

Blocking both signal 1 and signal 2 of T-cell activation prevents apoptosis of alloreactive T cells and induction of peripheral allograft tolerance

1999 • 762 citations

Mice deficient for the CD40 ligand

1994 • 753 citations

Requirement for T-cell apoptosis in the induction of peripheral transplantation tolerance

1999 • 621 citations

The human T cell antigen gp39, a member of the TNF gene family, is a ligand for the CD40 receptor: expression of a soluble form of gp39 with B cell co-stimulatory activity.

1992 • 518 citations

Impairment of antigen-specific T-cell priming in mice lacking CD40 ligand

1995 • 476 citations

Prevention of Collagen-Induced Arthritis with an Antibody to gp39, the Ligand for CD40

1993 • 471 citations

Survival of mouse pancreatic islet allografts in recipients treated with allogeneic small lymphocytes and antibody to CD40 ligand.

1995 • 426 citations

Requirement for CD40 Ligand in Costimulation Induction, T Cell Activation, and Experimental Allergic Encephalomyelitis

1996 • 425 citations

CD40 ligand-transduced co-stimulation of T cells in the development of helper function

1995 • 425 citations

CD40 Ligand-Dependent T Cell Activation: Requirement of B7-CD28 Signaling Through CD40

1996 • 421 citations

Costimulatory function and expression of CD40 ligand, CD80, and CD86 in vascularized murine cardiac allograft rejection

1996 • 416 citations

Asialo GM1+ CD8+ T cells play a critical role in costimulation blockade–resistant allograft rejection

1999 • 351 citations

CD40 Ligand Is Required for Protective Cell-Mediated Immunity to Leishmania major

1996 • 332 citations

CD40-gp39 INTERACTIONS PLAY A CRITICAL ROLE DURING ALLOGRAFT REJECTION

1996 • 331 citations

A central role of CD40 ligand in the regulation of CD4+ T-cell responses

1996 • 329 citations

Constructing polycompetitor cDNAs for quantitative PCR

1993 • 323 citations

Activated human T cells express a ligand for the human B cell‐associated antigen CD40 which participates in T cell‐dependent activation of B lymphocytes

1992 • 323 citations

CD28-independent, TRAF2-dependent Costimulation of Resting T Cells by 4-1BB Ligand

1998 • 321 citations

Protective Role of CD40 in Leishmania major Infection at Two Distinct Phases of Cell-Mediated Immunity

1996 • 302 citations

TRANCE, a Tumor Necrosis Factor Family Member Critical for CD40 Ligand–independent T Helper Cell Activation

1999 • 262 citations

CD40 Ligand Blockade Induces CD4+ T Cell Tolerance and Linked Suppression

1999 • 251 citations

CD40 ligand-CD40 interactions are necessary for the initiation of insulitis and diabetes in nonobese diabetic mice.

1997 • 244 citations

The role of CD40/CD154 interactions in the priming, differentiation, and effector function of helper and cytotoxic T cells

1998 • 230 citations

Treatment of Allograft Recipients with Donor-Specific Transfusion and Anti-CD154 Antibody Leads to Deletion of Alloreactive CD8+ T Cells and Prolonged Graft Survival in a CTLA4-Dependent Manner

2000 • 216 citations

CTLA4 Signals Are Required to Optimally Induce Allograft Tolerance with Combined Donor-Specific Transfusion and Anti-CD154 Monoclonal Antibody Treatment

1999 • 177 citations

CD40 ligand-deficient mice generate a normal primary cytotoxic T-lymphocyte response but a defective humoral response to a viral infection

1996 • 154 citations

Cutting edge: blockade of the CD28/B7 costimulatory pathway inhibits intestinal allograft rejection mediated by CD4+ but not CD8+ T cells.

1999 • 143 citations

OX40 is differentially expressed on activated rat and mouse T cells and is the sole receptor for the OX40 ligand

1996 • 138 citations

Cutting Edge: Blockade of the CD28/B7 Costimulatory Pathway Inhibits Intestinal Allograft Rejection Mediated by CD4+ But Not CD8+ T Cells

1999 • 125 citations

ICAM-1 and B7-1 provide similar but distinct costimulation for CD8+ T cells, while CD4+ T cells are poorly costimulated by ICAM-1

1999 • 120 citations

Cutting Edge: Sustained Expansion of CD8+ T Cells Requires CD154 Expression by Th Cells in Acute Graft Versus Host Disease

1999 • 101 citations

CD40L is important for induction of, but not response to, costimulatory activity. ICAM-1 as the second costimulatory molecule rapidly up-regulated by CD40L.

1996 • 101 citations

The Role of the CD40 Pathway in Alloantigen-Induced Hyporesponsiveness In Vivo

1998 • 82 citations

CD40 ligand‐positive CD8⁺ T cell clones allow B cell growth and differentiation

1995 • 74 citations

CD40 Ligand Is Not Essential for Induction of Type 1 Cytokine Responses or Protective Immunity after Primary or Secondary Infection With Histoplasma capsulatum

1998 • 62 citations

Cytotoxicity and weak CD40 ligand expression of CD8⁺ type 2 cytotoxic T cells restricts their potential B cell helper activity

1997 • 62 citations

Deletion of alloantigen-reactive thymocytes as a mechanism of adult tolerance induction following intrathymic antigen administration

1997 • 42 citations

Disruption of CD154:CD40 Blocks Generation of Allograft Immunity Without Affecting APC Activation

1999 • 37 citations

Analysis of T cell activation requirements with the use of alloantigens or an anti-clonotypic monoclonal antibody.

1986 • 36 citations

ICAM-1 co-stimulation has differential effects on the activation of CD4+ and CD8+ T cells

1999 • 30 citations

T-Cell Activation, Proliferation, and Memory After Cardiac Transplantation In Vivo

1999 • 27 citations

INDUCTION OF UNRESPONSIVENESS TO ORGAN ALLOGRAFTS

1991 • 9 citations

Induction of unresponsiveness to organ allografts. A comparison of different immunosuppressive protocols in DA and WF strains of rats.

1991 • 8 citations