Tolerance to Antigen-Presenting Cell-Depleted Islet Allografts Is CD4 T Cell Dependent

Tolerance, Danger, and the Extended Family

1994 • 4,654 citations

Regulatory T Cell Clones Induced by Oral Tolerance: Suppression of Autoimmune Encephalomyelitis

1994 • 1,995 citations

A Cell Culture Model for T Lymphocyte Clonal Anergy

1990 • 1,894 citations

Long-term acceptance of skin and cardiac allografts after blocking CD40 and CD28 pathways

1996 • 1,457 citations

Characterization of the murine T cell surface molecule, designated L3T4, identified by monoclonal antibody GK1.5: similarity of L3T4 to the human Leu-3/T4 molecule.

1983 • 1,307 citations

Ablation of “tolerance” and induction of diabetes by virus infection in viral antigen transgenic mice

1991 • 1,187 citations

Antigen presentation by chemically modified splenocytes induces antigen-specific T cell unresponsiveness in vitro and in vivo.

1987 • 1,166 citations

Long-Term Survival of Xenogeneic Pancreatic Islet Grafts Induced by CTLA4lg

1992 • 1,156 citations

Phenotypically distinct subsets of CD4⁺ T cells induce or protect from chronic intestinal inflammation in C. B-17 scid mice

1993 • 1,064 citations

Extrathymic tolerance of mature T cells: Clonal elimination as a consequence of immunity

1990 • 904 citations

"Infectious" Transplantation Tolerance

1993 • 890 citations

Reconstitution with syngeneic plus allogeneic or xenogeneic bone marrow leads to specific acceptance of allografts or xenografts

1984 • 767 citations

AN IMPROVED METHOD FOR ISOLATION OF MOUSE PANCREATIC ISLETS

1985 • 548 citations

CD28-B7 blockade after alloantigenic challenge in vivo inhibits Th1 cytokines but spares Th2.

1995 • 532 citations

Immunobiology of Tissue Transplantation: A Return to the Passenger Leukocyte Concept

1983 • 524 citations

CD4+ T cells that express high levels of CD45RB induce wasting disease when transferred into congenic severe combined immunodeficient mice. Disease development is prevented by cotransfer of purified CD4+ T cells.

1993 • 471 citations

Evidence that the T cell repertoire of normal rats contains cells with the potential to cause diabetes. Characterization of the CD4+ T cell subset that inhibits this autoimmune potential.

1993 • 442 citations

OX-22high CD4+ T cells induce wasting disease with multiple organ pathology: prevention by the OX-22low subset.

1990 • 399 citations

Diversity of Cytokine Synthesis and Function of Mouse CD4⁺ T Cells

1991 • 371 citations

Indirect presentation of MHC antigens in transplantation

1994 • 362 citations

Role of intrathymic clonal deletion and peripheral anergy in transplantation tolerance induced by bone marrow transplantation in mice conditioned with a nonmyeloablative regimen.

1994 • 329 citations

The role of "indirect" recognition in initiating rejection of skin grafts from major histocompatibility complex class II-deficient mice.

1993 • 325 citations

TRANSPLANTATION TOLERANCE INDUCED BY CTLA4-Ig1

1994 • 303 citations

Increased Incidence of Congenital Malformations in the Offspring of Diabetic Rats and Their Prevention by Maternal Insulin Therapy

1982 • 296 citations

TRANSPLANTATION TOLERANCE INDUCED BY CTLA4-Ig1

1994 • 294 citations

Role of Cytokines in the Differentiation of CD4⁺ T‐Cell Subsets in vivo

1991 • 289 citations

Donor major histocompatibility complex (MHC) peptides are presented by recipient MHC molecules during graft rejection.

1992 • 266 citations

T cell-mediated inhibition of the transfer of autoimmune diabetes in NOD mice.

1989 • 257 citations

Donor cell chimerism permitted by immunosuppressive drugs: a new view of organ transplantation

1993 • 251 citations

Prolongation of Islet Allograft Survival Following in Vitro Culture (24°C) and a Single Injection of ALS

1979 • 246 citations

THE USE OF FICOLL IN THE PREPARATION OF VIABLE ISLETS OF LANGERHANS FROM THE RAT PANCREAS

1973 • 240 citations

Rejection of skin allografts by indirect allorecognition of donor class I major histocompatibility complex peptides.

1992 • 218 citations

Prevention of rejection of murine islet allografts by pretreatment with anti-dendritic cell antibody.

