CD40-ligand (CD154) gene therapy for chronic lymphocytic leukemia

Cancer statistics, 1999

1999 • 3,154 citations

CD28/B7 SYSTEM OF T CELL COSTIMULATION

1996 • 2,726 citations

THE INTERLEUKIN-12/INTERLEUKIN-12-RECEPTOR SYSTEM: Role in Normal and Pathologic Immune Responses

1998 • 1,253 citations

Chronic lymphocytic leukemia B cells express restricted sets of mutated and unmutated antigen receptors.

1998 • 899 citations

Activated T cells induce expression of B7/BB1 on normal or leukemic B cells through a CD40-dependent signal.

1993 • 622 citations

CD28/B7 Costimulation: A Review

1998 • 447 citations

CD40 antibody evokes a cytotoxic T-cell response that eradicates lymphoma and bypasses T-cell help

1999 • 423 citations

B-Cell Chronic Lymphocytic Leukemia: A Bird of a Different Feather

1999 • 408 citations

Special Article: Chronic Lymphocytic Leukemia—an Accumulative Disease of Immunologically Incompetent Lymphocytes

1967 • 347 citations

CD40-CD40 Ligand: A Multifunctional Receptor-Ligand Pair

1996 • 326 citations

Gene transfer of CD40-ligand induces autologous immune recognition of chronic lymphocytic leukemia B cells.

1998 • 247 citations

Ig VH1 genes expressed in B cell chronic lymphocytic leukemia exhibit distinctive molecular features.

1997 • 230 citations

Autoimmunity in chronic lymphocytic leukaemia.

1986 • 222 citations

B-chronic lymphocytic leukemia: a malignancy of anti-self B cells

1996 • 212 citations

Acquired CD40-ligand deficiency in chronic lymphocytic leukemia

1997 • 206 citations

Expression of CD27 and its ligand, CD70, on chronic lymphocytic leukemia B cells

1995 • 155 citations

T lymphocyte T cell-B cell-activating molecule/CD40-L molecules induce normal B cells or chronic lymphocytic leukemia B cells to express CD80 (B7/BB-1) and enhance their costimulatory activity.

1994 • 149 citations

CD40 Ligand Induces an Antileukemia Immune Response In Vivo

1997 • 142 citations

B7-mediated costimulation and the immune response

1996 • 128 citations

Lack of Allelic Exclusion in B Cell Chronic Lymphocytic Leukemia

1997 • 108 citations

CD40 triggering of chronic lymphocytic leukemia B cells results in efficient alloantigen presentation and cytotoxic T lymphocyte induction by up-regulation of CD80 and CD86 costimulatory molecules

1997 • 106 citations

Adenovirus vector infection of chronic lymphocytic leukemia B cells

1996 • 91 citations

Spectrum and frequency of autoimmune derangements in lymphoproliferative disorders: analysis of 637 cases and comparison with myeloproliferative diseases

1987 • 90 citations

Tumor Necrosis Factor-α Facilitates Induction of CD80 (B7-1) and CD54 on Human B Cells by Activated T Cells: Complex Regulation by IL-4, IL-10, and CD40L

1995 • 79 citations

Karyotype Correlates With Peripheral Blood Morphology and Immunophenotype in Chronic Lymphocytic Leukemia

1996 • 67 citations

Serial phenotypic, cytogenetic and molecular genetic studies in Richter's syndrome: demonstration of lymphoma development from the chronic lymphocytic leukaemia cells

1993 • 30 citations

Single Institution Experience with Recombinant Gamma-Interferon in the Treatment of Patients with Metastatic Renal Cell Carcinoma

1996 • 18 citations

Autoimmunity and Immunodeficiency Disease

2007 • 10 citations