1984 • 216 citations

MECHANISMS OF T CELL RECOGNITION OF ALLOANTIGEN

1994 • 205 citations

Phenotype, specificity, and function of T cell subsets and T cell interactions involved in skin allograft rejection.

1987 • 198 citations

Mechanisms of Peripheral Tolerance and Suppression Induced by Monoclonal Antibodies to CD4 and CD8

1996 • 195 citations

Prolongation of murine islet allograft survival by pretreatment of islets with antibody directed to Ia determinants.

1981 • 186 citations

Mixed allogeneic chimerism as an approach to transplantation tolerance

1988 • 173 citations

Specific unresponsiveness in rats with prolonged cardiac allograft survival after treatment with cyclosporine. Mediation of specific suppression by T helper/inducer cells.

1985 • 163 citations

Immunologically ignorant autoreactive T cells, epitope spreading and repertoire limitation

1995 • 147 citations

Prolongation of Rat Islet Allograft Survival by Direct Ultraviolet Irradiation of the Graft

1984 • 143 citations

Construction and properties of new Lyt-congenic strains and anti-Lyt-2.2 and anti-Lyt-3.1 monoclonal antibodies

1980 • 136 citations

Transplantation tolerance induced by antigen pretreatment and depleting anti‐CD4 antibody depends on CD4⁺ T cell regulation during the induction phase of the response

1995 • 134 citations

Blocking the CD28-B7 T cell costimulation pathway induces long term cardiac allograft acceptance in the absence of IL-4.

1997 • 129 citations

Induction of "infectious" tolerance to MHC-incompatible cardiac allografts in CD4 monoclonal antibody-treated sensitized rat recipients.

1996 • 126 citations

Self‐Ignorance in the Peripheral T‐Cell Pool

1993 • 124 citations

Successful Allotransplantation of Mouse Pancreatic Islets to Nonimmunosuppressed Recipients

1980 • 124 citations

The Physiological Role of Regulatory T Cells in the Prevention of Autoimmunity: the Function of the Thymus in the Generation of the Regulatory T Cell Subset

1996 • 121 citations

Specific cytotoxic T cells are found in the nonrejected kidneys of blood-transfused rats.

1987 • 119 citations

EVIDENCE THAT THE CONTINUED PRESENCE OF THE ORGAN GRAFT AND NOT PERIPHERAL DONOR MICROCHIMERISM IS ESSENTIAL FOR MAINTENANCE OF TOLERANCE TO ALLOANTIGEN IN VIVO IN ANTI-CD4 TREATED RECIPIENTS1,2

1996 • 113 citations

CELLULAR CHANGES IN CULTURED MOUSE THYROID GLANDS AND ISLETS OF LANGERHANS

1980 • 105 citations

Anti-CD4 mediates clonal anergy during transplantation tolerance induction.

1991 • 104 citations

Distinct mechanisms for the induction and maintenance of allograft tolerance with CTLA4-Fc treatment.

1997 • 98 citations

INDEFINITE SURVIVAL OF MHC CLASS I-DEFICIENT MURINE PANCREATIC ISLET ALLOGRAFTS

1992 • 86 citations

DONOR-RECIPIENT MICROCHIMERISM IS NOT REQUIRED FOR TOLERANCE INDUCTION FOLLOWING RECIPIENT PRETREATMENT WITH DONOR-SPECIFIC TRANSFUSION AND ANTI-CD4 ANTIBODY

1995 • 86 citations

INDIRECT T CELL ALLORECOGNITION OF DONOR ANTIGENS CONTRIBUTES TO THE REJECTION OF VASCULARIZED KIDNEY ALLOGRAFTS

1995 • 74 citations

T cell recognition of donor major histocompatibility complex class Ipeptides during allograft rejection

1992 • 73 citations

BALANCING THE IMMUNE SYSTEM FOR TOLERANCE

1997 • 71 citations

Mechanisms maintaining enhancement of allografts. I. Demonstration of a specific suppressor cell.

1985 • 63 citations

CD8+ EFFECTOR CELLS RESPONDING TO RESIDUAL CLASS I ANTIGENS, WITH HELP FROM CD4+ CELLS STIMULATED INDIRECTLY, CAUSE REJECTION OF ???MAJOR HISTOCOMPATIBILITY COMPLEX-DEFICIENT??? SKIN GRAFTS1

1997 • 59 citations

CD4-positive suppressor cells block allotransplant rejection.

1995 • 53 citations

MECHANISMS OF INDIRECT ALLORECOGNITION IN GRAFT REJECTION

1996 • 53 citations

Mechanisms maintaining antibody-induced enhancement of allografts. II. Mediation of specific suppression by short lived CD4+ T cells.

1989 • 51 citations

DONOR ANTIGEN-PRESENTING CELL–INDEPENDENT REJECTION OF ISLET XENOGRAFTS

1995 • 47 citations

Reversal Diabetes by Islet Transplantation: Vulnerability of the Established Allograft

1981 • 44 citations

STIMULATION OF CD4+ T LYMPHOCYTES BY ALLOGENEIC MHC PEPTIDES PRESENTED ON AUTOLOGOUS ANTIGEN-PRESENTING CELLS

1992 • 43 citations

Pancreatic Islet Allograft Immunity and Tolerance: the Two‐Signal Hypothesis Revisited

1996 • 42 citations

In vivo and in vitro characterization of specific hyporeactivity to skin xenografts in mixed xenogeneically reconstituted mice (B10 + F344 rat----B10).

1984 • 41 citations

TOLERANCE INDUCTION TO CULTURED ISLET ALLOGRAFTS

1994 • 35 citations

EVIDENCE OF ALLOREACTIVE T SUPPRESSOR CELLS IN THE MAINTENANCE PHASE OF SPONTANEOUS TOLERANCE AFTER ORTHOTOPIC LIVER TRANSPLANTATION IN THE RAT

1994 • 34 citations

H-2 COMPLEX AND Ia ANTIGENS ON CELLS DISSOCIATED FROM MOUSE THYROID GLANDS AND ISLETS OF LANGERHANS

1980 • 32 citations

EVIDENCE OF ALLOREACTIVE T SUPPRESSOR CELLS IN THE MAINTENANCE PHASE OF SPONTANEOUS TOLERANCE AFTER ORTHOTOPIC LIVER TRANSPLANTATION IN THE RAT

1994 • 29 citations

ASSESSMENT OF DONOR BONE MARROW CELL-DERIVED CHIMERISM IN TRANSPLANTATION TOLERANCE USING TRANSGENIC MICE

1994 • 26 citations

T lymphocyte indifference to extrathymic islet allografts.

1996 • 24 citations

Tissue immunogenicity: the role of MHC antigen and the lymphocyte costimulator B7-1.

1996 • 22 citations

Studies on the two-signal model for T cell activation in vivo.

1987 • 21 citations

MEDIATION OF ANTIGEN-INDUCED SUPPRESSION OF RENAL ALLOGRAFT REJECTION BY A CD4 (W3/25+) T CELL

1989 • 21 citations

TRANSFER OF SENSITISED LYT 2⁺ CELLS TRIGGERS ACUTE REJECTION OF PANCREATIC ISLET ALLOGRAFTS

1983 • 20 citations

The Surface Concentration of H-2 Antigens on Mouse Pancreatic β-Cells and Islet Cell Transplantation

1982 • 15 citations

LACK OF COGNATE HELP BY CD4+ T CELLS AND ANERGY OF CD8+ T CELLS ARE THE PRINCIPAL MECHANISMS FOR ANTI-LEUKOCYTE FUNCTION-ASSOCIATED ANTIGEN-1/INTERCELLULAR ADHESION MOLECULE-1-INDUCED CARDIAC ALLOGRAFT TOLERANCE

1997 • 14 citations

TOLERANCE INDUCTION TO CULTURED ISLET ALLOGRAFTS

1994 • 14 citations

Stability of tolerance in mice generated by CD4 and CD8 monoclonal antibody treatment: cell transfer experiments.

1993 • 14 citations

EVIDENCE THAT ANTI-CD8 ABROGATES ANTI-CD4-MEDIATED CLONAL ANERGY BUT ALLOWS ALLOGRAFT SURVIVAL IN MICE

1993 • 12 citations

ABROGATION OF MOUSE PANCREATIC ISLET ALLOGRAFT REJECTION BY A FOUR-DAY CULTURE

1988 • 8 citations

Abrogation of mouse pancreatic islet allograft rejection by a four-day culture.

1988 • 8 citations

Tolerance Induction in Adult Animals

1986 • 7 citations

Sensitized Lyt-2+ T cells trigger rejection of grafts expressing class I major histocompatibility complex alloantigens.

1986 • 6 citations

Spontaneous tolerance induction in adult animals transplanted with allogeneic islets.

1988 • 3 citations